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Protein

Superoxide dismutase [Fe] 1, chloroplastic

Gene

FSD1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Fe cation1 PublicationNote: Binds 1 Fe cation per subunit.1 Publication

Enzyme regulationi

Activated by cpn20/cpn21.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi35IronBy similarity1
Metal bindingi87IronBy similarity1
Metal bindingi169IronBy similarity1
Metal bindingi173IronBy similarity1

GO - Molecular functioni

  • copper ion binding Source: TAIR
  • protein domain specific binding Source: CAFA
  • superoxide dismutase activity Source: TAIR

GO - Biological processi

  • circadian rhythm Source: TAIR
  • response to cadmium ion Source: TAIR
  • response to copper ion Source: TAIR
  • response to light intensity Source: UniProtKB
  • response to oxidative stress Source: TAIR
  • response to ozone Source: UniProtKB

Keywordsi

Molecular functionOxidoreductase
LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Fe] 1, chloroplastic (EC:1.15.1.1)
Alternative name(s):
Protein FE SUPEROXIDE DISMUTASE 1
Gene namesi
Name:FSD1
Synonyms:SODB
Ordered Locus Names:At4g25100
ORF Names:F13M23.240
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G25100
TAIRilocus:2117273 AT4G25100

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Chloroplast, Membrane, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000032889? – 212Superoxide dismutase [Fe] 1, chloroplastic
Initiator methionineiRemovedCombined sources
Transit peptidei2 – ?ChloroplastSequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP21276

PTM databases

iPTMnetiP21276

Expressioni

Inductioni

Circadian-regulation. Down-regulated upon photosynthetically active radiation (PAR) (e.g. light fluence) increase and in response to ozone fumigation.1 Publication

Gene expression databases

ExpressionAtlasiP21276 baseline and differential
GenevisibleiP21276 AT

Interactioni

Subunit structurei

Homodimer. Interacts with cpn20/cpn21.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CPN20O652822EBI-4466816,EBI-4435709

GO - Molecular functioni

  • protein domain specific binding Source: CAFA

Protein-protein interaction databases

BioGridi13900, 7 interactors
IntActiP21276, 2 interactors
STRINGi3702.AT4G25100.1

Structurei

3D structure databases

ProteinModelPortaliP21276
SMRiP21276
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0876 Eukaryota
COG0605 LUCA
HOGENOMiHOG000013584
InParanoidiP21276
KOiK04564
OMAiYIKYWEN
OrthoDBiEOG09360IDF
PhylomeDBiP21276

Family and domain databases

Gene3Di1.10.287.990, 1 hit
2.40.500.20, 1 hit
InterProiView protein in InterPro
IPR001189 Mn/Fe_SOD
IPR019833 Mn/Fe_SOD_BS
IPR019832 Mn/Fe_SOD_C
IPR019831 Mn/Fe_SOD_N
IPR036324 Mn/Fe_SOD_N_sf
IPR036314 SOD_C_sf
PfamiView protein in Pfam
PF02777 Sod_Fe_C, 1 hit
PF00081 Sod_Fe_N, 1 hit
PIRSFiPIRSF000349 SODismutase, 1 hit
PRINTSiPR01703 MNSODISMTASE
SUPFAMiSSF46609 SSF46609, 1 hit
SSF54719 SSF54719, 1 hit
PROSITEiView protein in PROSITE
PS00088 SOD_MN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: P21276-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASSAVTAN YVLKPPPFAL DALEPHMSKQ TLEFHWGKHH RAYVDNLKKQ
60 70 80 90 100
VLGTELEGKP LEHIIHSTYN NGDLLPAFNN AAQAWNHEFF WESMKPGGGG
110 120 130 140 150
KPSGELLALL ERDFTSYEKF YEEFNAAAAT QFGAGWAWLA YSNEKLKVVK
160 170 180 190 200
TPNAVNPLVL GSFPLLTIDV WEHAYYLDFQ NRRPDYIKTF MTNLVSWEAV
210
SARLEAAKAA SA
Length:212
Mass (Da):23,791
Last modified:December 15, 2003 - v4
Checksum:iBCFDA057F040F9DD
GO

Sequence cautioni

The sequence AAA32791 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAB36752 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB79419 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55910 mRNA Translation: AAA32791.1 Different initiation.
AL035523 Genomic DNA Translation: CAB36752.1 Sequence problems.
AL161562 Genomic DNA Translation: CAB79419.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE85007.1
CP002687 Genomic DNA Translation: AEE85008.1
CP002687 Genomic DNA Translation: AEE85009.1
CP002687 Genomic DNA Translation: AEE85011.1
AF326862 mRNA Translation: AAG41444.1
AF324711 mRNA Translation: AAG40062.1
AF339685 mRNA Translation: AAK00367.1
AY039560 mRNA Translation: AAK62615.1
AY129470 mRNA Translation: AAM91056.1
AY087220 mRNA Translation: AAM64776.1
PIRiB39267
G85289
T05531
RefSeqiNP_001190834.1, NM_001203905.1 [P21276-1]
NP_194240.1, NM_118642.2 [P21276-1]
NP_849440.1, NM_179109.3 [P21276-1]
NP_849441.1, NM_179110.2 [P21276-1]
UniGeneiAt.22638
At.47521
At.486

Genome annotation databases

EnsemblPlantsiAT4G25100.1; AT4G25100.1; AT4G25100 [P21276-1]
AT4G25100.2; AT4G25100.2; AT4G25100 [P21276-1]
AT4G25100.3; AT4G25100.3; AT4G25100 [P21276-1]
AT4G25100.5; AT4G25100.5; AT4G25100 [P21276-1]
GeneIDi828613
GrameneiAT4G25100.1; AT4G25100.1; AT4G25100 [P21276-1]
AT4G25100.2; AT4G25100.2; AT4G25100 [P21276-1]
AT4G25100.3; AT4G25100.3; AT4G25100 [P21276-1]
AT4G25100.5; AT4G25100.5; AT4G25100 [P21276-1]
KEGGiath:AT4G25100

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSODF1_ARATH
AccessioniPrimary (citable) accession number: P21276
Secondary accession number(s): Q9FE21, Q9SW16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: December 15, 2003
Last modified: April 25, 2018
This is version 159 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health