P21275 (BMP4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bone morphogenetic protein 4
Short name=BMP-4

Alternative name(s):
Bone morphogenetic protein 2B
Short name=BMP-2B

Gene names

Name:	Bmp4
Synonyms:	Bmp-4, Dvr-4

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	408 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. Ref.9 Ref.10 Ref.15
Subunit structure	Homodimer; disulfide-linked By similarity. Interacts with SOSTDC1, GREM2, RGMA, RGMB and RGMC. Part of a complex consisting of TWSG1 and CHRD. Interacts with the serine proteases, HTRA1 and HTRA3; the interaction with either inhibits BMP4-mediated signaling. The HTRA protease activity is required for this inhibition. Ref.7 Ref.8 Ref.9 Ref.10 Ref.11 Ref.12 Ref.13 Ref.14 Ref.16
Subcellular location	Secreted › extracellular space › extracellular matrix.
Sequence similarities	Belongs to the TGF-beta family.
Sequence caution	The sequence AAC37698.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Chondrogenesis Differentiation Osteogenesis
Cellular component	Extracellular matrix Secreted
Domain	Signal
Molecular function	Cytokine Developmental protein Growth factor
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	BMP signaling pathway involved in heart induction Inferred from sequence or structural similarity. Source: UniProtKB BMP signaling pathway involved in nephric duct formation Inferred from sequence or structural similarity. Source: UniProtKB BMP signaling pathway involved in renal system segmentation Inferred from mutant phenotype PubMed 17442697. Source: UniProtKB BMP signaling pathway involved in ureter morphogenesis Inferred from direct assay PubMed 17442697. Source: UniProtKB SMAD protein signal transduction Inferred from sequence or structural similarity. Source: UniProtKB activation of MAPKK activity Inferred from sequence or structural similarity. Source: UniProtKB anterior/posterior axis specification Inferred from genetic interaction PubMed 10964473. Source: MGI blood vessel endothelial cell proliferation involved in sprouting angiogenesis Inferred from sequence or structural similarity. Source: UniProtKB branching involved in prostate gland morphogenesis Inferred from mutant phenotype PubMed 11401393. Source: MGI branching involved in ureteric bud morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB bronchus development Inferred from sequence orthology PubMed 8674409. Source: MGI bud dilation involved in lung branching Inferred from sequence orthology PubMed 8674409. Source: MGI bud elongation involved in lung branching Inferred from direct assay PubMed 18367557. Source: MGI cardiac muscle cell differentiation Inferred from expression pattern PubMed 9857019. Source: UniProtKB cellular response to growth factor stimulus Inferred from direct assay PubMed 7848824. Source: MGI chondrocyte differentiation Inferred from mutant phenotype PubMed 20059955. Source: UniProtKB cloacal septation Inferred from expression pattern PubMed 17442697. Source: UniProtKB common-partner SMAD protein phosphorylation Inferred from sequence or structural similarity. Source: UniProtKB cranial suture morphogenesis Inferred from direct assay PubMed 9477322. Source: MGI deltoid tuberosity development Inferred from mutant phenotype PubMed 20059955. Source: UniProtKB dorsal/ventral neural tube patterning Inferred from direct assay PubMed 15218525. Source: MGI embryonic cranial skeleton morphogenesis Inferred from mutant phenotype PubMed 9268572. Source: MGI embryonic digit morphogenesis Inferred from genetic interaction PubMed 9268572. Source: MGI embryonic hindlimb morphogenesis Inferred from genetic interaction PubMed 10964473. Source: MGI embryonic skeletal joint morphogenesis Inferred from mutant phenotype PubMed 9664686. Source: MGI endochondral ossification Inferred from mutant phenotype PubMed 20059955. Source: UniProtKB epithelial cell proliferation involved in lung morphogenesis Inferred from sequence orthology PubMed 8674409. Source: MGI epithelial-mesenchymal cell signaling Inferred from direct assay PubMed 8104708. Source: MGI erythrocyte differentiation Inferred from direct assay PubMed 15591122. Source: MGI germ cell development Inferred from mutant phenotype PubMed 15289457. Source: MGI glomerular capillary formation Inferred from mutant phenotype PubMed 18272846. Source: UniProtKB glomerular visceral epithelial cell development Inferred from expression pattern PubMed 17442697. Source: UniProtKB inner ear receptor cell differentiation Inferred from genetic interaction PubMed 17555714. Source: MGI intermediate mesodermal cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB lens induction in camera-type eye Inferred from mutant phenotype PubMed 9851982. Source: MGI lung alveolus development Inferred from sequence orthology PubMed 8674409. Source: MGI lymphoid progenitor cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB macrophage differentiation Inferred from electronic annotation. Source: Compara mammary gland formation Inferred from mutant phenotype PubMed 17071745. Source: MGI mesenchymal cell differentiation involved in kidney development Inferred from mutant phenotype PubMed 17442697. Source: UniProtKB mesenchymal cell proliferation involved in ureter development Inferred from expression pattern PubMed 17442697. Source: UniProtKB mesenchymal cell proliferation involved in ureteric bud development Inferred from expression pattern PubMed 17442697. Source: UniProtKB mesenchymal to epithelial transition involved in metanephros morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB mesodermal cell fate determination Inferred from mutant phenotype PubMed 7657163. Source: MGI mesonephros development Inferred from sequence or structural similarity. Source: UniProtKB metanephric collecting duct development Inferred from mutant phenotype PubMed 17442697. Source: UniProtKB monocyte differentiation Inferred from electronic annotation. Source: Compara negative regulation of MAP kinase activity Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of T cell differentiation in thymus Inferred from electronic annotation. Source: Compara negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of branching involved in ureteric bud morphogenesis Inferred from direct assay PubMed 15634693. Source: UniProtKB negative regulation of cell proliferation involved in heart morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of chondrocyte differentiation Inferred from direct assay PubMed 17481601. Source: MGI negative regulation of epithelial cell proliferation Inferred from mutant phenotype PubMed 11401393. Source: MGI negative regulation of glomerular mesangial cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of glomerulus development Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of immature T cell proliferation in thymus Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of mesenchymal cell proliferation involved in ureter development Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of metanephric S-shaped body morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of metanephric comma-shaped body morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of mitosis Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of myoblast differentiation Inferred from electronic annotation. Source: Compara negative regulation of prostatic bud formation Inferred from direct assay PubMed 18393306. Source: MGI negative regulation of striated muscle tissue development Inferred from electronic annotation. Source: Compara negative regulation of thymocyte apoptotic process Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 9585504. Source: MGI neural tube closure Inferred from direct assay PubMed 19850029. Source: MGI neuron fate commitment Inferred from direct assay PubMed 17698011. Source: MGI odontogenesis of dentin-containing tooth Inferred from direct assay PubMed 15525533PubMed 16179481. Source: MGI osteoblast differentiation Inferred from sequence or structural similarity. Source: UniProtKB pituitary gland development Inferred from mutant phenotype PubMed 9806931. Source: MGI positive regulation of BMP signaling pathway Inferred from direct assay PubMed 20059955. Source: UniProtKB positive regulation of DNA-dependent DNA replication Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of ERK1 and ERK2 cascade Inferred from direct assay PubMed 18692041. Source: MGI positive regulation of SMAD protein import into nucleus Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of apoptotic process Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of bone mineralization Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of branching involved in lung morphogenesis Inferred from mutant phenotype PubMed 17350185. Source: UniProtKB positive regulation of cardiac muscle fiber development Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of cartilage development Inferred from sequence orthology PubMed 3201241. Source: MGI positive regulation of collagen biosynthetic process Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of endothelial cell differentiation Inferred from direct assay PubMed 20406889. Source: DFLAT positive regulation of endothelial cell migration Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of endothelial cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of kidney development Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of neuron differentiation Inferred from direct assay PubMed 9786991. Source: MGI positive regulation of osteoblast differentiation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of pathway-restricted SMAD protein phosphorylation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of smooth muscle cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 10391928PubMed 18692041PubMed 18776146PubMed 8104708PubMed 8769660PubMed 8898217PubMed 9477322PubMed 9501024. Source: MGI positive regulation of vascular endothelial growth factor receptor signaling pathway Traceable author statement PubMed 20406889. Source: DFLAT post-embryonic development Inferred from mutant phenotype PubMed 9268572. Source: MGI protein localization to nucleus Inferred from sequence or structural similarity. Source: UniProtKB pulmonary artery endothelial tube morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB regulation of branching involved in prostate gland morphogenesis Inferred from mutant phenotype PubMed 15772937. Source: MGI regulation of odontogenesis of dentin-containing tooth Inferred from genetic interaction PubMed 9244299. Source: MGI regulation of smooth muscle cell differentiation Inferred from direct assay PubMed 17881493. Source: MGI renal system process Inferred from mutant phenotype PubMed 9268572. Source: MGI secondary heart field specification Inferred from sequence or structural similarity. Source: UniProtKB smoothened signaling pathway Inferred from electronic annotation. Source: Compara specification of organ position Inferred from mutant phenotype PubMed 17071745. Source: MGI specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB steroid hormone mediated signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB telencephalon regionalization Inferred from direct assay PubMed 16855091. Source: MGI tendon cell differentiation Inferred from mutant phenotype PubMed 20059955. Source: UniProtKB trachea formation Inferred from mutant phenotype PubMed 18692041. Source: MGI type B pancreatic cell development Inferred from sequence or structural similarity. Source: UniProtKB ureter epithelial cell differentiation Inferred from mutant phenotype PubMed 17442697. Source: UniProtKB ureter smooth muscle cell differentiation Inferred from mutant phenotype PubMed 17442697. Source: UniProtKB
Cellular_component	extracellular space Inferred from direct assay PubMed 17481601. Source: MGI proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	BMP receptor binding Inferred from sequence or structural similarity. Source: UniProtKB chemoattractant activity Inferred from sequence or structural similarity. Source: UniProtKB heparin binding Inferred from direct assay PubMed 15381701. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Propeptide	20 – 292	273			PRO_0000033858
	Chain	293 – 408	116	Bone morphogenetic protein 4		PRO_0000033859
Amino acid modifications
	Glycosylation	144	1	N-linked (GlcNAc...) Potential
	Glycosylation	209	1	N-linked (GlcNAc...) Potential
	Glycosylation	350	1	N-linked (GlcNAc...) Potential
	Glycosylation	365	1	N-linked (GlcNAc...) Potential
	Disulfide bond	308 ↔ 373		By similarity
	Disulfide bond	337 ↔ 405		By similarity
	Disulfide bond	341 ↔ 407		By similarity
	Disulfide bond	372		Interchain By similarity
Experimental info
	Sequence conflict	407	1	C → S in BAA03555. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P21275 [UniParc]. Last modified February 1, 1994. Version 2. Checksum: 35053D844624EF9D	FASTA	408	46,497
	10 20 30 40 50 60 MIPGNRMLMV VLLCQVLLGG ASHASLIPET GKKKVAEIQG HAGGRRSGQS HELLRDFEAT 70 80 90 100 110 120 LLQMFGLRRR PQPSKSAVIP DYMRDLYRLQ SGEEEEEEQS QGTGLEYPER PASRANTVRS 130 140 150 160 170 180 FHHEEHLENI PGTSESSAFR FLFNLSSIPE NEVISSAELR LFREQVDQGP DWEQGFHRIN 190 200 210 220 230 240 IYEVMKPPAE MVPGHLITRL LDTRLVHHNV TRWETFDVSP AVLRWTREKQ PNYGLAIEVT 250 260 270 280 290 300 HLHQTRTHQG QHVRISRSLP QGSGDWAQLR PLLVTFGHDG RGHTLTRRRA KRSPKHHPQR 310 320 330 340 350 360 SRKKNKNCRR HSLYVDFSDV GWNDWIVAPP GYQAFYCHGD CPFPLADHLN STNHAIVQTL 370 380 390 400 VNSVNSSIPK ACCVPTELSA ISMLYLDEYD KVVLKNYQEM VVEGCGCR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of the mouse bone morphogenetic protein-4 (BMP-4) cDNA." Dickinson M.E., van der Meer-De Jong R., Hogan B.L.M. Submitted (OCT-1992) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Murine bone morphogenetic protein-4 gene: existence of multiple promoters and exons for the 5'-untranslated region." Kurihara T., Kitamura K., Takaoka K., Nakazato H. Biochem. Biophys. Res. Commun. 192:1049-1056(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Gene cloning and expression of a bone morphogenetic protein derived from a murine osteosarcoma." Takaoka K., Yoshikawa H., Hasimoto J., Masuhara K., Miyamoto S., Suzuki S., Ono K., Matsui M., Oikawa S., Tsuruoka N. Clin. Orthop. Relat. Res. 294:344-352(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The mouse bone morphogenetic protein-4 gene. Analysis of promoter utilization in fetal rat calvarial osteoblasts and regulation by COUP-TFI orphan receptor." Feng J.Q., Chen D., Cooney A.J., Tsai M., Harris M.A., Tsai S.Y., Feng M., Mundy G.R., Harris S.E. J. Biol. Chem. 270:28364-28373(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/Sv. Tissue: Liver.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C3H/He and FVB/N. Tissue: Colon, Osteoblast and Salivary gland.
[6]	"Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci." Dickinson M.E., Kobrin M.S., Silan C.M., Kingsley D.M., Justice M.J., Miller D.A., Ceci J.D., Lock L.F., Lee A., Buchberg A.M., Siracusa L.D., Lyons K.M., Derynck R., Hogan B.L.M., Copeland N.G., Jenkins N.A. Genomics 6:505-520(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 241-408.
[7]	"Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling." Scott I.C., Blitz I.L., Pappano W.N., Maas S.A., Cho K.W.Y., Greenspan D.S. Nature 410:475-478(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TWSG1 AND CHRD.
[8]	"Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot." Laurikkala J., Kassai Y., Pakkasjaervi L., Thesleff I., Itoh N. Dev. Biol. 264:91-105(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SOSTDC1.
[9]	"Developmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signaling." Tocharus J., Tsuchiya A., Kajikawa M., Ueta Y., Oka C., Kawaichi M. Dev. Growth Differ. 46:257-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH HTRA3, FUNCTION.
[10]	"HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins." Oka C., Tsujimoto R., Kajikawa M., Koshiba-Takeuchi K., Ina J., Yano M., Tsuchiya A., Ueta Y., Soma A., Kanda H., Matsumoto M., Kawaichi M. Development 131:1041-1053(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH HTRA1, FUNCTION.
[11]	"Protein related to DAN and cerberus is a bone morphogenetic protein antagonist that participates in ovarian paracrine regulation." Sudo S., Avsian-Kretchmer O., Wang L.S., Hsueh A.J. J. Biol. Chem. 279:23134-23141(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH GREM2.
[12]	"DRAGON, a bone morphogenetic protein co-receptor." Samad T.A., Rebbapragada A., Bell E., Zhang Y., Sidis Y., Jeong S.-J., Campagna J.A., Perusini S., Fabrizio D.A., Schneyer A.L., Lin H.Y., Brivanlou A.H., Attisano L., Woolf C.J. J. Biol. Chem. 280:14122-14129(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH RGMB.
[13]	"Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor." Babitt J.L., Zhang Y., Samad T.A., Xia Y., Tang J., Campagna J.A., Schneyer A.L., Woolf C.J., Lin H.Y. J. Biol. Chem. 280:29820-29827(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH RGMA.
[14]	"Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression." Babitt J.L., Huang F.W., Wrighting D.M., Xia Y., Sidis Y., Samad T.A., Campagna J.A., Chung R.T., Schneyer A.L., Woolf C.J., Andrews N.C., Lin H.Y. Nat. Genet. 38:531-539(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH RGMC.
[15]	"BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction." Hens J.R., Dann P., Zhang J.P., Harris S., Robinson G.W., Wysolmerski J. Development 134:1221-1230(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[16]	"Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4." Xia Y., Yu P.B., Sidis Y., Beppu H., Bloch K.D., Schneyer A.L., Lin H.Y. J. Biol. Chem. 282:18129-18140(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH RGMA.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X56848 mRNA. Translation: CAA40179.1. D14814 Genomic DNA. Translation: BAA03555.1. S65032 mRNA. Translation: AAB28021.1. L47480 Genomic DNA. Translation: AAC37698.1. Different initiation. BC013459 mRNA. Translation: AAH13459.1. BC034053 mRNA. Translation: AAH34053.1. BC052846 mRNA. Translation: AAH52846.1.
IPI	IPI00761842.
PIR	I49541. JH0801.
RefSeq	NP_031580.2. NM_007554.2.
UniGene	Mm.6813.
3D structure databases
ProteinModelPortal	P21275.
SMR	P21275. Positions 307-408.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000098242.
PTM databases
PhosphoSite	P21275.
Proteomic databases
PRIDE	P21275.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000074077; ENSMUSP00000073720; ENSMUSG00000021835. ENSMUST00000100676; ENSMUSP00000098242; ENSMUSG00000021835.
GeneID	12159.
KEGG	mmu:12159.
Organism-specific databases
CTD	652.
MGI	MGI:88180. Bmp4.
Phylogenomic databases
eggNOG	NOG243555.
HOGENOM	HOG000249478.
HOVERGEN	HBG004860.
InParanoid	P21275.
KO	K04662.
OMA	QGFHRIN.
OrthoDB	EOG4JT05K.
Gene expression databases
ArrayExpress	P21275.
Bgee	P21275.
CleanEx	MM_BMP4.
Genevestigator	P21275.
GermOnline	ENSMUSG00000021835. Mus musculus.
Family and domain databases
InterPro	IPR001839. TGF-b_C. IPR001111. TGF-b_N. IPR015615. TGF-beta-rel. IPR017948. TGFb_CS. [Graphical view]
PANTHER	PTHR11848. PTHR11848. 1 hit.
Pfam	PF00019. TGF_beta. 1 hit. PF00688. TGFb_propeptide. 1 hit. [Graphical view]
SMART	SM00204. TGFB. 1 hit. [Graphical view]
PROSITE	PS00250. TGF_BETA_1. 1 hit. PS51362. TGF_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	280503.
SOURCE	Search...

Entry information

Entry name

BMP4_MOUSE

Accession

Primary (citable) accession number: P21275

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
Last sequence update:	February 1, 1994
Last modified:	April 3, 2013
This is version 140 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program