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P21275

- BMP4_MOUSE

UniProt

P21275 - BMP4_MOUSE

Protein

Bone morphogenetic protein 4

Gene

Bmp4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 153 (01 Oct 2014)
      Sequence version 2 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction.3 Publications

    GO - Molecular functioni

    1. BMP receptor binding Source: UniProtKB
    2. chemoattractant activity Source: UniProtKB
    3. heparin binding Source: MGI
    4. protein binding Source: UniProtKB

    GO - Biological processi

    1. activation of MAPKK activity Source: UniProtKB
    2. anatomical structure formation involved in morphogenesis Source: MGI
    3. angiogenesis Source: MGI
    4. anterior/posterior axis specification Source: MGI
    5. blood vessel development Source: MGI
    6. blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: UniProtKB
    7. BMP signaling pathway Source: UniProtKB
    8. BMP signaling pathway involved in heart induction Source: UniProtKB
    9. BMP signaling pathway involved in nephric duct formation Source: UniProtKB
    10. BMP signaling pathway involved in renal system segmentation Source: UniProtKB
    11. BMP signaling pathway involved in ureter morphogenesis Source: UniProtKB
    12. bone development Source: MGI
    13. branching involved in prostate gland morphogenesis Source: MGI
    14. branching involved in ureteric bud morphogenesis Source: UniProtKB
    15. branching morphogenesis of an epithelial tube Source: UniProtKB
    16. bronchus development Source: MGI
    17. bud dilation involved in lung branching Source: MGI
    18. bud elongation involved in lung branching Source: MGI
    19. camera-type eye development Source: MGI
    20. camera-type eye morphogenesis Source: MGI
    21. cardiac muscle cell differentiation Source: UniProtKB
    22. cell fate commitment Source: MGI
    23. cellular response to growth factor stimulus Source: MGI
    24. chondrocyte differentiation Source: UniProtKB
    25. cloacal septation Source: UniProtKB
    26. common-partner SMAD protein phosphorylation Source: UniProtKB
    27. cranial suture morphogenesis Source: MGI
    28. deltoid tuberosity development Source: UniProtKB
    29. dorsal/ventral neural tube patterning Source: MGI
    30. embryonic cranial skeleton morphogenesis Source: MGI
    31. embryonic digit morphogenesis Source: MGI
    32. embryonic hindlimb morphogenesis Source: MGI
    33. embryonic limb morphogenesis Source: MGI
    34. embryonic morphogenesis Source: MGI
    35. embryonic skeletal joint morphogenesis Source: MGI
    36. embryonic skeletal system development Source: MGI
    37. embryonic skeletal system morphogenesis Source: MGI
    38. endochondral ossification Source: UniProtKB
    39. epithelial cell proliferation involved in lung morphogenesis Source: MGI
    40. epithelial-mesenchymal cell signaling Source: MGI
    41. epithelial tube branching involved in lung morphogenesis Source: MGI
    42. epithelium development Source: MGI
    43. erythrocyte differentiation Source: MGI
    44. forebrain development Source: MGI
    45. germ cell development Source: MGI
    46. glomerular capillary formation Source: UniProtKB
    47. glomerular visceral epithelial cell development Source: UniProtKB
    48. heart development Source: MGI
    49. hematopoietic progenitor cell differentiation Source: UniProtKB
    50. inner ear receptor cell differentiation Source: MGI
    51. intermediate mesodermal cell differentiation Source: UniProtKB
    52. kidney development Source: UniProtKB
    53. lens induction in camera-type eye Source: MGI
    54. lung alveolus development Source: MGI
    55. lung development Source: MGI
    56. lung morphogenesis Source: MGI
    57. lymphoid progenitor cell differentiation Source: UniProtKB
    58. macrophage differentiation Source: Ensembl
    59. mammary gland formation Source: MGI
    60. mesenchymal cell differentiation involved in kidney development Source: UniProtKB
    61. mesenchymal cell differentiation involved in renal system development Source: UniProtKB
    62. mesenchymal cell proliferation involved in ureter development Source: UniProtKB
    63. mesenchymal cell proliferation involved in ureteric bud development Source: UniProtKB
    64. mesenchymal to epithelial transition involved in metanephros morphogenesis Source: UniProtKB
    65. mesodermal cell differentiation Source: MGI
    66. mesodermal cell fate determination Source: MGI
    67. mesoderm formation Source: MGI
    68. mesonephros development Source: UniProtKB
    69. metanephric collecting duct development Source: UniProtKB
    70. metanephros development Source: MGI
    71. monocyte differentiation Source: Ensembl
    72. negative regulation of apoptotic process Source: UniProtKB
    73. negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway Source: UniProtKB
    74. negative regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
    75. negative regulation of cell cycle Source: UniProtKB
    76. negative regulation of cell death Source: UniProtKB
    77. negative regulation of cell proliferation Source: MGI
    78. negative regulation of cell proliferation involved in heart morphogenesis Source: UniProtKB
    79. negative regulation of chondrocyte differentiation Source: MGI
    80. negative regulation of epithelial cell proliferation Source: MGI
    81. negative regulation of gene expression Source: MGI
    82. negative regulation of glomerular mesangial cell proliferation Source: UniProtKB
    83. negative regulation of glomerulus development Source: UniProtKB
    84. negative regulation of immature T cell proliferation in thymus Source: UniProtKB
    85. negative regulation of MAP kinase activity Source: UniProtKB
    86. negative regulation of mesenchymal cell proliferation involved in ureter development Source: UniProtKB
    87. negative regulation of metanephric comma-shaped body morphogenesis Source: UniProtKB
    88. negative regulation of metanephric S-shaped body morphogenesis Source: UniProtKB
    89. negative regulation of mitosis Source: UniProtKB
    90. negative regulation of myoblast differentiation Source: Ensembl
    91. negative regulation of phosphorylation Source: UniProtKB
    92. negative regulation of prostatic bud formation Source: MGI
    93. negative regulation of striated muscle tissue development Source: Ensembl
    94. negative regulation of T cell differentiation in thymus Source: Ensembl
    95. negative regulation of thymocyte apoptotic process Source: UniProtKB
    96. negative regulation of transcription, DNA-templated Source: UniProtKB
    97. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    98. neural tube closure Source: MGI
    99. neuron fate commitment Source: MGI
    100. odontogenesis Source: UniProtKB
    101. odontogenesis of dentin-containing tooth Source: MGI
    102. organ induction Source: MGI
    103. osteoblast differentiation Source: UniProtKB
    104. pituitary gland development Source: MGI
    105. positive chemotaxis Source: UniProtKB
    106. positive regulation of apoptotic process Source: UniProtKB
    107. positive regulation of BMP signaling pathway Source: UniProtKB
    108. positive regulation of bone mineralization Source: UniProtKB
    109. positive regulation of branching involved in lung morphogenesis Source: UniProtKB
    110. positive regulation of cardiac muscle fiber development Source: UniProtKB
    111. positive regulation of cartilage development Source: MGI
    112. positive regulation of cell death Source: MGI
    113. positive regulation of cell differentiation Source: MGI
    114. positive regulation of cell proliferation Source: MGI
    115. positive regulation of collagen biosynthetic process Source: UniProtKB
    116. positive regulation of DNA-dependent DNA replication Source: UniProtKB
    117. positive regulation of endothelial cell differentiation Source: DFLAT
    118. positive regulation of endothelial cell migration Source: UniProtKB
    119. positive regulation of endothelial cell proliferation Source: UniProtKB
    120. positive regulation of epidermal cell differentiation Source: UniProt
    121. positive regulation of epithelial cell proliferation Source: BHF-UCL
    122. positive regulation of ERK1 and ERK2 cascade Source: MGI
    123. positive regulation of gene expression Source: MGI
    124. positive regulation of kidney development Source: UniProtKB
    125. positive regulation of neuron differentiation Source: MGI
    126. positive regulation of ossification Source: MGI
    127. positive regulation of osteoblast differentiation Source: UniProtKB
    128. positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
    129. positive regulation of protein binding Source: MGI
    130. positive regulation of protein phosphorylation Source: MGI
    131. positive regulation of SMAD protein import into nucleus Source: UniProtKB
    132. positive regulation of smooth muscle cell proliferation Source: UniProtKB
    133. positive regulation of transcription, DNA-templated Source: UniProtKB
    134. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    135. positive regulation of vascular endothelial growth factor receptor signaling pathway Source: DFLAT
    136. post-embryonic development Source: MGI
    137. prostate gland morphogenesis Source: MGI
    138. protein localization to nucleus Source: UniProtKB
    139. pulmonary artery endothelial tube morphogenesis Source: UniProtKB
    140. regulation of branching involved in prostate gland morphogenesis Source: MGI
    141. regulation of cartilage development Source: MGI
    142. regulation of cell differentiation Source: MGI
    143. regulation of cell fate commitment Source: UniProt
    144. regulation of endothelial cell proliferation Source: DFLAT
    145. regulation of gene expression Source: MGI
    146. regulation of morphogenesis of a branching structure Source: MGI
    147. regulation of odontogenesis of dentin-containing tooth Source: MGI
    148. regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
    149. regulation of smooth muscle cell differentiation Source: MGI
    150. regulation of smooth muscle cell proliferation Source: MGI
    151. renal system development Source: MGI
    152. renal system process Source: MGI
    153. secondary heart field specification Source: UniProtKB
    154. skeletal system development Source: MGI
    155. SMAD protein signal transduction Source: UniProtKB
    156. smoothened signaling pathway Source: Ensembl
    157. smooth muscle cell differentiation Source: MGI
    158. smooth muscle tissue development Source: UniProtKB
    159. specification of organ position Source: MGI
    160. specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway Source: UniProtKB
    161. steroid hormone mediated signaling pathway Source: UniProtKB
    162. telencephalon development Source: MGI
    163. telencephalon regionalization Source: MGI
    164. tendon cell differentiation Source: UniProtKB
    165. tissue development Source: MGI
    166. trachea development Source: MGI
    167. trachea formation Source: MGI
    168. type B pancreatic cell development Source: UniProtKB
    169. ureter epithelial cell differentiation Source: UniProtKB
    170. ureteric bud development Source: MGI
    171. ureter smooth muscle cell differentiation Source: UniProtKB
    172. vasculature development Source: MGI

    Keywords - Molecular functioni

    Cytokine, Developmental protein, Growth factor

    Keywords - Biological processi

    Chondrogenesis, Differentiation, Osteogenesis

    Enzyme and pathway databases

    ReactomeiREACT_198998. Molecules associated with elastic fibres.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bone morphogenetic protein 4
    Short name:
    BMP-4
    Alternative name(s):
    Bone morphogenetic protein 2B
    Short name:
    BMP-2B
    Gene namesi
    Name:Bmp4
    Synonyms:Bmp-4, Dvr-4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:88180. Bmp4.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: MGI
    2. extracellular space Source: MGI
    3. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Propeptidei20 – 292273PRO_0000033858Add
    BLAST
    Chaini293 – 408116Bone morphogenetic protein 4PRO_0000033859Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi308 ↔ 373By similarity
    Disulfide bondi337 ↔ 405By similarity
    Disulfide bondi341 ↔ 407By similarity
    Glycosylationi350 – 3501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi365 – 3651N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi372 – 372InterchainBy similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP21275.

    PTM databases

    PhosphoSiteiP21275.

    Expressioni

    Gene expression databases

    ArrayExpressiP21275.
    BgeeiP21275.
    CleanExiMM_BMP4.
    GenevestigatoriP21275.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked By similarity. Interacts with SOSTDC1, GREM2, RGMA, RGMB and RGMC. Part of a complex consisting of TWSG1 and CHRD. Interacts with the serine proteases, HTRA1 and HTRA3; the interaction with either inhibits BMP4-mediated signaling. The HTRA protease activity is required for this inhibition.By similarity9 Publications

    Protein-protein interaction databases

    BioGridi198364. 3 interactions.
    STRINGi10090.ENSMUSP00000098242.

    Structurei

    3D structure databases

    ProteinModelPortaliP21275.
    SMRiP21275. Positions 307-408.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG243555.
    HOGENOMiHOG000249478.
    HOVERGENiHBG004860.
    InParanoidiP21275.
    KOiK04662.
    OMAiGFHHEEH.
    OrthoDBiEOG7WHH9D.
    PhylomeDBiP21275.
    TreeFamiTF351789.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view]
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P21275-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIPGNRMLMV VLLCQVLLGG ASHASLIPET GKKKVAEIQG HAGGRRSGQS    50
    HELLRDFEAT LLQMFGLRRR PQPSKSAVIP DYMRDLYRLQ SGEEEEEEQS 100
    QGTGLEYPER PASRANTVRS FHHEEHLENI PGTSESSAFR FLFNLSSIPE 150
    NEVISSAELR LFREQVDQGP DWEQGFHRIN IYEVMKPPAE MVPGHLITRL 200
    LDTRLVHHNV TRWETFDVSP AVLRWTREKQ PNYGLAIEVT HLHQTRTHQG 250
    QHVRISRSLP QGSGDWAQLR PLLVTFGHDG RGHTLTRRRA KRSPKHHPQR 300
    SRKKNKNCRR HSLYVDFSDV GWNDWIVAPP GYQAFYCHGD CPFPLADHLN 350
    STNHAIVQTL VNSVNSSIPK ACCVPTELSA ISMLYLDEYD KVVLKNYQEM 400
    VVEGCGCR 408
    Length:408
    Mass (Da):46,497
    Last modified:February 1, 1994 - v2
    Checksum:i35053D844624EF9D
    GO

    Sequence cautioni

    The sequence AAC37698.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti407 – 4071C → S in BAA03555. (PubMed:8507180)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56848 mRNA. Translation: CAA40179.1.
    D14814 Genomic DNA. Translation: BAA03555.1.
    S65032 mRNA. Translation: AAB28021.1.
    L47480 Genomic DNA. Translation: AAC37698.1. Different initiation.
    BC013459 mRNA. Translation: AAH13459.1.
    BC034053 mRNA. Translation: AAH34053.1.
    BC052846 mRNA. Translation: AAH52846.1.
    CCDSiCCDS36897.1.
    PIRiI49541.
    JH0801.
    RefSeqiNP_031580.2. NM_007554.2.
    XP_006518530.1. XM_006518467.1.
    XP_006518531.1. XM_006518468.1.
    UniGeneiMm.6813.

    Genome annotation databases

    EnsembliENSMUST00000074077; ENSMUSP00000073720; ENSMUSG00000021835.
    ENSMUST00000100676; ENSMUSP00000098242; ENSMUSG00000021835.
    GeneIDi12159.
    KEGGimmu:12159.
    UCSCiuc007thd.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56848 mRNA. Translation: CAA40179.1 .
    D14814 Genomic DNA. Translation: BAA03555.1 .
    S65032 mRNA. Translation: AAB28021.1 .
    L47480 Genomic DNA. Translation: AAC37698.1 . Different initiation.
    BC013459 mRNA. Translation: AAH13459.1 .
    BC034053 mRNA. Translation: AAH34053.1 .
    BC052846 mRNA. Translation: AAH52846.1 .
    CCDSi CCDS36897.1.
    PIRi I49541.
    JH0801.
    RefSeqi NP_031580.2. NM_007554.2.
    XP_006518530.1. XM_006518467.1.
    XP_006518531.1. XM_006518468.1.
    UniGenei Mm.6813.

    3D structure databases

    ProteinModelPortali P21275.
    SMRi P21275. Positions 307-408.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198364. 3 interactions.
    STRINGi 10090.ENSMUSP00000098242.

    Chemistry

    ChEMBLi CHEMBL2384894.

    PTM databases

    PhosphoSitei P21275.

    Proteomic databases

    PRIDEi P21275.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000074077 ; ENSMUSP00000073720 ; ENSMUSG00000021835 .
    ENSMUST00000100676 ; ENSMUSP00000098242 ; ENSMUSG00000021835 .
    GeneIDi 12159.
    KEGGi mmu:12159.
    UCSCi uc007thd.2. mouse.

    Organism-specific databases

    CTDi 652.
    MGIi MGI:88180. Bmp4.

    Phylogenomic databases

    eggNOGi NOG243555.
    HOGENOMi HOG000249478.
    HOVERGENi HBG004860.
    InParanoidi P21275.
    KOi K04662.
    OMAi GFHHEEH.
    OrthoDBi EOG7WHH9D.
    PhylomeDBi P21275.
    TreeFami TF351789.

    Enzyme and pathway databases

    Reactomei REACT_198998. Molecules associated with elastic fibres.

    Miscellaneous databases

    NextBioi 280503.
    PROi P21275.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P21275.
    Bgeei P21275.
    CleanExi MM_BMP4.
    Genevestigatori P21275.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view ]
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the mouse bone morphogenetic protein-4 (BMP-4) cDNA."
      Dickinson M.E., van der Meer-De Jong R., Hogan B.L.M.
      Submitted (OCT-1992) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Murine bone morphogenetic protein-4 gene: existence of multiple promoters and exons for the 5'-untranslated region."
      Kurihara T., Kitamura K., Takaoka K., Nakazato H.
      Biochem. Biophys. Res. Commun. 192:1049-1056(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Gene cloning and expression of a bone morphogenetic protein derived from a murine osteosarcoma."
      Takaoka K., Yoshikawa H., Hasimoto J., Masuhara K., Miyamoto S., Suzuki S., Ono K., Matsui M., Oikawa S., Tsuruoka N.
      Clin. Orthop. Relat. Res. 294:344-352(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The mouse bone morphogenetic protein-4 gene. Analysis of promoter utilization in fetal rat calvarial osteoblasts and regulation by COUP-TFI orphan receptor."
      Feng J.Q., Chen D., Cooney A.J., Tsai M., Harris M.A., Tsai S.Y., Feng M., Mundy G.R., Harris S.E.
      J. Biol. Chem. 270:28364-28373(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
      Tissue: Liver.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C3H/He and FVB/N.
      Tissue: Colon, Osteoblast and Salivary gland.
    6. "Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci."
      Dickinson M.E., Kobrin M.S., Silan C.M., Kingsley D.M., Justice M.J., Miller D.A., Ceci J.D., Lock L.F., Lee A., Buchberg A.M., Siracusa L.D., Lyons K.M., Derynck R., Hogan B.L.M., Copeland N.G., Jenkins N.A.
      Genomics 6:505-520(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 241-408.
    7. "Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling."
      Scott I.C., Blitz I.L., Pappano W.N., Maas S.A., Cho K.W.Y., Greenspan D.S.
      Nature 410:475-478(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TWSG1 AND CHRD.
    8. "Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot."
      Laurikkala J., Kassai Y., Pakkasjaervi L., Thesleff I., Itoh N.
      Dev. Biol. 264:91-105(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SOSTDC1.
    9. "Developmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signaling."
      Tocharus J., Tsuchiya A., Kajikawa M., Ueta Y., Oka C., Kawaichi M.
      Dev. Growth Differ. 46:257-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HTRA3, FUNCTION.
    10. Cited for: INTERACTION WITH HTRA1, FUNCTION.
    11. "Protein related to DAN and cerberus is a bone morphogenetic protein antagonist that participates in ovarian paracrine regulation."
      Sudo S., Avsian-Kretchmer O., Wang L.S., Hsueh A.J.
      J. Biol. Chem. 279:23134-23141(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GREM2.
    12. Cited for: INTERACTION WITH RGMB.
    13. "Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor."
      Babitt J.L., Zhang Y., Samad T.A., Xia Y., Tang J., Campagna J.A., Schneyer A.L., Woolf C.J., Lin H.Y.
      J. Biol. Chem. 280:29820-29827(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RGMA.
    14. Cited for: INTERACTION WITH RGMC.
    15. "BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction."
      Hens J.R., Dann P., Zhang J.P., Harris S., Robinson G.W., Wysolmerski J.
      Development 134:1221-1230(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    16. "Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4."
      Xia Y., Yu P.B., Sidis Y., Beppu H., Bloch K.D., Schneyer A.L., Lin H.Y.
      J. Biol. Chem. 282:18129-18140(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RGMA.

    Entry informationi

    Entry nameiBMP4_MOUSE
    AccessioniPrimary (citable) accession number: P21275
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 153 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3