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Protein

Bone morphogenetic protein 4

Gene

Bmp4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction.3 Publications

GO - Molecular functioni

GO - Biological processi

  • activation of MAPKK activity Source: UniProtKB
  • anatomical structure formation involved in morphogenesis Source: MGI
  • anatomical structure regression Source: Ensembl
  • angiogenesis Source: MGI
  • anterior/posterior axis specification Source: MGI
  • blood vessel development Source: MGI
  • blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: UniProtKB
  • BMP signaling pathway Source: UniProtKB
  • BMP signaling pathway involved in heart induction Source: UniProtKB
  • BMP signaling pathway involved in nephric duct formation Source: UniProtKB
  • BMP signaling pathway involved in renal system segmentation Source: UniProtKB
  • BMP signaling pathway involved in ureter morphogenesis Source: UniProtKB
  • bone development Source: MGI
  • branching involved in prostate gland morphogenesis Source: MGI
  • branching involved in ureteric bud morphogenesis Source: UniProtKB
  • branching morphogenesis of an epithelial tube Source: UniProtKB
  • bronchus development Source: MGI
  • bud dilation involved in lung branching Source: MGI
  • bud elongation involved in lung branching Source: MGI
  • camera-type eye development Source: MGI
  • camera-type eye morphogenesis Source: MGI
  • cardiac muscle cell differentiation Source: UniProtKB
  • cell fate commitment Source: MGI
  • cellular response to BMP stimulus Source: Ensembl
  • cellular response to growth factor stimulus Source: MGI
  • cellular response to mechanical stimulus Source: Ensembl
  • cellular response to oxidative stress Source: Ensembl
  • cellular response to thyroid hormone stimulus Source: Ensembl
  • chondrocyte differentiation Source: UniProtKB
  • cloacal septation Source: UniProtKB
  • common-partner SMAD protein phosphorylation Source: UniProtKB
  • cranial suture morphogenesis Source: MGI
  • deltoid tuberosity development Source: UniProtKB
  • dorsal/ventral neural tube patterning Source: MGI
  • embryonic cranial skeleton morphogenesis Source: MGI
  • embryonic digit morphogenesis Source: MGI
  • embryonic hindlimb morphogenesis Source: MGI
  • embryonic limb morphogenesis Source: MGI
  • embryonic morphogenesis Source: MGI
  • embryonic skeletal joint morphogenesis Source: MGI
  • embryonic skeletal system development Source: MGI
  • embryonic skeletal system morphogenesis Source: MGI
  • endochondral ossification Source: UniProtKB
  • epithelial cell proliferation involved in lung morphogenesis Source: MGI
  • epithelial-mesenchymal cell signaling Source: MGI
  • epithelial tube branching involved in lung morphogenesis Source: MGI
  • epithelium development Source: MGI
  • erythrocyte differentiation Source: MGI
  • forebrain development Source: MGI
  • germ cell development Source: MGI
  • glomerular capillary formation Source: UniProtKB
  • glomerular visceral epithelial cell development Source: UniProtKB
  • heart development Source: MGI
  • hematopoietic progenitor cell differentiation Source: UniProtKB
  • inner ear receptor cell differentiation Source: MGI
  • intermediate mesodermal cell differentiation Source: UniProtKB
  • kidney development Source: UniProtKB
  • lens induction in camera-type eye Source: MGI
  • lung alveolus development Source: MGI
  • lung development Source: MGI
  • lung lobe development Source: Ensembl
  • lung morphogenesis Source: MGI
  • lymphoid progenitor cell differentiation Source: UniProtKB
  • macrophage differentiation Source: MGI
  • mammary gland formation Source: MGI
  • mesenchymal cell differentiation involved in kidney development Source: UniProtKB
  • mesenchymal cell differentiation involved in renal system development Source: UniProtKB
  • mesenchymal cell proliferation involved in ureter development Source: UniProtKB
  • mesenchymal cell proliferation involved in ureteric bud development Source: UniProtKB
  • mesenchymal to epithelial transition involved in metanephros morphogenesis Source: UniProtKB
  • mesodermal cell differentiation Source: MGI
  • mesodermal cell fate determination Source: MGI
  • mesoderm formation Source: MGI
  • mesonephros development Source: UniProtKB
  • metanephric collecting duct development Source: UniProtKB
  • metanephros development Source: MGI
  • monocyte differentiation Source: MGI
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway Source: UniProtKB
  • negative regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
  • negative regulation of cell cycle Source: UniProtKB
  • negative regulation of cell death Source: UniProtKB
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of cell proliferation involved in heart morphogenesis Source: UniProtKB
  • negative regulation of chondrocyte differentiation Source: MGI
  • negative regulation of epithelial cell proliferation Source: MGI
  • negative regulation of gene expression Source: MGI
  • negative regulation of glomerular mesangial cell proliferation Source: UniProtKB
  • negative regulation of glomerulus development Source: UniProtKB
  • negative regulation of immature T cell proliferation in thymus Source: UniProtKB
  • negative regulation of MAP kinase activity Source: UniProtKB
  • negative regulation of mesenchymal cell proliferation involved in ureter development Source: UniProtKB
  • negative regulation of metanephric comma-shaped body morphogenesis Source: UniProtKB
  • negative regulation of metanephric S-shaped body morphogenesis Source: UniProtKB
  • negative regulation of mitotic nuclear division Source: UniProtKB
  • negative regulation of myoblast differentiation Source: MGI
  • negative regulation of oligodendrocyte differentiation Source: Ensembl
  • negative regulation of phosphorylation Source: UniProtKB
  • negative regulation of prostatic bud formation Source: MGI
  • negative regulation of striated muscle tissue development Source: MGI
  • negative regulation of T cell differentiation in thymus Source: MGI
  • negative regulation of thymocyte apoptotic process Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • neural tube closure Source: MGI
  • neuron fate commitment Source: MGI
  • odontogenesis Source: UniProtKB
  • odontogenesis of dentin-containing tooth Source: MGI
  • organ induction Source: MGI
  • osteoblast differentiation Source: UniProtKB
  • ovarian follicle development Source: Ensembl
  • pituitary gland development Source: MGI
  • positive chemotaxis Source: UniProtKB
  • positive regulation of apoptotic process Source: UniProtKB
  • positive regulation of BMP signaling pathway Source: UniProtKB
  • positive regulation of bone mineralization Source: UniProtKB
  • positive regulation of branching involved in lung morphogenesis Source: UniProtKB
  • positive regulation of calcium ion transport into cytosol Source: Ensembl
  • positive regulation of cardiac muscle fiber development Source: UniProtKB
  • positive regulation of cartilage development Source: MGI
  • positive regulation of cell death Source: MGI
  • positive regulation of cell differentiation Source: MGI
  • positive regulation of cell migration Source: CACAO
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of collagen biosynthetic process Source: UniProtKB
  • positive regulation of DNA-dependent DNA replication Source: UniProtKB
  • positive regulation of endothelial cell apoptotic process Source: Ensembl
  • positive regulation of endothelial cell differentiation Source: DFLAT
  • positive regulation of endothelial cell migration Source: UniProtKB
  • positive regulation of endothelial cell proliferation Source: UniProtKB
  • positive regulation of epidermal cell differentiation Source: UniProtKB
  • positive regulation of epithelial cell proliferation Source: BHF-UCL
  • positive regulation of ERK1 and ERK2 cascade Source: MGI
  • positive regulation of gene expression Source: CACAO
  • positive regulation of hepatocyte differentiation Source: Ensembl
  • positive regulation of kidney development Source: UniProtKB
  • positive regulation of mesenchymal stem cell proliferation Source: Ensembl
  • positive regulation of neuron differentiation Source: MGI
  • positive regulation of neuron projection development Source: Ensembl
  • positive regulation of ossification Source: MGI
  • positive regulation of osteoblast differentiation Source: UniProtKB
  • positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
  • positive regulation of protein binding Source: MGI
  • positive regulation of protein phosphorylation Source: MGI
  • positive regulation of SMAD protein import into nucleus Source: UniProtKB
  • positive regulation of smooth muscle cell proliferation Source: UniProtKB
  • positive regulation of store-operated calcium channel activity Source: Ensembl
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • positive regulation of vascular endothelial growth factor receptor signaling pathway Source: DFLAT
  • post-embryonic development Source: MGI
  • prostate gland morphogenesis Source: MGI
  • protein localization to nucleus Source: UniProtKB
  • pulmonary artery endothelial tube morphogenesis Source: UniProtKB
  • regulation of branching involved in prostate gland morphogenesis Source: MGI
  • regulation of cartilage development Source: MGI
  • regulation of cell differentiation Source: MGI
  • regulation of cell fate commitment Source: UniProtKB
  • regulation of endothelial cell proliferation Source: DFLAT
  • regulation of gene expression Source: MGI
  • regulation of morphogenesis of a branching structure Source: MGI
  • regulation of odontogenesis of dentin-containing tooth Source: MGI
  • regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
  • regulation of protein import into nucleus Source: MGI
  • regulation of smooth muscle cell differentiation Source: MGI
  • regulation of smooth muscle cell proliferation Source: MGI
  • renal system development Source: MGI
  • renal system process Source: MGI
  • response to estradiol Source: Ensembl
  • response to glucocorticoid Source: Ensembl
  • response to nitric oxide Source: Ensembl
  • response to retinoic acid Source: Ensembl
  • response to testosterone Source: Ensembl
  • secondary heart field specification Source: UniProtKB
  • skeletal system development Source: MGI
  • SMAD protein signal transduction Source: UniProtKB
  • smoothened signaling pathway Source: Ensembl
  • smooth muscle cell differentiation Source: MGI
  • smooth muscle tissue development Source: UniProtKB
  • specification of organ position Source: MGI
  • specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway Source: UniProtKB
  • steroid hormone mediated signaling pathway Source: UniProtKB
  • telencephalon development Source: MGI
  • telencephalon regionalization Source: MGI
  • tendon cell differentiation Source: UniProtKB
  • tissue development Source: MGI
  • tongue morphogenesis Source: Ensembl
  • trachea development Source: MGI
  • trachea formation Source: MGI
  • type B pancreatic cell development Source: UniProtKB
  • ureter epithelial cell differentiation Source: UniProtKB
  • ureteric bud development Source: MGI
  • ureter smooth muscle cell differentiation Source: UniProtKB
  • vasculature development Source: MGI
  • wound healing Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Enzyme and pathway databases

ReactomeiREACT_332220. Molecules associated with elastic fibres.

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 4
Short name:
BMP-4
Alternative name(s):
Bone morphogenetic protein 2B
Short name:
BMP-2B
Gene namesi
Name:Bmp4
Synonyms:Bmp-4, Dvr-4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:88180. Bmp4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: Ensembl
  • extracellular region Source: MGI
  • extracellular space Source: MGI
  • membrane-bounded vesicle Source: Ensembl
  • proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Propeptidei20 – 292273PRO_0000033858Add
BLAST
Chaini293 – 408116Bone morphogenetic protein 4PRO_0000033859Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi308 ↔ 373By similarity
Disulfide bondi337 ↔ 405By similarity
Disulfide bondi341 ↔ 407By similarity
Glycosylationi350 – 3501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi365 – 3651N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi372 – 372InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP21275.
PRIDEiP21275.

PTM databases

PhosphoSiteiP21275.

Expressioni

Gene expression databases

BgeeiP21275.
CleanExiMM_BMP4.
ExpressionAtlasiP21275. baseline and differential.
GenevisibleiP21275. MM.

Interactioni

Subunit structurei

Homodimer; disulfide-linked (By similarity). Interacts with SOSTDC1, GREM2, RGMA, RGMB and RGMC. Part of a complex consisting of TWSG1 and CHRD. Interacts with the serine proteases, HTRA1 and HTRA3; the interaction with either inhibits BMP4-mediated signaling. The HTRA protease activity is required for this inhibition.By similarity9 Publications

Protein-protein interaction databases

BioGridi198364. 3 interactions.
STRINGi10090.ENSMUSP00000073720.

Structurei

3D structure databases

ProteinModelPortaliP21275.
SMRiP21275. Positions 307-408.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG243555.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249478.
HOVERGENiHBG004860.
InParanoidiP21275.
KOiK04662.
OMAiATLLHMF.
OrthoDBiEOG7WHH9D.
PhylomeDBiP21275.
TreeFamiTF351789.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21275-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPGNRMLMV VLLCQVLLGG ASHASLIPET GKKKVAEIQG HAGGRRSGQS
60 70 80 90 100
HELLRDFEAT LLQMFGLRRR PQPSKSAVIP DYMRDLYRLQ SGEEEEEEQS
110 120 130 140 150
QGTGLEYPER PASRANTVRS FHHEEHLENI PGTSESSAFR FLFNLSSIPE
160 170 180 190 200
NEVISSAELR LFREQVDQGP DWEQGFHRIN IYEVMKPPAE MVPGHLITRL
210 220 230 240 250
LDTRLVHHNV TRWETFDVSP AVLRWTREKQ PNYGLAIEVT HLHQTRTHQG
260 270 280 290 300
QHVRISRSLP QGSGDWAQLR PLLVTFGHDG RGHTLTRRRA KRSPKHHPQR
310 320 330 340 350
SRKKNKNCRR HSLYVDFSDV GWNDWIVAPP GYQAFYCHGD CPFPLADHLN
360 370 380 390 400
STNHAIVQTL VNSVNSSIPK ACCVPTELSA ISMLYLDEYD KVVLKNYQEM

VVEGCGCR
Length:408
Mass (Da):46,497
Last modified:February 1, 1994 - v2
Checksum:i35053D844624EF9D
GO

Sequence cautioni

The sequence AAC37698.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti407 – 4071C → S in BAA03555 (PubMed:8507180).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56848 mRNA. Translation: CAA40179.1.
D14814 Genomic DNA. Translation: BAA03555.1.
S65032 mRNA. Translation: AAB28021.1.
L47480 Genomic DNA. Translation: AAC37698.1. Different initiation.
BC013459 mRNA. Translation: AAH13459.1.
BC034053 mRNA. Translation: AAH34053.1.
BC052846 mRNA. Translation: AAH52846.1.
CCDSiCCDS36897.1.
PIRiI49541.
JH0801.
RefSeqiNP_031580.2. NM_007554.2.
XP_006518530.1. XM_006518467.2.
XP_006518531.1. XM_006518468.2.
XP_011243236.1. XM_011244934.1.
XP_011243237.1. XM_011244935.1.
UniGeneiMm.6813.

Genome annotation databases

EnsembliENSMUST00000074077; ENSMUSP00000073720; ENSMUSG00000021835.
ENSMUST00000100676; ENSMUSP00000098242; ENSMUSG00000021835.
GeneIDi12159.
KEGGimmu:12159.
UCSCiuc007thd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56848 mRNA. Translation: CAA40179.1.
D14814 Genomic DNA. Translation: BAA03555.1.
S65032 mRNA. Translation: AAB28021.1.
L47480 Genomic DNA. Translation: AAC37698.1. Different initiation.
BC013459 mRNA. Translation: AAH13459.1.
BC034053 mRNA. Translation: AAH34053.1.
BC052846 mRNA. Translation: AAH52846.1.
CCDSiCCDS36897.1.
PIRiI49541.
JH0801.
RefSeqiNP_031580.2. NM_007554.2.
XP_006518530.1. XM_006518467.2.
XP_006518531.1. XM_006518468.2.
XP_011243236.1. XM_011244934.1.
XP_011243237.1. XM_011244935.1.
UniGeneiMm.6813.

3D structure databases

ProteinModelPortaliP21275.
SMRiP21275. Positions 307-408.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198364. 3 interactions.
STRINGi10090.ENSMUSP00000073720.

Chemistry

BindingDBiP21275.
ChEMBLiCHEMBL2384894.

PTM databases

PhosphoSiteiP21275.

Proteomic databases

MaxQBiP21275.
PRIDEiP21275.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000074077; ENSMUSP00000073720; ENSMUSG00000021835.
ENSMUST00000100676; ENSMUSP00000098242; ENSMUSG00000021835.
GeneIDi12159.
KEGGimmu:12159.
UCSCiuc007thd.2. mouse.

Organism-specific databases

CTDi652.
MGIiMGI:88180. Bmp4.

Phylogenomic databases

eggNOGiNOG243555.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249478.
HOVERGENiHBG004860.
InParanoidiP21275.
KOiK04662.
OMAiATLLHMF.
OrthoDBiEOG7WHH9D.
PhylomeDBiP21275.
TreeFamiTF351789.

Enzyme and pathway databases

ReactomeiREACT_332220. Molecules associated with elastic fibres.

Miscellaneous databases

NextBioi280503.
PROiP21275.
SOURCEiSearch...

Gene expression databases

BgeeiP21275.
CleanExiMM_BMP4.
ExpressionAtlasiP21275. baseline and differential.
GenevisibleiP21275. MM.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the mouse bone morphogenetic protein-4 (BMP-4) cDNA."
    Dickinson M.E., van der Meer-De Jong R., Hogan B.L.M.
    Submitted (OCT-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Murine bone morphogenetic protein-4 gene: existence of multiple promoters and exons for the 5'-untranslated region."
    Kurihara T., Kitamura K., Takaoka K., Nakazato H.
    Biochem. Biophys. Res. Commun. 192:1049-1056(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Gene cloning and expression of a bone morphogenetic protein derived from a murine osteosarcoma."
    Takaoka K., Yoshikawa H., Hasimoto J., Masuhara K., Miyamoto S., Suzuki S., Ono K., Matsui M., Oikawa S., Tsuruoka N.
    Clin. Orthop. Relat. Res. 294:344-352(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The mouse bone morphogenetic protein-4 gene. Analysis of promoter utilization in fetal rat calvarial osteoblasts and regulation by COUP-TFI orphan receptor."
    Feng J.Q., Chen D., Cooney A.J., Tsai M., Harris M.A., Tsai S.Y., Feng M., Mundy G.R., Harris S.E.
    J. Biol. Chem. 270:28364-28373(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
    Tissue: Liver.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C3H/He and FVB/N.
    Tissue: Colon, Osteoblast and Salivary gland.
  6. "Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci."
    Dickinson M.E., Kobrin M.S., Silan C.M., Kingsley D.M., Justice M.J., Miller D.A., Ceci J.D., Lock L.F., Lee A., Buchberg A.M., Siracusa L.D., Lyons K.M., Derynck R., Hogan B.L.M., Copeland N.G., Jenkins N.A.
    Genomics 6:505-520(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 241-408.
  7. "Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling."
    Scott I.C., Blitz I.L., Pappano W.N., Maas S.A., Cho K.W.Y., Greenspan D.S.
    Nature 410:475-478(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TWSG1 AND CHRD.
  8. "Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot."
    Laurikkala J., Kassai Y., Pakkasjaervi L., Thesleff I., Itoh N.
    Dev. Biol. 264:91-105(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SOSTDC1.
  9. "Developmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signaling."
    Tocharus J., Tsuchiya A., Kajikawa M., Ueta Y., Oka C., Kawaichi M.
    Dev. Growth Differ. 46:257-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HTRA3, FUNCTION.
  10. Cited for: INTERACTION WITH HTRA1, FUNCTION.
  11. "Protein related to DAN and cerberus is a bone morphogenetic protein antagonist that participates in ovarian paracrine regulation."
    Sudo S., Avsian-Kretchmer O., Wang L.S., Hsueh A.J.
    J. Biol. Chem. 279:23134-23141(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GREM2.
  12. Cited for: INTERACTION WITH RGMB.
  13. "Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor."
    Babitt J.L., Zhang Y., Samad T.A., Xia Y., Tang J., Campagna J.A., Schneyer A.L., Woolf C.J., Lin H.Y.
    J. Biol. Chem. 280:29820-29827(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RGMA.
  14. Cited for: INTERACTION WITH RGMC.
  15. "BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction."
    Hens J.R., Dann P., Zhang J.P., Harris S., Robinson G.W., Wysolmerski J.
    Development 134:1221-1230(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  16. "Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4."
    Xia Y., Yu P.B., Sidis Y., Beppu H., Bloch K.D., Schneyer A.L., Lin H.Y.
    J. Biol. Chem. 282:18129-18140(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RGMA.

Entry informationi

Entry nameiBMP4_MOUSE
AccessioniPrimary (citable) accession number: P21275
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: February 1, 1994
Last modified: July 22, 2015
This is version 162 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.