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P21275

- BMP4_MOUSE

UniProt

P21275 - BMP4_MOUSE

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Protein

Bone morphogenetic protein 4

Gene

Bmp4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction.3 Publications

GO - Molecular functioni

  1. BMP receptor binding Source: UniProtKB
  2. chemoattractant activity Source: UniProtKB
  3. heparin binding Source: MGI

GO - Biological processi

  1. activation of MAPKK activity Source: UniProtKB
  2. anatomical structure formation involved in morphogenesis Source: MGI
  3. angiogenesis Source: MGI
  4. anterior/posterior axis specification Source: MGI
  5. blood vessel development Source: MGI
  6. blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: UniProtKB
  7. BMP signaling pathway Source: UniProtKB
  8. BMP signaling pathway involved in heart induction Source: UniProtKB
  9. BMP signaling pathway involved in nephric duct formation Source: UniProtKB
  10. BMP signaling pathway involved in renal system segmentation Source: UniProtKB
  11. BMP signaling pathway involved in ureter morphogenesis Source: UniProtKB
  12. bone development Source: MGI
  13. branching involved in prostate gland morphogenesis Source: MGI
  14. branching involved in ureteric bud morphogenesis Source: UniProtKB
  15. branching morphogenesis of an epithelial tube Source: UniProtKB
  16. bronchus development Source: MGI
  17. bud dilation involved in lung branching Source: MGI
  18. bud elongation involved in lung branching Source: MGI
  19. camera-type eye development Source: MGI
  20. camera-type eye morphogenesis Source: MGI
  21. cardiac muscle cell differentiation Source: UniProtKB
  22. cell fate commitment Source: MGI
  23. cellular response to growth factor stimulus Source: MGI
  24. chondrocyte differentiation Source: UniProtKB
  25. cloacal septation Source: UniProtKB
  26. common-partner SMAD protein phosphorylation Source: UniProtKB
  27. cranial suture morphogenesis Source: MGI
  28. deltoid tuberosity development Source: UniProtKB
  29. dorsal/ventral neural tube patterning Source: MGI
  30. embryonic cranial skeleton morphogenesis Source: MGI
  31. embryonic digit morphogenesis Source: MGI
  32. embryonic hindlimb morphogenesis Source: MGI
  33. embryonic limb morphogenesis Source: MGI
  34. embryonic morphogenesis Source: MGI
  35. embryonic skeletal joint morphogenesis Source: MGI
  36. embryonic skeletal system development Source: MGI
  37. embryonic skeletal system morphogenesis Source: MGI
  38. endochondral ossification Source: UniProtKB
  39. epithelial cell proliferation involved in lung morphogenesis Source: MGI
  40. epithelial-mesenchymal cell signaling Source: MGI
  41. epithelial tube branching involved in lung morphogenesis Source: MGI
  42. epithelium development Source: MGI
  43. erythrocyte differentiation Source: MGI
  44. forebrain development Source: MGI
  45. germ cell development Source: MGI
  46. glomerular capillary formation Source: UniProtKB
  47. glomerular visceral epithelial cell development Source: UniProtKB
  48. heart development Source: MGI
  49. hematopoietic progenitor cell differentiation Source: UniProtKB
  50. inner ear receptor cell differentiation Source: MGI
  51. intermediate mesodermal cell differentiation Source: UniProtKB
  52. kidney development Source: UniProtKB
  53. lens induction in camera-type eye Source: MGI
  54. lung alveolus development Source: MGI
  55. lung development Source: MGI
  56. lung morphogenesis Source: MGI
  57. lymphoid progenitor cell differentiation Source: UniProtKB
  58. macrophage differentiation Source: Ensembl
  59. mammary gland formation Source: MGI
  60. mesenchymal cell differentiation involved in kidney development Source: UniProtKB
  61. mesenchymal cell differentiation involved in renal system development Source: UniProtKB
  62. mesenchymal cell proliferation involved in ureter development Source: UniProtKB
  63. mesenchymal cell proliferation involved in ureteric bud development Source: UniProtKB
  64. mesenchymal to epithelial transition involved in metanephros morphogenesis Source: UniProtKB
  65. mesodermal cell differentiation Source: MGI
  66. mesodermal cell fate determination Source: MGI
  67. mesoderm formation Source: MGI
  68. mesonephros development Source: UniProtKB
  69. metanephric collecting duct development Source: UniProtKB
  70. metanephros development Source: MGI
  71. monocyte differentiation Source: Ensembl
  72. negative regulation of apoptotic process Source: UniProtKB
  73. negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway Source: UniProtKB
  74. negative regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
  75. negative regulation of cell cycle Source: UniProtKB
  76. negative regulation of cell death Source: UniProtKB
  77. negative regulation of cell proliferation Source: MGI
  78. negative regulation of cell proliferation involved in heart morphogenesis Source: UniProtKB
  79. negative regulation of chondrocyte differentiation Source: MGI
  80. negative regulation of epithelial cell proliferation Source: MGI
  81. negative regulation of gene expression Source: MGI
  82. negative regulation of glomerular mesangial cell proliferation Source: UniProtKB
  83. negative regulation of glomerulus development Source: UniProtKB
  84. negative regulation of immature T cell proliferation in thymus Source: UniProtKB
  85. negative regulation of MAP kinase activity Source: UniProtKB
  86. negative regulation of mesenchymal cell proliferation involved in ureter development Source: UniProtKB
  87. negative regulation of metanephric comma-shaped body morphogenesis Source: UniProtKB
  88. negative regulation of metanephric S-shaped body morphogenesis Source: UniProtKB
  89. negative regulation of mitosis Source: UniProtKB
  90. negative regulation of myoblast differentiation Source: Ensembl
  91. negative regulation of phosphorylation Source: UniProtKB
  92. negative regulation of prostatic bud formation Source: MGI
  93. negative regulation of striated muscle tissue development Source: Ensembl
  94. negative regulation of T cell differentiation in thymus Source: Ensembl
  95. negative regulation of thymocyte apoptotic process Source: UniProtKB
  96. negative regulation of transcription, DNA-templated Source: UniProtKB
  97. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  98. neural tube closure Source: MGI
  99. neuron fate commitment Source: MGI
  100. odontogenesis Source: UniProtKB
  101. odontogenesis of dentin-containing tooth Source: MGI
  102. organ induction Source: MGI
  103. osteoblast differentiation Source: UniProtKB
  104. pituitary gland development Source: MGI
  105. positive chemotaxis Source: UniProtKB
  106. positive regulation of apoptotic process Source: UniProtKB
  107. positive regulation of BMP signaling pathway Source: UniProtKB
  108. positive regulation of bone mineralization Source: UniProtKB
  109. positive regulation of branching involved in lung morphogenesis Source: UniProtKB
  110. positive regulation of cardiac muscle fiber development Source: UniProtKB
  111. positive regulation of cartilage development Source: MGI
  112. positive regulation of cell death Source: MGI
  113. positive regulation of cell differentiation Source: MGI
  114. positive regulation of cell proliferation Source: MGI
  115. positive regulation of collagen biosynthetic process Source: UniProtKB
  116. positive regulation of DNA-dependent DNA replication Source: UniProtKB
  117. positive regulation of endothelial cell differentiation Source: DFLAT
  118. positive regulation of endothelial cell migration Source: UniProtKB
  119. positive regulation of endothelial cell proliferation Source: UniProtKB
  120. positive regulation of epidermal cell differentiation Source: UniProt
  121. positive regulation of epithelial cell proliferation Source: BHF-UCL
  122. positive regulation of ERK1 and ERK2 cascade Source: MGI
  123. positive regulation of gene expression Source: MGI
  124. positive regulation of kidney development Source: UniProtKB
  125. positive regulation of neuron differentiation Source: MGI
  126. positive regulation of ossification Source: MGI
  127. positive regulation of osteoblast differentiation Source: UniProtKB
  128. positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
  129. positive regulation of protein binding Source: MGI
  130. positive regulation of protein phosphorylation Source: MGI
  131. positive regulation of SMAD protein import into nucleus Source: UniProtKB
  132. positive regulation of smooth muscle cell proliferation Source: UniProtKB
  133. positive regulation of transcription, DNA-templated Source: UniProtKB
  134. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  135. positive regulation of vascular endothelial growth factor receptor signaling pathway Source: DFLAT
  136. post-embryonic development Source: MGI
  137. prostate gland morphogenesis Source: MGI
  138. protein localization to nucleus Source: UniProtKB
  139. pulmonary artery endothelial tube morphogenesis Source: UniProtKB
  140. regulation of branching involved in prostate gland morphogenesis Source: MGI
  141. regulation of cartilage development Source: MGI
  142. regulation of cell differentiation Source: MGI
  143. regulation of cell fate commitment Source: UniProt
  144. regulation of endothelial cell proliferation Source: DFLAT
  145. regulation of gene expression Source: MGI
  146. regulation of morphogenesis of a branching structure Source: MGI
  147. regulation of odontogenesis of dentin-containing tooth Source: MGI
  148. regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
  149. regulation of smooth muscle cell differentiation Source: MGI
  150. regulation of smooth muscle cell proliferation Source: MGI
  151. renal system development Source: MGI
  152. renal system process Source: MGI
  153. secondary heart field specification Source: UniProtKB
  154. skeletal system development Source: MGI
  155. SMAD protein signal transduction Source: UniProtKB
  156. smoothened signaling pathway Source: Ensembl
  157. smooth muscle cell differentiation Source: MGI
  158. smooth muscle tissue development Source: UniProtKB
  159. specification of organ position Source: MGI
  160. specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway Source: UniProtKB
  161. steroid hormone mediated signaling pathway Source: UniProtKB
  162. telencephalon development Source: MGI
  163. telencephalon regionalization Source: MGI
  164. tendon cell differentiation Source: UniProtKB
  165. tissue development Source: MGI
  166. trachea development Source: MGI
  167. trachea formation Source: MGI
  168. type B pancreatic cell development Source: UniProtKB
  169. ureter epithelial cell differentiation Source: UniProtKB
  170. ureteric bud development Source: MGI
  171. ureter smooth muscle cell differentiation Source: UniProtKB
  172. vasculature development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Enzyme and pathway databases

ReactomeiREACT_198998. Molecules associated with elastic fibres.

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 4
Short name:
BMP-4
Alternative name(s):
Bone morphogenetic protein 2B
Short name:
BMP-2B
Gene namesi
Name:Bmp4
Synonyms:Bmp-4, Dvr-4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:88180. Bmp4.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: MGI
  2. extracellular space Source: MGI
  3. proteinaceous extracellular matrix Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Propeptidei20 – 292273PRO_0000033858Add
BLAST
Chaini293 – 408116Bone morphogenetic protein 4PRO_0000033859Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi308 ↔ 373By similarity
Disulfide bondi337 ↔ 405By similarity
Disulfide bondi341 ↔ 407By similarity
Glycosylationi350 – 3501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi365 – 3651N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi372 – 372InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP21275.
PRIDEiP21275.

PTM databases

PhosphoSiteiP21275.

Expressioni

Gene expression databases

BgeeiP21275.
CleanExiMM_BMP4.
ExpressionAtlasiP21275. baseline and differential.
GenevestigatoriP21275.

Interactioni

Subunit structurei

Homodimer; disulfide-linked (By similarity). Interacts with SOSTDC1, GREM2, RGMA, RGMB and RGMC. Part of a complex consisting of TWSG1 and CHRD. Interacts with the serine proteases, HTRA1 and HTRA3; the interaction with either inhibits BMP4-mediated signaling. The HTRA protease activity is required for this inhibition.By similarity9 Publications

Protein-protein interaction databases

BioGridi198364. 3 interactions.
STRINGi10090.ENSMUSP00000098242.

Structurei

3D structure databases

ProteinModelPortaliP21275.
SMRiP21275. Positions 307-408.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG243555.
HOGENOMiHOG000249478.
HOVERGENiHBG004860.
InParanoidiP21275.
KOiK04662.
OMAiGFHHEEH.
OrthoDBiEOG7WHH9D.
PhylomeDBiP21275.
TreeFamiTF351789.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21275 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIPGNRMLMV VLLCQVLLGG ASHASLIPET GKKKVAEIQG HAGGRRSGQS
60 70 80 90 100
HELLRDFEAT LLQMFGLRRR PQPSKSAVIP DYMRDLYRLQ SGEEEEEEQS
110 120 130 140 150
QGTGLEYPER PASRANTVRS FHHEEHLENI PGTSESSAFR FLFNLSSIPE
160 170 180 190 200
NEVISSAELR LFREQVDQGP DWEQGFHRIN IYEVMKPPAE MVPGHLITRL
210 220 230 240 250
LDTRLVHHNV TRWETFDVSP AVLRWTREKQ PNYGLAIEVT HLHQTRTHQG
260 270 280 290 300
QHVRISRSLP QGSGDWAQLR PLLVTFGHDG RGHTLTRRRA KRSPKHHPQR
310 320 330 340 350
SRKKNKNCRR HSLYVDFSDV GWNDWIVAPP GYQAFYCHGD CPFPLADHLN
360 370 380 390 400
STNHAIVQTL VNSVNSSIPK ACCVPTELSA ISMLYLDEYD KVVLKNYQEM

VVEGCGCR
Length:408
Mass (Da):46,497
Last modified:February 1, 1994 - v2
Checksum:i35053D844624EF9D
GO

Sequence cautioni

The sequence AAC37698.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti407 – 4071C → S in BAA03555. (PubMed:8507180)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56848 mRNA. Translation: CAA40179.1.
D14814 Genomic DNA. Translation: BAA03555.1.
S65032 mRNA. Translation: AAB28021.1.
L47480 Genomic DNA. Translation: AAC37698.1. Different initiation.
BC013459 mRNA. Translation: AAH13459.1.
BC034053 mRNA. Translation: AAH34053.1.
BC052846 mRNA. Translation: AAH52846.1.
CCDSiCCDS36897.1.
PIRiI49541.
JH0801.
RefSeqiNP_031580.2. NM_007554.2.
XP_006518530.1. XM_006518467.1.
XP_006518531.1. XM_006518468.1.
UniGeneiMm.6813.

Genome annotation databases

EnsembliENSMUST00000074077; ENSMUSP00000073720; ENSMUSG00000021835.
ENSMUST00000100676; ENSMUSP00000098242; ENSMUSG00000021835.
GeneIDi12159.
KEGGimmu:12159.
UCSCiuc007thd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56848 mRNA. Translation: CAA40179.1 .
D14814 Genomic DNA. Translation: BAA03555.1 .
S65032 mRNA. Translation: AAB28021.1 .
L47480 Genomic DNA. Translation: AAC37698.1 . Different initiation.
BC013459 mRNA. Translation: AAH13459.1 .
BC034053 mRNA. Translation: AAH34053.1 .
BC052846 mRNA. Translation: AAH52846.1 .
CCDSi CCDS36897.1.
PIRi I49541.
JH0801.
RefSeqi NP_031580.2. NM_007554.2.
XP_006518530.1. XM_006518467.1.
XP_006518531.1. XM_006518468.1.
UniGenei Mm.6813.

3D structure databases

ProteinModelPortali P21275.
SMRi P21275. Positions 307-408.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198364. 3 interactions.
STRINGi 10090.ENSMUSP00000098242.

Chemistry

ChEMBLi CHEMBL2384894.

PTM databases

PhosphoSitei P21275.

Proteomic databases

MaxQBi P21275.
PRIDEi P21275.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000074077 ; ENSMUSP00000073720 ; ENSMUSG00000021835 .
ENSMUST00000100676 ; ENSMUSP00000098242 ; ENSMUSG00000021835 .
GeneIDi 12159.
KEGGi mmu:12159.
UCSCi uc007thd.2. mouse.

Organism-specific databases

CTDi 652.
MGIi MGI:88180. Bmp4.

Phylogenomic databases

eggNOGi NOG243555.
HOGENOMi HOG000249478.
HOVERGENi HBG004860.
InParanoidi P21275.
KOi K04662.
OMAi GFHHEEH.
OrthoDBi EOG7WHH9D.
PhylomeDBi P21275.
TreeFami TF351789.

Enzyme and pathway databases

Reactomei REACT_198998. Molecules associated with elastic fibres.

Miscellaneous databases

NextBioi 280503.
PROi P21275.
SOURCEi Search...

Gene expression databases

Bgeei P21275.
CleanExi MM_BMP4.
ExpressionAtlasi P21275. baseline and differential.
Genevestigatori P21275.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view ]
PANTHERi PTHR11848. PTHR11848. 1 hit.
Pfami PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view ]
SMARTi SM00204. TGFB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the mouse bone morphogenetic protein-4 (BMP-4) cDNA."
    Dickinson M.E., van der Meer-De Jong R., Hogan B.L.M.
    Submitted (OCT-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Murine bone morphogenetic protein-4 gene: existence of multiple promoters and exons for the 5'-untranslated region."
    Kurihara T., Kitamura K., Takaoka K., Nakazato H.
    Biochem. Biophys. Res. Commun. 192:1049-1056(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Gene cloning and expression of a bone morphogenetic protein derived from a murine osteosarcoma."
    Takaoka K., Yoshikawa H., Hasimoto J., Masuhara K., Miyamoto S., Suzuki S., Ono K., Matsui M., Oikawa S., Tsuruoka N.
    Clin. Orthop. Relat. Res. 294:344-352(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The mouse bone morphogenetic protein-4 gene. Analysis of promoter utilization in fetal rat calvarial osteoblasts and regulation by COUP-TFI orphan receptor."
    Feng J.Q., Chen D., Cooney A.J., Tsai M., Harris M.A., Tsai S.Y., Feng M., Mundy G.R., Harris S.E.
    J. Biol. Chem. 270:28364-28373(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
    Tissue: Liver.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C3H/He and FVB/N.
    Tissue: Colon, Osteoblast and Salivary gland.
  6. "Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci."
    Dickinson M.E., Kobrin M.S., Silan C.M., Kingsley D.M., Justice M.J., Miller D.A., Ceci J.D., Lock L.F., Lee A., Buchberg A.M., Siracusa L.D., Lyons K.M., Derynck R., Hogan B.L.M., Copeland N.G., Jenkins N.A.
    Genomics 6:505-520(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 241-408.
  7. "Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling."
    Scott I.C., Blitz I.L., Pappano W.N., Maas S.A., Cho K.W.Y., Greenspan D.S.
    Nature 410:475-478(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TWSG1 AND CHRD.
  8. "Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot."
    Laurikkala J., Kassai Y., Pakkasjaervi L., Thesleff I., Itoh N.
    Dev. Biol. 264:91-105(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SOSTDC1.
  9. "Developmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signaling."
    Tocharus J., Tsuchiya A., Kajikawa M., Ueta Y., Oka C., Kawaichi M.
    Dev. Growth Differ. 46:257-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HTRA3, FUNCTION.
  10. Cited for: INTERACTION WITH HTRA1, FUNCTION.
  11. "Protein related to DAN and cerberus is a bone morphogenetic protein antagonist that participates in ovarian paracrine regulation."
    Sudo S., Avsian-Kretchmer O., Wang L.S., Hsueh A.J.
    J. Biol. Chem. 279:23134-23141(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GREM2.
  12. Cited for: INTERACTION WITH RGMB.
  13. "Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor."
    Babitt J.L., Zhang Y., Samad T.A., Xia Y., Tang J., Campagna J.A., Schneyer A.L., Woolf C.J., Lin H.Y.
    J. Biol. Chem. 280:29820-29827(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RGMA.
  14. Cited for: INTERACTION WITH RGMC.
  15. "BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction."
    Hens J.R., Dann P., Zhang J.P., Harris S., Robinson G.W., Wysolmerski J.
    Development 134:1221-1230(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  16. "Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4."
    Xia Y., Yu P.B., Sidis Y., Beppu H., Bloch K.D., Schneyer A.L., Lin H.Y.
    J. Biol. Chem. 282:18129-18140(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RGMA.

Entry informationi

Entry nameiBMP4_MOUSE
AccessioniPrimary (citable) accession number: P21275
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: February 1, 1994
Last modified: October 29, 2014
This is version 154 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3