Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Bone morphogenetic protein 2

Gene

Bmp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.By similarity

GO - Molecular functioni

GO - Biological processi

  • activation of MAPK activity Source: MGI
  • animal organ morphogenesis Source: MGI
  • atrioventricular valve morphogenesis Source: MGI
  • BMP signaling pathway Source: MGI
  • BMP signaling pathway involved in heart induction Source: MGI
  • bone mineralization Source: MGI
  • bone mineralization involved in bone maturation Source: MGI
  • branching involved in ureteric bud morphogenesis Source: MGI
  • cardiac epithelial to mesenchymal transition Source: MGI
  • cardiac muscle cell differentiation Source: BHF-UCL
  • cardiac muscle tissue morphogenesis Source: MGI
  • cardiocyte differentiation Source: MGI
  • cell fate commitment Source: MGI
  • cellular response to BMP stimulus Source: MGI
  • cellular response to growth factor stimulus Source: MGI
  • cellular response to organic cyclic compound Source: MGI
  • chondrocyte differentiation Source: MGI
  • corticotropin hormone secreting cell differentiation Source: MGI
  • embryonic heart tube anterior/posterior pattern specification Source: MGI
  • endocardial cushion morphogenesis Source: BHF-UCL
  • epithelial to mesenchymal transition Source: MGI
  • growth Source: InterPro
  • heart development Source: MGI
  • inflammatory response Source: UniProtKB
  • inner ear development Source: MGI
  • in utero embryonic development Source: MGI
  • mesenchymal cell differentiation Source: UniProtKB
  • mesenchymal cell proliferation involved in ureteric bud development Source: UniProtKB
  • mesenchyme development Source: BHF-UCL
  • negative regulation of aldosterone biosynthetic process Source: MGI
  • negative regulation of calcium-independent cell-cell adhesion Source: MGI
  • negative regulation of canonical Wnt signaling pathway Source: Ensembl
  • negative regulation of cardiac muscle cell differentiation Source: MGI
  • negative regulation of cell cycle Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of cortisol biosynthetic process Source: MGI
  • negative regulation of gene expression Source: MGI
  • negative regulation of insulin-like growth factor receptor signaling pathway Source: MGI
  • negative regulation of steroid biosynthetic process Source: MGI
  • negative regulation of transcription, DNA-templated Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • negative regulation of Wnt signaling pathway involved in heart development Source: MGI
  • Notch signaling pathway Source: MGI
  • odontogenesis of dentin-containing tooth Source: MGI
  • osteoblast differentiation Source: MGI
  • pathway-restricted SMAD protein phosphorylation Source: MGI
  • pericardium development Source: MGI
  • positive regulation of apoptotic process Source: MGI
  • positive regulation of astrocyte differentiation Source: MGI
  • positive regulation of bone mineralization Source: MGI
  • positive regulation of cartilage development Source: MGI
  • positive regulation of cell differentiation Source: MGI
  • positive regulation of cell migration Source: BHF-UCL
  • positive regulation of endothelial cell proliferation Source: MGI
  • positive regulation of epithelial to mesenchymal transition Source: MGI
  • positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
  • positive regulation of fat cell differentiation Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of MAPK cascade Source: MGI
  • positive regulation of neurogenesis Source: MGI
  • positive regulation of neuron differentiation Source: MGI
  • positive regulation of odontogenesis Source: MGI
  • positive regulation of ossification Source: MGI
  • positive regulation of osteoblast differentiation Source: BHF-UCL
  • positive regulation of osteoblast proliferation Source: BHF-UCL
  • positive regulation of p38MAPK cascade Source: MGI
  • positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
  • positive regulation of phosphatase activity Source: MGI
  • positive regulation of pri-miRNA transcription from RNA polymerase II promoter Source: BHF-UCL
  • positive regulation of protein binding Source: MGI
  • positive regulation of protein phosphorylation Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus Source: MGI
  • positive regulation of Wnt signaling pathway Source: MGI
  • positive regulation of Wnt signaling pathway by BMP signaling pathway Source: MGI
  • protein destabilization Source: MGI
  • protein phosphorylation Source: MGI
  • proteoglycan metabolic process Source: MGI
  • regulation of apoptotic process Source: GO_Central
  • regulation of MAPK cascade Source: GO_Central
  • regulation of odontogenesis of dentin-containing tooth Source: MGI
  • regulation of transcription, DNA-templated Source: MGI
  • response to hypoxia Source: MGI
  • SMAD protein signal transduction Source: UniProtKB
  • telencephalon development Source: MGI
  • telencephalon regionalization Source: MGI
  • thyroid-stimulating hormone-secreting cell differentiation Source: MGI
  • transforming growth factor beta receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Enzyme and pathway databases

ReactomeiR-MMU-201451. Signaling by BMP.
R-MMU-2129379. Molecules associated with elastic fibres.

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 2
Short name:
BMP-2
Alternative name(s):
Bone morphogenetic protein 2A
Short name:
BMP-2A
Gene namesi
Name:Bmp2
Synonyms:Bmp-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:88177. Bmp2.

Subcellular locationi

GO - Cellular componenti

  • BMP receptor complex Source: MGI
  • cell surface Source: MGI
  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000003382620 – 280Cleaved by PCSK5CuratedAdd BLAST261
ChainiPRO_0000033827281 – 394Bone morphogenetic protein 2Add BLAST114

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei86PhosphoserineBy similarity1
Glycosylationi134N-linked (GlcNAc...)Sequence analysis1
Glycosylationi162N-linked (GlcNAc...)Sequence analysis1
Glycosylationi198N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi294 ↔ 359By similarity
Disulfide bondi323 ↔ 391By similarity
Disulfide bondi327 ↔ 393By similarity
Glycosylationi336N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi358InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP21274.
PRIDEiP21274.

PTM databases

PhosphoSitePlusiP21274.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027358.
CleanExiMM_BMP2.
GenevisibleiP21274. MM.

Interactioni

Subunit structurei

Homodimer; disulfide-linked (By similarity). Interacts with SOSTDC1, GREM2, RGMA, RGMB and RGMC. Interacts with ASPN. Interacts with MFAP5. Interacts with FBN1 (via N-terminal domain) and FBN2 (By similarity).By similarity8 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198363. 1 interactor.
STRINGi10090.ENSMUSP00000028836.

Structurei

3D structure databases

ProteinModelPortaliP21274.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249478.
HOVERGENiHBG004860.
InParanoidiP21274.
KOiK04662.
OMAiDEHSWSQ.
OrthoDBiEOG091G0K7Z.
TreeFamiTF351789.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21274-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAGTRCLLV LLLPQVLLGG AAGLIPELGR KKFAAASSRP LSRPSEDVLS
60 70 80 90 100
EFELRLLSMF GLKQRPTPSK DVVVPPYMLD LYRRHSGQPG APAPDHRLER
110 120 130 140 150
AASRANTVRS FHHEEAVEEL PEMSGKTARR FFFNLSSVPS DEFLTSAELQ
160 170 180 190 200
IFREQIQEAL GNSSFQHRIN IYEIIKPAAA NLKFPVTRLL DTRLVNQNTS
210 220 230 240 250
QWESFDVTPA VMRWTTQGHT NHGFVVEVAH LEENPGVSKR HVRISRSLHQ
260 270 280 290 300
DEHSWSQIRP LLVTFGHDGK GHPLHKREKR QAKHKQRKRL KSSCKRHPLY
310 320 330 340 350
VDFSDVGWND WIVAPPGYHA FYCHGECPFP LADHLNSTNH AIVQTLVNSV
360 370 380 390
NSKIPKACCV PTELSAISML YLDENEKVVL KNYQDMVVEG CGCR
Length:394
Mass (Da):44,525
Last modified:July 27, 2011 - v3
Checksum:iD0C03B63B1D5C4E2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti110S → T in AAB05665 (PubMed:8018727).Curated1
Sequence conflicti113 – 114HE → QL in AAB05665 (PubMed:8018727).Curated2
Sequence conflicti271G → R no nucleotide entry (PubMed:1970330).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25602 Genomic DNA. Translation: AAB05665.1.
AK133923 mRNA. Translation: BAE21928.1.
AK161862 mRNA. Translation: BAE36612.1.
AL831753 Genomic DNA. Translation: CAM22737.1.
CH466519 Genomic DNA. Translation: EDL28371.1.
BC100344 mRNA. Translation: AAI00345.1.
CCDSiCCDS16782.1.
PIRiA34201.
S45355.
RefSeqiNP_031579.2. NM_007553.3.
UniGeneiMm.103205.

Genome annotation databases

EnsembliENSMUST00000028836; ENSMUSP00000028836; ENSMUSG00000027358.
GeneIDi12156.
KEGGimmu:12156.
UCSCiuc008mnr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25602 Genomic DNA. Translation: AAB05665.1.
AK133923 mRNA. Translation: BAE21928.1.
AK161862 mRNA. Translation: BAE36612.1.
AL831753 Genomic DNA. Translation: CAM22737.1.
CH466519 Genomic DNA. Translation: EDL28371.1.
BC100344 mRNA. Translation: AAI00345.1.
CCDSiCCDS16782.1.
PIRiA34201.
S45355.
RefSeqiNP_031579.2. NM_007553.3.
UniGeneiMm.103205.

3D structure databases

ProteinModelPortaliP21274.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198363. 1 interactor.
STRINGi10090.ENSMUSP00000028836.

PTM databases

PhosphoSitePlusiP21274.

Proteomic databases

PaxDbiP21274.
PRIDEiP21274.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028836; ENSMUSP00000028836; ENSMUSG00000027358.
GeneIDi12156.
KEGGimmu:12156.
UCSCiuc008mnr.2. mouse.

Organism-specific databases

CTDi650.
MGIiMGI:88177. Bmp2.

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249478.
HOVERGENiHBG004860.
InParanoidiP21274.
KOiK04662.
OMAiDEHSWSQ.
OrthoDBiEOG091G0K7Z.
TreeFamiTF351789.

Enzyme and pathway databases

ReactomeiR-MMU-201451. Signaling by BMP.
R-MMU-2129379. Molecules associated with elastic fibres.

Miscellaneous databases

PROiP21274.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027358.
CleanExiMM_BMP2.
GenevisibleiP21274. MM.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBMP2_MOUSE
AccessioniPrimary (citable) accession number: P21274
Secondary accession number(s): Q497W8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 156 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.