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Protein

Bone morphogenetic protein 2

Gene

Bmp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.By similarity

GO - Molecular functioni

GO - Biological processi

  • activation of MAPK activity Source: MGI
  • animal organ morphogenesis Source: MGI
  • atrioventricular valve morphogenesis Source: MGI
  • BMP signaling pathway Source: MGI
  • BMP signaling pathway involved in heart induction Source: MGI
  • bone mineralization Source: MGI
  • bone mineralization involved in bone maturation Source: MGI
  • branching involved in ureteric bud morphogenesis Source: MGI
  • cardiac epithelial to mesenchymal transition Source: MGI
  • cardiac muscle cell differentiation Source: BHF-UCL
  • cardiac muscle tissue morphogenesis Source: MGI
  • cardiocyte differentiation Source: MGI
  • cell fate commitment Source: MGI
  • cellular response to BMP stimulus Source: MGI
  • cellular response to growth factor stimulus Source: MGI
  • cellular response to organic cyclic compound Source: MGI
  • chondrocyte differentiation Source: MGI
  • corticotropin hormone secreting cell differentiation Source: MGI
  • embryonic heart tube anterior/posterior pattern specification Source: MGI
  • endocardial cushion morphogenesis Source: BHF-UCL
  • epithelial to mesenchymal transition Source: MGI
  • heart development Source: MGI
  • inflammatory response Source: UniProtKB
  • inner ear development Source: MGI
  • in utero embryonic development Source: MGI
  • mesenchymal cell differentiation Source: UniProtKB
  • mesenchymal cell proliferation involved in ureteric bud development Source: UniProtKB
  • mesenchyme development Source: BHF-UCL
  • negative regulation of aldosterone biosynthetic process Source: MGI
  • negative regulation of calcium-independent cell-cell adhesion Source: MGI
  • negative regulation of canonical Wnt signaling pathway Source: Ensembl
  • negative regulation of cardiac muscle cell differentiation Source: MGI
  • negative regulation of cell cycle Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of cortisol biosynthetic process Source: MGI
  • negative regulation of gene expression Source: MGI
  • negative regulation of insulin-like growth factor receptor signaling pathway Source: MGI
  • negative regulation of steroid biosynthetic process Source: MGI
  • negative regulation of transcription, DNA-templated Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • negative regulation of Wnt signaling pathway involved in heart development Source: MGI
  • Notch signaling pathway Source: MGI
  • odontogenesis of dentin-containing tooth Source: MGI
  • osteoblast differentiation Source: MGI
  • pathway-restricted SMAD protein phosphorylation Source: MGI
  • pericardium development Source: MGI
  • positive regulation of apoptotic process Source: MGI
  • positive regulation of astrocyte differentiation Source: MGI
  • positive regulation of bone mineralization Source: MGI
  • positive regulation of cartilage development Source: MGI
  • positive regulation of cell differentiation Source: MGI
  • positive regulation of cell migration Source: BHF-UCL
  • positive regulation of endothelial cell proliferation Source: MGI
  • positive regulation of epithelial to mesenchymal transition Source: MGI
  • positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
  • positive regulation of fat cell differentiation Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of MAPK cascade Source: MGI
  • positive regulation of neurogenesis Source: MGI
  • positive regulation of neuron differentiation Source: MGI
  • positive regulation of odontogenesis Source: MGI
  • positive regulation of ossification Source: MGI
  • positive regulation of osteoblast differentiation Source: MGI
  • positive regulation of osteoblast proliferation Source: BHF-UCL
  • positive regulation of p38MAPK cascade Source: MGI
  • positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
  • positive regulation of phosphatase activity Source: MGI
  • positive regulation of pri-miRNA transcription by RNA polymerase II Source: BHF-UCL
  • positive regulation of protein binding Source: MGI
  • positive regulation of protein phosphorylation Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus Source: MGI
  • positive regulation of Wnt signaling pathway Source: MGI
  • positive regulation of Wnt signaling pathway by BMP signaling pathway Source: MGI
  • protein destabilization Source: MGI
  • protein phosphorylation Source: MGI
  • proteoglycan metabolic process Source: MGI
  • regulation of apoptotic process Source: GO_Central
  • regulation of MAPK cascade Source: GO_Central
  • regulation of odontogenesis of dentin-containing tooth Source: MGI
  • regulation of transcription, DNA-templated Source: MGI
  • response to hypoxia Source: MGI
  • SMAD protein signal transduction Source: UniProtKB
  • telencephalon development Source: MGI
  • telencephalon regionalization Source: MGI
  • thyroid-stimulating hormone-secreting cell differentiation Source: MGI
  • transforming growth factor beta receptor signaling pathway Source: MGI

Keywordsi

Molecular functionCytokine, Developmental protein, Growth factor
Biological processChondrogenesis, Differentiation, Osteogenesis

Enzyme and pathway databases

ReactomeiR-MMU-201451 Signaling by BMP
R-MMU-2129379 Molecules associated with elastic fibres

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 2
Short name:
BMP-2
Alternative name(s):
Bone morphogenetic protein 2A
Short name:
BMP-2A
Gene namesi
Name:Bmp2
Synonyms:Bmp-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:88177 Bmp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000003382620 – 280Cleaved by PCSK5CuratedAdd BLAST261
ChainiPRO_0000033827281 – 394Bone morphogenetic protein 2Add BLAST114

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei86PhosphoserineBy similarity1
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi198N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi294 ↔ 359By similarity
Disulfide bondi323 ↔ 391By similarity
Disulfide bondi327 ↔ 393By similarity
Glycosylationi336N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi358InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP21274
PaxDbiP21274
PRIDEiP21274

PTM databases

PhosphoSitePlusiP21274

Expressioni

Gene expression databases

BgeeiENSMUSG00000027358
CleanExiMM_BMP2
GenevisibleiP21274 MM

Interactioni

Subunit structurei

Homodimer; disulfide-linked (By similarity). Interacts with SOSTDC1, GREM2, RGMA, RGMB and RGMC. Interacts with ASPN. Interacts with MFAP5. Interacts with FBN1 (via N-terminal domain) and FBN2 (By similarity).By similarity8 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi1983631 interactor.
STRINGi10090.ENSMUSP00000028836

Structurei

3D structure databases

ProteinModelPortaliP21274
SMRiP21274
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00760000118883
HOGENOMiHOG000249478
HOVERGENiHBG004860
InParanoidiP21274
KOiK21283
OMAiQGVSKRH
OrthoDBiEOG091G0K7Z
TreeFamiTF351789

Family and domain databases

Gene3Di2.10.90.101 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21274-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAGTRCLLV LLLPQVLLGG AAGLIPELGR KKFAAASSRP LSRPSEDVLS
60 70 80 90 100
EFELRLLSMF GLKQRPTPSK DVVVPPYMLD LYRRHSGQPG APAPDHRLER
110 120 130 140 150
AASRANTVRS FHHEEAVEEL PEMSGKTARR FFFNLSSVPS DEFLTSAELQ
160 170 180 190 200
IFREQIQEAL GNSSFQHRIN IYEIIKPAAA NLKFPVTRLL DTRLVNQNTS
210 220 230 240 250
QWESFDVTPA VMRWTTQGHT NHGFVVEVAH LEENPGVSKR HVRISRSLHQ
260 270 280 290 300
DEHSWSQIRP LLVTFGHDGK GHPLHKREKR QAKHKQRKRL KSSCKRHPLY
310 320 330 340 350
VDFSDVGWND WIVAPPGYHA FYCHGECPFP LADHLNSTNH AIVQTLVNSV
360 370 380 390
NSKIPKACCV PTELSAISML YLDENEKVVL KNYQDMVVEG CGCR
Length:394
Mass (Da):44,525
Last modified:July 27, 2011 - v3
Checksum:iD0C03B63B1D5C4E2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti110S → T in AAB05665 (PubMed:8018727).Curated1
Sequence conflicti113 – 114HE → QL in AAB05665 (PubMed:8018727).Curated2
Sequence conflicti271G → R no nucleotide entry (PubMed:1970330).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25602 Genomic DNA Translation: AAB05665.1
AK133923 mRNA Translation: BAE21928.1
AK161862 mRNA Translation: BAE36612.1
AL831753 Genomic DNA Translation: CAM22737.1
CH466519 Genomic DNA Translation: EDL28371.1
BC100344 mRNA Translation: AAI00345.1
CCDSiCCDS16782.1
PIRiA34201
S45355
RefSeqiNP_031579.2, NM_007553.3
UniGeneiMm.103205

Genome annotation databases

EnsembliENSMUST00000028836; ENSMUSP00000028836; ENSMUSG00000027358
GeneIDi12156
KEGGimmu:12156
UCSCiuc008mnr.2 mouse

Similar proteinsi

Entry informationi

Entry nameiBMP2_MOUSE
AccessioniPrimary (citable) accession number: P21274
Secondary accession number(s): Q497W8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 165 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome