P21264 (PUR6_YEAST) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 132.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Phosphoribosylaminoimidazole carboxylase EC=4.1.1.21 Alternative name(s): AIR carboxylase Short name=AIRC | ||||||
| Gene names |
| ||||||
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome] | ||||||
| Taxonomic identifier | 559292 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › ![]() |
Protein attributes
| Sequence length | 571 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Catalytic activity | 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2. |
| Pathway | |
| Miscellaneous | Present with 5410 molecules/cell in log phase SD medium. |
| Sequence similarities | In the C-terminal section; belongs to the AIR carboxylase family. Contains 1 ATP-grasp domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Purine biosynthesis |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Decarboxylase Lyase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | 'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway purine nucleobase metabolic processInferred from mutant phenotype PubMed 8939809. Source: SGD |
| Cellular_component | cytoplasm Inferred from direct assay PubMed 14562095. Source: SGD |
| Molecular_function | 5-(carboxyamino)imidazole ribonucleotide mutase activity Inferred from electronic annotation. Source: InterPro ATP bindingInferred from electronic annotation. Source: UniProtKB-KW metal ion bindingInferred from electronic annotation. Source: InterPro phosphoribosylaminoimidazole carboxylase activityInferred from mutant phenotype PubMed 5767024. Source: SGD |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 571 | 571 | Phosphoribosylaminoimidazole carboxylase | PRO_0000075028 | |||||
Regions | |||||||||
| Domain | 110 – 298 | 189 | ATP-grasp | ||||||
| Nucleotide binding | 138 – 193 | 56 | ATP By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 101 | 1 | R → G in AAA34407. Ref.2 | ||||||
| Sequence conflict | 186 | 1 | A → G in AAA34407. Ref.2 | ||||||
| Sequence conflict | 206 | 1 | S → F in AAA34407. Ref.2 | ||||||
| Sequence conflict | 241 – 253 | 13 | ENAIK…GCGIF → KMQSNFSRLWYI Ref.2 | ||||||
| Sequence conflict | 387 | 1 | I → L in AAA34407. Ref.2 | ||||||
| Sequence conflict | 407 | 1 | I → V in AAA34407. Ref.2 | ||||||
| Sequence conflict | 431 | 1 | P → T in AAA34407. Ref.2 | ||||||
| Sequence conflict | 434 | 1 | V → L in AAA34407. Ref.2 | ||||||
| Sequence conflict | 502 | 1 | I → T in AAA34407. Ref.2 | ||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "The ADE2 gene from Saccharomyces cerevisiae: sequence and new vectors." Stotz A., Linder P. Gene 95:91-98(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Molecular cloning and analysis of autonomous replicating sequence of Candida maltosa." Sasnauskas K., Jomantiene R., Lebediene E., Lebedys J., Januska A., Janulaitis A. Yeast 8:253-259(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "Sequencing and analysis of 51 kb on the right arm of chromosome XV from Saccharomyces cerevisiae reveals 30 open reading frames." Wiemann S., Rechmann S., Benes V., Voss H., Schwager C., Vlcek C., Stegemann J., Zimmermann J., Erfle H., Paces V., Ansorge W. Yeast 12:281-288(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679. |
| [4] | "DNA sequencing and analysis of 130 kb from yeast chromosome XV." Voss H., Benes V., Andrade M.A., Valencia A., Rechmann S., Teodoru C., Schwager C., Paces V., Sander C., Ansorge W. Yeast 13:655-672(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [5] | "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV." Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D. Kleine K.Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679. |
| [6] | Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c. |
| [7] | "Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | M59824 Genomic DNA. Translation: AAA34401.1. M58324 Genomic DNA. Translation: AAA34407.1. X90518 Genomic DNA. Translation: CAA62125.1. X94335 Genomic DNA. Translation: CAA64047.1. Z75036 Genomic DNA. Translation: CAA99327.1. BK006948 Genomic DNA. Translation: DAA10902.1. |
| PIR | DEBYP. JN0098. |
| RefSeq | NP_014771.3. NM_001183547.3. |
3D structure databases | |
| ProteinModelPortal | P21264. |
| SMR | P21264. Positions 16-376, 403-571. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP-1171N. |
| IntAct | P21264. 9 interactions. |
| MINT | MINT-387849. |
| STRING | 4932.YOR128C. |
Proteomic databases | |
| PaxDb | P21264. |
| PeptideAtlas | P21264. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblFungi | YOR128C; YOR128C; YOR128C. |
| GeneID | 854295. |
| KEGG | sce:YOR128C. sce:YOR130C. |
Organism-specific databases | |
| CYGD | YOR128c. |
| SGD | S000005654. ADE2. |
Phylogenomic databases | |
| eggNOG | COG0026. |
| HOGENOM | HOG000034027. |
| KO | K11808. K15114. |
| OMA | PLYAEKW. |
| OrthoDB | EOG4TXG17. |
Enzyme and pathway databases | |
| BioCyc | MetaCyc:MONOMER-487. |
| BRENDA | 4.1.1.21. 984. |
| UniPathway | UPA00074; UER00130. |
Gene expression databases | |
| Genevestigator | P21264. |
| GermOnline | YOR128C. Saccharomyces cerevisiae. |
Family and domain databases | |
| Gene3D | 3.30.1490.20. 1 hit. 3.30.470.20. 1 hit. 3.40.50.20. 1 hit. 3.40.50.7700. 1 hit. |
| InterPro | IPR016301. AIR_COase. IPR005875. AIR_COase_ATPase-su. IPR011761. ATP-grasp. IPR003135. ATP-grasp_carboxylate-amine. IPR013815. ATP_grasp_subdomain_1. IPR013816. ATP_grasp_subdomain_2. IPR000031. N5-CAIR_Mutase_PurE_dom. IPR016185. PreATP-grasp_dom. IPR011054. Rudment_hybrid_motif. [Graphical view] |
| Pfam | PF00731. AIRC. 1 hit. PF02222. ATP-grasp. 1 hit. [Graphical view] |
| PIRSF | PIRSF001340. AIR_carboxylase. 1 hit. |
| SMART | SM01001. AIRC. 1 hit. [Graphical view] |
| SUPFAM | SSF52255. AIR_carboxyl. 1 hit. SSF52440. PreATP-grasp-like. 1 hit. SSF51246. Rudmnt_hyb_motif. 1 hit. |
| TIGRFAMs | TIGR01162. purE. 1 hit. TIGR01161. purK. 1 hit. |
| PROSITE | PS50975. ATP_GRASP. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 976290. |
Entry information
| Entry name | PUR6_YEAST | ||||||||
| Accession | Primary (citable) accession number: P21264 Secondary accession number(s): D6W2I6 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |
| Yeast chromosome XV Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with
