P21248HEM4_BACSUUroporphyrinogen-III synthaseUROS4.2.1.75Hydroxymethylbilane hydrolyase [cyclizing]Uroporphyrinogen-III cosynthasehemDBSU28140Bacillus subtilis (strain 168)BacteriaBacillotaBacilliBacillalesBacillaceaeBacillusThe Bacillus subtilis hemAXCDBL gene cluster, which encodes enzymes of the biosynthetic pathway from glutamate to uroporphyrinogen III.NUCLEOTIDE SEQUENCE [GENOMIC DNA]The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]Cloning and characterization of the hemA region of the Bacillus subtilis chromosome.NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-130Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.hydroxymethylbilane = H2O + uroporphyrinogen IIIPorphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.Monomer.Belongs to the uroporphyrinogen-III synthase family.LyasePorphyrin biosynthesisReference proteomeMENDFPLKGKTVLVTRNKAQAASFQQKVEALGGKAVLTSLITFRRALPNDVAEQVREDLAAPGWLVFTSVNGADFFFSYLKENQLILPAHKKIAAVGEKTARRLKMHNVSVDVMPQEYIAEQLADALKQHAEPGETITVMKGNLSRDVIKQELVPLGFEVKEWVLYETIPDEEGIEALKDAAGQYSFDYVTFTSSSTVHTFMHVLGEELKKWKANGTACISIGPLTNDALLTYGITSHTPDTFTIDGMLELMCSMSREEERI
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