SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P21248

- HEM4_BACSU

UniProt

P21248 - HEM4_BACSU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Uroporphyrinogen-III synthase
Gene
hemD, BSU28140
Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III By similarity.

Catalytic activityi

Hydroxymethylbilane = uroporphyrinogen III + H2O.

Pathwayi

GO - Molecular functioni

  1. uroporphyrinogen-III synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Porphyrin biosynthesis

Enzyme and pathway databases

BioCyciBSUB:BSU28140-MONOMER.
UniPathwayiUPA00251; UER00320.

Names & Taxonomyi

Protein namesi
Recommended name:
Uroporphyrinogen-III synthase (EC:4.2.1.75)
Short name:
UROS
Alternative name(s):
Hydroxymethylbilane hydrolyase [cyclizing]
Uroporphyrinogen-III cosynthase
Gene namesi
Name:hemD
Ordered Locus Names:BSU28140
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU28140. [Micado]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 262262Uroporphyrinogen-III synthase
PRO_0000135240Add
BLAST

Proteomic databases

PaxDbiP21248.

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

STRINGi224308.BSU28140.

Structurei

3D structure databases

ProteinModelPortaliP21248.
SMRiP21248. Positions 37-255.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1587.
HOGENOMiHOG000247992.
KOiK01719.
OMAiCTEITVY.
OrthoDBiEOG6JQH1B.
PhylomeDBiP21248.

Family and domain databases

InterProiIPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view]
PfamiPF02602. HEM4. 1 hit.
[Graphical view]
SUPFAMiSSF69618. SSF69618. 1 hit.

Sequencei

Sequence statusi: Complete.

P21248-1 [UniParc]FASTAAdd to Basket

« Hide

MENDFPLKGK TVLVTRNKAQ AASFQQKVEA LGGKAVLTSL ITFRRALPND    50
VAEQVREDLA APGWLVFTSV NGADFFFSYL KENQLILPAH KKIAAVGEKT 100
ARRLKMHNVS VDVMPQEYIA EQLADALKQH AEPGETITVM KGNLSRDVIK 150
QELVPLGFEV KEWVLYETIP DEEGIEALKD AAGQYSFDYV TFTSSSTVHT 200
FMHVLGEELK KWKANGTACI SIGPLTNDAL LTYGITSHTP DTFTIDGMLE 250
LMCSMSREEE RI 262
Length:262
Mass (Da):29,114
Last modified:July 1, 1993 - v2
Checksum:iDB4B80D93A643F64
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M57676 Genomic DNA. Translation: AAA22513.1.
AL009126 Genomic DNA. Translation: CAB14774.1.
PIRiB42728.
RefSeqiNP_390692.1. NC_000964.3.
WP_003229629.1. NZ_CM000487.1.

Genome annotation databases

EnsemblBacteriaiCAB14774; CAB14774; BSU28140.
GeneIDi937287.
KEGGibsu:BSU28140.
PATRICi18977504. VBIBacSub10457_2941.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M57676 Genomic DNA. Translation: AAA22513.1 .
AL009126 Genomic DNA. Translation: CAB14774.1 .
PIRi B42728.
RefSeqi NP_390692.1. NC_000964.3.
WP_003229629.1. NZ_CM000487.1.

3D structure databases

ProteinModelPortali P21248.
SMRi P21248. Positions 37-255.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224308.BSU28140.

Proteomic databases

PaxDbi P21248.

Protocols and materials databases

DNASUi 937287.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB14774 ; CAB14774 ; BSU28140 .
GeneIDi 937287.
KEGGi bsu:BSU28140.
PATRICi 18977504. VBIBacSub10457_2941.

Organism-specific databases

GenoListi BSU28140. [Micado ]

Phylogenomic databases

eggNOGi COG1587.
HOGENOMi HOG000247992.
KOi K01719.
OMAi CTEITVY.
OrthoDBi EOG6JQH1B.
PhylomeDBi P21248.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00320 .
BioCyci BSUB:BSU28140-MONOMER.

Family and domain databases

InterProi IPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view ]
Pfami PF02602. HEM4. 1 hit.
[Graphical view ]
SUPFAMi SSF69618. SSF69618. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Bacillus subtilis hemAXCDBL gene cluster, which encodes enzymes of the biosynthetic pathway from glutamate to uroporphyrinogen III."
    Hansson M., Rutberg L., Schroeder I., Hederstedt L.
    J. Bacteriol. 173:2590-2599(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  3. "Cloning and characterization of the hemA region of the Bacillus subtilis chromosome."
    Petricek M., Rutberg L., Schroeder I., Hederstedt L.
    J. Bacteriol. 172:2250-2258(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-130.

Entry informationi

Entry nameiHEM4_BACSU
AccessioniPrimary (citable) accession number: P21248
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: July 1, 1993
Last modified: September 3, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi