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P21248

- HEM4_BACSU

UniProt

P21248 - HEM4_BACSU

Protein

Uroporphyrinogen-III synthase

Gene

hemD

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.By similarity

    Catalytic activityi

    Hydroxymethylbilane = uroporphyrinogen III + H2O.

    Pathwayi

    GO - Molecular functioni

    1. uroporphyrinogen-III synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Enzyme and pathway databases

    BioCyciBSUB:BSU28140-MONOMER.
    UniPathwayiUPA00251; UER00320.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uroporphyrinogen-III synthase (EC:4.2.1.75)
    Short name:
    UROS
    Alternative name(s):
    Hydroxymethylbilane hydrolyase [cyclizing]
    Uroporphyrinogen-III cosynthase
    Gene namesi
    Name:hemD
    Ordered Locus Names:BSU28140
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU28140. [Micado]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 262262Uroporphyrinogen-III synthasePRO_0000135240Add
    BLAST

    Proteomic databases

    PaxDbiP21248.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi224308.BSU28140.

    Structurei

    3D structure databases

    ProteinModelPortaliP21248.
    SMRiP21248. Positions 37-255.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1587.
    HOGENOMiHOG000247992.
    KOiK01719.
    OMAiCTEITVY.
    OrthoDBiEOG6JQH1B.
    PhylomeDBiP21248.

    Family and domain databases

    InterProiIPR003754. 4pyrrol_synth_uPrphyn_synth.
    [Graphical view]
    PfamiPF02602. HEM4. 1 hit.
    [Graphical view]
    SUPFAMiSSF69618. SSF69618. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P21248-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENDFPLKGK TVLVTRNKAQ AASFQQKVEA LGGKAVLTSL ITFRRALPND    50
    VAEQVREDLA APGWLVFTSV NGADFFFSYL KENQLILPAH KKIAAVGEKT 100
    ARRLKMHNVS VDVMPQEYIA EQLADALKQH AEPGETITVM KGNLSRDVIK 150
    QELVPLGFEV KEWVLYETIP DEEGIEALKD AAGQYSFDYV TFTSSSTVHT 200
    FMHVLGEELK KWKANGTACI SIGPLTNDAL LTYGITSHTP DTFTIDGMLE 250
    LMCSMSREEE RI 262
    Length:262
    Mass (Da):29,114
    Last modified:July 1, 1993 - v2
    Checksum:iDB4B80D93A643F64
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M57676 Genomic DNA. Translation: AAA22513.1.
    AL009126 Genomic DNA. Translation: CAB14774.1.
    PIRiB42728.
    RefSeqiNP_390692.1. NC_000964.3.
    WP_003229629.1. NZ_CM000487.1.

    Genome annotation databases

    EnsemblBacteriaiCAB14774; CAB14774; BSU28140.
    GeneIDi937287.
    KEGGibsu:BSU28140.
    PATRICi18977504. VBIBacSub10457_2941.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M57676 Genomic DNA. Translation: AAA22513.1 .
    AL009126 Genomic DNA. Translation: CAB14774.1 .
    PIRi B42728.
    RefSeqi NP_390692.1. NC_000964.3.
    WP_003229629.1. NZ_CM000487.1.

    3D structure databases

    ProteinModelPortali P21248.
    SMRi P21248. Positions 37-255.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224308.BSU28140.

    Proteomic databases

    PaxDbi P21248.

    Protocols and materials databases

    DNASUi 937287.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB14774 ; CAB14774 ; BSU28140 .
    GeneIDi 937287.
    KEGGi bsu:BSU28140.
    PATRICi 18977504. VBIBacSub10457_2941.

    Organism-specific databases

    GenoListi BSU28140. [Micado ]

    Phylogenomic databases

    eggNOGi COG1587.
    HOGENOMi HOG000247992.
    KOi K01719.
    OMAi CTEITVY.
    OrthoDBi EOG6JQH1B.
    PhylomeDBi P21248.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00320 .
    BioCyci BSUB:BSU28140-MONOMER.

    Family and domain databases

    InterProi IPR003754. 4pyrrol_synth_uPrphyn_synth.
    [Graphical view ]
    Pfami PF02602. HEM4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF69618. SSF69618. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The Bacillus subtilis hemAXCDBL gene cluster, which encodes enzymes of the biosynthetic pathway from glutamate to uroporphyrinogen III."
      Hansson M., Rutberg L., Schroeder I., Hederstedt L.
      J. Bacteriol. 173:2590-2599(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.
    3. "Cloning and characterization of the hemA region of the Bacillus subtilis chromosome."
      Petricek M., Rutberg L., Schroeder I., Hederstedt L.
      J. Bacteriol. 172:2250-2258(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-130.

    Entry informationi

    Entry nameiHEM4_BACSU
    AccessioniPrimary (citable) accession number: P21248
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3