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Protein

Pleiotrophin

Gene

PTN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells (PubMed:1768439, PubMed:1733956). Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation (PubMed:11278720). Binds to cell-surface target proteins via their chondroitin sulfate groups (PubMed:26896299). Down-regulates PTPRZ1 activity (PubMed:16814777).4 Publications

GO - Molecular functioni

  • chondroitin sulfate binding Source: UniProtKB
  • chondroitin sulfate proteoglycan binding Source: Ensembl
  • growth factor activity Source: UniProtKB
  • heparan sulfate binding Source: Ensembl
  • heparin binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • protein phosphatase inhibitor activity Source: ProtInc
  • vascular endothelial growth factor binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionGrowth factor, Heparin-binding, Mitogen

Enzyme and pathway databases

SignaLinkiP21246.
SIGNORiP21246.

Names & Taxonomyi

Protein namesi
Recommended name:
Pleiotrophin
Short name:
PTN
Alternative name(s):
Heparin-binding brain mitogen
Short name:
HBBM
Heparin-binding growth factor 8
Short name:
HBGF-8
Heparin-binding growth-associated molecule
Short name:
HB-GAM
Heparin-binding neurite outgrowth-promoting factor 1
Short name:
HBNF-1
Osteoblast-specific factor 1
Short name:
OSF-1
Gene namesi
Name:PTN
Synonyms:HBNF1, NEGF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000105894.11.
HGNCiHGNC:9630. PTN.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5764.
OpenTargetsiENSG00000105894.
PharmGKBiPA33974.

Polymorphism and mutation databases

BioMutaiPTN.
DMDMi131553.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 323 PublicationsAdd BLAST32
ChainiPRO_000002465933 – 168PleiotrophinAdd BLAST136

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47 ↔ 76Combined sources2 Publications
Disulfide bondi55 ↔ 85Combined sources2 Publications
Disulfide bondi62 ↔ 89Combined sources2 Publications
Disulfide bondi99 ↔ 131Combined sources2 Publications
Disulfide bondi109 ↔ 141Combined sources2 Publications

Post-translational modificationi

Phosphorylated by NEK6.1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP21246.
PaxDbiP21246.
PeptideAtlasiP21246.
PRIDEiP21246.

PTM databases

iPTMnetiP21246.
PhosphoSitePlusiP21246.

Miscellaneous databases

PMAP-CutDBiP21246.

Expressioni

Tissue specificityi

Osteoblast and brain.

Inductioni

By heparin and retinoic acid.2 Publications

Gene expression databases

BgeeiENSG00000105894.
CleanExiHS_PTN.
ExpressionAtlasiP21246. baseline and differential.
GenevisibleiP21246. HS.

Organism-specific databases

HPAiCAB017685.

Interactioni

Subunit structurei

Interacts with ALK and NEK6 (PubMed:11278720, PubMed:20873783). Interacts with PTPRZ1 (probably via chondroitin sulfate groups) (PubMed:16814777, PubMed:26896299).1 Publication3 Publications

GO - Molecular functioni

  • chondroitin sulfate proteoglycan binding Source: Ensembl
  • growth factor activity Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • vascular endothelial growth factor binding Source: Ensembl

Protein-protein interaction databases

BioGridi111731. 94 interactors.
DIPiDIP-5953N.
IntActiP21246. 91 interactors.
MINTiMINT-1374580.
STRINGi9606.ENSP00000341170.

Structurei

Secondary structure

1168
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi48 – 52Combined sources5
Beta strandi60 – 62Combined sources3
Beta strandi66 – 72Combined sources7
Beta strandi78 – 84Combined sources7
Beta strandi97 – 104Combined sources8
Turni111 – 114Combined sources4
Beta strandi115 – 124Combined sources10
Beta strandi133 – 142Combined sources10
Turni163 – 166Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N6FNMR-A33-168[»]
DisProtiDP00887.
ProteinModelPortaliP21246.
SMRiP21246.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni92 – 99Chondroitin sulfate binding1 Publication8
Regioni123 – 131Chondroitin sulfate binding1 Publication9
Regioni147 – 168Chondroitin sulfate A binding1 PublicationAdd BLAST22

Sequence similaritiesi

Belongs to the pleiotrophin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWNA. Eukaryota.
ENOG4111ZWP. LUCA.
GeneTreeiENSGT00390000007640.
HOGENOMiHOG000231473.
HOVERGENiHBG008317.
InParanoidiP21246.
KOiK16642.
OMAiGEDICNS.
OrthoDBiEOG091G0VCN.
PhylomeDBiP21246.
TreeFamiTF332376.

Family and domain databases

Gene3Di2.20.60.10. 1 hit.
InterProiView protein in InterPro
IPR000762. Midkine_heparin-bd_GF.
IPR020090. PTN/MK_C_dom.
IPR020091. PTN/MK_diS_sf.
IPR020089. PTN/MK_N_dom.
IPR037122. PTN/MK_N_dom_sf.
IPR020092. PTN_MK_heparin-bd_GF_CS.
PANTHERiPTHR13850. PTHR13850. 1 hit.
PfamiView protein in Pfam
PF01091. PTN_MK_C. 1 hit.
PF05196. PTN_MK_N. 1 hit.
PRINTSiPR00269. PTNMIDKINE.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005592. PTN_MK_hepar_bd. 1 hit.
SMARTiView protein in SMART
SM00193. PTN. 1 hit.
SUPFAMiSSF57288. SSF57288. 2 hits.
PROSITEiView protein in PROSITE
PS00619. PTN_MK_1. 1 hit.
PS00620. PTN_MK_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21246-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAQQYQQQR RKFAAAFLAF IFILAAVDTA EAGKKEKPEK KVKKSDCGEW
60 70 80 90 100
QWSVCVPTSG DCGLGTREGT RTGAECKQTM KTQRCKIPCN WKKQFGAECK
110 120 130 140 150
YQFQAWGECD LNTALKTRTG SLKRALHNAE CQKTVTISKP CGKLTKPKPQ
160
AESKKKKKEG KKQEKMLD
Length:168
Mass (Da):18,942
Last modified:May 1, 1991 - v1
Checksum:i0359C08B6497B579
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42V → K AA sequence (PubMed:1733956).Curated1
Sequence conflicti47C → D AA sequence (PubMed:1733956).Curated1
Sequence conflicti75E → G in AAV38498 (Ref. 9) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90226 mRNA. Translation: BAA14261.1.
X52946 mRNA. Translation: CAA37121.1.
M57399 mRNA. Translation: AAA35961.1.
S50409
, S50405, S50408, S50394 Genomic DNA. Translation: AAB24425.1.
S60110
, S59641, S60111, S60736 Genomic DNA. Translation: AAB26456.1.
AB004306 Genomic DNA. Translation: BAA22944.1.
AK290488 mRNA. Translation: BAF83177.1.
AK313424 mRNA. Translation: BAG36216.1.
CR450338 mRNA. Translation: CAG29334.1.
BT019692 mRNA. Translation: AAV38498.1.
CH236950 Genomic DNA. Translation: EAL24052.1.
CH471070 Genomic DNA. Translation: EAW83869.1.
BC005916 mRNA. Translation: AAH05916.1.
CCDSiCCDS5844.1.
PIRiJN0474. C37780.
RefSeqiNP_001308315.1. NM_001321386.2.
NP_001308316.1. NM_001321387.2.
NP_002816.1. NM_002825.6.
UniGeneiHs.371249.

Genome annotation databases

EnsembliENST00000348225; ENSP00000341170; ENSG00000105894.
GeneIDi5764.
KEGGihsa:5764.
UCSCiuc003vtq.4. human.

Similar proteinsi

Entry informationi

Entry nameiPTN_HUMAN
AccessioniPrimary (citable) accession number: P21246
Secondary accession number(s): Q5U0B0, Q6ICQ5, Q9UCC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: November 22, 2017
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families