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Protein

Pleiotrophin

Gene

PTN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation.2 Publications

GO - Molecular functioni

  • heparin binding Source: UniProtKB-KW
  • protein phosphatase inhibitor activity Source: ProtInc

GO - Biological processi

  • bone mineralization Source: Ensembl
  • learning Source: Ensembl
  • negative regulation of catalytic activity Source: GOC
  • nervous system development Source: ProtInc
  • positive regulation of cell division Source: UniProtKB-KW
  • positive regulation of cell proliferation Source: ProtInc
  • transmembrane receptor protein tyrosine phosphatase signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Mitogen

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

SignaLinkiP21246.

Names & Taxonomyi

Protein namesi
Recommended name:
Pleiotrophin
Short name:
PTN
Alternative name(s):
Heparin-binding brain mitogen
Short name:
HBBM
Heparin-binding growth factor 8
Short name:
HBGF-8
Heparin-binding growth-associated molecule
Short name:
HB-GAM
Heparin-binding neurite outgrowth-promoting factor 1
Short name:
HBNF-1
Osteoblast-specific factor 1
Short name:
OSF-1
Gene namesi
Name:PTN
Synonyms:HBNF1, NEGF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:9630. PTN.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: LIFEdb
  • extracellular space Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33974.

Polymorphism and mutation databases

BioMutaiPTN.
DMDMi131553.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 32323 PublicationsAdd
BLAST
Chaini33 – 168136PleiotrophinPRO_0000024659Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi47 ↔ 761 Publication
Disulfide bondi55 ↔ 851 Publication
Disulfide bondi62 ↔ 891 Publication
Disulfide bondi99 ↔ 1311 Publication
Disulfide bondi109 ↔ 1411 Publication

Post-translational modificationi

Phosphorylated by NEK6.1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP21246.
PRIDEiP21246.

PTM databases

PhosphoSiteiP21246.

Miscellaneous databases

PMAP-CutDBP21246.

Expressioni

Tissue specificityi

Osteoblast and brain.

Inductioni

By heparin and retinoic acid.2 Publications

Gene expression databases

BgeeiP21246.
CleanExiHS_PTN.
ExpressionAtlasiP21246. baseline and differential.
GenevisibleiP21246. HS.

Organism-specific databases

HPAiCAB017685.
HPA054601.

Interactioni

Subunit structurei

Interacts with ALK and NEK6.2 Publications

Protein-protein interaction databases

BioGridi111731. 94 interactions.
DIPiDIP-5953N.
IntActiP21246. 91 interactions.
MINTiMINT-1374580.
STRINGi9606.ENSP00000341170.

Structurei

3D structure databases

ProteinModelPortaliP21246.
SMRiP21246. Positions 45-141.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pleiotrophin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39583.
GeneTreeiENSGT00390000007640.
HOGENOMiHOG000231473.
HOVERGENiHBG008317.
InParanoidiP21246.
KOiK16642.
OMAiGEDICNS.
OrthoDBiEOG7B05G6.
PhylomeDBiP21246.
TreeFamiTF332376.

Family and domain databases

Gene3Di2.20.60.10. 1 hit.
2.30.90.10. 1 hit.
InterProiIPR000762. Midkine_heparin-bd_GF.
IPR020090. PTN/MK_C_dom.
IPR020091. PTN/MK_diS.
IPR020089. PTN/MK_N_dom.
IPR020092. PTN_MK_heparin-bd_GF_CS.
[Graphical view]
PANTHERiPTHR13850. PTHR13850. 1 hit.
PfamiPF01091. PTN_MK_C. 1 hit.
PF05196. PTN_MK_N. 1 hit.
[Graphical view]
PRINTSiPR00269. PTNMIDKINE.
ProDomiPD005592. PTN_MK_hepar_bd. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00193. PTN. 1 hit.
[Graphical view]
SUPFAMiSSF57288. SSF57288. 2 hits.
PROSITEiPS00619. PTN_MK_1. 1 hit.
PS00620. PTN_MK_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21246-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAQQYQQQR RKFAAAFLAF IFILAAVDTA EAGKKEKPEK KVKKSDCGEW
60 70 80 90 100
QWSVCVPTSG DCGLGTREGT RTGAECKQTM KTQRCKIPCN WKKQFGAECK
110 120 130 140 150
YQFQAWGECD LNTALKTRTG SLKRALHNAE CQKTVTISKP CGKLTKPKPQ
160
AESKKKKKEG KKQEKMLD
Length:168
Mass (Da):18,942
Last modified:May 1, 1991 - v1
Checksum:i0359C08B6497B579
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 421V → K AA sequence (PubMed:1733956).Curated
Sequence conflicti47 – 471C → D AA sequence (PubMed:1733956).Curated
Sequence conflicti75 – 751E → G in AAV38498 (Ref. 9) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90226 mRNA. Translation: BAA14261.1.
X52946 mRNA. Translation: CAA37121.1.
M57399 mRNA. Translation: AAA35961.1.
S50409
, S50405, S50408, S50394 Genomic DNA. Translation: AAB24425.1.
S60110
, S59641, S60111, S60736 Genomic DNA. Translation: AAB26456.1.
AB004306 Genomic DNA. Translation: BAA22944.1.
AK290488 mRNA. Translation: BAF83177.1.
AK313424 mRNA. Translation: BAG36216.1.
CR450338 mRNA. Translation: CAG29334.1.
BT019692 mRNA. Translation: AAV38498.1.
CH236950 Genomic DNA. Translation: EAL24052.1.
CH471070 Genomic DNA. Translation: EAW83869.1.
BC005916 mRNA. Translation: AAH05916.1.
CCDSiCCDS5844.1.
PIRiJN0474. C37780.
RefSeqiNP_002816.1. NM_002825.5.
XP_005250572.1. XM_005250515.2.
UniGeneiHs.371249.

Genome annotation databases

EnsembliENST00000348225; ENSP00000341170; ENSG00000105894.
GeneIDi5764.
KEGGihsa:5764.
UCSCiuc003vtq.2. human.

Cross-referencesi

Web resourcesi

Wikipedia

Pleiotrophin entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90226 mRNA. Translation: BAA14261.1.
X52946 mRNA. Translation: CAA37121.1.
M57399 mRNA. Translation: AAA35961.1.
S50409
, S50405, S50408, S50394 Genomic DNA. Translation: AAB24425.1.
S60110
, S59641, S60111, S60736 Genomic DNA. Translation: AAB26456.1.
AB004306 Genomic DNA. Translation: BAA22944.1.
AK290488 mRNA. Translation: BAF83177.1.
AK313424 mRNA. Translation: BAG36216.1.
CR450338 mRNA. Translation: CAG29334.1.
BT019692 mRNA. Translation: AAV38498.1.
CH236950 Genomic DNA. Translation: EAL24052.1.
CH471070 Genomic DNA. Translation: EAW83869.1.
BC005916 mRNA. Translation: AAH05916.1.
CCDSiCCDS5844.1.
PIRiJN0474. C37780.
RefSeqiNP_002816.1. NM_002825.5.
XP_005250572.1. XM_005250515.2.
UniGeneiHs.371249.

3D structure databases

ProteinModelPortaliP21246.
SMRiP21246. Positions 45-141.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111731. 94 interactions.
DIPiDIP-5953N.
IntActiP21246. 91 interactions.
MINTiMINT-1374580.
STRINGi9606.ENSP00000341170.

PTM databases

PhosphoSiteiP21246.

Polymorphism and mutation databases

BioMutaiPTN.
DMDMi131553.

Proteomic databases

PaxDbiP21246.
PRIDEiP21246.

Protocols and materials databases

DNASUi5764.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000348225; ENSP00000341170; ENSG00000105894.
GeneIDi5764.
KEGGihsa:5764.
UCSCiuc003vtq.2. human.

Organism-specific databases

CTDi5764.
GeneCardsiGC07M136912.
HGNCiHGNC:9630. PTN.
HPAiCAB017685.
HPA054601.
MIMi162095. gene.
neXtProtiNX_P21246.
PharmGKBiPA33974.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG39583.
GeneTreeiENSGT00390000007640.
HOGENOMiHOG000231473.
HOVERGENiHBG008317.
InParanoidiP21246.
KOiK16642.
OMAiGEDICNS.
OrthoDBiEOG7B05G6.
PhylomeDBiP21246.
TreeFamiTF332376.

Enzyme and pathway databases

SignaLinkiP21246.

Miscellaneous databases

ChiTaRSiPTN. human.
GeneWikiiPleiotrophin.
GenomeRNAii5764.
NextBioi22426.
PMAP-CutDBP21246.
PROiP21246.
SOURCEiSearch...

Gene expression databases

BgeeiP21246.
CleanExiHS_PTN.
ExpressionAtlasiP21246. baseline and differential.
GenevisibleiP21246. HS.

Family and domain databases

Gene3Di2.20.60.10. 1 hit.
2.30.90.10. 1 hit.
InterProiIPR000762. Midkine_heparin-bd_GF.
IPR020090. PTN/MK_C_dom.
IPR020091. PTN/MK_diS.
IPR020089. PTN/MK_N_dom.
IPR020092. PTN_MK_heparin-bd_GF_CS.
[Graphical view]
PANTHERiPTHR13850. PTHR13850. 1 hit.
PfamiPF01091. PTN_MK_C. 1 hit.
PF05196. PTN_MK_N. 1 hit.
[Graphical view]
PRINTSiPR00269. PTNMIDKINE.
ProDomiPD005592. PTN_MK_hepar_bd. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00193. PTN. 1 hit.
[Graphical view]
SUPFAMiSSF57288. SSF57288. 2 hits.
PROSITEiPS00619. PTN_MK_1. 1 hit.
PS00620. PTN_MK_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of mouse and human cDNA clones encoding a protein expressed specifically in osteoblasts and brain tissues."
    Tezuka K.I., Takeshita S., Hakeda Y., Kumegawa M., Kikuno R., Hashimoto-Gotoh T.
    Biochem. Biophys. Res. Commun. 173:246-251(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activity."
    Li Y.-S., Milner P.G., Chauhan A.K., Watson M.A., Hoffman R.M., Kodner C.M., Milbrandt J., Deuel T.F.
    Science 250:1690-1694(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  3. "Cloning, characterization and developmental regulation of two members of a novel human gene family of neurite outgrowth-promoting proteins."
    Kretschmer P.J., Fairhurst J.L., Decker M.M., Chan C.P., Gluzman Y., Boehlen P., Kovesdi I.
    Growth Factors 5:99-114(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION.
  4. "Cloning, nucleotide sequence, and chromosome localization of the human pleiotrophin gene."
    Milner P.G., Shah D., Veile R., Donis-Keller H., Kumar B.V.
    Biochemistry 31:12023-12028(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Genomic organization of the human HBNF gene and characterization of an HBNF variant protein as a splice mutant."
    Kretschmer P.J., Fairhurst J.L., Hulmes J.D., Popjes M.L., Boehlen P., Kovesdi I.
    Biochem. Biophys. Res. Commun. 192:420-429(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "Bone mass loss due to estrogen deficiency is compensated in transgenic mice overexpressing human osteoblast stimulating factor-1."
    Masuda H., Tsujimura A., Yoshioka M., Arai Y., Kuboki Y., Mukai T., Nakamura T., Tsuji H., Nakagawa M., Hashimoto-Gotoh T.
    Biochem. Biophys. Res. Commun. 238:528-533(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Cerebellum.
  8. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  9. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  10. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  12. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  13. "Amino-terminal sequences of a novel heparin-binding protein from human, bovine, rat, and chick brain: high interspecies homology."
    Huber D., Gautschi-Sova P., Bohlen P.
    Neurochem. Res. 15:435-439(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 33-58.
    Tissue: Brain.
  14. "A heparin-binding growth factor secreted from breast cancer cells homologous to a developmentally regulated cytokine."
    Wellsein A., Fang W., Khatri A., Lu Y., Swain S.S., Dickson R.B., Sasse J., Riegel A.T., Lippman M.E.
    J. Biol. Chem. 267:2582-2587(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 33-52.
  15. "Identification of novel heparin-releasable proteins, as well as the cytokines midkine and pleiotrophin, in human postheparin plasma."
    Novotny W.F., Maffi T., Mehta R.L., Milner P.G.
    Arterioscler. Thromb. 13:1798-1805(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 33-49, INDUCTION.
    Tissue: Plasma.
  16. "Comparison of the disulfide bond arrangements of human recombinant and bovine brain heparin binding neurite-promoting factors."
    Hulmes J.D., Seddon A.P., Decker M.M., Bohlen P.
    Biochem. Biophys. Res. Commun. 192:738-746(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BONDS.
  17. "Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin."
    Stoica G.E., Kuo A., Aigner A., Sunitha I., Souttou B., Malerczyk C., Caughey D.J., Wen D., Karavanov A., Riegel A.T., Wellstein A.
    J. Biol. Chem. 276:16772-16779(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ALK, FUNCTION.
  18. "Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome."
    Vaz Meirelles G., Ferreira Lanza D.C., da Silva J.C., Santana Bernachi J., Paes Leme A.F., Kobarg J.
    J. Proteome Res. 9:6298-6316(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NEK6, PHOSPHORYLATION BY NEK6.

Entry informationi

Entry nameiPTN_HUMAN
AccessioniPrimary (citable) accession number: P21246
Secondary accession number(s): Q5U0B0, Q6ICQ5, Q9UCC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: June 24, 2015
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.