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P21246

- PTN_HUMAN

UniProt

P21246 - PTN_HUMAN

Protein

Pleiotrophin

Gene

PTN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation.2 Publications

    GO - Molecular functioni

    1. heparin binding Source: UniProtKB-KW
    2. protein phosphatase inhibitor activity Source: ProtInc

    GO - Biological processi

    1. bone mineralization Source: Ensembl
    2. learning Source: Ensembl
    3. negative regulation of catalytic activity Source: GOC
    4. nervous system development Source: ProtInc
    5. positive regulation of cell division Source: UniProtKB-KW
    6. positive regulation of cell proliferation Source: ProtInc
    7. transmembrane receptor protein tyrosine phosphatase signaling pathway Source: ProtInc

    Keywords - Molecular functioni

    Growth factor, Mitogen

    Keywords - Ligandi

    Heparin-binding

    Enzyme and pathway databases

    SignaLinkiP21246.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pleiotrophin
    Short name:
    PTN
    Alternative name(s):
    Heparin-binding brain mitogen
    Short name:
    HBBM
    Heparin-binding growth factor 8
    Short name:
    HBGF-8
    Heparin-binding growth-associated molecule
    Short name:
    HB-GAM
    Heparin-binding neurite outgrowth-promoting factor 1
    Short name:
    HBNF-1
    Osteoblast-specific factor 1
    Short name:
    OSF-1
    Gene namesi
    Name:PTN
    Synonyms:HBNF1, NEGF1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:9630. PTN.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: LIFEdb
    2. extracellular space Source: ProtInc

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33974.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 32323 PublicationsAdd
    BLAST
    Chaini33 – 168136PleiotrophinPRO_0000024659Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi47 ↔ 761 Publication
    Disulfide bondi55 ↔ 851 Publication
    Disulfide bondi62 ↔ 891 Publication
    Disulfide bondi99 ↔ 1311 Publication
    Disulfide bondi109 ↔ 1411 Publication

    Post-translational modificationi

    Phosphorylated by NEK6.1 Publication

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP21246.
    PRIDEiP21246.

    PTM databases

    PhosphoSiteiP21246.

    Miscellaneous databases

    PMAP-CutDBP21246.

    Expressioni

    Tissue specificityi

    Osteoblast and brain.

    Inductioni

    By heparin and retinoic acid.2 Publications

    Gene expression databases

    ArrayExpressiP21246.
    BgeeiP21246.
    CleanExiHS_PTN.
    GenevestigatoriP21246.

    Organism-specific databases

    HPAiCAB017685.
    HPA054601.

    Interactioni

    Subunit structurei

    Interacts with ALK and NEK6.2 Publications

    Protein-protein interaction databases

    BioGridi111731. 94 interactions.
    DIPiDIP-5953N.
    IntActiP21246. 91 interactions.
    MINTiMINT-1374580.
    STRINGi9606.ENSP00000341170.

    Structurei

    3D structure databases

    ProteinModelPortaliP21246.
    SMRiP21246. Positions 45-141.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pleiotrophin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG39583.
    HOGENOMiHOG000231473.
    HOVERGENiHBG008317.
    InParanoidiP21246.
    KOiK16642.
    OMAiQQRRMFT.
    OrthoDBiEOG7B05G6.
    PhylomeDBiP21246.
    TreeFamiTF332376.

    Family and domain databases

    Gene3Di2.20.60.10. 1 hit.
    2.30.90.10. 1 hit.
    InterProiIPR000762. Midkine_heparin-bd_GF.
    IPR020090. PTN/MK_C_dom.
    IPR020091. PTN/MK_diS.
    IPR020089. PTN/MK_N_dom.
    IPR020092. PTN_MK_heparin-bd_GF_CS.
    [Graphical view]
    PANTHERiPTHR13850. PTHR13850. 1 hit.
    PfamiPF01091. PTN_MK_C. 1 hit.
    PF05196. PTN_MK_N. 1 hit.
    [Graphical view]
    PRINTSiPR00269. PTNMIDKINE.
    ProDomiPD005592. PTN_MK_hepar_bd. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00193. PTN. 1 hit.
    [Graphical view]
    SUPFAMiSSF57288. SSF57288. 2 hits.
    PROSITEiPS00619. PTN_MK_1. 1 hit.
    PS00620. PTN_MK_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P21246-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQAQQYQQQR RKFAAAFLAF IFILAAVDTA EAGKKEKPEK KVKKSDCGEW    50
    QWSVCVPTSG DCGLGTREGT RTGAECKQTM KTQRCKIPCN WKKQFGAECK 100
    YQFQAWGECD LNTALKTRTG SLKRALHNAE CQKTVTISKP CGKLTKPKPQ 150
    AESKKKKKEG KKQEKMLD 168
    Length:168
    Mass (Da):18,942
    Last modified:May 1, 1991 - v1
    Checksum:i0359C08B6497B579
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti42 – 421V → K AA sequence (PubMed:1733956)Curated
    Sequence conflicti47 – 471C → D AA sequence (PubMed:1733956)Curated
    Sequence conflicti75 – 751E → G in AAV38498. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D90226 mRNA. Translation: BAA14261.1.
    X52946 mRNA. Translation: CAA37121.1.
    M57399 mRNA. Translation: AAA35961.1.
    S50409
    , S50405, S50408, S50394 Genomic DNA. Translation: AAB24425.1.
    S60110
    , S59641, S60111, S60736 Genomic DNA. Translation: AAB26456.1.
    AB004306 Genomic DNA. Translation: BAA22944.1.
    AK290488 mRNA. Translation: BAF83177.1.
    AK313424 mRNA. Translation: BAG36216.1.
    CR450338 mRNA. Translation: CAG29334.1.
    BT019692 mRNA. Translation: AAV38498.1.
    CH236950 Genomic DNA. Translation: EAL24052.1.
    CH471070 Genomic DNA. Translation: EAW83869.1.
    BC005916 mRNA. Translation: AAH05916.1.
    CCDSiCCDS5844.1.
    PIRiJN0474. C37780.
    RefSeqiNP_002816.1. NM_002825.5.
    XP_005250572.1. XM_005250515.1.
    UniGeneiHs.371249.

    Genome annotation databases

    EnsembliENST00000348225; ENSP00000341170; ENSG00000105894.
    GeneIDi5764.
    KEGGihsa:5764.
    UCSCiuc003vtq.2. human.

    Polymorphism databases

    DMDMi131553.

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Pleiotrophin entry

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D90226 mRNA. Translation: BAA14261.1 .
    X52946 mRNA. Translation: CAA37121.1 .
    M57399 mRNA. Translation: AAA35961.1 .
    S50409
    , S50405 , S50408 , S50394 Genomic DNA. Translation: AAB24425.1 .
    S60110
    , S59641 , S60111 , S60736 Genomic DNA. Translation: AAB26456.1 .
    AB004306 Genomic DNA. Translation: BAA22944.1 .
    AK290488 mRNA. Translation: BAF83177.1 .
    AK313424 mRNA. Translation: BAG36216.1 .
    CR450338 mRNA. Translation: CAG29334.1 .
    BT019692 mRNA. Translation: AAV38498.1 .
    CH236950 Genomic DNA. Translation: EAL24052.1 .
    CH471070 Genomic DNA. Translation: EAW83869.1 .
    BC005916 mRNA. Translation: AAH05916.1 .
    CCDSi CCDS5844.1.
    PIRi JN0474. C37780.
    RefSeqi NP_002816.1. NM_002825.5.
    XP_005250572.1. XM_005250515.1.
    UniGenei Hs.371249.

    3D structure databases

    ProteinModelPortali P21246.
    SMRi P21246. Positions 45-141.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111731. 94 interactions.
    DIPi DIP-5953N.
    IntActi P21246. 91 interactions.
    MINTi MINT-1374580.
    STRINGi 9606.ENSP00000341170.

    PTM databases

    PhosphoSitei P21246.

    Polymorphism databases

    DMDMi 131553.

    Proteomic databases

    PaxDbi P21246.
    PRIDEi P21246.

    Protocols and materials databases

    DNASUi 5764.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000348225 ; ENSP00000341170 ; ENSG00000105894 .
    GeneIDi 5764.
    KEGGi hsa:5764.
    UCSCi uc003vtq.2. human.

    Organism-specific databases

    CTDi 5764.
    GeneCardsi GC07M136912.
    HGNCi HGNC:9630. PTN.
    HPAi CAB017685.
    HPA054601.
    MIMi 162095. gene.
    neXtProti NX_P21246.
    PharmGKBi PA33974.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39583.
    HOGENOMi HOG000231473.
    HOVERGENi HBG008317.
    InParanoidi P21246.
    KOi K16642.
    OMAi QQRRMFT.
    OrthoDBi EOG7B05G6.
    PhylomeDBi P21246.
    TreeFami TF332376.

    Enzyme and pathway databases

    SignaLinki P21246.

    Miscellaneous databases

    ChiTaRSi PTN. human.
    GeneWikii Pleiotrophin.
    GenomeRNAii 5764.
    NextBioi 22426.
    PMAP-CutDB P21246.
    PROi P21246.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P21246.
    Bgeei P21246.
    CleanExi HS_PTN.
    Genevestigatori P21246.

    Family and domain databases

    Gene3Di 2.20.60.10. 1 hit.
    2.30.90.10. 1 hit.
    InterProi IPR000762. Midkine_heparin-bd_GF.
    IPR020090. PTN/MK_C_dom.
    IPR020091. PTN/MK_diS.
    IPR020089. PTN/MK_N_dom.
    IPR020092. PTN_MK_heparin-bd_GF_CS.
    [Graphical view ]
    PANTHERi PTHR13850. PTHR13850. 1 hit.
    Pfami PF01091. PTN_MK_C. 1 hit.
    PF05196. PTN_MK_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00269. PTNMIDKINE.
    ProDomi PD005592. PTN_MK_hepar_bd. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00193. PTN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57288. SSF57288. 2 hits.
    PROSITEi PS00619. PTN_MK_1. 1 hit.
    PS00620. PTN_MK_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of mouse and human cDNA clones encoding a protein expressed specifically in osteoblasts and brain tissues."
      Tezuka K.I., Takeshita S., Hakeda Y., Kumegawa M., Kikuno R., Hashimoto-Gotoh T.
      Biochem. Biophys. Res. Commun. 173:246-251(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activity."
      Li Y.-S., Milner P.G., Chauhan A.K., Watson M.A., Hoffman R.M., Kodner C.M., Milbrandt J., Deuel T.F.
      Science 250:1690-1694(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    3. "Cloning, characterization and developmental regulation of two members of a novel human gene family of neurite outgrowth-promoting proteins."
      Kretschmer P.J., Fairhurst J.L., Decker M.M., Chan C.P., Gluzman Y., Boehlen P., Kovesdi I.
      Growth Factors 5:99-114(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INDUCTION.
    4. "Cloning, nucleotide sequence, and chromosome localization of the human pleiotrophin gene."
      Milner P.G., Shah D., Veile R., Donis-Keller H., Kumar B.V.
      Biochemistry 31:12023-12028(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Genomic organization of the human HBNF gene and characterization of an HBNF variant protein as a splice mutant."
      Kretschmer P.J., Fairhurst J.L., Hulmes J.D., Popjes M.L., Boehlen P., Kovesdi I.
      Biochem. Biophys. Res. Commun. 192:420-429(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. "Bone mass loss due to estrogen deficiency is compensated in transgenic mice overexpressing human osteoblast stimulating factor-1."
      Masuda H., Tsujimura A., Yoshioka M., Arai Y., Kuboki Y., Mukai T., Nakamura T., Tsuji H., Nakagawa M., Hashimoto-Gotoh T.
      Biochem. Biophys. Res. Commun. 238:528-533(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Cerebellum.
    8. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    9. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    10. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    12. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.
    13. "Amino-terminal sequences of a novel heparin-binding protein from human, bovine, rat, and chick brain: high interspecies homology."
      Huber D., Gautschi-Sova P., Bohlen P.
      Neurochem. Res. 15:435-439(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 33-58.
      Tissue: Brain.
    14. "A heparin-binding growth factor secreted from breast cancer cells homologous to a developmentally regulated cytokine."
      Wellsein A., Fang W., Khatri A., Lu Y., Swain S.S., Dickson R.B., Sasse J., Riegel A.T., Lippman M.E.
      J. Biol. Chem. 267:2582-2587(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 33-52.
    15. "Identification of novel heparin-releasable proteins, as well as the cytokines midkine and pleiotrophin, in human postheparin plasma."
      Novotny W.F., Maffi T., Mehta R.L., Milner P.G.
      Arterioscler. Thromb. 13:1798-1805(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 33-49, INDUCTION.
      Tissue: Plasma.
    16. "Comparison of the disulfide bond arrangements of human recombinant and bovine brain heparin binding neurite-promoting factors."
      Hulmes J.D., Seddon A.P., Decker M.M., Bohlen P.
      Biochem. Biophys. Res. Commun. 192:738-746(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISULFIDE BONDS.
    17. "Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin."
      Stoica G.E., Kuo A., Aigner A., Sunitha I., Souttou B., Malerczyk C., Caughey D.J., Wen D., Karavanov A., Riegel A.T., Wellstein A.
      J. Biol. Chem. 276:16772-16779(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ALK, FUNCTION.
    18. "Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome."
      Vaz Meirelles G., Ferreira Lanza D.C., da Silva J.C., Santana Bernachi J., Paes Leme A.F., Kobarg J.
      J. Proteome Res. 9:6298-6316(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NEK6, PHOSPHORYLATION BY NEK6.

    Entry informationi

    Entry nameiPTN_HUMAN
    AccessioniPrimary (citable) accession number: P21246
    Secondary accession number(s): Q5U0B0, Q6ICQ5, Q9UCC6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: May 1, 1991
    Last modified: October 1, 2014
    This is version 141 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3