ID PSA1_YEAST Reviewed; 252 AA. AC P21243; D6VUC6; P15708; DT 01-MAY-1991, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1991, sequence version 1. DT 27-MAR-2024, entry version 244. DE RecName: Full=Proteasome subunit alpha type-1; DE AltName: Full=Macropain subunit C7-alpha; DE AltName: Full=Multicatalytic endopeptidase complex C7; DE AltName: Full=Proteasome component C7-alpha; DE AltName: Full=Proteasome component Y8; DE AltName: Full=Proteinase YSCE subunit 7; DE AltName: Full=SCL1 suppressor protein; GN Name=SCL1; Synonyms=PRC2, PRS2; OrderedLocusNames=YGL011C; OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; Saccharomycetaceae; Saccharomyces. OX NCBI_TaxID=559292; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=2684789; DOI=10.1016/0378-1119(89)90113-3; RA Balzi E., Chen W., Capieaux E., McCusker J.H., Haber J.E., Goffeau A.; RT "The suppressor gene scl1+ of Saccharomyces cerevisiae is essential for RT growth."; RL Gene 83:271-279(1989). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 174-187 AND 189-198. RX PubMed=1697860; DOI=10.1016/s0021-9258(17)46265-x; RA Fujiwara T., Tanaka K., Orino E., Yoshimura T., Kumatori A., Tamura T., RA Chung C.H., Nakai T., Yamaguchi K., Shin S., Kakizuka A., Nakanishi S., RA Ichihara A.; RT "Proteasomes are essential for yeast proliferation. cDNA cloning and gene RT disruption of two major subunits."; RL J. Biol. Chem. 265:16604-16613(1990). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE. RC STRAIN=ATCC 26786 / X2180-1A; RX PubMed=1898763; DOI=10.1128/mcb.11.1.344-353.1991; RA Emori Y., Tsukahara T., Kawasaki H., Ishiura S., Sugita H., Suzuki K.; RT "Molecular cloning and functional analysis of three subunits of yeast RT proteasome."; RL Mol. Cell. Biol. 11:344-353(1991). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=ATCC 46191 / IL125-2B; RX PubMed=1882553; DOI=10.1002/yea.320070311; RA Chen W., Balzi E., Capieaux E., Choder M., Goffeau A.; RT "The DNA sequencing of the 17 kb HindIII fragment spanning the LEU1 and RT ATE1 loci on chromosome VII from Saccharomyces cerevisiae reveals the PDR6 RT gene, a new member of the genetic network controlling pleiotropic drug RT resistance."; RL Yeast 7:287-299(1991). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 204508 / S288c; RX PubMed=9169869; RA Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., RA Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., RA Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., RA Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H., RA Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., RA Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., RA Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., RA Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., RA Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., RA Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., RA Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., RA Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., RA Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., RA Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., RA Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., RA Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., RA Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., RA Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., RA Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., RA Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., RA Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., RA Zaccaria P., Zimmermann M., Zollner A., Kleine K.; RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."; RL Nature 387:81-84(1997). RN [6] RP GENOME REANNOTATION. RC STRAIN=ATCC 204508 / S288c; RX PubMed=24374639; DOI=10.1534/g3.113.008995; RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.; RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now."; RL G3 (Bethesda) 4:389-398(2014). RN [7] RP INTERACTION WITH CIC1. RX PubMed=11500370; DOI=10.1093/emboj/20.16.4423; RA Jaeger S., Strayle J., Heinemeyer W., Wolf D.H.; RT "Cic1, an adaptor protein specifically linking the 26S proteasome to its RT substrate, the SCF component Cdc4."; RL EMBO J. 20:4423-4431(2001). RN [8] RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. RX PubMed=14562095; DOI=10.1038/nature02026; RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., RA Weissman J.S., O'Shea E.K.; RT "Global analysis of protein localization in budding yeast."; RL Nature 425:686-691(2003). RN [9] RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]. RX PubMed=14562106; DOI=10.1038/nature02046; RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., RA O'Shea E.K., Weissman J.S.; RT "Global analysis of protein expression in yeast."; RL Nature 425:737-741(2003). RN [10] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-237, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200; RA Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; RT "A multidimensional chromatography technology for in-depth phosphoproteome RT analysis."; RL Mol. Cell. Proteomics 7:1389-1396(2008). RN [11] RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY RP [LARGE SCALE ANALYSIS]. RX PubMed=22814378; DOI=10.1073/pnas.1210303109; RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.; RT "N-terminal acetylome analyses and functional insights of the N-terminal RT acetyltransferase NatB."; RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012). RN [12] RP UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-232, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=22106047; DOI=10.1002/pmic.201100166; RA Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.; RT "Sites of ubiquitin attachment in Saccharomyces cerevisiae."; RL Proteomics 12:236-240(2012). RN [13] RP X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 10-252 OF COMPLEX WITH THE 20S RP PROTEASOME. RX PubMed=9087403; DOI=10.1038/386463a0; RA Groll M., Ditzel L., Loewe J., Stock D., Bochtler M., Bartunik H.D., RA Huber R.; RT "Structure of 20S proteasome from yeast at 2.4-A resolution."; RL Nature 386:463-471(1997). RN [14] RP X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF COMPLEX WITH THE 20S PROTEASOME. RX PubMed=11081519; DOI=10.1038/35040607; RA Whitby F.G., Masters E.I., Kramer L., Knowlton J.R., Yao Y., Wang C.C., RA Hill C.P.; RT "Structural basis for the activation of 20S proteasomes by 11S RT regulators."; RL Nature 408:115-120(2000). RN [15] RP X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 10-252 OF COMPLEX WITH THE 20S RP PROTEASOME. RX PubMed=11062564; DOI=10.1038/80992; RA Groll M., Bajorek M., Koehler A., Moroder L., Rubin D.M., Huber R., RA Glickman M.H., Finley D.; RT "A gated channel into the proteasome core particle."; RL Nat. Struct. Biol. 7:1062-1067(2000). RN [16] RP X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 10-252 OF COMPLEX WITH THE 20S RP PROTEASOME. RX PubMed=11493007; DOI=10.1006/jmbi.2001.4869; RA Groll M., Koguchi Y., Huber R., Kohno J.; RT "Crystal structure of the 20 S proteasome:TMC-95A complex: a non-covalent RT proteasome inhibitor."; RL J. Mol. Biol. 311:543-548(2001). RN [17] RP X-RAY CRYSTALLOGRAPHY (2.81 ANGSTROMS) OF 10-252 OF COMPLEX WITH THE 20S RP PROTEASOME. RX PubMed=16793518; DOI=10.1016/j.chembiol.2006.04.005; RA Groll M., Goetz M., Kaiser M., Weyher E., Moroder L.; RT "TMC-95-based inhibitor design provides evidence for the catalytic RT versatility of the proteasome."; RL Chem. Biol. 13:607-614(2006). RN [18] RP X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 10-252 OF COMPLEX WITH THE 20S RP PROTEASOME. RX PubMed=16608349; DOI=10.1021/ja058320b; RA Groll M., Huber R., Potts B.C.M.; RT "Crystal structures of salinosporamide A (NPI-0052) and B (NPI-0047) in RT complex with the 20S proteasome reveal important consequences of beta- RT lactone ring opening and a mechanism for irreversible binding."; RL J. Am. Chem. Soc. 128:5136-5141(2006). RN [19] RP X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 10-252 OF COMPLEX WITH THE 20S RP PROTEASOME. RX PubMed=16531229; DOI=10.1016/j.str.2005.11.019; RA Groll M., Berkers C.R., Ploegh H.L., Ovaa H.; RT "Crystal structure of the boronic acid-based proteasome inhibitor RT bortezomib in complex with the yeast 20S proteasome."; RL Structure 14:451-456(2006). RN [20] RP X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 10-252 IN COMPLEX WITH THE RP PROTEASOME. RX PubMed=20227375; DOI=10.1016/j.molcel.2010.02.002; RA Sadre-Bazzaz K., Whitby F.G., Robinson H., Formosa T., Hill C.P.; RT "Structure of a Blm10 complex reveals common mechanisms for proteasome RT binding and gate opening."; RL Mol. Cell 37:728-735(2010). RN [21] RP STRUCTURE BY ELECTRON MICROSCOPY (7.4 ANGSTROMS) OF THE 26S PROTEASOME. RX PubMed=22927375; DOI=10.1073/pnas.1213333109; RA Beck F., Unverdorben P., Bohn S., Schweitzer A., Pfeifer G., Sakata E., RA Nickell S., Plitzko J.M., Villa E., Baumeister W., Forster F.; RT "Near-atomic resolution structural model of the yeast 26S proteasome."; RL Proc. Natl. Acad. Sci. U.S.A. 109:14870-14875(2012). CC -!- FUNCTION: The proteasome degrades poly-ubiquitinated proteins in the CC cytoplasm and in the nucleus. It is essential for the regulated CC turnover of proteins and for the removal of misfolded proteins. The CC proteasome is a multicatalytic proteinase complex that is characterized CC by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu CC adjacent to the leaving group at neutral or slightly basic pH. It has CC an ATP-dependent proteolytic activity. CC -!- SUBUNIT: The 26S proteasome consists of a 20S proteasome core and two CC 19S regulatory subunits. The 20S proteasome core is composed of 28 CC subunits that are arranged in four stacked rings, resulting in a CC barrel-shaped structure. The two end rings are each formed by seven CC alpha subunits, and the two central rings are each formed by seven beta CC subunits. The catalytic chamber with the active sites is on the inside CC of the barrel. Interacts with CIC1. {ECO:0000269|PubMed:11500370, CC ECO:0000269|PubMed:20227375}. CC -!- INTERACTION: CC P21243; P21242: PRE10; NbExp=10; IntAct=EBI-13975, EBI-13963; CC P21243; P30656: PRE2; NbExp=8; IntAct=EBI-13975, EBI-14001; CC P21243; P23639: PRE8; NbExp=8; IntAct=EBI-13975, EBI-13959; CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus CC {ECO:0000269|PubMed:14562095}. CC -!- MISCELLANEOUS: Present with 15200 molecules/cell in log phase SD CC medium. {ECO:0000269|PubMed:14562106}. CC -!- SIMILARITY: Belongs to the peptidase T1A family. {ECO:0000255|PROSITE- CC ProRule:PRU00808}. CC -!- SEQUENCE CAUTION: CC Sequence=AAA35020.1; Type=Frameshift; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M31430; AAA35020.1; ALT_FRAME; Genomic_DNA. DR EMBL; X56971; CAA40292.1; -; Genomic_DNA. DR EMBL; M55440; AAA35228.1; -; mRNA. DR EMBL; M63641; AAA34909.1; -; Genomic_DNA. DR EMBL; X56732; CAA40056.1; -; Genomic_DNA. DR EMBL; S58126; AAD13894.1; -; Genomic_DNA. DR EMBL; Z72533; CAA96711.1; -; Genomic_DNA. DR EMBL; BK006941; DAA08087.1; -; Genomic_DNA. DR PIR; S11199; SNBYS1. DR RefSeq; NP_011504.3; NM_001180876.3. DR PDB; 1FNT; X-ray; 3.20 A; A/O=1-252. DR PDB; 1G0U; X-ray; 2.40 A; G/U=1-252. DR PDB; 1G65; X-ray; 2.25 A; G/U=10-252. DR PDB; 1JD2; X-ray; 3.00 A; 2/G=10-252. DR PDB; 1RYP; X-ray; 1.90 A; A/O=10-252. DR PDB; 1Z7Q; X-ray; 3.22 A; A/O=1-252. DR PDB; 2F16; X-ray; 2.80 A; G/U=10-252. DR PDB; 2FAK; X-ray; 2.80 A; G/U=10-252. DR PDB; 2GPL; X-ray; 2.81 A; G/U=10-252. DR PDB; 2ZCY; X-ray; 2.90 A; G/U=1-252. DR PDB; 3BDM; X-ray; 2.70 A; G/U=1-252. DR PDB; 3D29; X-ray; 2.60 A; G/U=12-252. DR PDB; 3DY3; X-ray; 2.81 A; G/U=10-252. DR PDB; 3DY4; X-ray; 2.80 A; G/U=10-252. DR PDB; 3E47; X-ray; 3.00 A; G/U=10-252. DR PDB; 3GPJ; X-ray; 2.70 A; G/U=10-252. DR PDB; 3GPT; X-ray; 2.41 A; G/U=10-252. DR PDB; 3GPW; X-ray; 2.50 A; G/U=10-252. DR PDB; 3HYE; X-ray; 2.50 A; G/U=10-252. DR PDB; 3JCO; EM; 4.80 A; A/a=1-252. DR PDB; 3JCP; EM; 4.60 A; A/a=1-252. DR PDB; 3MG0; X-ray; 2.68 A; G/U=10-252. DR PDB; 3MG4; X-ray; 3.11 A; G/U=10-252. DR PDB; 3MG6; X-ray; 2.60 A; G/U=1-252. DR PDB; 3MG7; X-ray; 2.78 A; G/U=1-252. DR PDB; 3MG8; X-ray; 2.59 A; G/U=1-252. DR PDB; 3NZJ; X-ray; 2.40 A; G/U=1-252. DR PDB; 3NZW; X-ray; 2.50 A; G/U=1-252. DR PDB; 3NZX; X-ray; 2.70 A; G/U=1-252. DR PDB; 3OEU; X-ray; 2.60 A; G/U=10-252. DR PDB; 3OEV; X-ray; 2.85 A; G/U=10-252. DR PDB; 3OKJ; X-ray; 2.70 A; G/U=10-252. DR PDB; 3SDI; X-ray; 2.65 A; G/U=10-252. DR PDB; 3SDK; X-ray; 2.70 A; G/U=10-252. DR PDB; 3SHJ; X-ray; 2.80 A; G/U=10-252. DR PDB; 3TDD; X-ray; 2.70 A; G/U=10-252. DR PDB; 3UN4; X-ray; 3.40 A; G/U=1-252. DR PDB; 3UN8; X-ray; 2.70 A; G/U=1-252. DR PDB; 3WXR; X-ray; 3.15 A; A/O=1-252. DR PDB; 4CR2; EM; 7.70 A; A=1-252. DR PDB; 4CR3; EM; 9.30 A; A=1-252. DR PDB; 4CR4; EM; 8.80 A; A=1-252. DR PDB; 4EU2; X-ray; 2.51 A; A/O=10-250. DR PDB; 4FZC; X-ray; 2.80 A; G/U=10-252. DR PDB; 4FZG; X-ray; 3.00 A; G/U=10-252. DR PDB; 4G4S; X-ray; 2.49 A; A=1-252. DR PDB; 4GK7; X-ray; 2.80 A; G/U=10-252. DR PDB; 4HNP; X-ray; 2.80 A; G/U=10-252. DR PDB; 4HRC; X-ray; 2.80 A; G/U=10-252. DR PDB; 4HRD; X-ray; 2.80 A; G/U=10-252. DR PDB; 4INR; X-ray; 2.70 A; G/U=1-252. DR PDB; 4INT; X-ray; 2.90 A; G/U=1-252. DR PDB; 4INU; X-ray; 3.10 A; G/U=1-252. DR PDB; 4J70; X-ray; 2.80 A; G/U=1-252. DR PDB; 4JSQ; X-ray; 2.80 A; G/U=1-252. DR PDB; 4JSU; X-ray; 2.90 A; G/U=1-252. DR PDB; 4JT0; X-ray; 3.10 A; G/U=1-252. DR PDB; 4LQI; X-ray; 2.70 A; G/U=10-252. DR PDB; 4LTC; X-ray; 2.50 A; G/U=1-252. DR PDB; 4NNN; X-ray; 2.50 A; G/U=1-252. DR PDB; 4NNW; X-ray; 2.60 A; G/U=1-252. DR PDB; 4NO1; X-ray; 2.50 A; G/U=1-252. DR PDB; 4NO6; X-ray; 3.00 A; G/U=1-252. DR PDB; 4NO8; X-ray; 2.70 A; G/U=1-252. DR PDB; 4NO9; X-ray; 2.90 A; G/U=1-252. DR PDB; 4Q1S; X-ray; 2.60 A; G/U=1-252. DR PDB; 4QBY; X-ray; 3.00 A; G/U=1-252. DR PDB; 4QLQ; X-ray; 2.40 A; G/U=1-252. DR PDB; 4QLS; X-ray; 2.80 A; G/U=1-252. DR PDB; 4QLT; X-ray; 2.80 A; G/U=1-252. DR PDB; 4QLU; X-ray; 2.80 A; G/U=1-252. DR PDB; 4QLV; X-ray; 2.90 A; G/U=1-252. DR PDB; 4QUX; X-ray; 3.00 A; G/U=1-252. DR PDB; 4QUY; X-ray; 2.80 A; G/U=1-252. DR PDB; 4QV0; X-ray; 3.10 A; G/U=1-252. DR PDB; 4QV1; X-ray; 2.50 A; G/U=1-252. DR PDB; 4QV3; X-ray; 3.00 A; G/U=1-252. DR PDB; 4QV4; X-ray; 2.70 A; G/U=1-252. DR PDB; 4QV5; X-ray; 2.70 A; G/U=1-252. DR PDB; 4QV6; X-ray; 2.80 A; G/U=1-252. DR PDB; 4QV7; X-ray; 2.60 A; G/U=1-252. DR PDB; 4QV8; X-ray; 2.90 A; G/U=1-252. DR PDB; 4QV9; X-ray; 2.60 A; G/U=1-252. DR PDB; 4QVL; X-ray; 2.80 A; G/U=1-252. DR PDB; 4QVM; X-ray; 2.80 A; G/U=1-252. DR PDB; 4QVN; X-ray; 2.90 A; G/U=1-252. DR PDB; 4QVP; X-ray; 2.30 A; G/U=1-252. DR PDB; 4QVQ; X-ray; 2.60 A; G/U=1-252. DR PDB; 4QVV; X-ray; 2.80 A; G/U=1-252. DR PDB; 4QVW; X-ray; 3.00 A; G/U=1-252. DR PDB; 4QVY; X-ray; 2.51 A; G/U=1-252. DR PDB; 4QW0; X-ray; 2.90 A; G/U=1-252. DR PDB; 4QW1; X-ray; 2.90 A; G/U=1-252. DR PDB; 4QW3; X-ray; 2.90 A; G/U=1-252. DR PDB; 4QW4; X-ray; 2.80 A; G/U=1-252. DR PDB; 4QW5; X-ray; 3.00 A; G/U=1-252. DR PDB; 4QW6; X-ray; 2.90 A; G/U=1-252. DR PDB; 4QW7; X-ray; 2.70 A; G/U=1-252. DR PDB; 4QWF; X-ray; 3.00 A; G/U=1-252. DR PDB; 4QWG; X-ray; 2.60 A; G/U=1-252. DR PDB; 4QWI; X-ray; 2.60 A; G/U=1-252. DR PDB; 4QWJ; X-ray; 2.90 A; G/U=1-252. DR PDB; 4QWK; X-ray; 2.80 A; G/U=1-252. DR PDB; 4QWL; X-ray; 2.60 A; G/U=1-252. DR PDB; 4QWR; X-ray; 2.90 A; G/U=1-252. DR PDB; 4QWS; X-ray; 3.00 A; G/U=1-252. DR PDB; 4QWU; X-ray; 3.00 A; G/U=1-252. DR PDB; 4QWX; X-ray; 2.90 A; G/U=1-252. DR PDB; 4QXJ; X-ray; 2.80 A; G/U=1-252. DR PDB; 4QZ0; X-ray; 3.00 A; G/U=1-252. DR PDB; 4QZ1; X-ray; 3.00 A; G/U=1-252. DR PDB; 4QZ2; X-ray; 2.70 A; G/U=1-252. DR PDB; 4QZ3; X-ray; 2.80 A; G/U=1-252. DR PDB; 4QZ4; X-ray; 3.00 A; G/U=1-252. DR PDB; 4QZ5; X-ray; 2.80 A; G/U=1-252. DR PDB; 4QZ6; X-ray; 2.90 A; G/U=1-252. DR PDB; 4QZ7; X-ray; 2.80 A; G/U=1-252. DR PDB; 4QZW; X-ray; 3.00 A; G/U=1-252. DR PDB; 4QZX; X-ray; 2.60 A; G/U=1-252. DR PDB; 4QZZ; X-ray; 2.90 A; G/U=1-252. DR PDB; 4R00; X-ray; 2.80 A; G/U=1-252. DR PDB; 4R02; X-ray; 2.50 A; G/U=1-252. DR PDB; 4R17; X-ray; 2.10 A; G/U=1-252. DR PDB; 4R18; X-ray; 2.40 A; G/U=1-252. DR PDB; 4RUR; X-ray; 2.50 A; G/U=1-252. DR PDB; 4V7O; X-ray; 3.00 A; AA/AC/BA/BO=10-252. DR PDB; 4X6Z; X-ray; 2.70 A; A/O=1-252. DR PDB; 4Y69; X-ray; 2.90 A; G/U=1-252. DR PDB; 4Y6A; X-ray; 2.60 A; G/U=1-252. DR PDB; 4Y6V; X-ray; 2.80 A; G/U=1-252. DR PDB; 4Y6Z; X-ray; 2.70 A; G/U=1-252. DR PDB; 4Y70; X-ray; 2.40 A; G/U=1-252. DR PDB; 4Y74; X-ray; 2.70 A; G/U=1-252. DR PDB; 4Y75; X-ray; 2.80 A; G/U=1-252. DR PDB; 4Y77; X-ray; 2.50 A; G/U=1-252. DR PDB; 4Y78; X-ray; 2.80 A; G/U=1-252. DR PDB; 4Y7W; X-ray; 2.50 A; G/U=1-252. DR PDB; 4Y7X; X-ray; 2.60 A; G/U=1-252. DR PDB; 4Y7Y; X-ray; 2.40 A; G/U=1-252. DR PDB; 4Y80; X-ray; 2.50 A; G/U=1-252. DR PDB; 4Y81; X-ray; 2.80 A; G/U=1-252. DR PDB; 4Y82; X-ray; 2.80 A; G/U=1-252. DR PDB; 4Y84; X-ray; 2.70 A; G/U=1-252. DR PDB; 4Y8G; X-ray; 2.60 A; G/U=1-252. DR PDB; 4Y8H; X-ray; 2.50 A; G/U=1-252. DR PDB; 4Y8I; X-ray; 2.60 A; G/U=1-252. DR PDB; 4Y8J; X-ray; 2.70 A; G/U=1-252. DR PDB; 4Y8K; X-ray; 2.60 A; G/U=1-252. DR PDB; 4Y8L; X-ray; 2.40 A; G/U=1-252. DR PDB; 4Y8M; X-ray; 2.80 A; G/U=1-252. DR PDB; 4Y8N; X-ray; 2.60 A; G/U=1-252. DR PDB; 4Y8O; X-ray; 2.70 A; G/U=1-252. DR PDB; 4Y8P; X-ray; 2.80 A; G/U=1-252. DR PDB; 4Y8Q; X-ray; 2.60 A; G/U=1-252. DR PDB; 4Y8R; X-ray; 2.70 A; G/U=1-252. DR PDB; 4Y8S; X-ray; 2.70 A; G/U=1-252. DR PDB; 4Y8T; X-ray; 2.70 A; G/U=1-252. DR PDB; 4Y8U; X-ray; 2.90 A; G/U=1-252. DR PDB; 4Y9Y; X-ray; 2.80 A; G/U=1-252. DR PDB; 4Y9Z; X-ray; 2.80 A; G/U=1-252. DR PDB; 4YA0; X-ray; 2.80 A; G/U=1-252. DR PDB; 4YA1; X-ray; 2.90 A; G/U=1-252. DR PDB; 4YA2; X-ray; 2.70 A; G/U=1-252. DR PDB; 4YA3; X-ray; 2.70 A; G/U=1-252. DR PDB; 4YA4; X-ray; 2.90 A; G/U=1-252. DR PDB; 4YA5; X-ray; 2.50 A; G/U=1-252. DR PDB; 4YA7; X-ray; 2.70 A; G/U=1-252. DR PDB; 4YA9; X-ray; 2.70 A; G/U=1-252. DR PDB; 4Z1L; X-ray; 3.00 A; G/U=1-252. DR PDB; 5A5B; EM; 9.50 A; A=1-252. DR PDB; 5AHJ; X-ray; 2.80 A; G/U=1-252. DR PDB; 5BOU; X-ray; 2.60 A; G/U=1-252. DR PDB; 5BXL; X-ray; 2.80 A; G/U=1-252. DR PDB; 5BXN; X-ray; 2.80 A; G/U=1-252. DR PDB; 5CGF; X-ray; 2.80 A; G/U=1-252. DR PDB; 5CGG; X-ray; 2.90 A; G/U=1-252. DR PDB; 5CGH; X-ray; 2.50 A; G/U=1-252. DR PDB; 5CGI; X-ray; 2.80 A; G/U=1-252. DR PDB; 5CZ4; X-ray; 2.30 A; G/U=1-252. DR PDB; 5CZ5; X-ray; 2.80 A; G/U=1-252. DR PDB; 5CZ6; X-ray; 2.70 A; G/U=1-252. DR PDB; 5CZ7; X-ray; 2.50 A; G/U=1-252. DR PDB; 5CZ8; X-ray; 2.80 A; G/U=1-252. DR PDB; 5CZ9; X-ray; 2.90 A; G/U=1-252. DR PDB; 5CZA; X-ray; 2.50 A; G/U=1-252. DR PDB; 5D0S; X-ray; 2.50 A; G/U=1-252. DR PDB; 5D0T; X-ray; 2.60 A; G/U=1-252. DR PDB; 5D0V; X-ray; 2.90 A; G/U=1-252. DR PDB; 5D0W; X-ray; 2.80 A; G/U=1-252. DR PDB; 5D0X; X-ray; 2.60 A; G/U=1-252. DR PDB; 5D0Z; X-ray; 2.90 A; G/U=1-252. DR PDB; 5DKI; X-ray; 2.80 A; G/U=1-252. DR PDB; 5DKJ; X-ray; 2.80 A; G/U=1-252. DR PDB; 5FG7; X-ray; 2.70 A; G/U=1-252. DR PDB; 5FG9; X-ray; 2.60 A; G/U=1-252. DR PDB; 5FGA; X-ray; 2.70 A; G/U=1-252. DR PDB; 5FGD; X-ray; 2.80 A; G/U=1-252. DR PDB; 5FGE; X-ray; 2.60 A; G/U=1-252. DR PDB; 5FGF; X-ray; 2.60 A; G/U=1-252. DR PDB; 5FGG; X-ray; 2.70 A; G/U=1-252. DR PDB; 5FGH; X-ray; 2.80 A; G/U=1-252. DR PDB; 5FGI; X-ray; 2.90 A; G/U=1-252. DR PDB; 5FHS; X-ray; 2.70 A; G/U=1-252. DR PDB; 5JHR; X-ray; 2.90 A; G/U=1-252. DR PDB; 5JHS; X-ray; 3.00 A; G/U=1-252. DR PDB; 5L52; X-ray; 2.70 A; G/U=1-252. DR PDB; 5L54; X-ray; 2.80 A; G/U=1-252. DR PDB; 5L55; X-ray; 2.90 A; G/U=1-252. DR PDB; 5L5A; X-ray; 2.40 A; G/U=1-252. DR PDB; 5L5B; X-ray; 2.80 A; G/U=1-252. DR PDB; 5L5D; X-ray; 2.80 A; G/U=1-252. DR PDB; 5L5E; X-ray; 2.90 A; G/U=1-252. DR PDB; 5L5F; X-ray; 2.50 A; G/U=1-252. DR PDB; 5L5H; X-ray; 2.60 A; G/U=1-252. DR PDB; 5L5I; X-ray; 2.90 A; G/U=1-252. DR PDB; 5L5J; X-ray; 2.90 A; G/U=1-252. DR PDB; 5L5O; X-ray; 2.60 A; G/U=1-252. DR PDB; 5L5P; X-ray; 2.80 A; G/U=1-252. DR PDB; 5L5Q; X-ray; 2.80 A; G/U=1-252. DR PDB; 5L5R; X-ray; 2.90 A; G/U=1-252. DR PDB; 5L5S; X-ray; 2.60 A; G/U=1-252. DR PDB; 5L5T; X-ray; 2.90 A; G/U=1-252. DR PDB; 5L5U; X-ray; 2.60 A; G/U=1-252. DR PDB; 5L5V; X-ray; 2.70 A; G/U=1-252. DR PDB; 5L5W; X-ray; 2.80 A; G/U=1-252. DR PDB; 5L5X; X-ray; 2.90 A; G/U=1-252. DR PDB; 5L5Y; X-ray; 2.70 A; G/U=1-252. DR PDB; 5L5Z; X-ray; 2.70 A; G/U=1-252. DR PDB; 5L60; X-ray; 2.70 A; G/U=1-252. DR PDB; 5L61; X-ray; 2.80 A; G/U=1-252. DR PDB; 5L62; X-ray; 2.80 A; G/U=1-252. DR PDB; 5L63; X-ray; 2.70 A; G/U=1-252. DR PDB; 5L64; X-ray; 2.70 A; G/U=1-252. DR PDB; 5L65; X-ray; 2.90 A; G/U=1-252. DR PDB; 5L66; X-ray; 2.80 A; G/U=1-252. DR PDB; 5L67; X-ray; 2.60 A; G/U=1-252. DR PDB; 5L68; X-ray; 2.80 A; G/U=1-252. DR PDB; 5L69; X-ray; 2.70 A; G/U=1-252. DR PDB; 5L6A; X-ray; 2.80 A; G/U=1-252. DR PDB; 5L6B; X-ray; 2.60 A; G/U=1-252. DR PDB; 5L6C; X-ray; 2.60 A; G/U=1-252. DR PDB; 5LAI; X-ray; 2.50 A; G/U=1-252. DR PDB; 5LAJ; X-ray; 2.90 A; G/U=1-252. DR PDB; 5LTT; X-ray; 2.70 A; G/U=1-252. DR PDB; 5M2B; X-ray; 2.70 A; G/U=1-252. DR PDB; 5MP9; EM; 4.10 A; A/a=1-252. DR PDB; 5MPA; EM; 4.50 A; A/a=1-252. DR PDB; 5MPB; EM; 7.80 A; A/a=1-252. DR PDB; 5MPC; EM; 7.70 A; A/a=1-252. DR PDB; 5NIF; X-ray; 3.00 A; A/O=1-252. DR PDB; 5WVI; EM; 6.30 A; A/c=1-252. DR PDB; 5WVK; EM; 4.20 A; A/c=1-252. DR PDB; 6EF0; EM; 4.43 A; A=11-248. DR PDB; 6EF1; EM; 4.73 A; A=13-251. DR PDB; 6EF2; EM; 4.27 A; A=10-247. DR PDB; 6EF3; EM; 4.17 A; A=1-252. DR PDB; 6FVT; EM; 4.10 A; A/a=11-251. DR PDB; 6FVU; EM; 4.50 A; A/a=10-251. DR PDB; 6FVV; EM; 5.40 A; A/a=11-251. DR PDB; 6FVW; EM; 4.50 A; A/a=8-251. DR PDB; 6FVX; EM; 4.90 A; A/a=10-251. DR PDB; 6FVY; EM; 6.10 A; A/a=8-251. DR PDB; 6G7F; X-ray; 2.70 A; G/U=1-252. DR PDB; 6G8M; X-ray; 2.70 A; G/U=1-252. DR PDB; 6G8N; X-ray; 3.00 A; G/U=1-252. DR PDB; 6GOP; X-ray; 2.90 A; G/U=1-252. DR PDB; 6H39; X-ray; 2.50 A; G/U=1-252. DR PDB; 6HTB; X-ray; 2.70 A; G/U=1-252. DR PDB; 6HTC; X-ray; 2.80 A; G/U=1-252. DR PDB; 6HTD; X-ray; 3.00 A; G/U=1-252. DR PDB; 6HTP; X-ray; 3.00 A; G/U=1-252. DR PDB; 6HTR; X-ray; 2.60 A; G/U=1-252. DR PDB; 6HUB; X-ray; 2.90 A; G/U=1-252. DR PDB; 6HUC; X-ray; 3.00 A; G/U=1-252. DR PDB; 6HUQ; X-ray; 3.00 A; G/U=1-252. DR PDB; 6HUU; X-ray; 2.80 A; G/U=1-252. DR PDB; 6HUV; X-ray; 3.10 A; G/U=1-252. DR PDB; 6HV3; X-ray; 2.70 A; G/U=1-252. DR PDB; 6HV4; X-ray; 3.00 A; G/U=1-252. DR PDB; 6HV5; X-ray; 3.00 A; G/U=1-252. DR PDB; 6HV7; X-ray; 3.40 A; G/U=1-252. DR PDB; 6HVA; X-ray; 2.90 A; G/U=1-252. DR PDB; 6HVR; X-ray; 2.70 A; G/U=1-252. DR PDB; 6HVS; X-ray; 3.10 A; G/U=1-252. DR PDB; 6HVT; X-ray; 2.90 A; G/U=1-252. DR PDB; 6HVU; X-ray; 2.90 A; G/U=1-252. DR PDB; 6HVV; X-ray; 2.70 A; G/U=1-252. DR PDB; 6HVW; X-ray; 3.00 A; G/U=1-252. DR PDB; 6HVX; X-ray; 2.80 A; G/U=1-252. DR PDB; 6HVY; X-ray; 2.70 A; G/U=1-252. DR PDB; 6HW0; X-ray; 2.80 A; G/U=1-252. DR PDB; 6HW3; X-ray; 2.60 A; G/U=1-252. DR PDB; 6HW4; X-ray; 2.90 A; G/U=1-252. DR PDB; 6HW5; X-ray; 2.90 A; G/U=1-252. DR PDB; 6HW6; X-ray; 2.70 A; G/U=1-252. DR PDB; 6HW7; X-ray; 2.70 A; G/U=1-252. DR PDB; 6HW8; X-ray; 2.80 A; G/U=1-252. DR PDB; 6HW9; X-ray; 2.80 A; G/U=1-252. DR PDB; 6HWA; X-ray; 2.80 A; G/U=1-252. DR PDB; 6HWB; X-ray; 2.60 A; G/U=1-252. DR PDB; 6HWC; X-ray; 2.80 A; G/U=1-252. DR PDB; 6HWD; X-ray; 2.80 A; G/U=1-252. DR PDB; 6HWE; X-ray; 2.30 A; G/U=1-252. DR PDB; 6HWF; X-ray; 2.50 A; G/U=1-252. DR PDB; 6J2C; EM; 7.00 A; A/c=1-252. DR PDB; 6J2N; EM; 7.50 A; A/c=1-252. DR PDB; 6J2Q; EM; 3.80 A; A/c=1-252. DR PDB; 6J2X; EM; 3.80 A; A/c=1-252. DR PDB; 6J30; EM; 4.50 A; A/c=1-252. DR PDB; 6ZOU; X-ray; 2.90 A; G/U=1-252. DR PDB; 6ZP6; X-ray; 2.80 A; G/U=1-252. DR PDB; 6ZP8; X-ray; 3.00 A; G/U=1-252. DR PDB; 7LS5; EM; 2.74 A; A/O=1-252. DR PDB; 7LS6; EM; 3.17 A; A=1-252. DR PDB; 7LSX; EM; 3.61 A; A=1-252. DR PDB; 7O2L; X-ray; 3.00 A; G/U=1-252. DR PDB; 7QO3; EM; 6.10 A; A/a=1-252. DR PDB; 7QO5; EM; 6.00 A; A/a=1-252. DR PDB; 7TEJ; EM; 2.74 A; A/O=1-252. DR PDB; 7TEO; EM; 2.97 A; A/O=1-252. DR PDB; 8OLR; X-ray; 2.80 A; G/U=1-252. DR PDB; 8T08; EM; 3.00 A; A/R=1-252. DR PDB; 8T0M; EM; 2.40 A; A/O=1-252. DR PDBsum; 1FNT; -. DR PDBsum; 1G0U; -. DR PDBsum; 1G65; -. DR PDBsum; 1JD2; -. DR PDBsum; 1RYP; -. DR PDBsum; 1Z7Q; -. DR PDBsum; 2F16; -. DR PDBsum; 2FAK; -. DR PDBsum; 2GPL; -. DR PDBsum; 2ZCY; -. DR PDBsum; 3BDM; -. DR PDBsum; 3D29; -. DR PDBsum; 3DY3; -. DR PDBsum; 3DY4; -. DR PDBsum; 3E47; -. DR PDBsum; 3GPJ; -. DR PDBsum; 3GPT; -. DR PDBsum; 3GPW; -. DR PDBsum; 3HYE; -. DR PDBsum; 3JCO; -. DR PDBsum; 3JCP; -. DR PDBsum; 3MG0; -. DR PDBsum; 3MG4; -. DR PDBsum; 3MG6; -. DR PDBsum; 3MG7; -. DR PDBsum; 3MG8; -. DR PDBsum; 3NZJ; -. DR PDBsum; 3NZW; -. DR PDBsum; 3NZX; -. DR PDBsum; 3OEU; -. DR PDBsum; 3OEV; -. DR PDBsum; 3OKJ; -. DR PDBsum; 3SDI; -. DR PDBsum; 3SDK; -. DR PDBsum; 3SHJ; -. DR PDBsum; 3TDD; -. DR PDBsum; 3UN4; -. DR PDBsum; 3UN8; -. DR PDBsum; 3WXR; -. DR PDBsum; 4CR2; -. DR PDBsum; 4CR3; -. DR PDBsum; 4CR4; -. DR PDBsum; 4EU2; -. DR PDBsum; 4FZC; -. DR PDBsum; 4FZG; -. DR PDBsum; 4G4S; -. DR PDBsum; 4GK7; -. DR PDBsum; 4HNP; -. DR PDBsum; 4HRC; -. DR PDBsum; 4HRD; -. DR PDBsum; 4INR; -. DR PDBsum; 4INT; -. DR PDBsum; 4INU; -. DR PDBsum; 4J70; -. DR PDBsum; 4JSQ; -. DR PDBsum; 4JSU; -. DR PDBsum; 4JT0; -. DR PDBsum; 4LQI; -. DR PDBsum; 4LTC; -. DR PDBsum; 4NNN; -. DR PDBsum; 4NNW; -. DR PDBsum; 4NO1; -. DR PDBsum; 4NO6; -. DR PDBsum; 4NO8; -. DR PDBsum; 4NO9; -. DR PDBsum; 4Q1S; -. DR PDBsum; 4QBY; -. DR PDBsum; 4QLQ; -. DR PDBsum; 4QLS; -. DR PDBsum; 4QLT; -. DR PDBsum; 4QLU; -. DR PDBsum; 4QLV; -. DR PDBsum; 4QUX; -. DR PDBsum; 4QUY; -. DR PDBsum; 4QV0; -. DR PDBsum; 4QV1; -. DR PDBsum; 4QV3; -. DR PDBsum; 4QV4; -. DR PDBsum; 4QV5; -. DR PDBsum; 4QV6; -. DR PDBsum; 4QV7; -. DR PDBsum; 4QV8; -. DR PDBsum; 4QV9; -. DR PDBsum; 4QVL; -. DR PDBsum; 4QVM; -. DR PDBsum; 4QVN; -. DR PDBsum; 4QVP; -. DR PDBsum; 4QVQ; -. DR PDBsum; 4QVV; -. DR PDBsum; 4QVW; -. DR PDBsum; 4QVY; -. DR PDBsum; 4QW0; -. DR PDBsum; 4QW1; -. DR PDBsum; 4QW3; -. DR PDBsum; 4QW4; -. DR PDBsum; 4QW5; -. DR PDBsum; 4QW6; -. DR PDBsum; 4QW7; -. DR PDBsum; 4QWF; -. DR PDBsum; 4QWG; -. DR PDBsum; 4QWI; -. DR PDBsum; 4QWJ; -. DR PDBsum; 4QWK; -. DR PDBsum; 4QWL; -. DR PDBsum; 4QWR; -. DR PDBsum; 4QWS; -. DR PDBsum; 4QWU; -. DR PDBsum; 4QWX; -. DR PDBsum; 4QXJ; -. DR PDBsum; 4QZ0; -. DR PDBsum; 4QZ1; -. DR PDBsum; 4QZ2; -. DR PDBsum; 4QZ3; -. DR PDBsum; 4QZ4; -. DR PDBsum; 4QZ5; -. DR PDBsum; 4QZ6; -. DR PDBsum; 4QZ7; -. DR PDBsum; 4QZW; -. DR PDBsum; 4QZX; -. DR PDBsum; 4QZZ; -. DR PDBsum; 4R00; -. DR PDBsum; 4R02; -. DR PDBsum; 4R17; -. DR PDBsum; 4R18; -. DR PDBsum; 4RUR; -. DR PDBsum; 4V7O; -. DR PDBsum; 4X6Z; -. DR PDBsum; 4Y69; -. DR PDBsum; 4Y6A; -. DR PDBsum; 4Y6V; -. DR PDBsum; 4Y6Z; -. DR PDBsum; 4Y70; -. DR PDBsum; 4Y74; -. DR PDBsum; 4Y75; -. DR PDBsum; 4Y77; -. DR PDBsum; 4Y78; -. DR PDBsum; 4Y7W; -. DR PDBsum; 4Y7X; -. DR PDBsum; 4Y7Y; -. DR PDBsum; 4Y80; -. DR PDBsum; 4Y81; -. DR PDBsum; 4Y82; -. DR PDBsum; 4Y84; -. DR PDBsum; 4Y8G; -. DR PDBsum; 4Y8H; -. DR PDBsum; 4Y8I; -. DR PDBsum; 4Y8J; -. DR PDBsum; 4Y8K; -. DR PDBsum; 4Y8L; -. DR PDBsum; 4Y8M; -. DR PDBsum; 4Y8N; -. DR PDBsum; 4Y8O; -. DR PDBsum; 4Y8P; -. DR PDBsum; 4Y8Q; -. DR PDBsum; 4Y8R; -. DR PDBsum; 4Y8S; -. DR PDBsum; 4Y8T; -. DR PDBsum; 4Y8U; -. DR PDBsum; 4Y9Y; -. DR PDBsum; 4Y9Z; -. DR PDBsum; 4YA0; -. DR PDBsum; 4YA1; -. DR PDBsum; 4YA2; -. DR PDBsum; 4YA3; -. DR PDBsum; 4YA4; -. DR PDBsum; 4YA5; -. DR PDBsum; 4YA7; -. DR PDBsum; 4YA9; -. DR PDBsum; 4Z1L; -. DR PDBsum; 5A5B; -. DR PDBsum; 5AHJ; -. DR PDBsum; 5BOU; -. DR PDBsum; 5BXL; -. DR PDBsum; 5BXN; -. DR PDBsum; 5CGF; -. DR PDBsum; 5CGG; -. DR PDBsum; 5CGH; -. DR PDBsum; 5CGI; -. DR PDBsum; 5CZ4; -. DR PDBsum; 5CZ5; -. DR PDBsum; 5CZ6; -. DR PDBsum; 5CZ7; -. DR PDBsum; 5CZ8; -. DR PDBsum; 5CZ9; -. DR PDBsum; 5CZA; -. DR PDBsum; 5D0S; -. DR PDBsum; 5D0T; -. DR PDBsum; 5D0V; -. DR PDBsum; 5D0W; -. DR PDBsum; 5D0X; -. DR PDBsum; 5D0Z; -. DR PDBsum; 5DKI; -. DR PDBsum; 5DKJ; -. DR PDBsum; 5FG7; -. DR PDBsum; 5FG9; -. DR PDBsum; 5FGA; -. DR PDBsum; 5FGD; -. DR PDBsum; 5FGE; -. DR PDBsum; 5FGF; -. DR PDBsum; 5FGG; -. DR PDBsum; 5FGH; -. DR PDBsum; 5FGI; -. DR PDBsum; 5FHS; -. DR PDBsum; 5JHR; -. DR PDBsum; 5JHS; -. DR PDBsum; 5L52; -. DR PDBsum; 5L54; -. DR PDBsum; 5L55; -. DR PDBsum; 5L5A; -. DR PDBsum; 5L5B; -. DR PDBsum; 5L5D; -. DR PDBsum; 5L5E; -. DR PDBsum; 5L5F; -. DR PDBsum; 5L5H; -. DR PDBsum; 5L5I; -. DR PDBsum; 5L5J; -. DR PDBsum; 5L5O; -. DR PDBsum; 5L5P; -. DR PDBsum; 5L5Q; -. DR PDBsum; 5L5R; -. DR PDBsum; 5L5S; -. DR PDBsum; 5L5T; -. DR PDBsum; 5L5U; -. DR PDBsum; 5L5V; -. DR PDBsum; 5L5W; -. DR PDBsum; 5L5X; -. DR PDBsum; 5L5Y; -. DR PDBsum; 5L5Z; -. DR PDBsum; 5L60; -. DR PDBsum; 5L61; -. DR PDBsum; 5L62; -. DR PDBsum; 5L63; -. DR PDBsum; 5L64; -. DR PDBsum; 5L65; -. DR PDBsum; 5L66; -. DR PDBsum; 5L67; -. DR PDBsum; 5L68; -. DR PDBsum; 5L69; -. DR PDBsum; 5L6A; -. DR PDBsum; 5L6B; -. DR PDBsum; 5L6C; -. DR PDBsum; 5LAI; -. DR PDBsum; 5LAJ; -. DR PDBsum; 5LTT; -. DR PDBsum; 5M2B; -. DR PDBsum; 5MP9; -. DR PDBsum; 5MPA; -. DR PDBsum; 5MPB; -. DR PDBsum; 5MPC; -. DR PDBsum; 5NIF; -. DR PDBsum; 5WVI; -. DR PDBsum; 5WVK; -. DR PDBsum; 6EF0; -. DR PDBsum; 6EF1; -. DR PDBsum; 6EF2; -. DR PDBsum; 6EF3; -. DR PDBsum; 6FVT; -. DR PDBsum; 6FVU; -. DR PDBsum; 6FVV; -. DR PDBsum; 6FVW; -. DR PDBsum; 6FVX; -. DR PDBsum; 6FVY; -. DR PDBsum; 6G7F; -. DR PDBsum; 6G8M; -. DR PDBsum; 6G8N; -. DR PDBsum; 6GOP; -. DR PDBsum; 6H39; -. DR PDBsum; 6HTB; -. DR PDBsum; 6HTC; -. DR PDBsum; 6HTD; -. DR PDBsum; 6HTP; -. DR PDBsum; 6HTR; -. DR PDBsum; 6HUB; -. DR PDBsum; 6HUC; -. DR PDBsum; 6HUQ; -. DR PDBsum; 6HUU; -. DR PDBsum; 6HUV; -. DR PDBsum; 6HV3; -. DR PDBsum; 6HV4; -. DR PDBsum; 6HV5; -. DR PDBsum; 6HV7; -. DR PDBsum; 6HVA; -. DR PDBsum; 6HVR; -. DR PDBsum; 6HVS; -. DR PDBsum; 6HVT; -. DR PDBsum; 6HVU; -. DR PDBsum; 6HVV; -. DR PDBsum; 6HVW; -. DR PDBsum; 6HVX; -. DR PDBsum; 6HVY; -. DR PDBsum; 6HW0; -. DR PDBsum; 6HW3; -. DR PDBsum; 6HW4; -. DR PDBsum; 6HW5; -. DR PDBsum; 6HW6; -. DR PDBsum; 6HW7; -. DR PDBsum; 6HW8; -. DR PDBsum; 6HW9; -. DR PDBsum; 6HWA; -. DR PDBsum; 6HWB; -. DR PDBsum; 6HWC; -. DR PDBsum; 6HWD; -. DR PDBsum; 6HWE; -. DR PDBsum; 6HWF; -. DR PDBsum; 6J2C; -. DR PDBsum; 6J2N; -. DR PDBsum; 6J2Q; -. DR PDBsum; 6J2X; -. DR PDBsum; 6J30; -. DR PDBsum; 6ZOU; -. DR PDBsum; 6ZP6; -. DR PDBsum; 6ZP8; -. DR PDBsum; 7LS5; -. DR PDBsum; 7LS6; -. DR PDBsum; 7LSX; -. DR PDBsum; 7O2L; -. DR PDBsum; 7QO3; -. DR PDBsum; 7QO5; -. DR PDBsum; 7TEJ; -. DR PDBsum; 7TEO; -. DR PDBsum; 8OLR; -. DR PDBsum; 8T08; -. DR PDBsum; 8T0M; -. DR AlphaFoldDB; P21243; -. DR EMDB; EMD-40938; -. DR EMDB; EMD-40944; -. DR SMR; P21243; -. DR BioGRID; 33235; 401. DR ComplexPortal; CPX-2262; 26S Proteasome complex. DR DIP; DIP-2810N; -. DR IntAct; P21243; 30. DR MINT; P21243; -. DR STRING; 4932.YGL011C; -. DR MEROPS; T01.971; -. DR iPTMnet; P21243; -. DR MaxQB; P21243; -. DR PaxDb; 4932-YGL011C; -. DR PeptideAtlas; P21243; -. DR EnsemblFungi; YGL011C_mRNA; YGL011C; YGL011C. DR GeneID; 852873; -. DR KEGG; sce:YGL011C; -. DR AGR; SGD:S000002979; -. DR SGD; S000002979; SCL1. DR VEuPathDB; FungiDB:YGL011C; -. DR eggNOG; KOG0182; Eukaryota. DR GeneTree; ENSGT00550000074807; -. DR HOGENOM; CLU_035750_4_1_1; -. DR InParanoid; P21243; -. DR OMA; YGYDMPV; -. DR OrthoDB; 166567at2759; -. DR BioCyc; YEAST:G3O-30533-MONOMER; -. DR BRENDA; 3.4.25.1; 984. DR Reactome; R-SCE-1236978; Cross-presentation of soluble exogenous antigens (endosomes). DR Reactome; R-SCE-5668541; TNFR2 non-canonical NF-kB pathway. DR Reactome; R-SCE-5689880; Ub-specific processing proteases. DR BioGRID-ORCS; 852873; 0 hits in 10 CRISPR screens. DR EvolutionaryTrace; P21243; -. DR PRO; PR:P21243; -. DR Proteomes; UP000002311; Chromosome VII. DR RNAct; P21243; Protein. DR GO; GO:0005739; C:mitochondrion; HDA:SGD. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0000502; C:proteasome complex; IPI:ComplexPortal. DR GO; GO:0019773; C:proteasome core complex, alpha-subunit complex; IDA:SGD. DR GO; GO:0010498; P:proteasomal protein catabolic process; IBA:GO_Central. DR GO; GO:0010499; P:proteasomal ubiquitin-independent protein catabolic process; IDA:SGD. DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IDA:SGD. DR CDD; cd03754; proteasome_alpha_type_6; 1. DR Gene3D; 3.60.20.10; Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1; 1. DR InterPro; IPR029055; Ntn_hydrolases_N. DR InterPro; IPR023332; Proteasome_alpha-type. DR InterPro; IPR000426; Proteasome_asu_N. DR InterPro; IPR001353; Proteasome_sua/b. DR InterPro; IPR034642; Proteasome_subunit_alpha6. DR PANTHER; PTHR11599:SF11; PROTEASOME SUBUNIT ALPHA TYPE-6; 1. DR PANTHER; PTHR11599; PROTEASOME SUBUNIT ALPHA/BETA; 1. DR Pfam; PF00227; Proteasome; 1. DR Pfam; PF10584; Proteasome_A_N; 1. DR SMART; SM00948; Proteasome_A_N; 1. DR SUPFAM; SSF56235; N-terminal nucleophile aminohydrolases (Ntn hydrolases); 1. DR PROSITE; PS00388; PROTEASOME_ALPHA_1; 1. DR PROSITE; PS51475; PROTEASOME_ALPHA_2; 1. DR UCD-2DPAGE; P21243; -. PE 1: Evidence at protein level; KW 3D-structure; Acetylation; Cytoplasm; Direct protein sequencing; KW Isopeptide bond; Nucleus; Phosphoprotein; Proteasome; Reference proteome; KW Ubl conjugation. FT INIT_MET 1 FT /note="Removed" FT /evidence="ECO:0007744|PubMed:22814378" FT CHAIN 2..252 FT /note="Proteasome subunit alpha type-1" FT /id="PRO_0000124141" FT MOD_RES 2 FT /note="N-acetylserine" FT /evidence="ECO:0007744|PubMed:22814378" FT MOD_RES 237 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:18407956" FT CROSSLNK 232 FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with FT G-Cter in ubiquitin)" FT /evidence="ECO:0007744|PubMed:22106047" FT HELIX 11..14 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 16..18 FT /evidence="ECO:0007829|PDB:1RYP" FT TURN 21..23 FT /evidence="ECO:0007829|PDB:1JD2" FT HELIX 26..34 FT /evidence="ECO:0007829|PDB:1RYP" FT TURN 35..38 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 42..46 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 48..56 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 62..64 FT /evidence="ECO:0007829|PDB:3D29" FT HELIX 66..68 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 71..74 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 76..78 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 80..85 FT /evidence="ECO:0007829|PDB:1RYP" FT HELIX 87..108 FT /evidence="ECO:0007829|PDB:1RYP" FT HELIX 114..130 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 131..134 FT /evidence="ECO:0007829|PDB:4QVP" FT STRAND 140..147 FT /evidence="ECO:0007829|PDB:1RYP" FT TURN 148..150 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 151..157 FT /evidence="ECO:0007829|PDB:1RYP" FT TURN 159..161 FT /evidence="ECO:0007829|PDB:1G0U" FT STRAND 163..172 FT /evidence="ECO:0007829|PDB:1RYP" FT HELIX 175..189 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 191..193 FT /evidence="ECO:0007829|PDB:1RYP" FT HELIX 199..214 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 222..229 FT /evidence="ECO:0007829|PDB:1RYP" FT STRAND 232..235 FT /evidence="ECO:0007829|PDB:1RYP" FT HELIX 238..248 FT /evidence="ECO:0007829|PDB:1RYP" FT TURN 249..251 FT /evidence="ECO:0007829|PDB:1G65" SQ SEQUENCE 252 AA; 28001 MW; 5B938C862BC8D7EB CRC64; MSGAAAASAA GYDRHITIFS PEGRLYQVEY AFKATNQTNI NSLAVRGKDC TVVISQKKVP DKLLDPTTVS YIFCISRTIG MVVNGPIPDA RNAALRAKAE AAEFRYKYGY DMPCDVLAKR MANLSQIYTQ RAYMRPLGVI LTFVSVDEEL GPSIYKTDPA GYYVGYKATA TGPKQQEITT NLENHFKKSK IDHINEESWE KVVEFAITHM IDALGTEFSK NDLEVGVATK DKFFTLSAEN IEERLVAIAE QD //