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Protein

Brain-derived neurotrophic factor

Gene

Bdnf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.

GO - Molecular functioni

GO - Biological processi

  • axon extension Source: MGI
  • axon guidance Source: MGI
  • axon target recognition Source: MGI
  • behavioral fear response Source: MGI
  • circadian rhythm Source: UniProtKB
  • collateral sprouting Source: MGI
  • dendrite development Source: MGI
  • dendrite extension Source: MGI
  • fear response Source: MGI
  • feeding behavior Source: MGI
  • gamma-aminobutyric acid signaling pathway Source: MGI
  • glutamate secretion Source: MGI
  • inhibitory postsynaptic potential Source: MGI
  • inner ear development Source: MGI
  • learning or memory Source: MGI
  • mechanoreceptor differentiation Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of cell death Source: MGI
  • negative regulation of neuroblast proliferation Source: MGI
  • negative regulation of neuron apoptotic process Source: MGI
  • negative regulation of synaptic transmission, GABAergic Source: MGI
  • nerve development Source: MGI
  • neuron recognition Source: MGI
  • positive regulation of collateral sprouting Source: MGI
  • positive regulation of DNA binding transcription factor activity Source: MGI
  • positive regulation of glucocorticoid receptor signaling pathway Source: MGI
  • positive regulation of neuron differentiation Source: MGI
  • positive regulation of peptidyl-serine phosphorylation Source: MGI
  • positive regulation of receptor binding Source: MGI
  • positive regulation of synapse assembly Source: MGI
  • regulation of collateral sprouting Source: MGI
  • regulation of metabolic process Source: MGI
  • regulation of neuron apoptotic process Source: MGI
  • regulation of retinal cell programmed cell death Source: MGI
  • regulation of synaptic plasticity Source: MGI
  • response to drug Source: MGI
  • retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission Source: SynGO
  • synapse assembly Source: MGI
  • taste bud development Source: MGI
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
  • ureteric bud development Source: MGI

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

ReactomeiR-MMU-9026527 Activated NTRK2 signals through PLCG1
R-MMU-9028731 Activated NTRK2 signals through FRS2 and FRS3

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-derived neurotrophic factor
Short name:
BDNF
Gene namesi
Name:Bdnf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:88145 Bdnf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi68V → M: Reduced hippocampal volume, dendritic complexity and context-dependent memory. Increased anxiety-related behaviors. 1 Publication1
Mutagenesisi130R → K: Forms homodimers processed at L-112 that seem more stable than the wild-type. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000001963519 – 1301 PublicationAdd BLAST112
ChainiPRO_0000019636131 – 249Brain-derived neurotrophic factorAdd BLAST119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi123N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi143 ↔ 210By similarity
Disulfide bondi188 ↔ 239By similarity
Disulfide bondi198 ↔ 241By similarity

Post-translational modificationi

Converted into mature BDNF by plasmin (PLG).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei57 – 58Cleavage; by S1PBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP21237
PRIDEiP21237

PTM databases

iPTMnetiP21237
PhosphoSitePlusiP21237

Expressioni

Inductioni

Expression oscillates in a circadian manner in the suprachiasmatic nucleus (SCN) of the brain. Expressed at higher levels during the dark period and at lower levels during the light period.1 Publication

Gene expression databases

BgeeiENSMUSG00000048482
CleanExiMM_BDNF
ExpressionAtlasiP21237 baseline and differential
GenevisibleiP21237 MM

Interactioni

Subunit structurei

Monomers and homodimers. Binds to NTRK2/TRKB.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-5724N
IntActiP21237, 2 interactors
STRINGi10090.ENSMUSP00000057989

Structurei

3D structure databases

ProteinModelPortaliP21237
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IH7X Eukaryota
ENOG410XRPH LUCA
GeneTreeiENSGT00390000007725
HOGENOMiHOG000231516
HOVERGENiHBG006494
InParanoidiP21237
KOiK04355

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR020430 Brain-der_neurotrophic_factor
IPR029034 Cystine-knot_cytokine
IPR020408 Nerve_growth_factor-like
IPR002072 Nerve_growth_factor-rel
IPR019846 Nerve_growth_factor_CS
PANTHERiPTHR11589 PTHR11589, 1 hit
PTHR11589:SF3 PTHR11589:SF3, 1 hit
PfamiView protein in Pfam
PF00243 NGF, 1 hit
PIRSFiPIRSF001789 NGF, 1 hit
PRINTSiPR01912 BDNFACTOR
PR00268 NGF
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002052 Nerve_growth_factor-rel, 1 hit
SMARTiView protein in SMART
SM00140 NGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00248 NGF_1, 1 hit
PS50270 NGF_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21237-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTILFLTMVI SYFGCMKAAP MKEVNVHGQG NLAYPGVRTH GTLESVNGPR
60 70 80 90 100
AGSRGLTTTS LADTFEHVIE ELLDEDQKVR PNEENHKDAD LYTSRVMLSS
110 120 130 140 150
QVPLEPPLLF LLEEYKNYLD AANMSMRVRR HSDPARRGEL SVCDSISEWV
160 170 180 190 200
TAADKKTAVD MSGGTVTVLE KVPVSKGQLK QYFYETKCNP MGYTKEGCRG
210 220 230 240
IDKRHWNSQC RTTQSYVRAL TMDSKKRIGW RFIRIDTSCV CTLTIKRGR
Length:249
Mass (Da):28,123
Last modified:May 1, 1991 - v1
Checksum:i90CE1F16BB235C97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55573 mRNA Translation: CAA39159.1
BC034862 mRNA Translation: AAH34862.1
CCDSiCCDS38194.1
PIRiS12555
RefSeqiNP_001041604.1, NM_001048139.1
NP_001041606.1, NM_001048141.1
NP_001041607.1, NM_001048142.1
NP_001272345.1, NM_001285416.1
NP_001272346.1, NM_001285417.1
NP_001272347.1, NM_001285418.1
NP_001272348.1, NM_001285419.1
NP_001272349.1, NM_001285420.1
NP_001272350.1, NM_001285421.1
NP_001272351.1, NM_001285422.1
NP_001303239.1, NM_001316310.1
UniGeneiMm.1442

Genome annotation databases

EnsembliENSMUST00000111043; ENSMUSP00000106672; ENSMUSG00000048482
ENSMUST00000111044; ENSMUSP00000106673; ENSMUSG00000048482
ENSMUST00000111045; ENSMUSP00000106674; ENSMUSG00000048482
ENSMUST00000111046; ENSMUSP00000106675; ENSMUSG00000048482
ENSMUST00000111047; ENSMUSP00000106676; ENSMUSG00000048482
ENSMUST00000111049; ENSMUSP00000106678; ENSMUSG00000048482
ENSMUST00000111050; ENSMUSP00000106679; ENSMUSG00000048482
ENSMUST00000111051; ENSMUSP00000106680; ENSMUSG00000048482
ENSMUST00000176893; ENSMUSP00000135762; ENSMUSG00000048482
GeneIDi12064
KEGGimmu:12064
UCSCiuc008lme.1 mouse

Similar proteinsi

Entry informationi

Entry nameiBDNF_MOUSE
AccessioniPrimary (citable) accession number: P21237
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: May 23, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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