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P21237

- BDNF_MOUSE

UniProt

P21237 - BDNF_MOUSE

Protein

Brain-derived neurotrophic factor

Gene

Bdnf

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 May 1991)
      Previous versions | rss
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    Functioni

    During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei57 – 582Cleavage; by S1PBy similarity

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. axon extension Source: MGI
    2. axon guidance Source: MGI
    3. axon target recognition Source: MGI
    4. behavioral fear response Source: MGI
    5. circadian rhythm Source: UniProtKB
    6. dendrite development Source: MGI
    7. dendrite extension Source: MGI
    8. fear response Source: MGI
    9. feeding behavior Source: MGI
    10. gamma-aminobutyric acid signaling pathway Source: MGI
    11. glutamate secretion Source: MGI
    12. inner ear development Source: MGI
    13. learning or memory Source: MGI
    14. mechanoreceptor differentiation Source: MGI
    15. negative regulation of apoptotic process Source: MGI
    16. negative regulation of cell death Source: MGI
    17. negative regulation of neuroblast proliferation Source: MGI
    18. negative regulation of neuron apoptotic process Source: MGI
    19. negative regulation of synaptic transmission, GABAergic Source: MGI
    20. nerve development Source: MGI
    21. neuron recognition Source: MGI
    22. positive regulation of neuron differentiation Source: MGI
    23. positive regulation of peptidyl-serine phosphorylation Source: MGI
    24. regulation of metabolic process Source: MGI
    25. regulation of neuron apoptotic process Source: MGI
    26. regulation of retinal cell programmed cell death Source: MGI
    27. regulation of synaptic plasticity Source: MGI
    28. response to drug Source: MGI
    29. taste bud development Source: MGI
    30. ureteric bud development Source: MGI

    Keywords - Molecular functioni

    Growth factor

    Enzyme and pathway databases

    ReactomeiREACT_206713. NGF processing.
    REACT_209641. NRAGE signals death through JNK.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Brain-derived neurotrophic factor
    Short name:
    BDNF
    Gene namesi
    Name:Bdnf
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:88145. Bdnf.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytoplasmic membrane-bounded vesicle Source: MGI
    3. endoplasmic reticulum lumen Source: Reactome
    4. extracellular region Source: Reactome
    5. perinuclear region of cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi68 – 681V → M: Reduced hippocampal volume, dendritic complexity and context-dependent memory. Increased anxiety-related behaviors. 1 Publication
    Mutagenesisi130 – 1301R → K: Forms homodimers processed at L-112 that seem more stable than the wild-type. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Propeptidei19 – 1301121 PublicationPRO_0000019635Add
    BLAST
    Chaini131 – 249119Brain-derived neurotrophic factorPRO_0000019636Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi123 – 1231N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi143 ↔ 210By similarity
    Disulfide bondi188 ↔ 239By similarity
    Disulfide bondi198 ↔ 241By similarity

    Post-translational modificationi

    Converted into mature BDNF by plasmin (PLG).

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP21237.

    PTM databases

    PhosphoSiteiP21237.

    Expressioni

    Inductioni

    Expression oscillates in a circadian manner in the suprachiasmatic nucleus (SCN) of the brain. Expressed at higher levels during the dark period and at lower levels during the light period.1 Publication

    Gene expression databases

    ArrayExpressiP21237.
    BgeeiP21237.
    CleanExiMM_BDNF.
    GenevestigatoriP21237.

    Interactioni

    Subunit structurei

    Monomers and homodimers. Binds to NTRK2/TRKB.1 Publication

    Protein-protein interaction databases

    DIPiDIP-5724N.
    IntActiP21237. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP21237.
    SMRiP21237. Positions 138-246.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG45248.
    HOGENOMiHOG000231516.
    HOVERGENiHBG006494.
    InParanoidiP21237.
    KOiK04355.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR020430. Brain-der_neurotrophic_factor.
    IPR029034. Cystine-knot_cytokine.
    IPR020408. Nerve_growth_factor-like.
    IPR002072. Nerve_growth_factor-rel.
    IPR019846. Nerve_growth_factor_CS.
    [Graphical view]
    PANTHERiPTHR11589. PTHR11589. 1 hit.
    PfamiPF00243. NGF. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001789. NGF. 1 hit.
    PRINTSiPR01912. BDNFACTOR.
    PR00268. NGF.
    ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00140. NGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00248. NGF_1. 1 hit.
    PS50270. NGF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P21237-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTILFLTMVI SYFGCMKAAP MKEVNVHGQG NLAYPGVRTH GTLESVNGPR    50
    AGSRGLTTTS LADTFEHVIE ELLDEDQKVR PNEENHKDAD LYTSRVMLSS 100
    QVPLEPPLLF LLEEYKNYLD AANMSMRVRR HSDPARRGEL SVCDSISEWV 150
    TAADKKTAVD MSGGTVTVLE KVPVSKGQLK QYFYETKCNP MGYTKEGCRG 200
    IDKRHWNSQC RTTQSYVRAL TMDSKKRIGW RFIRIDTSCV CTLTIKRGR 249
    Length:249
    Mass (Da):28,123
    Last modified:May 1, 1991 - v1
    Checksum:i90CE1F16BB235C97
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55573 mRNA. Translation: CAA39159.1.
    BC034862 mRNA. Translation: AAH34862.1.
    CCDSiCCDS38194.1.
    PIRiS12555.
    RefSeqiNP_001041604.1. NM_001048139.1.
    NP_001041606.1. NM_001048141.1.
    NP_001041607.1. NM_001048142.1.
    NP_001272345.1. NM_001285416.1.
    NP_001272346.1. NM_001285417.1.
    NP_001272347.1. NM_001285418.1.
    NP_001272348.1. NM_001285419.1.
    NP_001272349.1. NM_001285420.1.
    NP_001272350.1. NM_001285421.1.
    NP_001272351.1. NM_001285422.1.
    UniGeneiMm.1442.

    Genome annotation databases

    EnsembliENSMUST00000111043; ENSMUSP00000106672; ENSMUSG00000048482.
    ENSMUST00000111044; ENSMUSP00000106673; ENSMUSG00000048482.
    ENSMUST00000111045; ENSMUSP00000106674; ENSMUSG00000048482.
    ENSMUST00000111046; ENSMUSP00000106675; ENSMUSG00000048482.
    ENSMUST00000111047; ENSMUSP00000106676; ENSMUSG00000048482.
    ENSMUST00000111049; ENSMUSP00000106678; ENSMUSG00000048482.
    ENSMUST00000111050; ENSMUSP00000106679; ENSMUSG00000048482.
    ENSMUST00000111051; ENSMUSP00000106680; ENSMUSG00000048482.
    ENSMUST00000176893; ENSMUSP00000135762; ENSMUSG00000048482.
    GeneIDi12064.
    KEGGimmu:12064.
    UCSCiuc008lme.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55573 mRNA. Translation: CAA39159.1 .
    BC034862 mRNA. Translation: AAH34862.1 .
    CCDSi CCDS38194.1.
    PIRi S12555.
    RefSeqi NP_001041604.1. NM_001048139.1.
    NP_001041606.1. NM_001048141.1.
    NP_001041607.1. NM_001048142.1.
    NP_001272345.1. NM_001285416.1.
    NP_001272346.1. NM_001285417.1.
    NP_001272347.1. NM_001285418.1.
    NP_001272348.1. NM_001285419.1.
    NP_001272349.1. NM_001285420.1.
    NP_001272350.1. NM_001285421.1.
    NP_001272351.1. NM_001285422.1.
    UniGenei Mm.1442.

    3D structure databases

    ProteinModelPortali P21237.
    SMRi P21237. Positions 138-246.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-5724N.
    IntActi P21237. 1 interaction.

    PTM databases

    PhosphoSitei P21237.

    Proteomic databases

    PRIDEi P21237.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000111043 ; ENSMUSP00000106672 ; ENSMUSG00000048482 .
    ENSMUST00000111044 ; ENSMUSP00000106673 ; ENSMUSG00000048482 .
    ENSMUST00000111045 ; ENSMUSP00000106674 ; ENSMUSG00000048482 .
    ENSMUST00000111046 ; ENSMUSP00000106675 ; ENSMUSG00000048482 .
    ENSMUST00000111047 ; ENSMUSP00000106676 ; ENSMUSG00000048482 .
    ENSMUST00000111049 ; ENSMUSP00000106678 ; ENSMUSG00000048482 .
    ENSMUST00000111050 ; ENSMUSP00000106679 ; ENSMUSG00000048482 .
    ENSMUST00000111051 ; ENSMUSP00000106680 ; ENSMUSG00000048482 .
    ENSMUST00000176893 ; ENSMUSP00000135762 ; ENSMUSG00000048482 .
    GeneIDi 12064.
    KEGGi mmu:12064.
    UCSCi uc008lme.1. mouse.

    Organism-specific databases

    CTDi 627.
    MGIi MGI:88145. Bdnf.

    Phylogenomic databases

    eggNOGi NOG45248.
    HOGENOMi HOG000231516.
    HOVERGENi HBG006494.
    InParanoidi P21237.
    KOi K04355.

    Enzyme and pathway databases

    Reactomei REACT_206713. NGF processing.
    REACT_209641. NRAGE signals death through JNK.

    Miscellaneous databases

    NextBioi 280377.
    PROi P21237.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P21237.
    Bgeei P21237.
    CleanExi MM_BDNF.
    Genevestigatori P21237.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR020430. Brain-der_neurotrophic_factor.
    IPR029034. Cystine-knot_cytokine.
    IPR020408. Nerve_growth_factor-like.
    IPR002072. Nerve_growth_factor-rel.
    IPR019846. Nerve_growth_factor_CS.
    [Graphical view ]
    PANTHERi PTHR11589. PTHR11589. 1 hit.
    Pfami PF00243. NGF. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001789. NGF. 1 hit.
    PRINTSi PR01912. BDNFACTOR.
    PR00268. NGF.
    ProDomi PD002052. Nerve_growth_factor-rel. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00140. NGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00248. NGF_1. 1 hit.
    PS50270. NGF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain."
      Hofer M., Pagliusi S.R., Hohn A., Leibrock J., Barde Y.-A.
      EMBO J. 9:2459-2464(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.
    3. "Characterisation of neurotrophin dimers and monomers."
      Kolbeck R., Jungbluth S., Barde Y.-A.
      Eur. J. Biochem. 225:995-1003(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 112-121 AND 131-135, SUBUNIT, MUTAGENESIS OF ARG-130.
    4. "Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity."
      Pang P.T., Teng H.K., Zaitsev E., Woo N.T., Sakata K., Zhen S., Teng K.K., Yung W.-H., Hempstead B.L., Lu B.
      Science 306:487-491(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACTIVATION BY PLG.
    5. "Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior."
      Chen Z.-Y., Jing D., Bath K.G., Ieraci A., Khan T., Siao C.-J., Herrera D.G., Toth M., Yang C., McEwen B.S., Hempstead B.L., Lee F.S.
      Science 314:140-143(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF VAL-68.
    6. "p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks."
      Baeza-Raja B., Eckel-Mahan K., Zhang L., Vagena E., Tsigelny I.F., Sassone-Corsi P., Ptacek L.J., Akassoglou K.
      J. Neurosci. 33:10221-10234(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.

    Entry informationi

    Entry nameiBDNF_MOUSE
    AccessioniPrimary (citable) accession number: P21237
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: May 1, 1991
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3