Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P21237

- BDNF_MOUSE

UniProt

P21237 - BDNF_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Brain-derived neurotrophic factor

Gene

Bdnf

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei57 – 582Cleavage; by S1PBy similarity

GO - Biological processi

  1. axon extension Source: MGI
  2. axon guidance Source: MGI
  3. axon target recognition Source: MGI
  4. behavioral fear response Source: MGI
  5. circadian rhythm Source: UniProtKB
  6. dendrite development Source: MGI
  7. dendrite extension Source: MGI
  8. fear response Source: MGI
  9. feeding behavior Source: MGI
  10. gamma-aminobutyric acid signaling pathway Source: MGI
  11. glutamate secretion Source: MGI
  12. inner ear development Source: MGI
  13. learning or memory Source: MGI
  14. mechanoreceptor differentiation Source: MGI
  15. negative regulation of apoptotic process Source: MGI
  16. negative regulation of cell death Source: MGI
  17. negative regulation of neuroblast proliferation Source: MGI
  18. negative regulation of neuron apoptotic process Source: MGI
  19. negative regulation of synaptic transmission, GABAergic Source: MGI
  20. nerve development Source: MGI
  21. neuron recognition Source: MGI
  22. positive regulation of neuron differentiation Source: MGI
  23. positive regulation of peptidyl-serine phosphorylation Source: MGI
  24. regulation of metabolic process Source: MGI
  25. regulation of neuron apoptotic process Source: MGI
  26. regulation of retinal cell programmed cell death Source: MGI
  27. regulation of synaptic plasticity Source: MGI
  28. response to drug Source: MGI
  29. taste bud development Source: MGI
  30. ureteric bud development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiREACT_206713. NGF processing.
REACT_209641. NRAGE signals death through JNK.

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-derived neurotrophic factor
Short name:
BDNF
Gene namesi
Name:Bdnf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:88145. Bdnf.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytoplasmic membrane-bounded vesicle Source: MGI
  3. endoplasmic reticulum lumen Source: Reactome
  4. extracellular region Source: Reactome
  5. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi68 – 681V → M: Reduced hippocampal volume, dendritic complexity and context-dependent memory. Increased anxiety-related behaviors. 1 Publication
Mutagenesisi130 – 1301R → K: Forms homodimers processed at L-112 that seem more stable than the wild-type. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Propeptidei19 – 1301121 PublicationPRO_0000019635Add
BLAST
Chaini131 – 249119Brain-derived neurotrophic factorPRO_0000019636Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi123 – 1231N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi143 ↔ 210By similarity
Disulfide bondi188 ↔ 239By similarity
Disulfide bondi198 ↔ 241By similarity

Post-translational modificationi

Converted into mature BDNF by plasmin (PLG).

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP21237.
PRIDEiP21237.

PTM databases

PhosphoSiteiP21237.

Expressioni

Inductioni

Expression oscillates in a circadian manner in the suprachiasmatic nucleus (SCN) of the brain. Expressed at higher levels during the dark period and at lower levels during the light period.1 Publication

Gene expression databases

BgeeiP21237.
CleanExiMM_BDNF.
ExpressionAtlasiP21237. baseline and differential.
GenevestigatoriP21237.

Interactioni

Subunit structurei

Monomers and homodimers. Binds to NTRK2/TRKB.1 Publication

Protein-protein interaction databases

DIPiDIP-5724N.
IntActiP21237. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP21237.
SMRiP21237. Positions 138-246.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45248.
HOGENOMiHOG000231516.
HOVERGENiHBG006494.
InParanoidiP21237.
KOiK04355.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR020430. Brain-der_neurotrophic_factor.
IPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
[Graphical view]
PANTHERiPTHR11589. PTHR11589. 1 hit.
PfamiPF00243. NGF. 1 hit.
[Graphical view]
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01912. BDNFACTOR.
PR00268. NGF.
ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21237-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTILFLTMVI SYFGCMKAAP MKEVNVHGQG NLAYPGVRTH GTLESVNGPR
60 70 80 90 100
AGSRGLTTTS LADTFEHVIE ELLDEDQKVR PNEENHKDAD LYTSRVMLSS
110 120 130 140 150
QVPLEPPLLF LLEEYKNYLD AANMSMRVRR HSDPARRGEL SVCDSISEWV
160 170 180 190 200
TAADKKTAVD MSGGTVTVLE KVPVSKGQLK QYFYETKCNP MGYTKEGCRG
210 220 230 240
IDKRHWNSQC RTTQSYVRAL TMDSKKRIGW RFIRIDTSCV CTLTIKRGR
Length:249
Mass (Da):28,123
Last modified:May 1, 1991 - v1
Checksum:i90CE1F16BB235C97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55573 mRNA. Translation: CAA39159.1.
BC034862 mRNA. Translation: AAH34862.1.
CCDSiCCDS38194.1.
PIRiS12555.
RefSeqiNP_001041604.1. NM_001048139.1.
NP_001041606.1. NM_001048141.1.
NP_001041607.1. NM_001048142.1.
NP_001272345.1. NM_001285416.1.
NP_001272346.1. NM_001285417.1.
NP_001272347.1. NM_001285418.1.
NP_001272348.1. NM_001285419.1.
NP_001272349.1. NM_001285420.1.
NP_001272350.1. NM_001285421.1.
NP_001272351.1. NM_001285422.1.
UniGeneiMm.1442.

Genome annotation databases

EnsembliENSMUST00000111043; ENSMUSP00000106672; ENSMUSG00000048482.
ENSMUST00000111044; ENSMUSP00000106673; ENSMUSG00000048482.
ENSMUST00000111045; ENSMUSP00000106674; ENSMUSG00000048482.
ENSMUST00000111046; ENSMUSP00000106675; ENSMUSG00000048482.
ENSMUST00000111047; ENSMUSP00000106676; ENSMUSG00000048482.
ENSMUST00000111049; ENSMUSP00000106678; ENSMUSG00000048482.
ENSMUST00000111050; ENSMUSP00000106679; ENSMUSG00000048482.
ENSMUST00000111051; ENSMUSP00000106680; ENSMUSG00000048482.
ENSMUST00000176893; ENSMUSP00000135762; ENSMUSG00000048482.
GeneIDi12064.
KEGGimmu:12064.
UCSCiuc008lme.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55573 mRNA. Translation: CAA39159.1 .
BC034862 mRNA. Translation: AAH34862.1 .
CCDSi CCDS38194.1.
PIRi S12555.
RefSeqi NP_001041604.1. NM_001048139.1.
NP_001041606.1. NM_001048141.1.
NP_001041607.1. NM_001048142.1.
NP_001272345.1. NM_001285416.1.
NP_001272346.1. NM_001285417.1.
NP_001272347.1. NM_001285418.1.
NP_001272348.1. NM_001285419.1.
NP_001272349.1. NM_001285420.1.
NP_001272350.1. NM_001285421.1.
NP_001272351.1. NM_001285422.1.
UniGenei Mm.1442.

3D structure databases

ProteinModelPortali P21237.
SMRi P21237. Positions 138-246.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-5724N.
IntActi P21237. 1 interaction.

PTM databases

PhosphoSitei P21237.

Proteomic databases

MaxQBi P21237.
PRIDEi P21237.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000111043 ; ENSMUSP00000106672 ; ENSMUSG00000048482 .
ENSMUST00000111044 ; ENSMUSP00000106673 ; ENSMUSG00000048482 .
ENSMUST00000111045 ; ENSMUSP00000106674 ; ENSMUSG00000048482 .
ENSMUST00000111046 ; ENSMUSP00000106675 ; ENSMUSG00000048482 .
ENSMUST00000111047 ; ENSMUSP00000106676 ; ENSMUSG00000048482 .
ENSMUST00000111049 ; ENSMUSP00000106678 ; ENSMUSG00000048482 .
ENSMUST00000111050 ; ENSMUSP00000106679 ; ENSMUSG00000048482 .
ENSMUST00000111051 ; ENSMUSP00000106680 ; ENSMUSG00000048482 .
ENSMUST00000176893 ; ENSMUSP00000135762 ; ENSMUSG00000048482 .
GeneIDi 12064.
KEGGi mmu:12064.
UCSCi uc008lme.1. mouse.

Organism-specific databases

CTDi 627.
MGIi MGI:88145. Bdnf.

Phylogenomic databases

eggNOGi NOG45248.
HOGENOMi HOG000231516.
HOVERGENi HBG006494.
InParanoidi P21237.
KOi K04355.

Enzyme and pathway databases

Reactomei REACT_206713. NGF processing.
REACT_209641. NRAGE signals death through JNK.

Miscellaneous databases

NextBioi 280377.
PROi P21237.
SOURCEi Search...

Gene expression databases

Bgeei P21237.
CleanExi MM_BDNF.
ExpressionAtlasi P21237. baseline and differential.
Genevestigatori P21237.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR020430. Brain-der_neurotrophic_factor.
IPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
[Graphical view ]
PANTHERi PTHR11589. PTHR11589. 1 hit.
Pfami PF00243. NGF. 1 hit.
[Graphical view ]
PIRSFi PIRSF001789. NGF. 1 hit.
PRINTSi PR01912. BDNFACTOR.
PR00268. NGF.
ProDomi PD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00140. NGF. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain."
    Hofer M., Pagliusi S.R., Hohn A., Leibrock J., Barde Y.-A.
    EMBO J. 9:2459-2464(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  3. "Characterisation of neurotrophin dimers and monomers."
    Kolbeck R., Jungbluth S., Barde Y.-A.
    Eur. J. Biochem. 225:995-1003(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 112-121 AND 131-135, SUBUNIT, MUTAGENESIS OF ARG-130.
  4. "Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity."
    Pang P.T., Teng H.K., Zaitsev E., Woo N.T., Sakata K., Zhen S., Teng K.K., Yung W.-H., Hempstead B.L., Lu B.
    Science 306:487-491(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACTIVATION BY PLG.
  5. "Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior."
    Chen Z.-Y., Jing D., Bath K.G., Ieraci A., Khan T., Siao C.-J., Herrera D.G., Toth M., Yang C., McEwen B.S., Hempstead B.L., Lee F.S.
    Science 314:140-143(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF VAL-68.
  6. "p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks."
    Baeza-Raja B., Eckel-Mahan K., Zhang L., Vagena E., Tsigelny I.F., Sassone-Corsi P., Ptacek L.J., Akassoglou K.
    J. Neurosci. 33:10221-10234(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiBDNF_MOUSE
AccessioniPrimary (citable) accession number: P21237
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: October 29, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3