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P21237 (BDNF_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Brain-derived neurotrophic factor

Short name=BDNF
Gene names
Name:Bdnf
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length249 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.

Subunit structure

Monomers and homodimers. Binds to NTRK2/TRKB. Ref.3

Subcellular location

Secreted.

Post-translational modification

Converted into mature BDNF by plasmin (PLG).

Sequence similarities

Belongs to the NGF-beta family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionGrowth factor
   PTMCleavage on pair of basic residues
Disulfide bond
Glycoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processaxon guidance

Inferred from mutant phenotype PubMed 15014133. Source: MGI

axon target recognition

Inferred from mutant phenotype PubMed 15464571. Source: MGI

behavioral fear response

Inferred from mutant phenotype PubMed 15249684. Source: MGI

dendrite development

Inferred from mutant phenotype PubMed 12890780. Source: MGI

fear response

Inferred from mutant phenotype PubMed 15249684. Source: MGI

feeding behavior

Inferred from mutant phenotype PubMed 12796784. Source: MGI

gamma-aminobutyric acid signaling pathway

Inferred from direct assay PubMed 16754670. Source: MGI

glutamate secretion

Inferred from physical interaction PubMed 16819522. Source: MGI

inner ear development

Inferred from mutant phenotype PubMed 7605630. Source: MGI

learning or memory

Inferred from mutant phenotype PubMed 15249684. Source: MGI

mechanoreceptor differentiation

Inferred from genetic interaction PubMed 15376326. Source: MGI

negative regulation of apoptotic process

Inferred from direct assay PubMed 12904469. Source: MGI

negative regulation of neuroblast proliferation

Inferred from direct assay PubMed 12798291. Source: MGI

negative regulation of neuron apoptotic process

Inferred from mutant phenotype PubMed 15869495PubMed 8861722. Source: MGI

negative regulation of synaptic transmission, GABAergic

Inferred from direct assay PubMed 16754670. Source: MGI

nerve development

Inferred from mutant phenotype PubMed 7605630. Source: MGI

neuron recognition

Inferred from mutant phenotype PubMed 15844198. Source: MGI

positive regulation of neuron differentiation

Inferred from direct assay PubMed 12798291. Source: MGI

positive regulation of peptidyl-serine phosphorylation

Inferred from direct assay PubMed 16754670. Source: MGI

regulation of metabolic process

Inferred from mutant phenotype PubMed 12106019. Source: MGI

regulation of neuron apoptotic process

Inferred from direct assay PubMed 16516892. Source: MGI

regulation of retinal cell programmed cell death

Inferred from direct assay PubMed 11747369. Source: MGI

regulation of synaptic plasticity

Inferred from direct assay PubMed 16819522PubMed 17442827. Source: MGI

response to drug

Inferred from mutant phenotype PubMed 15249684. Source: MGI

ureteric bud development

Inferred from direct assay PubMed 16018995. Source: MGI

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 22209827. Source: UniProtKB

cytoplasmic membrane-bounded vesicle

Inferred from direct assay PubMed 14715936PubMed 15242649. Source: MGI

endoplasmic reticulum lumen

Traceable author statement. Source: Reactome

extracellular region

Traceable author statement. Source: Reactome

perinuclear region of cytoplasm

Inferred from direct assay PubMed 22209827. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Propeptide19 – 130112
PRO_0000019635
Chain131 – 249119Brain-derived neurotrophic factor
PRO_0000019636

Sites

Site57 – 582Cleavage; by S1P By similarity

Amino acid modifications

Glycosylation1231N-linked (GlcNAc...) Potential
Disulfide bond143 ↔ 210 By similarity
Disulfide bond188 ↔ 239 By similarity
Disulfide bond198 ↔ 241 By similarity

Experimental info

Mutagenesis681V → M: Reduced hippocampal volume, dendritic complexity and context-dependent memory. Increased anxiety-related behaviors. Ref.5
Mutagenesis1301R → K: Forms homodimers processed at L-112 that seem more stable than the wild-type. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P21237 [UniParc].

Last modified May 1, 1991. Version 1.
Checksum: 90CE1F16BB235C97

FASTA24928,123
        10         20         30         40         50         60 
MTILFLTMVI SYFGCMKAAP MKEVNVHGQG NLAYPGVRTH GTLESVNGPR AGSRGLTTTS 

        70         80         90        100        110        120 
LADTFEHVIE ELLDEDQKVR PNEENHKDAD LYTSRVMLSS QVPLEPPLLF LLEEYKNYLD 

       130        140        150        160        170        180 
AANMSMRVRR HSDPARRGEL SVCDSISEWV TAADKKTAVD MSGGTVTVLE KVPVSKGQLK 

       190        200        210        220        230        240 
QYFYETKCNP MGYTKEGCRG IDKRHWNSQC RTTQSYVRAL TMDSKKRIGW RFIRIDTSCV 


CTLTIKRGR 

« Hide

References

« Hide 'large scale' references
[1]"Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain."
Hofer M., Pagliusi S.R., Hohn A., Leibrock J., Barde Y.-A.
EMBO J. 9:2459-2464(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Mammary gland.
[3]"Characterisation of neurotrophin dimers and monomers."
Kolbeck R., Jungbluth S., Barde Y.-A.
Eur. J. Biochem. 225:995-1003(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 112-121 AND 131-135, SUBUNIT, MUTAGENESIS OF ARG-130.
[4]"Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity."
Pang P.T., Teng H.K., Zaitsev E., Woo N.T., Sakata K., Zhen S., Teng K.K., Yung W.-H., Hempstead B.L., Lu B.
Science 306:487-491(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: ACTIVATION BY PLG.
[5]"Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior."
Chen Z.-Y., Jing D., Bath K.G., Ieraci A., Khan T., Siao C.-J., Herrera D.G., Toth M., Yang C., McEwen B.S., Hempstead B.L., Lee F.S.
Science 314:140-143(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: MUTAGENESIS OF VAL-68.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X55573 mRNA. Translation: CAA39159.1.
BC034862 mRNA. Translation: AAH34862.1.
PIRS12555.
RefSeqNP_001041604.1. NM_001048139.1.
NP_001041606.1. NM_001048141.1.
NP_001041607.1. NM_001048142.1.
NP_001272345.1. NM_001285416.1.
NP_001272346.1. NM_001285417.1.
NP_001272347.1. NM_001285418.1.
NP_001272348.1. NM_001285419.1.
NP_001272349.1. NM_001285420.1.
NP_001272350.1. NM_001285421.1.
NP_001272351.1. NM_001285422.1.
UniGeneMm.1442.

3D structure databases

ProteinModelPortalP21237.
SMRP21237. Positions 138-246.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-5724N.
IntActP21237. 1 interaction.

PTM databases

PhosphoSiteP21237.

Proteomic databases

PRIDEP21237.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000111043; ENSMUSP00000106672; ENSMUSG00000048482.
ENSMUST00000111044; ENSMUSP00000106673; ENSMUSG00000048482.
ENSMUST00000111045; ENSMUSP00000106674; ENSMUSG00000048482.
ENSMUST00000111046; ENSMUSP00000106675; ENSMUSG00000048482.
ENSMUST00000111047; ENSMUSP00000106676; ENSMUSG00000048482.
ENSMUST00000111049; ENSMUSP00000106678; ENSMUSG00000048482.
ENSMUST00000111050; ENSMUSP00000106679; ENSMUSG00000048482.
ENSMUST00000111051; ENSMUSP00000106680; ENSMUSG00000048482.
ENSMUST00000176893; ENSMUSP00000135762; ENSMUSG00000048482.
GeneID12064.
KEGGmmu:12064.
UCSCuc008lme.1. mouse.

Organism-specific databases

CTD627.
MGIMGI:88145. Bdnf.

Phylogenomic databases

eggNOGNOG45248.
HOGENOMHOG000231516.
HOVERGENHBG006494.
InParanoidP21237.
KOK04355.

Enzyme and pathway databases

ReactomeREACT_188257. Signal Transduction.

Gene expression databases

ArrayExpressP21237.
BgeeP21237.
CleanExMM_BDNF.
GenevestigatorP21237.

Family and domain databases

InterProIPR020430. Brain-der_neurotrophic_factor.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
[Graphical view]
PANTHERPTHR11589. PTHR11589. 1 hit.
PfamPF00243. NGF. 1 hit.
[Graphical view]
PIRSFPIRSF001789. NGF. 1 hit.
PRINTSPR01912. BDNFACTOR.
PR00268. NGF.
ProDomPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00140. NGF. 1 hit.
[Graphical view]
PROSITEPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio280377.
PROP21237.
SOURCESearch...

Entry information

Entry nameBDNF_MOUSE
AccessionPrimary (citable) accession number: P21237
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: April 16, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot