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Reviewed, UniProtKB/Swiss-Prot P21236 (ERM_STRPN)

Last modified June 16, 2009. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    rRNA adenine N-6-methyltransferase
    EC=2.1.1.48
Alternative name(s):
    ErmAM
    Macrolide-lincosamide-streptogramin B resistance protein
Gene names
Name: erm
OrganismStreptococcus pneumoniae
Taxonomic identifier1313 [NCBI]
Taxonomic lineageBacteriaFirmicutesLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length245 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

This protein produces a dimethylation of the adenine residue at position 2058 in 23S rRNA, resulting in reduced affinity between ribosomes and macrolide-lincosamide-streptogramin B antibiotics.

Catalytic activity

S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine.

Sequence similarities

Belongs to the rRNA adenine N(6)-methyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 245245rRNA adenine N-6-methyltransferase
PRO_0000101690

Secondary structure

.............................................. 245
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P21236-1 [UniParc].

Last modified May 1, 1991. Version 1.
Checksum: 5E3AB1BAAA6511C5

FASTA24528,783
        10         20         30         40         50         60 
MNKNIKYSQN FLTSEKVLNQ IIKQLNLKET DTVYEIGTGK GHLTTKLAKI SKQVTSIELD 

        70         80         90        100        110        120 
SHLFNLSSEK LKLNIRVTLI HQDILQFQFP NKQRYKIVGS IPYHLSTQII KKVVFESHAS 

       130        140        150        160        170        180 
DIYLIVEEGF YKRTLDIHRT LGLLLHTQVS IQQLLKLPAE CFHPKPKVNS VLIKLTRHTT 

       190        200        210        220        230        240 
DVPDKYWKLY TYFVSKWVNR EYRQLFTKNQ FHQAMKHAKV NNLSTITYEQ VLSIFNSYLL 


FNGRK 

« Hide

References

[1]"Nucleotide sequence of the erythromycin resistance gene of the conjugative transposon Tn1545."
Trieu-Cuot P., Poyart-Salmeron C., Carlier C., Courvalin P.
Nucleic Acids Res. 18:3660-3660(1990) [PubMed: 2163525] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Transposon: Tn1545.
[2]"Solution structure of an rRNA methyltransferase (ErmAM) that confers macrolide-lincosamide-streptogramin antibiotic resistance."
Yu L., Petros A.M., Schnuchel A., Zhong P., Severin J.M., Walter K., Holzman T.F., Fesik S.W.
Nat. Struct. Biol. 4:483-489(1997) [PubMed: 9187657] [Abstract]
Cited for: STRUCTURE BY NMR.
[3]Erratum
Yu L., Petros A.M., Schnuchel A., Zhong P., Severin J.M., Walter K., Holzman T.F., Fesik S.W.
Nat. Struct. Biol. 4:592-592(1997)

Cross-references

Sequence databases

X52632 Genomic DNA. No translation available.
PIRS12727.

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1YUBNMR-A1-245[»]
SMRP21236. Positions 1-245.
ModBaseSearch...

Enzyme and pathway databases

BRENDA2.1.1.48. 600.

Family and domain databases

InterProIPR001737. RRNA_Ade_Mease_Trfase.
[Graphical view]
PANTHERPTHR11727. RRNA_meth_trans. 1 hit.
PfamPF00398. RrnaAD. 1 hit.
[Graphical view]
SMARTSM00650. rADc. 1 hit.
[Graphical view]
PROSITEPS01131. RRNA_A_DIMETH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameERM_STRPN
AccessionPrimary (citable) accession number: P21236
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: June 16, 2009
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents