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Protein

Regulatory protein alcR

Gene

alcR

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Positive regulatory protein for the ethanol regulon, alcA and aldA. It control positively its own expression and possibly in a negative fashion the expression of the gene coding for ADH-II.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi12 – 121Zinc 1
Metal bindingi12 – 121Zinc 2
Metal bindingi15 – 151Zinc 1
Metal bindingi22 – 221Zinc 1
Metal bindingi39 – 391Zinc 1
Metal bindingi39 – 391Zinc 2
Metal bindingi42 – 421Zinc 2
Metal bindingi49 – 491Zinc 2

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi12 – 4938Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: ASPGD
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: InterPro
  • transcription factor activity, sequence-specific DNA binding Source: ASPGD
  • transcription regulatory region DNA binding Source: ASPGD
  • zinc ion binding Source: ASPGD

GO - Biological processi

  • acetaldehyde catabolic process Source: ASPGD
  • chromatin remodeling Source: ASPGD
  • ethanol catabolic process Source: ASPGD
  • positive regulation of transcription from RNA polymerase II promoter Source: ASPGD
  • threonine catabolic process Source: ASPGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Regulatory protein alcR
Gene namesi
Name:alcR
ORF Names:AN8978
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome VII
  • UP000005890 Componenti: Partially assembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:AN8978.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: ASPGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 821821Regulatory protein alcRPRO_0000114931Add
BLAST

Expressioni

Inductioni

By ethanol, threonine and acetaldehyde. Expression is autoregulated and subject to carbon catabolite repression.

Structurei

Secondary structure

1
821
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni2 – 43Combined sources
Beta strandi5 – 84Combined sources
Helixi13 – 186Combined sources
Helixi28 – 336Combined sources
Helixi40 – 445Combined sources
Helixi52 – 576Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1F4SNMR-P1-60[»]
1F5ENMR-P1-63[»]
2ALCNMR-A1-63[»]
3ALCNMR-A1-63[»]
ProteinModelPortaliP21228.
SMRiP21228. Positions 1-60.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP21228.

Family & Domainsi

Sequence similaritiesi

Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000173158.
InParanoidiP21228.
OMAiPRWPCSY.
OrthoDBiEOG092C1EU2.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21228-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADTRRRQNH SCDPCRKGKR RCDAPENRNE ANENGWVSCS NCKRWNKDCT
60 70 80 90 100
FNWLSSQRSK AKGAAPRART KKARTATTTS EPSTSAATIP TPESDNHDAP
110 120 130 140 150
PVINSHDALP SWTQGLLSHP GDLFDFSHSA IPANAEDAAN VQSDAPFPWD
160 170 180 190 200
LAIPGDFSMG QQLEKPLSPL SFQAVLLPPH SPNTDDLIRE LEEQTTDPDS
210 220 230 240 250
VTDTNSVQQV AQDGSLWSDR QSPLLPENSL CMASDSTARR YARSTMTKNL
260 270 280 290 300
MRIYHDSMEN ALSCWLTEHN CPYSDQISYL PPKQRAEWGP NWSNRMCIRV
310 320 330 340 350
CRLDRVSTSL RGRALSAEED KAAARALHLA IVAFASQWTQ HAQRGAGLNV
360 370 380 390 400
PADIAADERS IRRNAWNEAR HALQHTTGIP SFRVIFANII FSLTQSVLDD
410 420 430 440 450
DEQHGMGARL DKLLENDGAP VFLETANRQL YTFRHKFARM QRRGKAFNRL
460 470 480 490 500
PGGSVASTFA GIFETPTPSS ESPQLDPVVA SEEHRSTLSL MFWLGIMFDT
510 520 530 540 550
LSAAMYQRPL VVSDEDSQIS SASPPRRGAE TPINLDCWEP PRQVPSNQEK
560 570 580 590 600
SDVWGDLFLR TSDSLPDHES HTQISQPAAR WPCTYEQAAA ALSSATPVKV
610 620 630 640 650
LLYRRVTQLQ TLLYRGASPA RLEAAIQRTL YVYNHWTAKY QPFMQDCVAN
660 670 680 690 700
HELLPSRIQS WYVILDGHWH LAAMLLADVL ESIDRDSYSD INHIDLVTKL
710 720 730 740 750
RLDNALAVSA LARSSLRGQE LDPGKASPMY RHFHDSLTEV AFLVEPWTVV
760 770 780 790 800
LIHSFAKAAY ILLDCLDLDG QGNALAGYLQ LRQNCNYCIR ALQFLGRKSD
810 820
MAALVAKDLE RGLNGKVDSF L
Length:821
Mass (Da):91,686
Last modified:November 1, 1995 - v2
Checksum:iEF7E783964D1A449
GO

Sequence cautioni

The sequence EAA64310 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF496548 Genomic DNA. Translation: AAQ06627.1.
AACD01000168 Genomic DNA. Translation: EAA64310.1. Sequence problems.
BN001307 Genomic DNA. Translation: CBF84528.1.
PIRiJS0076.
S14292.
RefSeqiXP_682247.1. XM_677155.1.

Genome annotation databases

EnsemblFungiiCADANIAT00007877; CADANIAP00007877; CADANIAG00007877.
EAA64310; EAA64310; AN8978.2.
GeneIDi2868306.
KEGGiani:AN8978.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF496548 Genomic DNA. Translation: AAQ06627.1.
AACD01000168 Genomic DNA. Translation: EAA64310.1. Sequence problems.
BN001307 Genomic DNA. Translation: CBF84528.1.
PIRiJS0076.
S14292.
RefSeqiXP_682247.1. XM_677155.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1F4SNMR-P1-60[»]
1F5ENMR-P1-63[»]
2ALCNMR-A1-63[»]
3ALCNMR-A1-63[»]
ProteinModelPortaliP21228.
SMRiP21228. Positions 1-60.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANIAT00007877; CADANIAP00007877; CADANIAG00007877.
EAA64310; EAA64310; AN8978.2.
GeneIDi2868306.
KEGGiani:AN8978.2.

Organism-specific databases

EuPathDBiFungiDB:AN8978.

Phylogenomic databases

HOGENOMiHOG000173158.
InParanoidiP21228.
OMAiPRWPCSY.
OrthoDBiEOG092C1EU2.

Miscellaneous databases

EvolutionaryTraceiP21228.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALCR_EMENI
AccessioniPrimary (citable) accession number: P21228
Secondary accession number(s): C8VL74, Q59DL3, Q5ARV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.