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P21217

- FUT3_HUMAN

UniProt

P21217 - FUT3_HUMAN

Protein

Galactoside 3(4)-L-fucosyltransferase

Gene

FUT3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 154 (01 Oct 2014)
      Sequence version 1 (01 May 1991)
      Previous versions | rss
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    Functioni

    May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive (Le+) individuals have an active enzyme while Lewis-negative (Le-) individuals have an inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links.

    Catalytic activityi

    GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R.

    Pathwayi

    GO - Molecular functioni

    1. 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity Source: UniProtKB-EC
    2. alpha-(1->3)-fucosyltransferase activity Source: BHF-UCL
    3. fucosyltransferase activity Source: BHF-UCL

    GO - Biological processi

    1. cell-cell recognition Source: BHF-UCL
    2. fucosylation Source: GOC
    3. macromolecule glycosylation Source: BHF-UCL
    4. oligosaccharide biosynthetic process Source: BHF-UCL
    5. protein glycosylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Blood group antigen, Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BRENDAi2.4.1.65. 2681.
    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT10. Glycosyltransferase Family 10.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Galactoside 3(4)-L-fucosyltransferase (EC:2.4.1.65)
    Alternative name(s):
    Blood group Lewis alpha-4-fucosyltransferase
    Short name:
    Lewis FT
    Fucosyltransferase 3
    Fucosyltransferase III
    Short name:
    FucT-III
    Gene namesi
    Name:FUT3
    Synonyms:FT3B, LE
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:4014. FUT3.

    Subcellular locationi

    Golgi apparatusGolgi stack membrane; Single-pass type II membrane protein
    Note: Membrane-bound form in trans cisternae of Golgi.

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. Golgi cisterna membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. membrane Source: BHF-UCL

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    MIMi111100. gene+phenotype.
    PharmGKBiPA28430.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 361361Galactoside 3(4)-L-fucosyltransferasePRO_0000221096Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi154 – 1541N-linked (GlcNAc...)Curated
    Glycosylationi185 – 1851N-linked (GlcNAc...)Curated

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP21217.
    PRIDEiP21217.

    PTM databases

    PhosphoSiteiP21217.

    Expressioni

    Tissue specificityi

    Highly expressed in stomach, colon, small intestine, lung and kidney and to a lesser extent in salivary gland, bladder, uterus and liver.

    Gene expression databases

    ArrayExpressiP21217.
    BgeeiP21217.
    CleanExiHS_FUT3.
    GenevestigatoriP21217.

    Organism-specific databases

    HPAiHPA046966.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000305603.

    Structurei

    3D structure databases

    ProteinModelPortaliP21217.
    SMRiP21217. Positions 187-325.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1515CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini35 – 361327LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei16 – 3419Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 10 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG283180.
    HOGENOMiHOG000045583.
    HOVERGENiHBG000274.
    InParanoidiP21217.
    KOiK00716.
    OrthoDBiEOG7RJPS6.
    PhylomeDBiP21217.
    TreeFamiTF316348.

    Family and domain databases

    InterProiIPR001503. Glyco_trans_10.
    [Graphical view]
    PANTHERiPTHR11929. PTHR11929. 1 hit.
    PfamiPF00852. Glyco_transf_10. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P21217-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPLGAAKPQ WPWRRCLAAL LFQLLVAVCF FSYLRVSRDD ATGSPRAPSG    50
    SSRQDTTPTR PTLLILLWTW PFHIPVALSR CSEMVPGTAD CHITADRKVY 100
    PQADTVIVHH WDIMSNPKSR LPPSPRPQGQ RWIWFNLEPP PNCQHLEALD 150
    RYFNLTMSYR SDSDIFTPYG WLEPWSGQPA HPPLNLSAKT ELVAWAVSNW 200
    KPDSARVRYY QSLQAHLKVD VYGRSHKPLP KGTMMETLSR YKFYLAFENS 250
    LHPDYITEKL WRNALEAWAV PVVLGPSRSN YERFLPPDAF IHVDDFQSPK 300
    DLARYLQELD KDHARYLSYF RWRETLRPRS FSWALDFCKA CWKLQQESRY 350
    QTVRSIAAWF T 361
    Length:361
    Mass (Da):42,117
    Last modified:May 1, 1991 - v1
    Checksum:iBF4398044F19C284
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti5 – 51G → S.1 Publication
    Corresponds to variant rs28362458 [ dbSNP | Ensembl ].
    VAR_022200
    Natural varianti20 – 201L → R in Le(-). 5 Publications
    Corresponds to variant rs28362459 [ dbSNP | Ensembl ].
    VAR_003426
    Natural varianti68 – 681W → R in Le(-). 5 Publications
    Corresponds to variant rs812936 [ dbSNP | Ensembl ].
    VAR_007959
    Natural varianti102 – 1021Q → K in Le(+). 1 Publication
    Corresponds to variant rs59796499 [ dbSNP | Ensembl ].
    VAR_007960
    Natural varianti105 – 1051T → M in Le(-). 6 Publications
    Corresponds to variant rs778986 [ dbSNP | Ensembl ].
    VAR_003427
    Natural varianti124 – 1241S → A in Le(+). 1 Publication
    VAR_007961
    Natural varianti160 – 1601R → C.1 Publication
    Corresponds to variant rs28362462 [ dbSNP | Ensembl ].
    VAR_022201
    Natural varianti162 – 1621D → N in Le(-). 2 Publications
    Corresponds to variant rs28362463 [ dbSNP | Ensembl ].
    VAR_007962
    Natural varianti170 – 1701G → S in Le(-); completely inactive. 3 Publications
    Corresponds to variant rs28362464 [ dbSNP | Ensembl ].
    VAR_003428
    Natural varianti223 – 2231G → R in Le(-). 2 Publications
    Corresponds to variant rs28362466 [ dbSNP | Ensembl ].
    VAR_007963
    Natural varianti270 – 2701V → M in Le(-). 2 Publications
    Corresponds to variant rs28381968 [ dbSNP | Ensembl ].
    VAR_007964
    Natural varianti325 – 3251T → M.1 Publication
    Corresponds to variant rs28381969 [ dbSNP | Ensembl ].
    VAR_022202
    Natural varianti327 – 3271R → Q.1 Publication
    Corresponds to variant rs28381970 [ dbSNP | Ensembl ].
    VAR_022203
    Natural varianti336 – 3361D → A in Le(-). 1 Publication
    VAR_003429
    Natural varianti356 – 3561I → K in Le(-); less than 10% reduction in activity. 3 Publications
    Corresponds to variant rs3894326 [ dbSNP | Ensembl ].
    VAR_003430

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53578 mRNA. Translation: CAA37641.1.
    U27326 mRNA. Translation: AAC50185.1.
    U27327 mRNA. Translation: AAC50186.1.
    U27328 mRNA. Translation: AAC50187.1.
    D89324 Genomic DNA. Translation: BAA13941.1.
    D89325 Genomic DNA. Translation: BAA13942.1.
    AF131913 mRNA. Translation: AAD33514.1.
    FM210024 Genomic DNA. Translation: CAR64692.1.
    FM210025 Genomic DNA. Translation: CAR64693.1.
    AY870341 Genomic DNA. Translation: AAW34365.1.
    AC024592 Genomic DNA. No translation available.
    BC074836 mRNA. Translation: AAH74836.1.
    BC074837 mRNA. Translation: AAH74837.1.
    BC108675 mRNA. Translation: AAI08676.1.
    CCDSiCCDS12153.1.
    PIRiA36669.
    RefSeqiNP_000140.1. NM_000149.3.
    NP_001091108.1. NM_001097639.1.
    NP_001091109.1. NM_001097640.1.
    NP_001091110.1. NM_001097641.1.
    UniGeneiHs.169238.

    Genome annotation databases

    EnsembliENST00000303225; ENSP00000305603; ENSG00000171124.
    ENST00000458379; ENSP00000416443; ENSG00000171124.
    ENST00000589620; ENSP00000465804; ENSG00000171124.
    ENST00000589918; ENSP00000468123; ENSG00000171124.
    GeneIDi2525.
    KEGGihsa:2525.
    UCSCiuc002mdj.2. human.

    Polymorphism databases

    DMDMi121137.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    dbRBC/BGMUT

    Blood group antigen gene mutation database

    GGDB

    GlycoGene database

    SeattleSNPs
    Functional Glycomics Gateway - GTase

    Fucosyltransferase 3

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53578 mRNA. Translation: CAA37641.1 .
    U27326 mRNA. Translation: AAC50185.1 .
    U27327 mRNA. Translation: AAC50186.1 .
    U27328 mRNA. Translation: AAC50187.1 .
    D89324 Genomic DNA. Translation: BAA13941.1 .
    D89325 Genomic DNA. Translation: BAA13942.1 .
    AF131913 mRNA. Translation: AAD33514.1 .
    FM210024 Genomic DNA. Translation: CAR64692.1 .
    FM210025 Genomic DNA. Translation: CAR64693.1 .
    AY870341 Genomic DNA. Translation: AAW34365.1 .
    AC024592 Genomic DNA. No translation available.
    BC074836 mRNA. Translation: AAH74836.1 .
    BC074837 mRNA. Translation: AAH74837.1 .
    BC108675 mRNA. Translation: AAI08676.1 .
    CCDSi CCDS12153.1.
    PIRi A36669.
    RefSeqi NP_000140.1. NM_000149.3.
    NP_001091108.1. NM_001097639.1.
    NP_001091109.1. NM_001097640.1.
    NP_001091110.1. NM_001097641.1.
    UniGenei Hs.169238.

    3D structure databases

    ProteinModelPortali P21217.
    SMRi P21217. Positions 187-325.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000305603.

    Chemistry

    ChEMBLi CHEMBL3269.

    Protein family/group databases

    CAZyi GT10. Glycosyltransferase Family 10.

    PTM databases

    PhosphoSitei P21217.

    Polymorphism databases

    DMDMi 121137.

    Proteomic databases

    PaxDbi P21217.
    PRIDEi P21217.

    Protocols and materials databases

    DNASUi 2525.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000303225 ; ENSP00000305603 ; ENSG00000171124 .
    ENST00000458379 ; ENSP00000416443 ; ENSG00000171124 .
    ENST00000589620 ; ENSP00000465804 ; ENSG00000171124 .
    ENST00000589918 ; ENSP00000468123 ; ENSG00000171124 .
    GeneIDi 2525.
    KEGGi hsa:2525.
    UCSCi uc002mdj.2. human.

    Organism-specific databases

    CTDi 2525.
    GeneCardsi GC19M005843.
    HGNCi HGNC:4014. FUT3.
    HPAi HPA046966.
    MIMi 111100. gene+phenotype.
    neXtProti NX_P21217.
    PharmGKBi PA28430.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG283180.
    HOGENOMi HOG000045583.
    HOVERGENi HBG000274.
    InParanoidi P21217.
    KOi K00716.
    OrthoDBi EOG7RJPS6.
    PhylomeDBi P21217.
    TreeFami TF316348.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .
    BRENDAi 2.4.1.65. 2681.

    Miscellaneous databases

    GeneWikii Fucosyltransferase_3.
    GenomeRNAii 2525.
    NextBioi 9943.
    PROi P21217.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P21217.
    Bgeei P21217.
    CleanExi HS_FUT3.
    Genevestigatori P21217.

    Family and domain databases

    InterProi IPR001503. Glyco_trans_10.
    [Graphical view ]
    PANTHERi PTHR11929. PTHR11929. 1 hit.
    Pfami PF00852. Glyco_transf_10. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase."
      Kukowska-Latallo J.F., Larsen R.D., Nair R.P., Lowe J.B.
      Genes Dev. 4:1288-1303(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms."
      Cameron H.S., Szczepaniak D., Weston B.W.
      J. Biol. Chem. 270:20112-20122(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    3. "Isolation and expression of human alpha (1,3/1,4) fucosyltransferase."
      Rahim I., Schmidt L.R., Wahl D., Drayson E., Maslanik W., Stranahan P.L., Pettijohn D.E.
      Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Squamous cell carcinoma.
    4. "Allele frequencies of fucosyltransferases 1, 2, and 3 of Styrian blood donors."
      Matzhold E.M.
      Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-68 AND MET-105.
      Tissue: Blood.
    5. SeattleSNPs variation discovery resource
      Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-5; ARG-20; ARG-68; MET-105; CYS-160; ASN-162; SER-170; ARG-223; MET-270; MET-325 AND GLN-327.
    6. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS ARG-68 AND MET-105.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon and Lung.
    8. "Genotypic heterogeneity among Lewis negative individuals."
      Elmgren A., Rydberg L., Larson G.
      Biochem. Biophys. Res. Commun. 196:515-520(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT LE(-) MET-105.
    9. "Alpha (1,3/1,4)fucosyltransferase (FucT-III) gene is inactivated by a single amino acid substitution in Lewis histo-blood type negative individuals."
      Nishihara S., Yazawa S., Iwasaki H., Nakazato M., Kudo T., Ando T., Narimatsu H.
      Biochem. Biophys. Res. Commun. 196:624-631(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS LE(-) ARG-20; SER-170 AND ALA-336.
    10. "Analysis of Lewis fucosyltransferase genes from the human gastric mucosa of Lewis-positive and -negative individuals."
      Koda Y., Kimura H., Mekada E.
      Blood 82:2915-2919(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS LE(-) ARG-20 AND SER-170.
    11. "Molecular basis for Lewis alpha(1,3/1,4)-fucosyltransferase gene deficiency (FUT3) found in Lewis-negative Indonesian pedigrees."
      Mollicone R., Reguigne I., Kelly R.J., Fletcher A., Watt J., Chatfield S., Aziz A., Cameron H.S., Weston B.W., Lowe J.B., Oriol R.
      J. Biol. Chem. 269:20987-20994(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS LE(-) ARG-20 AND LYS-356.
    12. "Molecular genetic analysis of the human Lewis histo-blood group system."
      Nishihara S., Narimatsu H., Iwasaki H., Yazawa S., Akamatsu S., Ando T., Seno T., Narimatsu I.
      J. Biol. Chem. 269:29271-29278(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT LE(-) LYS-356.
    13. "DNA sequencing and screening for point mutations in the human Lewis 'FUT3' gene enables molecular genotyping of the human Lewis blood group system."
      Elmgren A., Boerjeson C., Svensson L., Rydberg L., Larson G.
      Vox Sang. 70:97-103(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS LE(-) ARG-20; ARG-68; MET-105 AND LYS-356.
    14. "Significance of individual point mutations, T202C and C314T, in the human Lewis 'FUT3' gene for expression of Lewis antigens by the human alpha'1,3/1,4'-fucosyltransferase, Fuc-TIII."
      Elmgren A., Mollicone R., Costache M., Boerjeson C., Oriol R., Harrington J., Larson G.
      J. Biol. Chem. 272:21994-21998(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS LE(-) ARG-68 AND MET-105.
    15. "Five novel missense mutations of the Lewis gene 'FUT3' in African 'Xhosa' and Caucasian populations in South Africa."
      Pang H., Liu Y., Koda Y., Soejima M., Jia J., Schlaphoff T., du Toit E.D., Kimura H.
      Hum. Genet. 102:675-680(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS LE(+) LYS-102 AND ALA-124, VARIANTS LE(-) ASN-162; ARG-223 AND MET-270.

    Entry informationi

    Entry nameiFUT3_HUMAN
    AccessioniPrimary (citable) accession number: P21217
    Secondary accession number(s): B5U7U9
    , B5U7V0, Q32NE7, Q99448, Q99449
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: May 1, 1991
    Last modified: October 1, 2014
    This is version 154 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Blood group antigen proteins
      Nomenclature of blood group antigens and list of entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3