Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Soluble inorganic pyrophosphatase 2

Gene

PPA2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Diphosphate + H2O = 2 phosphate.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei68SubstrateBy similarity1
Binding sitei82SubstrateBy similarity1
Active sitei90Proton donorBy similarity1
Binding sitei94SubstrateBy similarity1
Metal bindingi104Magnesium 1By similarity1
Metal bindingi109Magnesium 1By similarity1
Metal bindingi109Magnesium 2By similarity1
Metal bindingi141Magnesium 1By similarity1
Binding sitei178SubstrateBy similarity1

GO - Molecular functioni

  • inorganic diphosphatase activity Source: TAIR
  • magnesium ion binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Soluble inorganic pyrophosphatase 21 Publication (EC:3.6.1.1By similarity)
Alternative name(s):
Pyrophosphate phospho-hydrolase 21 Publication
Short name:
PPase 21 Publication
Gene namesi
Name:PPA21 Publication
Synonyms:PPA11 Publication
Ordered Locus Names:At2g18230Imported
ORF Names:T30D6.26Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G18230.
TAIRilocus:2062195. AT2G18230.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001375741 – 218Soluble inorganic pyrophosphatase 2Add BLAST218

Proteomic databases

PaxDbiP21216.
PRIDEiP21216.

Expressioni

Gene expression databases

ExpressionAtlasiP21216. baseline and differential.
GenevisibleiP21216. AT.

Interactioni

Protein-protein interaction databases

BioGridi1695. 1 interactor.
STRINGi3702.AT2G18230.1.

Structurei

3D structure databases

ProteinModelPortaliP21216.
SMRiP21216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase family.Curated

Phylogenomic databases

eggNOGiKOG1626. Eukaryota.
COG0221. LUCA.
HOGENOMiHOG000236472.
InParanoidiP21216.
KOiK01507.
OMAiNTENMAN.
OrthoDBiEOG09360MB0.
PhylomeDBiP21216.

Family and domain databases

CDDicd00412. pyrophosphatase. 1 hit.
Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase. 1 hit.
InterProiView protein in InterPro
IPR008162. Pyrophosphatase.
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiView protein in Pfam
PF00719. Pyrophosphatase. 1 hit.
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiView protein in PROSITE
PS00387. PPASE. 1 hit.

Sequencei

Sequence statusi: Complete.

P21216-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEIKDEGSA KGYAFPLRNP NVTLNERNFA AFTHRSAAAH PWHDLEIGPE
60 70 80 90 100
APTVFNCVVE ISKGGKVKYE LDKNSGLIKV DRVLYSSIVY PHNYGFIPRT
110 120 130 140 150
ICEDSDPMDV LVLMQEPVLT GSFLRARAIG LMPMIDQGEK DDKIIAVCAD
160 170 180 190 200
DPEFRHYRDI KELPPHRLAE IRRFFEDYKK NENKKVDVEA FLPAQAAIDA
210
IKDSMDLYAA YIKAGLQR
Length:218
Mass (Da):24,671
Last modified:December 6, 2002 - v2
Checksum:i884DCFAB6B1B239A
GO

Sequence cautioni

The sequence CAA40764 differs from that shown. Reason: Frameshift at position 209.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12G → A in AAM66110 (Ref. 5) Curated1
Sequence conflicti37A → S in AAM66110 (Ref. 5) Curated1
Sequence conflicti58V → A in CAA40764 (PubMed:1654155).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57545 mRNA. Translation: CAA40764.1. Frameshift.
AC006439 Genomic DNA. Translation: AAD15513.1.
CP002685 Genomic DNA. Translation: AEC06742.1.
AY048209 mRNA. Translation: AAK82472.1.
AY091698 mRNA. Translation: AAM10297.1.
AY088579 mRNA. Translation: AAM66110.1.
PIRiH84561.
S13379.
RefSeqiNP_179415.1. NM_127380.4.
UniGeneiAt.22749.

Genome annotation databases

EnsemblPlantsiAT2G18230.1; AT2G18230.1; AT2G18230.
GeneIDi816338.
GrameneiAT2G18230.1; AT2G18230.1; AT2G18230.
KEGGiath:AT2G18230.

Similar proteinsi

Entry informationi

Entry nameiIPYR2_ARATH
AccessioniPrimary (citable) accession number: P21216
Secondary accession number(s): Q8L988, Q9ZPV6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: December 6, 2002
Last modified: June 7, 2017
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families