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Protein

Histidine ammonia-lyase

Gene

Hal

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-histidine = urocanate + NH3.PROSITE-ProRule annotation1 Publication

Pathwayi: L-histidine degradation into L-glutamate

This protein is involved in step 1 of the subpathway that synthesizes N-formimidoyl-L-glutamate from L-histidine.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Histidine ammonia-lyase (Hal)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway L-histidine degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N-formimidoyl-L-glutamate from L-histidine, the pathway L-histidine degradation into L-glutamate and in Amino-acid degradation.

GO - Molecular functioni

  • histidine ammonia-lyase activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processHistidine metabolism

Enzyme and pathway databases

ReactomeiR-RNO-70921 Histidine catabolism
UniPathwayiUPA00379; UER00549

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine ammonia-lyase (EC:4.3.1.3)
Short name:
Histidase
Gene namesi
Name:Hal
Synonyms:Huth
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi68363 Hal

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi223S → A: 2.4% of activity. 1
Mutagenesisi254S → A: Complete loss of activity. 1 Publication1
Mutagenesisi508S → A: 75% of activity. 1
Mutagenesisi533S → A: 16% of activity. 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001610601 – 657Histidine ammonia-lyaseAdd BLAST657

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki253 ↔ 2555-imidazolinone (Ala-Gly)By similarity
Modified residuei2542,3-didehydroalanine (Ser)PROSITE-ProRule annotation1
Modified residuei396PhosphothreonineBy similarity1
Modified residuei635PhosphoserineCombined sources1
Modified residuei637PhosphothreonineBy similarity1
Modified residuei648PhosphoserineCombined sources1

Post-translational modificationi

Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP21213
PRIDEiP21213

PTM databases

iPTMnetiP21213
PhosphoSitePlusiP21213

Expressioni

Tissue specificityi

Liver and skin.

Gene expression databases

BgeeiENSRNOG00000004502
GenevisibleiP21213 RN

Interactioni

Protein-protein interaction databases

DIPiDIP-37290N
IntActiP21213, 1 interactor
STRINGi10116.ENSRNOP00000006971

Structurei

3D structure databases

ProteinModelPortaliP21213
SMRiP21213
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PAL/histidase family.Curated

Phylogenomic databases

eggNOGiKOG0222 Eukaryota
COG2986 LUCA
GeneTreeiENSGT00390000009047
HOGENOMiHOG000237619
HOVERGENiHBG004509
InParanoidiP21213
KOiK01745
OMAiCAPQVAG
OrthoDBiEOG091G036O
PhylomeDBiP21213
TreeFamiTF313824

Family and domain databases

CDDicd00332 PAL-HAL, 1 hit
Gene3Di1.10.275.10, 1 hit
InterProiView protein in InterPro
IPR001106 Aromatic_Lyase
IPR024083 Fumarase/histidase_N
IPR005921 HutH
IPR008948 L-Aspartase-like
IPR021922 Par3/HAL_N
IPR022313 Phe/His_NH3-lyase_AS
PANTHERiPTHR10362 PTHR10362, 1 hit
PfamiView protein in Pfam
PF12053 DUF3534, 1 hit
PF00221 Lyase_aromatic, 1 hit
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR01225 hutH, 1 hit
PROSITEiView protein in PROSITE
PS00488 PAL_HISTIDASE, 1 hit

Sequencei

Sequence statusi: Complete.

P21213-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRYTVHVRG EWLAVPCQDG KLSVGWLGRE AVRRYMKNKP DNGGFTSVDE
60 70 80 90 100
VRFLVRRCKG LGLLDNEDLL EVALEDNEFV EVVIEGDVMS PDFIPSQPEG
110 120 130 140 150
VFLYSKYREP EKYIALDGDS LSTEDLVNLG KGHYKIKLTS IAEKKVQQSR
160 170 180 190 200
EVIDSIIKER TVVYGITTGF GKFARTVIPA NKLQELQVNL VRSHSSGVGK
210 220 230 240 250
PLSPERCRML LALRINVLAK GYSGISLETL KQVIEVFNAS CLSYVPEKGT
260 270 280 290 300
VGASGDLAPL SHLALGLIGE GKMWSPKSGW ADAKYVLEAH GLKPIVLKPK
310 320 330 340 350
EGLALINGTQ MITSLGCEAV ERASAIARQA DIVAALTLEV LKGTTKAFDT
360 370 380 390 400
DIHAVRPHRG QIEVAFRFRS LLDSDHHPSE IAESHRFCDR VQDAYTLRCC
410 420 430 440 450
PQVHGVVNDT IAFVKDIITT ELNSATDNPM VFASRGETIS GGNFHGEYPA
460 470 480 490 500
KALDYLAIGV HELAAISERR IERLCNPSLS ELPAFLVAEG GLNSGFMIAH
510 520 530 540 550
CTAAALVSES KALCHPSSVD SLSTSAATED HVSMGGWAAR KALRVIEHVE
560 570 580 590 600
QVLAIELLAA CQGIEFLRPL KTTTPLEKVY DLVRSVVRPW IKDRFMAPDI
610 620 630 640 650
EAAHRLLLDQ KVWEVAAPYI EKYRMEHIPE SRPLSPTAFS LESLRKNSAT

IPESDDL
Length:657
Mass (Da):72,284
Last modified:May 1, 1991 - v1
Checksum:iCBED79FC6CD40FA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58308 mRNA Translation: AAA63491.1
BC089809 mRNA Translation: AAH89809.1
PIRiA36087
RefSeqiNP_058855.1, NM_017159.1
UniGeneiRn.10037

Genome annotation databases

EnsembliENSRNOT00000006971; ENSRNOP00000006971; ENSRNOG00000004502
GeneIDi29301
KEGGirno:29301
UCSCiRGD:68363 rat

Similar proteinsi

Entry informationi

Entry nameiHUTH_RAT
AccessioniPrimary (citable) accession number: P21213
Secondary accession number(s): Q5EBB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: May 23, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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