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P21203 (PHEA_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prephenate dehydratase
Short name=PDT
EC=4.2.1.51
Gene names
Name:pheA
Ordered Locus Names:BSU27900
OrganismBacillus subtilis
Taxonomic identifier1423 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length285 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Catalytic activity

Prephenate = phenylpyruvate + H2O + CO2.

Pathway

Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.

Sequence similarities

Contains 1 ACT domain.

Contains 1 prephenate dehydratase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 285285Prephenate dehydratase
PRO_0000119176

Regions

Domain2 – 183182Prephenate dehydratase
Domain202 – 27776ACT

Sites

Site1761Essential for activity By similarity

Sequences

Sequence LengthMass (Da)Tools
P21203 [UniParc].

Last modified May 1, 1991. Version 1.
Checksum: A480D3F931906EEF

FASTA28531,901
        10         20         30         40         50         60 
MKVGYLGPAA TFTHLAVSSC FQNGAEHVAY RTIPECIDAA VAGEVDFAFV PLENALEGSV 

        70         80         90        100        110        120 
NLTIDYLIHE QPLPIVGEMT LPIHQHLLVH PSRENAWKEL DKIYSHSHAI AQCHKFLHRH 

       130        140        150        160        170        180 
FPSVPYEYAN STGAAAKFVS DHPELNIGVI ANDMAASTYE LKIVKRDIQD YRDNHTRFVI 

       190        200        210        220        230        240 
LSPDENISFE VNSKLSSRPK TTLMVMLPQD DQSGALHRVL SAFSWRNLNL SKIESRPTKT 

       250        260        270        280 
GLGHYFFIID IEKAFDDVLI PGAMQELEAL GCKVRLLGAY QSYQL

« Hide

References

« Hide 'large scale' references
[1]"The Bacillus subtilis spo0B stage 0 sporulation operon encodes an essential GTP-binding protein."
Trach K., Hoch J.A.
J. Bacteriol. 171:1362-1371(1989) [PubMed: 2537815] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed: 9384377] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[3]"Cloning, nucleotide sequence, and regulation of the Bacillus subtilis nadB gene and a nifS-like gene, both of which are essential for NAD biosynthesis."
Sun D., Setlow P.L.
J. Bacteriol. 175:1423-1432(1993) [PubMed: 8444804] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 282-285.
Strain: 168.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M24537 Genomic DNA. Translation: AAA22507.1.
AL009126 Genomic DNA. Translation: CAB14750.1.
M98822 Genomic DNA. No translation available.
PIRC32804.
RefSeqNP_390668.1. NC_000964.3.

3D structure databases

ProteinModelPortalP21203.
SMRP21203. Positions 1-281.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000002971; EBBACP00000002971; EBBACG00000002965.
GeneID937513.
GenomeReviewsGene locus BSU27900 in contig AL009126_GR.
KEGGbsu:BSU27900.
NMPDRfig|224308.1.peg.2793.
PATRIC18977450. VBIBacSub10457_2914.

Organism-specific databases

GenoListBSU27900. [Micado]

Phylogenomic databases

GeneTreeEBGT00050000001546.
HOGENOMHBG693866.
OMAHPDNCTR.
PhylomeDBP21203.
ProtClustDBPRK11898.

Enzyme and pathway databases

BioCycBSUB:BSU27900-MONOMER.

Family and domain databases

InterProIPR002912. ACT-bd.
IPR001086. Preph_deHydtase.
IPR018528. Preph_deHydtase_CS.
[Graphical view]
KOK04518.
PfamPF01842. ACT. 1 hit.
PF00800. PDT. 1 hit.
[Graphical view]
PROSITEPS00857. PREPHENATE_DEHYDR_1. 1 hit.
PS00858. PREPHENATE_DEHYDR_2. 1 hit.
PS51171. PREPHENATE_DEHYDR_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePHEA_BACSU
AccessionPrimary (citable) accession number: P21203
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: January 25, 2012
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents