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Protein

Metallothionein expression activator

Gene

ACE2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in regulating basal-level expression of CUP1. Activates EGT2 transcription in the absence of SWI5.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri603 – 62725C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri633 – 65725C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri662 – 68524C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • core promoter proximal region sequence-specific DNA binding Source: SGD
  • metal ion binding Source: UniProtKB-KW
  • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: SGD

GO - Biological processi

  • positive regulation of cell separation after cytokinesis Source: SGD
  • regulation of transcription involved in G1/S transition of mitotic cell cycle Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-32273-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein expression activator
Gene namesi
Name:ACE2
Ordered Locus Names:YLR131C
ORF Names:L3123, L9606.10
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR131C.
SGDiS000004121. ACE2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 770770Metallothionein expression activatorPRO_0000046800Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei80 – 801PhosphoserineCombined sources
Modified residuei122 – 1221PhosphoserineCombined sources
Modified residuei247 – 2471PhosphoserineCombined sources
Modified residuei249 – 2491PhosphoserineCombined sources
Modified residuei253 – 2531PhosphoserineCombined sources
Modified residuei259 – 2591PhosphothreonineCombined sources
Modified residuei385 – 3851PhosphoserineCombined sources
Modified residuei392 – 3921PhosphoserineCombined sources
Modified residuei483 – 4831PhosphoserineCombined sources
Modified residuei486 – 4861PhosphothreonineCombined sources
Modified residuei501 – 5011PhosphothreonineCombined sources
Modified residuei564 – 5641PhosphoserineCombined sources
Modified residuei709 – 7091PhosphoserineCombined sources
Modified residuei714 – 7141PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP21192.

PTM databases

iPTMnetiP21192.

Interactioni

Protein-protein interaction databases

BioGridi31400. 137 interactions.
DIPiDIP-2012N.
IntActiP21192. 9 interactions.
MINTiMINT-388183.

Structurei

3D structure databases

ProteinModelPortaliP21192.
SMRiP21192. Positions 585-717.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri603 – 62725C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri633 – 65725C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri662 – 68524C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00790000123023.
HOGENOMiHOG000001123.
InParanoidiP21192.
KOiK09238.
OMAiFQHTPVK.
OrthoDBiEOG092C0TBX.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21192-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNVVDPWYI NPSGFAKDTQ DEEYVQHHDN VNPTIPPPDN YILNNENDDG
60 70 80 90 100
LDNLLGMDYY NIDDLLTQEL RDLDIPLVPS PKTGDGSSDK KNIDRTWNLG
110 120 130 140 150
DENNKVSHYS KKSMSSHKRG LSGTAIFGFL GHNKTLSISS LQQSILNMSK
160 170 180 190 200
DPQPMELINE LGNHNTVKNN NDDFDHIREN DGENSYLSQV LLKQQEELRI
210 220 230 240 250
ALEKQKEVNE KLEKQLRDNQ IQQEKLRKVL EEQEEVAQKL VSGATNSNSK
260 270 280 290 300
PGSPVILKTP AMQNGRMKDN AIIVTTNSAN GGYQFPPPTL ISPRMSNTSI
310 320 330 340 350
NGSPSRKYHR QRYPNKSPES NGLNLFSSNS GYLRDSELLS FSPQNYNLNL
360 370 380 390 400
DGLTYNDHNN TSDKNNNDKK NSTGDNIFRL FEKTSPGGLS ISPRINGNSL
410 420 430 440 450
RSPFLVGTDK SRDDRYAAGT FTPRTQLSPI HKKRESVVST VSTISQLQDD
460 470 480 490 500
TEPIHMRNTQ NPTLRNANAL ASSSVLPPIP GSSNNTPIKN SLPQKHVFQH
510 520 530 540 550
TPVKAPPKNG SNLAPLLNAP DLTDHQLEIK TPIRNNSHCE VESYPQVPPV
560 570 580 590 600
THDIHKSPTL HSTSPLPDEI IPRTTPMKIT KKPTTLPPGT IDQYVKELPD
610 620 630 640 650
KLFECLYPNC NKVFKRRYNI RSHIQTHLQD RPYSCDFPGC TKAFVRNHDL
660 670 680 690 700
IRHKISHNAK KYICPCGKRF NREDALMVHR SRMICTGGKK LEHSINKKLT
710 720 730 740 750
SPKKSLLDSP HDTSPVKETI ARDKDGSVLM KMEEQLRDDM RKHGLLDPPP
760 770
STAAHEQNSN RTLSNETDAL
Length:770
Mass (Da):86,634
Last modified:May 1, 1991 - v1
Checksum:iA7FCA8C506A2FD75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55619 Genomic DNA. Translation: AAA34387.1.
X91258 Genomic DNA. Translation: CAA62643.1.
Z73303 Genomic DNA. Translation: CAA97702.1.
U53881 Genomic DNA. Translation: AAB82398.1.
BK006945 Genomic DNA. Translation: DAA09442.1.
PIRiS12943. TWBYA2.
RefSeqiNP_013232.1. NM_001182018.1.

Genome annotation databases

EnsemblFungiiYLR131C; YLR131C; YLR131C.
GeneIDi850822.
KEGGisce:YLR131C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55619 Genomic DNA. Translation: AAA34387.1.
X91258 Genomic DNA. Translation: CAA62643.1.
Z73303 Genomic DNA. Translation: CAA97702.1.
U53881 Genomic DNA. Translation: AAB82398.1.
BK006945 Genomic DNA. Translation: DAA09442.1.
PIRiS12943. TWBYA2.
RefSeqiNP_013232.1. NM_001182018.1.

3D structure databases

ProteinModelPortaliP21192.
SMRiP21192. Positions 585-717.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31400. 137 interactions.
DIPiDIP-2012N.
IntActiP21192. 9 interactions.
MINTiMINT-388183.

PTM databases

iPTMnetiP21192.

Proteomic databases

MaxQBiP21192.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR131C; YLR131C; YLR131C.
GeneIDi850822.
KEGGisce:YLR131C.

Organism-specific databases

EuPathDBiFungiDB:YLR131C.
SGDiS000004121. ACE2.

Phylogenomic databases

GeneTreeiENSGT00790000123023.
HOGENOMiHOG000001123.
InParanoidiP21192.
KOiK09238.
OMAiFQHTPVK.
OrthoDBiEOG092C0TBX.

Enzyme and pathway databases

BioCyciYEAST:G3O-32273-MONOMER.

Miscellaneous databases

PROiP21192.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 2 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACE2_YEAST
AccessioniPrimary (citable) accession number: P21192
Secondary accession number(s): D6VYC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: September 7, 2016
This is version 167 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 538 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.