P21188 (AT1B3_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sodium/potassium-transporting ATPase subunit beta-3

Alternative name(s):
Sodium/potassium-dependent ATPase subunit beta-3
Short name=ATPB-3

Gene names

Name:

atp1b3

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	277 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The exact function of the beta-3 subunit is not known.
Subunit structure	Composed of three subunits: alpha (catalytic), beta and gamma.
Subcellular location	Membrane; Single-pass type II membrane protein.
Tissue specificity	Nervous system specific.
Developmental stage	During embryogenesis rapid accumulation of beta 3 mRNA begins at stage 14 (early neurula).
Sequence similarities	Belongs to the X(+)/potassium ATPases subunit beta family.

Ontologies

Keywords
Biological process	Ion transport Potassium transport Sodium transport Sodium/potassium transport Transport
Cellular component	Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Ligand	Potassium Sodium
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	sodium:potassium-exchanging ATPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 277	277	Sodium/potassium-transporting ATPase subunit beta-3		PRO_0000219112
Regions
	Topological domain	1 – 35	35	Cytoplasmic Potential
	Transmembrane	36 – 56	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	57 – 277	221	Extracellular Potential
Amino acid modifications
	Glycosylation	117	1	N-linked (GlcNAc...) Potential
	Glycosylation	147	1	N-linked (GlcNAc...) Potential
	Glycosylation	190	1	N-linked (GlcNAc...) Potential
	Glycosylation	238	1	N-linked (GlcNAc...) Potential
	Disulfide bond	127 ↔ 144		By similarity
	Disulfide bond	154 ↔ 170		By similarity
	Disulfide bond	191 ↔ 248		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P21188 [UniParc]. Last modified May 1, 1991. Version 1. Checksum: C4A541270555FE5A	FASTA	277	31,570
	10 20 30 40 50 60 MAKEENKGSE QSGSDWKQFI YNPQKGEFMG RTASSWALIL LFYLVFYGFL AGLFTLTMWV 70 80 90 100 110 120 MLQTLDDSVP KYRDRVSSPG LMISPKSAGL EIKFSRSKTQ SYMEYVQTLN TFLAPYNDSI 130 140 150 160 170 180 QAKNEFCPPG LYFDQDEEVE KKTCQFNRTS LGICSGIEDP MFGYGEGKPC VIVKINRIIG 190 200 210 220 230 240 LKPEGNPKIN CTSKTEDVNL QYFPDNGKID LMYFPYYGKK THVNYVQPVV AVKISPSNFT 250 260 270 SEEIAVECKI HGSRNLKNED ERDKFLGRVT FKVKITE

References

[1]	"A nervous system-specific isotype of the beta subunit of Na+,K(+)-ATPase expressed during early development of Xenopus laevis." Good P.J., Richter K., Dawid I.B. Proc. Natl. Acad. Sci. U.S.A. 87:9088-9092(1990) [PubMed: 2174552] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M37788 mRNA. Translation: AAA49650.1.
PIR	A38411.
UniGene	Xl.6045.
3D structure databases
ProteinModelPortal	P21188.
SMR	P21188. Positions 32-77.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG050603.
Family and domain databases
InterPro	IPR000402. ATPase_P-typ_cation-exchng_bsu. [Graphical view]
PANTHER	PTHR11523. ATPase_H_Na/K_b. 1 hit.
Pfam	PF00287. Na_K-ATPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITE	PS00390. ATPASE_NA_K_BETA_1. 1 hit. PS00391. ATPASE_NA_K_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AT1B3_XENLA

Accession

Primary (citable) accession number: P21188

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
Last sequence update:	May 1, 1991
Last modified:	August 10, 2010
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program