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Protein

Polyadenylate-binding protein

Gene

pAbp

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds the poly(A) tail of mRNA.1 Publication

GO - Molecular functioni

  • mRNA 3'-UTR binding Source: FlyBase
  • mRNA binding Source: FlyBase
  • poly(A) binding Source: FlyBase

GO - Biological processi

  • chemical synaptic transmission Source: FlyBase
  • dorsal/ventral pattern formation Source: FlyBase
  • male meiosis cytokinesis Source: FlyBase
  • male meiotic nuclear division Source: FlyBase
  • mRNA splicing, via spliceosome Source: FlyBase
  • negative regulation of neuron death Source: FlyBase
  • oocyte development Source: FlyBase
  • oogenesis Source: FlyBase
  • positive regulation of translation Source: FlyBase
  • regulation of compound eye photoreceptor development Source: FlyBase
  • spermatid nucleus differentiation Source: FlyBase
  • spermatogenesis Source: FlyBase

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyadenylate-binding protein
Short name:
PABP
Short name:
Poly(A)-binding protein
Gene namesi
Name:pAbp
ORF Names:CG5119
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0265297 pAbp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000817131 – 634Polyadenylate-binding proteinAdd BLAST634

Proteomic databases

PaxDbiP21187
PRIDEiP21187

Expressioni

Developmental stagei

Expressed both maternally and zygotically throughout development.1 Publication

Gene expression databases

BgeeiFBgn0265297
GenevisibleiP21187 DM

Interactioni

Subunit structurei

Interacts with gw; this interaction interferes with the binding of pAbp to eIF4G and is required for miRNA-mediated silencing. Interacts with larp.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi62753, 56 interactors
DIPiDIP-52140N
ELMiP21187
IntActiP21187, 34 interactors
MINTiP21187
STRINGi7227.FBpp0085915

Structurei

3D structure databases

ProteinModelPortaliP21187
SMRiP21187
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 80RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini90 – 167RRM 2PROSITE-ProRule annotationAdd BLAST78
Domaini181 – 259RRM 3PROSITE-ProRule annotationAdd BLAST79
Domaini285 – 362RRM 4PROSITE-ProRule annotationAdd BLAST78
Domaini552 – 629PABCPROSITE-ProRule annotationAdd BLAST78

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0123 Eukaryota
ENOG410XR5X LUCA
GeneTreeiENSGT00760000118913
InParanoidiP21187
KOiK13126
OMAiKKVYVGH
OrthoDBiEOG091G03ZE
PhylomeDBiP21187

Family and domain databases

Gene3Di3.30.70.330, 4 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR036053 PABP-dom
IPR006515 PABP_1234
IPR002004 PABP_HYD
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00658 PABP, 1 hit
PF00076 RRM_1, 4 hits
SMARTiView protein in SMART
SM00517 PolyA, 1 hit
SM00360 RRM, 4 hits
SUPFAMiSSF54928 SSF54928, 2 hits
SSF63570 SSF63570, 1 hit
TIGRFAMsiTIGR01628 PABP-1234, 1 hit
PROSITEiView protein in PROSITE
PS51309 PABC, 1 hit
PS50102 RRM, 4 hits

Sequencei

Sequence statusi: Complete.

P21187-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLYVGDLP QDVNESGLFD KFSSAGPVLS IRVCRDVITR RSLGYAYVNF
60 70 80 90 100
QQPADAERAL DTMNFDLVRN KPIRIMWSQR DPSLRRSGVG NVFIKNLDRA
110 120 130 140 150
IDNKAIYDTF SAFGNILSCK VATDEKGNSK GYGFVHFETE EAANTSIDKV
160 170 180 190 200
NGMLLNGKKV YVGKFIPRKE REKELGEKAK LFTNVYVKNF TEDFDDEKLK
210 220 230 240 250
EFFEPYGKIT SYKVMSKEDG KSKGFGFVAF ETTEAAEAAV QALNGKDMGE
260 270 280 290 300
GKSLYVARAQ KKAERQQELK RKFEELKQKR HESVFGVNLY VKNLDDTIDD
310 320 330 340 350
DRLRIAFSPY GNITSAKVMT DEEGRSKGFG FVCFNAASEA TCAVTELNGR
360 370 380 390 400
VVGSKPLYVA LAQRKEERKA HLASQYMRHM TGMRMQQLGQ IYQPNAASGF
410 420 430 440 450
FVPTLPSNQR FFGSQVATQM RNTPRWVPQV RPPAAIQGVQ AGAAAAGGFQ
460 470 480 490 500
GTAGAVPTQF RSAAAGARGA QPQVQGTHAA AAAANNMRNT GARAITGQQT
510 520 530 540 550
AAPNMQIPGA QIAGGAQQRT SNYKYTSNMR NPPVPQLHQT QPIPQQLQGK
560 570 580 590 600
NSEKLIASLL ANAKPQEQKQ ILGERLYPMI EHMHANLAGK ITGMLLEIEN
610 620 630
SELLHMIEDQ EALKAKVEEA VAVLQVHRVT EPAN
Length:634
Mass (Da):69,925
Last modified:September 27, 2005 - v3
Checksum:iA76B204ED206392E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti171 – 173REK → Q in AAA70421 (PubMed:2125288).Curated3
Sequence conflicti336 – 337AA → PE in AAA70421 (PubMed:2125288).Curated2
Sequence conflicti371H → D in AAA70421 (PubMed:2125288).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05109 mRNA Translation: AAA70421.1
AE013599 Genomic DNA Translation: AAF57746.1
AE013599 Genomic DNA Translation: AAM68175.1
AY118528 mRNA Translation: AAM49897.1
PIRiS30887
RefSeqiNP_476667.1, NM_057319.5
NP_725749.1, NM_166264.4
NP_725750.1, NM_166265.2
UniGeneiDm.7069

Genome annotation databases

EnsemblMetazoaiFBtr0086736; FBpp0085915; FBgn0265297
FBtr0086738; FBpp0085917; FBgn0265297
FBtr0086740; FBpp0085919; FBgn0265297
GeneIDi37070
KEGGidme:Dmel_CG5119

Similar proteinsi

Entry informationi

Entry nameiPABP_DROME
AccessioniPrimary (citable) accession number: P21187
Secondary accession number(s): A4UZM5, Q0E932, Q9V8C3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: September 27, 2005
Last modified: March 28, 2018
This is version 174 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health