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P21183 (IL5RA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-5 receptor subunit alpha

Short name=IL-5 receptor subunit alpha
Short name=IL-5R subunit alpha
Short name=IL-5R-alpha
Short name=IL-5RA
Alternative name(s):
CD_antigen=CD125
Gene names
Name:Il5ra
Synonyms:Il5r
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length415 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This is the receptor for interleukin-5. The alpha chain binds to IL5.

Subunit structure

Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. Interacts with SDCBP.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Expressed on eosinophils and basophils. Also on B-cells.

Domain

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

The box 1 motif is required for JAK interaction and/or activation.

Sequence similarities

Contains 2 fibronectin type-III domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717
Chain18 – 415398Interleukin-5 receptor subunit alpha
PRO_0000010894

Regions

Topological domain18 – 339322Extracellular Potential
Transmembrane340 – 36122Helical; Potential
Topological domain362 – 41554Cytoplasmic Potential
Domain29 – 12092Fibronectin type-III 1
Domain238 – 33194Fibronectin type-III 2
Motif319 – 3235WSXWS motif
Motif367 – 3759Box 1 motif

Amino acid modifications

Glycosylation321N-linked (GlcNAc...) Potential
Glycosylation1281N-linked (GlcNAc...) Potential
Glycosylation2131N-linked (GlcNAc...) Potential
Glycosylation2411N-linked (GlcNAc...) Potential
Disulfide bond131 ↔ 152 By similarity
Disulfide bond179 ↔ 193 By similarity
Disulfide bond266 ↔ 313 By similarity

Sequences

Sequence LengthMass (Da)Tools
P21183 [UniParc].

Last modified May 1, 1991. Version 1.
Checksum: A4326D2922571C08

FASTA41546,989
        10         20         30         40         50         60 
MVPVLLILVG ALATLQADLL NHKKFLLLPP VNFTIKATGL AQVLLHWDPN PDQEQRHVDL 

        70         80         90        100        110        120 
EYHVKINAPQ EDEYDTRKTE SKCVTPLHEG FAASVRTILK SSHTTLASSW VSAELKAPPG 

       130        140        150        160        170        180 
SPGTSVTNLT CTTHTVVSSH THLRPYQVSL RCTWLVGKDA PEDTQYFLYY RFGVLTEKCQ 

       190        200        210        220        230        240 
EYSRDALNRN TACWFPRTFI NSKGFEQLAV HINGSSKRAA IKPFDQLFSP LAIDQVNPPR 

       250        260        270        280        290        300 
NVTVEIESNS LYIQWEKPLS AFPDHCFNYE LKIYNTKNGH IQKEKLIANK FISKIDDVST 

       310        320        330        340        350        360 
YSIQVRAAVS SPCRMPGRWG EWSQPIYVGK ERKSLVEWHL IVLPTAACFV LLIFSLICRV 

       370        380        390        400        410 
CHLWTRLFPP VPAPKSNIKD LPVVTEYEKP SNETKIEVVH CVEEVGFEVM GNSTF 

« Hide

References

[1]"Molecular cloning and expression of the murine interleukin-5 receptor."
Takaki S., Tominaga A., Mita S., Sonoda E., Yamaguchi N., Takatsu K.
EMBO J. 9:4367-4374(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D90205 mRNA. Translation: BAA14231.1.
CCDSCCDS20396.1.
PIRS12357.
RefSeqNP_032396.1. NM_008370.2.
XP_006505682.1. XM_006505619.1.
UniGeneMm.3448.

3D structure databases

ProteinModelPortalP21183.
SMRP21183. Positions 24-329.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000005497.

PTM databases

PhosphoSiteP21183.

Proteomic databases

PRIDEP21183.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000167925; ENSMUSP00000129781; ENSMUSG00000005364.
GeneID16192.
KEGGmmu:16192.
UCSCuc009dcx.1. mouse.

Organism-specific databases

CTD3568.
MGIMGI:96558. Il5ra.

Phylogenomic databases

eggNOGNOG43089.
HOGENOMHOG000070224.
HOVERGENHBG052117.
InParanoidP21183.
KOK05067.
OMAAPEDTQY.
OrthoDBEOG71P2B1.
PhylomeDBP21183.
TreeFamTF331549.

Gene expression databases

ArrayExpressP21183.
BgeeP21183.
CleanExMM_IL5RA.
GenevestigatorP21183.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR015321. IL-6_rcpt_alpha-bd.
IPR003532. Short_hematopoietin_rcpt_2_CS.
[Graphical view]
PfamPF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SMARTSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMSSF49265. SSF49265. 2 hits.
PROSITEPS50853. FN3. 2 hits.
PS01356. HEMATOPO_REC_S_F2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio289105.
PROP21183.
SOURCESearch...

Entry information

Entry nameIL5RA_MOUSE
AccessionPrimary (citable) accession number: P21183
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: July 9, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot