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P21183

- IL5RA_MOUSE

UniProt

P21183 - IL5RA_MOUSE

Protein

Interleukin-5 receptor subunit alpha

Gene

Il5ra

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 1 (01 May 1991)
      Previous versions | rss
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    Functioni

    This is the receptor for interleukin-5. The alpha chain binds to IL5.

    GO - Molecular functioni

    1. cytokine receptor activity Source: InterPro

    GO - Biological processi

    1. cellular response to organic substance Source: MGI
    2. inflammatory response to antigenic stimulus Source: MGI
    3. regulation of interleukin-5 production Source: MGI

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    ReactomeiREACT_210793. Interleukin receptor SHC signaling.
    REACT_225836. Interleukin-3, 5 and GM-CSF signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-5 receptor subunit alpha
    Short name:
    IL-5 receptor subunit alpha
    Short name:
    IL-5R subunit alpha
    Short name:
    IL-5R-alpha
    Short name:
    IL-5RA
    Alternative name(s):
    CD_antigen: CD125
    Gene namesi
    Name:Il5ra
    Synonyms:Il5r
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:96558. Il5ra.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Add
    BLAST
    Chaini18 – 415398Interleukin-5 receptor subunit alphaPRO_0000010894Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi32 – 321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi131 ↔ 152By similarity
    Disulfide bondi179 ↔ 193By similarity
    Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi241 – 2411N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi266 ↔ 313By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP21183.

    PTM databases

    PhosphoSiteiP21183.

    Expressioni

    Tissue specificityi

    Expressed on eosinophils and basophils. Also on B-cells.

    Gene expression databases

    ArrayExpressiP21183.
    BgeeiP21183.
    CleanExiMM_IL5RA.
    GenevestigatoriP21183.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. Interacts with SDCBP.

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000005497.

    Structurei

    3D structure databases

    ProteinModelPortaliP21183.
    SMRiP21183. Positions 24-329.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini18 – 339322ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini362 – 41554CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei340 – 36122HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 12092Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini238 – 33194Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi319 – 3235WSXWS motif
    Motifi367 – 3759Box 1 motif

    Domaini

    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.

    Sequence similaritiesi

    Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG43089.
    HOGENOMiHOG000070224.
    HOVERGENiHBG052117.
    InParanoidiP21183.
    KOiK05067.
    OMAiAPEDTQY.
    OrthoDBiEOG71P2B1.
    PhylomeDBiP21183.
    TreeFamiTF331549.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR015321. IL-6_rcpt_alpha-bd.
    IPR003532. Short_hematopoietin_rcpt_2_CS.
    [Graphical view]
    PfamiPF09240. IL6Ra-bind. 1 hit.
    [Graphical view]
    SMARTiSM00060. FN3. 2 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.
    PROSITEiPS50853. FN3. 2 hits.
    PS01356. HEMATOPO_REC_S_F2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P21183-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVPVLLILVG ALATLQADLL NHKKFLLLPP VNFTIKATGL AQVLLHWDPN    50
    PDQEQRHVDL EYHVKINAPQ EDEYDTRKTE SKCVTPLHEG FAASVRTILK 100
    SSHTTLASSW VSAELKAPPG SPGTSVTNLT CTTHTVVSSH THLRPYQVSL 150
    RCTWLVGKDA PEDTQYFLYY RFGVLTEKCQ EYSRDALNRN TACWFPRTFI 200
    NSKGFEQLAV HINGSSKRAA IKPFDQLFSP LAIDQVNPPR NVTVEIESNS 250
    LYIQWEKPLS AFPDHCFNYE LKIYNTKNGH IQKEKLIANK FISKIDDVST 300
    YSIQVRAAVS SPCRMPGRWG EWSQPIYVGK ERKSLVEWHL IVLPTAACFV 350
    LLIFSLICRV CHLWTRLFPP VPAPKSNIKD LPVVTEYEKP SNETKIEVVH 400
    CVEEVGFEVM GNSTF 415
    Length:415
    Mass (Da):46,989
    Last modified:May 1, 1991 - v1
    Checksum:iA4326D2922571C08
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D90205 mRNA. Translation: BAA14231.1.
    CCDSiCCDS20396.1.
    PIRiS12357.
    RefSeqiNP_032396.1. NM_008370.2.
    XP_006505682.1. XM_006505619.1.
    UniGeneiMm.3448.

    Genome annotation databases

    EnsembliENSMUST00000167925; ENSMUSP00000129781; ENSMUSG00000005364.
    GeneIDi16192.
    KEGGimmu:16192.
    UCSCiuc009dcx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D90205 mRNA. Translation: BAA14231.1 .
    CCDSi CCDS20396.1.
    PIRi S12357.
    RefSeqi NP_032396.1. NM_008370.2.
    XP_006505682.1. XM_006505619.1.
    UniGenei Mm.3448.

    3D structure databases

    ProteinModelPortali P21183.
    SMRi P21183. Positions 24-329.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000005497.

    PTM databases

    PhosphoSitei P21183.

    Proteomic databases

    PRIDEi P21183.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000167925 ; ENSMUSP00000129781 ; ENSMUSG00000005364 .
    GeneIDi 16192.
    KEGGi mmu:16192.
    UCSCi uc009dcx.1. mouse.

    Organism-specific databases

    CTDi 3568.
    MGIi MGI:96558. Il5ra.

    Phylogenomic databases

    eggNOGi NOG43089.
    HOGENOMi HOG000070224.
    HOVERGENi HBG052117.
    InParanoidi P21183.
    KOi K05067.
    OMAi APEDTQY.
    OrthoDBi EOG71P2B1.
    PhylomeDBi P21183.
    TreeFami TF331549.

    Enzyme and pathway databases

    Reactomei REACT_210793. Interleukin receptor SHC signaling.
    REACT_225836. Interleukin-3, 5 and GM-CSF signaling.

    Miscellaneous databases

    NextBioi 289105.
    PROi P21183.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P21183.
    Bgeei P21183.
    CleanExi MM_IL5RA.
    Genevestigatori P21183.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR015321. IL-6_rcpt_alpha-bd.
    IPR003532. Short_hematopoietin_rcpt_2_CS.
    [Graphical view ]
    Pfami PF09240. IL6Ra-bind. 1 hit.
    [Graphical view ]
    SMARTi SM00060. FN3. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    PROSITEi PS50853. FN3. 2 hits.
    PS01356. HEMATOPO_REC_S_F2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and expression of the murine interleukin-5 receptor."
      Takaki S., Tominaga A., Mita S., Sonoda E., Yamaguchi N., Takatsu K.
      EMBO J. 9:4367-4374(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiIL5RA_MOUSE
    AccessioniPrimary (citable) accession number: P21183
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: May 1, 1991
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3