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Protein

Interleukin-5 receptor subunit alpha

Gene

Il5ra

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

This is the receptor for interleukin-5. The alpha chain binds to IL5.

GO - Molecular functioni

GO - Biological processi

  • cellular response to organic substance Source: MGI
  • inflammatory response to antigenic stimulus Source: MGI
  • regulation of interleukin-5 production Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-114604. GPVI-mediated activation cascade.
R-MMU-392451. G beta:gamma signalling through PI3Kgamma.
R-MMU-512988. Interleukin-3, 5 and GM-CSF signaling.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-912526. Interleukin receptor SHC signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-5 receptor subunit alpha
Short name:
IL-5 receptor subunit alpha
Short name:
IL-5R subunit alpha
Short name:
IL-5R-alpha
Short name:
IL-5RA
Alternative name(s):
CD_antigen: CD125
Gene namesi
Name:Il5ra
Synonyms:Il5r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:96558. Il5ra.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 339ExtracellularSequence analysisAdd BLAST322
Transmembranei340 – 361HelicalSequence analysisAdd BLAST22
Topological domaini362 – 415CytoplasmicSequence analysisAdd BLAST54

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Add BLAST17
ChainiPRO_000001089418 – 415Interleukin-5 receptor subunit alphaAdd BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi32N-linked (GlcNAc...)Sequence analysis1
Glycosylationi128N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi131 ↔ 152By similarity
Disulfide bondi179 ↔ 193By similarity
Glycosylationi213N-linked (GlcNAc...)Sequence analysis1
Glycosylationi241N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi266 ↔ 313By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP21183.
PRIDEiP21183.

PTM databases

PhosphoSitePlusiP21183.

Expressioni

Tissue specificityi

Expressed on eosinophils and basophils. Also on B-cells.

Gene expression databases

BgeeiENSMUSG00000005364.
CleanExiMM_IL5RA.
ExpressionAtlasiP21183. baseline and differential.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. Interacts with SDCBP.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000129781.

Structurei

3D structure databases

ProteinModelPortaliP21183.
SMRiP21183.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 120Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST92
Domaini238 – 331Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST94

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi319 – 323WSXWS motif5
Motifi367 – 375Box 1 motif9

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ36. Eukaryota.
ENOG4111ZG2. LUCA.
GeneTreeiENSGT00530000063295.
HOGENOMiHOG000070224.
HOVERGENiHBG052117.
InParanoidiP21183.
KOiK05067.
OMAiQYFLYYR.
OrthoDBiEOG091G0B29.
PhylomeDBiP21183.
TreeFamiTF331549.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR003532. Short_hematopoietin_rcpt_2_CS.
IPR015321. TypeI_recpt_CBD.
[Graphical view]
PfamiPF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
PS01356. HEMATOPO_REC_S_F2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21183-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPVLLILVG ALATLQADLL NHKKFLLLPP VNFTIKATGL AQVLLHWDPN
60 70 80 90 100
PDQEQRHVDL EYHVKINAPQ EDEYDTRKTE SKCVTPLHEG FAASVRTILK
110 120 130 140 150
SSHTTLASSW VSAELKAPPG SPGTSVTNLT CTTHTVVSSH THLRPYQVSL
160 170 180 190 200
RCTWLVGKDA PEDTQYFLYY RFGVLTEKCQ EYSRDALNRN TACWFPRTFI
210 220 230 240 250
NSKGFEQLAV HINGSSKRAA IKPFDQLFSP LAIDQVNPPR NVTVEIESNS
260 270 280 290 300
LYIQWEKPLS AFPDHCFNYE LKIYNTKNGH IQKEKLIANK FISKIDDVST
310 320 330 340 350
YSIQVRAAVS SPCRMPGRWG EWSQPIYVGK ERKSLVEWHL IVLPTAACFV
360 370 380 390 400
LLIFSLICRV CHLWTRLFPP VPAPKSNIKD LPVVTEYEKP SNETKIEVVH
410
CVEEVGFEVM GNSTF
Length:415
Mass (Da):46,989
Last modified:May 1, 1991 - v1
Checksum:iA4326D2922571C08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90205 mRNA. Translation: BAA14231.1.
CCDSiCCDS20396.1.
PIRiS12357.
RefSeqiNP_032396.1. NM_008370.2.
XP_017176895.1. XM_017321406.1.
UniGeneiMm.3448.

Genome annotation databases

EnsembliENSMUST00000167925; ENSMUSP00000129781; ENSMUSG00000005364.
ENSMUST00000204659; ENSMUSP00000144718; ENSMUSG00000005364.
GeneIDi16192.
KEGGimmu:16192.
UCSCiuc009dcx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90205 mRNA. Translation: BAA14231.1.
CCDSiCCDS20396.1.
PIRiS12357.
RefSeqiNP_032396.1. NM_008370.2.
XP_017176895.1. XM_017321406.1.
UniGeneiMm.3448.

3D structure databases

ProteinModelPortaliP21183.
SMRiP21183.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000129781.

PTM databases

PhosphoSitePlusiP21183.

Proteomic databases

PaxDbiP21183.
PRIDEiP21183.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000167925; ENSMUSP00000129781; ENSMUSG00000005364.
ENSMUST00000204659; ENSMUSP00000144718; ENSMUSG00000005364.
GeneIDi16192.
KEGGimmu:16192.
UCSCiuc009dcx.1. mouse.

Organism-specific databases

CTDi3568.
MGIiMGI:96558. Il5ra.

Phylogenomic databases

eggNOGiENOG410IJ36. Eukaryota.
ENOG4111ZG2. LUCA.
GeneTreeiENSGT00530000063295.
HOGENOMiHOG000070224.
HOVERGENiHBG052117.
InParanoidiP21183.
KOiK05067.
OMAiQYFLYYR.
OrthoDBiEOG091G0B29.
PhylomeDBiP21183.
TreeFamiTF331549.

Enzyme and pathway databases

ReactomeiR-MMU-114604. GPVI-mediated activation cascade.
R-MMU-392451. G beta:gamma signalling through PI3Kgamma.
R-MMU-512988. Interleukin-3, 5 and GM-CSF signaling.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-912526. Interleukin receptor SHC signaling.

Miscellaneous databases

PROiP21183.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005364.
CleanExiMM_IL5RA.
ExpressionAtlasiP21183. baseline and differential.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR003532. Short_hematopoietin_rcpt_2_CS.
IPR015321. TypeI_recpt_CBD.
[Graphical view]
PfamiPF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
PS01356. HEMATOPO_REC_S_F2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL5RA_MOUSE
AccessioniPrimary (citable) accession number: P21183
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: November 30, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.