Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interleukin-5 receptor subunit alpha

Gene

Il5ra

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

This is the receptor for interleukin-5. The alpha chain binds to IL5.

GO - Molecular functioni

  1. cytokine receptor activity Source: InterPro

GO - Biological processi

  1. cellular response to organic substance Source: MGI
  2. inflammatory response to antigenic stimulus Source: MGI
  3. regulation of interleukin-5 production Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_291272. G beta:gamma signalling through PI3Kgamma.
REACT_294984. Interleukin-3, 5 and GM-CSF signaling.
REACT_303160. Interleukin receptor SHC signaling.
REACT_337915. GPVI-mediated activation cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-5 receptor subunit alpha
Short name:
IL-5 receptor subunit alpha
Short name:
IL-5R subunit alpha
Short name:
IL-5R-alpha
Short name:
IL-5RA
Alternative name(s):
CD_antigen: CD125
Gene namesi
Name:Il5ra
Synonyms:Il5r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:96558. Il5ra.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 339322ExtracellularSequence AnalysisAdd
BLAST
Transmembranei340 – 36122HelicalSequence AnalysisAdd
BLAST
Topological domaini362 – 41554CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Add
BLAST
Chaini18 – 415398Interleukin-5 receptor subunit alphaPRO_0000010894Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi32 – 321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi131 ↔ 152By similarity
Disulfide bondi179 ↔ 193By similarity
Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi241 – 2411N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi266 ↔ 313By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP21183.

PTM databases

PhosphoSiteiP21183.

Expressioni

Tissue specificityi

Expressed on eosinophils and basophils. Also on B-cells.

Gene expression databases

BgeeiP21183.
CleanExiMM_IL5RA.
ExpressionAtlasiP21183. baseline and differential.
GenevestigatoriP21183.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. Interacts with SDCBP.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005497.

Structurei

3D structure databases

ProteinModelPortaliP21183.
SMRiP21183. Positions 24-329.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 12092Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini238 – 33194Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi319 – 3235WSXWS motif
Motifi367 – 3759Box 1 motif

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43089.
HOGENOMiHOG000070224.
HOVERGENiHBG052117.
InParanoidiP21183.
KOiK05067.
OMAiQYFLYYR.
OrthoDBiEOG71P2B1.
PhylomeDBiP21183.
TreeFamiTF331549.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR015321. IL-6_rcpt_alpha-bd.
IPR003532. Short_hematopoietin_rcpt_2_CS.
[Graphical view]
PfamiPF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
PS01356. HEMATOPO_REC_S_F2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21183-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPVLLILVG ALATLQADLL NHKKFLLLPP VNFTIKATGL AQVLLHWDPN
60 70 80 90 100
PDQEQRHVDL EYHVKINAPQ EDEYDTRKTE SKCVTPLHEG FAASVRTILK
110 120 130 140 150
SSHTTLASSW VSAELKAPPG SPGTSVTNLT CTTHTVVSSH THLRPYQVSL
160 170 180 190 200
RCTWLVGKDA PEDTQYFLYY RFGVLTEKCQ EYSRDALNRN TACWFPRTFI
210 220 230 240 250
NSKGFEQLAV HINGSSKRAA IKPFDQLFSP LAIDQVNPPR NVTVEIESNS
260 270 280 290 300
LYIQWEKPLS AFPDHCFNYE LKIYNTKNGH IQKEKLIANK FISKIDDVST
310 320 330 340 350
YSIQVRAAVS SPCRMPGRWG EWSQPIYVGK ERKSLVEWHL IVLPTAACFV
360 370 380 390 400
LLIFSLICRV CHLWTRLFPP VPAPKSNIKD LPVVTEYEKP SNETKIEVVH
410
CVEEVGFEVM GNSTF
Length:415
Mass (Da):46,989
Last modified:May 1, 1991 - v1
Checksum:iA4326D2922571C08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90205 mRNA. Translation: BAA14231.1.
CCDSiCCDS20396.1.
PIRiS12357.
RefSeqiNP_032396.1. NM_008370.2.
UniGeneiMm.3448.

Genome annotation databases

EnsembliENSMUST00000167925; ENSMUSP00000129781; ENSMUSG00000005364.
GeneIDi16192.
KEGGimmu:16192.
UCSCiuc009dcx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90205 mRNA. Translation: BAA14231.1.
CCDSiCCDS20396.1.
PIRiS12357.
RefSeqiNP_032396.1. NM_008370.2.
UniGeneiMm.3448.

3D structure databases

ProteinModelPortaliP21183.
SMRiP21183. Positions 24-329.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005497.

PTM databases

PhosphoSiteiP21183.

Proteomic databases

PRIDEiP21183.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000167925; ENSMUSP00000129781; ENSMUSG00000005364.
GeneIDi16192.
KEGGimmu:16192.
UCSCiuc009dcx.1. mouse.

Organism-specific databases

CTDi3568.
MGIiMGI:96558. Il5ra.

Phylogenomic databases

eggNOGiNOG43089.
HOGENOMiHOG000070224.
HOVERGENiHBG052117.
InParanoidiP21183.
KOiK05067.
OMAiQYFLYYR.
OrthoDBiEOG71P2B1.
PhylomeDBiP21183.
TreeFamiTF331549.

Enzyme and pathway databases

ReactomeiREACT_291272. G beta:gamma signalling through PI3Kgamma.
REACT_294984. Interleukin-3, 5 and GM-CSF signaling.
REACT_303160. Interleukin receptor SHC signaling.
REACT_337915. GPVI-mediated activation cascade.

Miscellaneous databases

NextBioi289105.
PROiP21183.
SOURCEiSearch...

Gene expression databases

BgeeiP21183.
CleanExiMM_IL5RA.
ExpressionAtlasiP21183. baseline and differential.
GenevestigatoriP21183.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR015321. IL-6_rcpt_alpha-bd.
IPR003532. Short_hematopoietin_rcpt_2_CS.
[Graphical view]
PfamiPF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
PS01356. HEMATOPO_REC_S_F2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and expression of the murine interleukin-5 receptor."
    Takaki S., Tominaga A., Mita S., Sonoda E., Yamaguchi N., Takatsu K.
    EMBO J. 9:4367-4374(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiIL5RA_MOUSE
AccessioniPrimary (citable) accession number: P21183
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: April 1, 2015
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.