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P21183

- IL5RA_MOUSE

UniProt

P21183 - IL5RA_MOUSE

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Protein

Interleukin-5 receptor subunit alpha

Gene

Il5ra

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

This is the receptor for interleukin-5. The alpha chain binds to IL5.

GO - Molecular functioni

  1. cytokine receptor activity Source: InterPro

GO - Biological processi

  1. cellular response to organic substance Source: MGI
  2. inflammatory response to antigenic stimulus Source: MGI
  3. regulation of interleukin-5 production Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_210793. Interleukin receptor SHC signaling.
REACT_225836. Interleukin-3, 5 and GM-CSF signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-5 receptor subunit alpha
Short name:
IL-5 receptor subunit alpha
Short name:
IL-5R subunit alpha
Short name:
IL-5R-alpha
Short name:
IL-5RA
Alternative name(s):
CD_antigen: CD125
Gene namesi
Name:Il5ra
Synonyms:Il5r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:96558. Il5ra.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Add
BLAST
Chaini18 – 415398Interleukin-5 receptor subunit alphaPRO_0000010894Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi32 – 321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi131 ↔ 152By similarity
Disulfide bondi179 ↔ 193By similarity
Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi241 – 2411N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi266 ↔ 313By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP21183.

PTM databases

PhosphoSiteiP21183.

Expressioni

Tissue specificityi

Expressed on eosinophils and basophils. Also on B-cells.

Gene expression databases

BgeeiP21183.
CleanExiMM_IL5RA.
ExpressionAtlasiP21183. baseline and differential.
GenevestigatoriP21183.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. Interacts with SDCBP.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005497.

Structurei

3D structure databases

ProteinModelPortaliP21183.
SMRiP21183. Positions 24-329.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 339322ExtracellularSequence AnalysisAdd
BLAST
Topological domaini362 – 41554CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei340 – 36122HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 12092Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini238 – 33194Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi319 – 3235WSXWS motif
Motifi367 – 3759Box 1 motif

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43089.
HOGENOMiHOG000070224.
HOVERGENiHBG052117.
InParanoidiP21183.
KOiK05067.
OMAiAPEDTQY.
OrthoDBiEOG71P2B1.
PhylomeDBiP21183.
TreeFamiTF331549.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR015321. IL-6_rcpt_alpha-bd.
IPR003532. Short_hematopoietin_rcpt_2_CS.
[Graphical view]
PfamiPF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
PS01356. HEMATOPO_REC_S_F2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21183-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVPVLLILVG ALATLQADLL NHKKFLLLPP VNFTIKATGL AQVLLHWDPN
60 70 80 90 100
PDQEQRHVDL EYHVKINAPQ EDEYDTRKTE SKCVTPLHEG FAASVRTILK
110 120 130 140 150
SSHTTLASSW VSAELKAPPG SPGTSVTNLT CTTHTVVSSH THLRPYQVSL
160 170 180 190 200
RCTWLVGKDA PEDTQYFLYY RFGVLTEKCQ EYSRDALNRN TACWFPRTFI
210 220 230 240 250
NSKGFEQLAV HINGSSKRAA IKPFDQLFSP LAIDQVNPPR NVTVEIESNS
260 270 280 290 300
LYIQWEKPLS AFPDHCFNYE LKIYNTKNGH IQKEKLIANK FISKIDDVST
310 320 330 340 350
YSIQVRAAVS SPCRMPGRWG EWSQPIYVGK ERKSLVEWHL IVLPTAACFV
360 370 380 390 400
LLIFSLICRV CHLWTRLFPP VPAPKSNIKD LPVVTEYEKP SNETKIEVVH
410
CVEEVGFEVM GNSTF
Length:415
Mass (Da):46,989
Last modified:May 1, 1991 - v1
Checksum:iA4326D2922571C08
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D90205 mRNA. Translation: BAA14231.1.
CCDSiCCDS20396.1.
PIRiS12357.
RefSeqiNP_032396.1. NM_008370.2.
XP_006505682.1. XM_006505619.1.
UniGeneiMm.3448.

Genome annotation databases

EnsembliENSMUST00000167925; ENSMUSP00000129781; ENSMUSG00000005364.
GeneIDi16192.
KEGGimmu:16192.
UCSCiuc009dcx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D90205 mRNA. Translation: BAA14231.1 .
CCDSi CCDS20396.1.
PIRi S12357.
RefSeqi NP_032396.1. NM_008370.2.
XP_006505682.1. XM_006505619.1.
UniGenei Mm.3448.

3D structure databases

ProteinModelPortali P21183.
SMRi P21183. Positions 24-329.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000005497.

PTM databases

PhosphoSitei P21183.

Proteomic databases

PRIDEi P21183.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000167925 ; ENSMUSP00000129781 ; ENSMUSG00000005364 .
GeneIDi 16192.
KEGGi mmu:16192.
UCSCi uc009dcx.1. mouse.

Organism-specific databases

CTDi 3568.
MGIi MGI:96558. Il5ra.

Phylogenomic databases

eggNOGi NOG43089.
HOGENOMi HOG000070224.
HOVERGENi HBG052117.
InParanoidi P21183.
KOi K05067.
OMAi APEDTQY.
OrthoDBi EOG71P2B1.
PhylomeDBi P21183.
TreeFami TF331549.

Enzyme and pathway databases

Reactomei REACT_210793. Interleukin receptor SHC signaling.
REACT_225836. Interleukin-3, 5 and GM-CSF signaling.

Miscellaneous databases

NextBioi 289105.
PROi P21183.
SOURCEi Search...

Gene expression databases

Bgeei P21183.
CleanExi MM_IL5RA.
ExpressionAtlasi P21183. baseline and differential.
Genevestigatori P21183.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR015321. IL-6_rcpt_alpha-bd.
IPR003532. Short_hematopoietin_rcpt_2_CS.
[Graphical view ]
Pfami PF09240. IL6Ra-bind. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
PROSITEi PS50853. FN3. 2 hits.
PS01356. HEMATOPO_REC_S_F2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and expression of the murine interleukin-5 receptor."
    Takaki S., Tominaga A., Mita S., Sonoda E., Yamaguchi N., Takatsu K.
    EMBO J. 9:4367-4374(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiIL5RA_MOUSE
AccessioniPrimary (citable) accession number: P21183
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: October 29, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3