Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Constitutive ornithine decarboxylase

Gene

speC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-ornithine = putrescine + CO2.

Cofactori

Pathwayi: putrescine biosynthesis via L-ornithine pathway

This protein is involved in step 1 of the subpathway that synthesizes putrescine from L-ornithine.
Proteins known to be involved in this subpathway in this organism are:
  1. Inducible ornithine decarboxylase (speF), Constitutive ornithine decarboxylase (speC)
This subpathway is part of the pathway putrescine biosynthesis via L-ornithine pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes putrescine from L-ornithine, the pathway putrescine biosynthesis via L-ornithine pathway and in Amine and polyamine biosynthesis.

GO - Molecular functioni

  • ornithine decarboxylase activity Source: EcoCyc
  • pyridoxal phosphate binding Source: EcoCyc

GO - Biological processi

  • putrescine biosynthetic process from ornithine Source: UniProtKB-UniPathway
  • spermidine biosynthetic process Source: EcoCyc

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processSpermidine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciEcoCyc:ORNDECARBOX-BIO-MONOMER
MetaCyc:ORNDECARBOX-BIO-MONOMER
BRENDAi4.1.1.17 2026
UniPathwayiUPA00535; UER00288

Names & Taxonomyi

Protein namesi
Recommended name:
Constitutive ornithine decarboxylase (EC:4.1.1.17)
Gene namesi
Name:speC
Ordered Locus Names:b2965, JW5482
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10961 speC

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002011341 – 711Constitutive ornithine decarboxylaseAdd BLAST711

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei347N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiP21169
PRIDEiP21169

Interactioni

Protein-protein interaction databases

BioGridi4262354, 4 interactors
DIPiDIP-10907N
STRINGi316385.ECDH10B_3148

Structurei

3D structure databases

ProteinModelPortaliP21169
SMRiP21169
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CXN Bacteria
COG1982 LUCA
HOGENOMiHOG000164393
InParanoidiP21169
KOiK01581
OMAiVYPPGIA
PhylomeDBiP21169

Family and domain databases

CDDicd00615 Orn_deC_like, 1 hit
Gene3Di3.40.50.220, 1 hit
3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR011006 CheY-like_superfamily
IPR005308 OKR_de-COase_N
IPR011193 Orn/lys/arg_de-COase
IPR000310 Orn/Lys/Arg_deCO2ase_major_dom
IPR027464 Ornithine_deCO2ase_N
IPR008286 Prn/Lys/Arg_de-COase_C
IPR036633 Prn/Lys/Arg_de-COase_C_sf
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF01276 OKR_DC_1, 1 hit
PF03711 OKR_DC_1_C, 1 hit
PF03709 OKR_DC_1_N, 1 hit
PIRSFiPIRSF009393 Orn_decarb, 1 hit
SUPFAMiSSF52172 SSF52172, 1 hit
SSF53383 SSF53383, 1 hit
SSF55904 SSF55904, 1 hit
PROSITEiView protein in PROSITE
PS00703 OKR_DC_1, 1 hit

Sequencei

Sequence statusi: Complete.

P21169-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSMNIAASS ELVSRLSSHR RVVALGDTDF TDVAAVVITA ADSRSGILAL
60 70 80 90 100
LKRTGFHLPV FLYSEHAVEL PAGVTAVING NEQQWLELES AACQYEENLL
110 120 130 140 150
PPFYDTLTQY VEMGNSTFAC PGHQHGAFFK KHPAGRHFYD FFGENVFRAD
160 170 180 190 200
MCNADVKLGD LLIHEGSAKD AQKFAAKVFH ADKTYFVLNG TSAANKVVTN
210 220 230 240 250
ALLTRGDLVL FDRNNHKSNH HGALIQAGAT PVYLEASRNP FGFIGGIDAH
260 270 280 290 300
CFNEEYLRQQ IRDVAPEKAD LPRPYRLAII QLGTYDGTVY NARQVIDTVG
310 320 330 340 350
HLCDYILFDS AWVGYEQFIP MMADSSPLLL ELNENDPGIF VTQSVHKQQA
360 370 380 390 400
GFSQTSQIHK KDNHIRGQAR FCPHKRLNNA FMLHASTSPF YPLFAALDVN
410 420 430 440 450
AKIHEGESGR RLWAECVEIG IEARKAILAR CKLFRPFIPP VVDGKLWQDY
460 470 480 490 500
PTSVLASDRR FFSFEPGAKW HGFEGYAADQ YFVDPCKLLL TTPGIDAETG
510 520 530 540 550
EYSDFGVPAT ILAHYLRENG IVPEKCDLNS ILFLLTPAES HEKLAQLVAM
560 570 580 590 600
LAQFEQHIED DSPLVEVLPS VYNKYPVRYR DYTLRQLCQE MHDLYVSFDV
610 620 630 640 650
KDLQKAMFRQ QSFPSVVMNP QDAHSAYIRG DVELVRIRDA EGRIAAEGAL
660 670 680 690 700
PYPPGVLCVV PGEVWGGAVQ RYFLALEEGV NLLPGFSPEL QGVYSETDAD
710
GVKRLYGYVL K
Length:711
Mass (Da):79,416
Last modified:April 27, 2001 - v2
Checksum:i37E54AC603853C3C
GO

Sequence cautioni

The sequence AAA66174 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAA69133 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33766 Genomic DNA Translation: AAA66174.1 Different initiation.
U28377 Genomic DNA Translation: AAA69133.1 Different initiation.
U00096 Genomic DNA Translation: AAC76002.2
AP009048 Genomic DNA Translation: BAE77028.1
PIRiI60729
RefSeqiNP_417440.4, NC_000913.3
WP_001326492.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76002; AAC76002; b2965
BAE77028; BAE77028; BAE77028
GeneIDi947457
KEGGiecj:JW5482
eco:b2965
PATRICifig|1411691.4.peg.3765

Entry informationi

Entry nameiDCOR_ECOLI
AccessioniPrimary (citable) accession number: P21169
Secondary accession number(s): Q2M9M8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: April 27, 2001
Last modified: March 28, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health