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Protein

Ornithine decarboxylase, constitutive

Gene

speC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-ornithine = putrescine + CO2.

Cofactori

Pathwayi: putrescine biosynthesis via L-ornithine pathway

This protein is involved in step 1 of the subpathway that synthesizes putrescine from L-ornithine.
Proteins known to be involved in this subpathway in this organism are:
  1. Ornithine decarboxylase, constitutive (speC), Ornithine decarboxylase, inducible (speF)
This subpathway is part of the pathway putrescine biosynthesis via L-ornithine pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes putrescine from L-ornithine, the pathway putrescine biosynthesis via L-ornithine pathway and in Amine and polyamine biosynthesis.

GO - Molecular functioni

  • ornithine decarboxylase activity Source: EcoCyc
  • pyridoxal phosphate binding Source: EcoCyc

GO - Biological processi

  • putrescine biosynthetic process from ornithine Source: UniProtKB-UniPathway
  • spermidine biosynthetic process Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Spermidine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciEcoCyc:ORNDECARBOX-BIO-MONOMER.
ECOL316407:JW5482-MONOMER.
MetaCyc:ORNDECARBOX-BIO-MONOMER.
BRENDAi4.1.1.17. 2026.
UniPathwayiUPA00535; UER00288.

Names & Taxonomyi

Protein namesi
Recommended name:
Ornithine decarboxylase, constitutive (EC:4.1.1.17)
Gene namesi
Name:speC
Ordered Locus Names:b2965, JW5482
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10961. speC.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 711711Ornithine decarboxylase, constitutivePRO_0000201134Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei347 – 3471N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PaxDbiP21169.
PRIDEiP21169.

Interactioni

Protein-protein interaction databases

BioGridi4262354. 4 interactions.
DIPiDIP-10907N.
STRINGi511145.b2965.

Structurei

3D structure databases

ProteinModelPortaliP21169.
SMRiP21169. Positions 94-699.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CXN. Bacteria.
COG1982. LUCA.
HOGENOMiHOG000164393.
InParanoidiP21169.
KOiK01581.
OMAiQYTEFGI.
OrthoDBiEOG696BRZ.
PhylomeDBiP21169.

Family and domain databases

Gene3Di3.40.50.220. 1 hit.
3.40.640.10. 1 hit.
3.90.100.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR005308. OKR_de-COase_N.
IPR011193. Orn/lys/arg_de-COase.
IPR000310. Orn/Lys/Arg_deCO2ase_major_dom.
IPR027464. Ornithine_deCO2ase_N.
IPR008286. Prn/Lys/Arg_de-COase_C.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF01276. OKR_DC_1. 1 hit.
PF03711. OKR_DC_1_C. 1 hit.
PF03709. OKR_DC_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF009393. Orn_decarb. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
SSF53383. SSF53383. 1 hit.
SSF55904. SSF55904. 1 hit.
PROSITEiPS00703. OKR_DC_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21169-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSMNIAASS ELVSRLSSHR RVVALGDTDF TDVAAVVITA ADSRSGILAL
60 70 80 90 100
LKRTGFHLPV FLYSEHAVEL PAGVTAVING NEQQWLELES AACQYEENLL
110 120 130 140 150
PPFYDTLTQY VEMGNSTFAC PGHQHGAFFK KHPAGRHFYD FFGENVFRAD
160 170 180 190 200
MCNADVKLGD LLIHEGSAKD AQKFAAKVFH ADKTYFVLNG TSAANKVVTN
210 220 230 240 250
ALLTRGDLVL FDRNNHKSNH HGALIQAGAT PVYLEASRNP FGFIGGIDAH
260 270 280 290 300
CFNEEYLRQQ IRDVAPEKAD LPRPYRLAII QLGTYDGTVY NARQVIDTVG
310 320 330 340 350
HLCDYILFDS AWVGYEQFIP MMADSSPLLL ELNENDPGIF VTQSVHKQQA
360 370 380 390 400
GFSQTSQIHK KDNHIRGQAR FCPHKRLNNA FMLHASTSPF YPLFAALDVN
410 420 430 440 450
AKIHEGESGR RLWAECVEIG IEARKAILAR CKLFRPFIPP VVDGKLWQDY
460 470 480 490 500
PTSVLASDRR FFSFEPGAKW HGFEGYAADQ YFVDPCKLLL TTPGIDAETG
510 520 530 540 550
EYSDFGVPAT ILAHYLRENG IVPEKCDLNS ILFLLTPAES HEKLAQLVAM
560 570 580 590 600
LAQFEQHIED DSPLVEVLPS VYNKYPVRYR DYTLRQLCQE MHDLYVSFDV
610 620 630 640 650
KDLQKAMFRQ QSFPSVVMNP QDAHSAYIRG DVELVRIRDA EGRIAAEGAL
660 670 680 690 700
PYPPGVLCVV PGEVWGGAVQ RYFLALEEGV NLLPGFSPEL QGVYSETDAD
710
GVKRLYGYVL K
Length:711
Mass (Da):79,416
Last modified:April 27, 2001 - v2
Checksum:i37E54AC603853C3C
GO

Sequence cautioni

The sequence AAA66174.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAA69133.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33766 Genomic DNA. Translation: AAA66174.1. Different initiation.
U28377 Genomic DNA. Translation: AAA69133.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76002.2.
AP009048 Genomic DNA. Translation: BAE77028.1.
PIRiI60729.
RefSeqiNP_417440.4. NC_000913.3.
WP_001326492.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76002; AAC76002; b2965.
BAE77028; BAE77028; BAE77028.
GeneIDi947457.
KEGGiecj:JW5482.
eco:b2965.
PATRICi32121346. VBIEscCol129921_3061.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33766 Genomic DNA. Translation: AAA66174.1. Different initiation.
U28377 Genomic DNA. Translation: AAA69133.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76002.2.
AP009048 Genomic DNA. Translation: BAE77028.1.
PIRiI60729.
RefSeqiNP_417440.4. NC_000913.3.
WP_001326492.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP21169.
SMRiP21169. Positions 94-699.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262354. 4 interactions.
DIPiDIP-10907N.
STRINGi511145.b2965.

Proteomic databases

PaxDbiP21169.
PRIDEiP21169.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76002; AAC76002; b2965.
BAE77028; BAE77028; BAE77028.
GeneIDi947457.
KEGGiecj:JW5482.
eco:b2965.
PATRICi32121346. VBIEscCol129921_3061.

Organism-specific databases

EchoBASEiEB0954.
EcoGeneiEG10961. speC.

Phylogenomic databases

eggNOGiENOG4105CXN. Bacteria.
COG1982. LUCA.
HOGENOMiHOG000164393.
InParanoidiP21169.
KOiK01581.
OMAiQYTEFGI.
OrthoDBiEOG696BRZ.
PhylomeDBiP21169.

Enzyme and pathway databases

UniPathwayiUPA00535; UER00288.
BioCyciEcoCyc:ORNDECARBOX-BIO-MONOMER.
ECOL316407:JW5482-MONOMER.
MetaCyc:ORNDECARBOX-BIO-MONOMER.
BRENDAi4.1.1.17. 2026.

Miscellaneous databases

PROiP21169.

Family and domain databases

Gene3Di3.40.50.220. 1 hit.
3.40.640.10. 1 hit.
3.90.100.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR005308. OKR_de-COase_N.
IPR011193. Orn/lys/arg_de-COase.
IPR000310. Orn/Lys/Arg_deCO2ase_major_dom.
IPR027464. Ornithine_deCO2ase_N.
IPR008286. Prn/Lys/Arg_de-COase_C.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF01276. OKR_DC_1. 1 hit.
PF03711. OKR_DC_1_C. 1 hit.
PF03709. OKR_DC_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF009393. Orn_decarb. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
SSF53383. SSF53383. 1 hit.
SSF55904. SSF55904. 1 hit.
PROSITEiPS00703. OKR_DC_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis and sequence of the speC (ornithine decarboxylase) gene of Escherichia coli."
    Barroso L.A., Moore R., Wright J., Patel T., Boyle S.M.
    Submitted (MAY-1990) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Escherichia coli proteome analysis using the gene-protein database."
    VanBogelen R.A., Abshire K.Z., Moldover B., Olson E.R., Neidhardt F.C.
    Electrophoresis 18:1243-1251(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY 2D-GEL.

Entry informationi

Entry nameiDCOR_ECOLI
AccessioniPrimary (citable) accession number: P21169
Secondary accession number(s): Q2M9M8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: April 27, 2001
Last modified: January 20, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.