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Reviewed, UniProtKB/Swiss-Prot P21169 (DCOR_ECOLI)

Last modified January 19, 2010. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Ornithine decarboxylase, constitutive
    EC=4.1.1.17
Gene names
Name: speC
Ordered Locus Names: b2965, JW5482
OrganismEscherichia coli (strain K12) [Complete proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

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Protein attributes

Sequence length711 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Catalytic activity

L-ornithine = putrescine + CO2.

Cofactor

Pyridoxal phosphate.

Pathway

Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-I family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 711711Ornithine decarboxylase, constitutive
PRO_0000201134

Amino acid modifications

Modified residue3471N6-(pyridoxal phosphate)lysine By similarity

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Sequences

Sequence LengthMass (Da)Tools
P21169-1 [UniParc].

Last modified April 27, 2001. Version 2.
Checksum: 37E54AC603853C3C

FASTA71179,416
        10         20         30         40         50         60 
MKSMNIAASS ELVSRLSSHR RVVALGDTDF TDVAAVVITA ADSRSGILAL LKRTGFHLPV 

        70         80         90        100        110        120 
FLYSEHAVEL PAGVTAVING NEQQWLELES AACQYEENLL PPFYDTLTQY VEMGNSTFAC 

       130        140        150        160        170        180 
PGHQHGAFFK KHPAGRHFYD FFGENVFRAD MCNADVKLGD LLIHEGSAKD AQKFAAKVFH 

       190        200        210        220        230        240 
ADKTYFVLNG TSAANKVVTN ALLTRGDLVL FDRNNHKSNH HGALIQAGAT PVYLEASRNP 

       250        260        270        280        290        300 
FGFIGGIDAH CFNEEYLRQQ IRDVAPEKAD LPRPYRLAII QLGTYDGTVY NARQVIDTVG 

       310        320        330        340        350        360 
HLCDYILFDS AWVGYEQFIP MMADSSPLLL ELNENDPGIF VTQSVHKQQA GFSQTSQIHK 

       370        380        390        400        410        420 
KDNHIRGQAR FCPHKRLNNA FMLHASTSPF YPLFAALDVN AKIHEGESGR RLWAECVEIG 

       430        440        450        460        470        480 
IEARKAILAR CKLFRPFIPP VVDGKLWQDY PTSVLASDRR FFSFEPGAKW HGFEGYAADQ 

       490        500        510        520        530        540 
YFVDPCKLLL TTPGIDAETG EYSDFGVPAT ILAHYLRENG IVPEKCDLNS ILFLLTPAES 

       550        560        570        580        590        600 
HEKLAQLVAM LAQFEQHIED DSPLVEVLPS VYNKYPVRYR DYTLRQLCQE MHDLYVSFDV 

       610        620        630        640        650        660 
KDLQKAMFRQ QSFPSVVMNP QDAHSAYIRG DVELVRIRDA EGRIAAEGAL PYPPGVLCVV 

       670        680        690        700        710 
PGEVWGGAVQ RYFLALEEGV NLLPGFSPEL QGVYSETDAD GVKRLYGYVL K

« Hide

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References

« Hide 'large scale' references
[1]"Analysis and sequence of the speC (ornithine decarboxylase) gene of Escherichia coli."
Barroso L.A., Moore R., Wright J., Patel T., Boyle S.M.
Submitted (MAY-1990) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M33766 Genomic DNA. Translation: AAA66174.1. Different initiation.
U28377 Genomic DNA. Translation: AAA69133.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76002.1. Different initiation.
AP009048 Genomic DNA. Translation: BAE77028.1.
PIRI60729.
RefSeqAP_003522.1.
NP_417440.4.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGP21169.

2-D gel databases

ECO2DBASEF080.0. 6TH EDITION.

Genome annotation databases

GeneID947457.
GenomeReviewsGene locus JW5482 in contig AP009048_GR.
Gene locus b2965 in contig U00096_GR.
KEGGecj:JW5482.
eco:b2965.

Organism-specific databases

EchoBASEEB0954.
EcoGeneEG10961. speC.
CMRSearch...

Phylogenomic databases

eggNOGCOG1982.
HOGENOMHBG301265.
OMADGIQRLY.

Enzyme and pathway databases

BioCycEcoCyc:ORNDECARBOX-BIO-MONOMER.
ECOL168927:B2965-MONOMER.
MetaCyc:ORNDECARBOX-BIO-MONOMER.

Gene expression databases

GenevestigatorP21169.

Family and domain databases

InterProIPR011006. CheY-like.
IPR005308. OKR_de-COase_N.
IPR011193. Orn/lys/arg_de-COase.
IPR000310. Orn/Lys/Arg_deCO2ase_major_dom.
IPR008286. Prn/Lys/Arg_de-COase_C.
IPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
Gene3DG3DSA:3.90.100.10. Decarbxylse_C. 1 hit.
G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
PfamPF01276. OKR_DC_1. 1 hit.
PF03711. OKR_DC_1_C. 1 hit.
PF03709. OKR_DC_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF009393. Orn_decarb. 1 hit.
PROSITEPS00703. OKR_DC_1. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameDCOR_ECOLI
AccessionPrimary (citable) accession number: P21169
Secondary accession number(s): Q2M9M8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: April 27, 2001
Last modified: January 19, 2010
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents