Reviewed, UniProtKB/Swiss-Prot P21169 (DCOR_ECOLI)

Names and origin

Protein names

Recommended name:
    Ornithine decarboxylase, constitutive
    EC=4.1.1.17

Gene names

Name:	speC
Ordered Locus Names:	b2965, JW5482

Organism

Escherichia coli (strain K12) [Complete proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	711 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	L-ornithine = putrescine + CO2.
Cofactor	Pyridoxal phosphate.
Pathway	Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.
Sequence similarities	Belongs to the Orn/Lys/Arg decarboxylase class-I family.

Ontologies

Keywords
Biological process	Spermidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro spermidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	ornithine decarboxylase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 711	711	Ornithine decarboxylase, constitutive		PRO_0000201134
Amino acid modifications
	Modified residue	347	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P21169-1 [UniParc]. Last modified April 27, 2001. Version 2. Checksum: 37E54AC603853C3C	FASTA	711	79,416
	10 20 30 40 50 60 MKSMNIAASS ELVSRLSSHR RVVALGDTDF TDVAAVVITA ADSRSGILAL LKRTGFHLPV 70 80 90 100 110 120 FLYSEHAVEL PAGVTAVING NEQQWLELES AACQYEENLL PPFYDTLTQY VEMGNSTFAC 130 140 150 160 170 180 PGHQHGAFFK KHPAGRHFYD FFGENVFRAD MCNADVKLGD LLIHEGSAKD AQKFAAKVFH 190 200 210 220 230 240 ADKTYFVLNG TSAANKVVTN ALLTRGDLVL FDRNNHKSNH HGALIQAGAT PVYLEASRNP 250 260 270 280 290 300 FGFIGGIDAH CFNEEYLRQQ IRDVAPEKAD LPRPYRLAII QLGTYDGTVY NARQVIDTVG 310 320 330 340 350 360 HLCDYILFDS AWVGYEQFIP MMADSSPLLL ELNENDPGIF VTQSVHKQQA GFSQTSQIHK 370 380 390 400 410 420 KDNHIRGQAR FCPHKRLNNA FMLHASTSPF YPLFAALDVN AKIHEGESGR RLWAECVEIG 430 440 450 460 470 480 IEARKAILAR CKLFRPFIPP VVDGKLWQDY PTSVLASDRR FFSFEPGAKW HGFEGYAADQ 490 500 510 520 530 540 YFVDPCKLLL TTPGIDAETG EYSDFGVPAT ILAHYLRENG IVPEKCDLNS ILFLLTPAES 550 560 570 580 590 600 HEKLAQLVAM LAQFEQHIED DSPLVEVLPS VYNKYPVRYR DYTLRQLCQE MHDLYVSFDV 610 620 630 640 650 660 KDLQKAMFRQ QSFPSVVMNP QDAHSAYIRG DVELVRIRDA EGRIAAEGAL PYPPGVLCVV 670 680 690 700 710 PGEVWGGAVQ RYFLALEEGV NLLPGFSPEL QGVYSETDAD GVKRLYGYVL K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis and sequence of the speC (ornithine decarboxylase) gene of Escherichia coli." Barroso L.A., Moore R., Wright J., Patel T., Boyle S.M. Submitted (MAY-1990) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M33766 Genomic DNA. Translation: AAA66174.1. Different initiation. U28377 Genomic DNA. Translation: AAA69133.1. Different initiation. U00096 Genomic DNA. Translation: AAC76002.1. Different initiation. AP009048 Genomic DNA. Translation: BAE77028.1.
PIR	I60729.
RefSeq	AP_003522.1. NP_417440.4.
3D structure databases
HSSP	HSSP built from PDB template 1C4K based on UniProtKB P43099.
ModBase	Search...
Protein-protein interaction databases
STRING	P21169.
2-D gel databases
ECO2DBASE	F080.0. 6TH EDITION.
Genome annotation databases
GeneID	947457.
GenomeReviews	Gene locus JW5482 in contig AP009048_GR. Gene locus b2965 in contig U00096_GR.
KEGG	ecj:JW5482. eco:b2965.
Organism-specific databases
EchoBASE	EB0954.
EcoGene	EG10961. speC.
CMR	Search...
Phylogenomic databases
HOGENOM	P21169.
OMA	DGIQRLY.
Enzyme and pathway databases
BioCyc	EcoCyc:ORNDECARBOX-BIO-MON. MetaCyc:ORNDECARBOX-BIO-MON.
Gene expression databases
Genevestigator	P21169.
Family and domain databases
InterPro	IPR000310. Decarbxylse1. IPR005308. OKR_de-COase_N. IPR011193. Orn/lys/arg_de-COase. IPR008286. Prn/Lys/Arg_de-COase_C. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.90.100.10. Decarbxylse_C. 1 hit. G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
Pfam	PF01276. OKR_DC_1. 1 hit. PF03711. OKR_DC_1_C. 1 hit. PF03709. OKR_DC_1_N. 1 hit. [Graphical view]
PIRSF	PIRSF009393. Orn_decarb. 1 hit.
PROSITE	PS00703. OKR_DC_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCOR_ECOLI

Accession

Primary (citable) accession number: P21169
Secondary accession number(s): Q2M9M8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
Last sequence update:	April 27, 2001
Last modified:	November 3, 2009
This is version 82 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)