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P21154 (GLNA_METVO) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamine synthetase

Short name=GS
EC=6.3.1.2
Alternative name(s):
Glutamate--ammonia ligase
Gene names
Name:glnA
OrganismMethanococcus voltae
Taxonomic identifier2188 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

Protein attributes

Sequence length446 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the glutamine synthetase family.

Caution

Lacks the tyrosine conserved in bacteria and other archaea, involved in feedback inhibition.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
Gene Ontology (GO)
   Biological_processglutamine biosynthetic process

Inferred from electronic annotation. Source: InterPro

nitrogen fixation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glutamate-ammonia ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 446446Glutamine synthetase
PRO_0000153207

Sequences

Sequence LengthMass (Da)Tools
P21154 [UniParc].

Last modified May 1, 1991. Version 1.
Checksum: 95449E4DE8542690

FASTA44650,199
        10         20         30         40         50         60 
MTSLEMALEY IKINNVKFLR FQFVDIHGEP KNIAYPVKLG TADGEEELMG VLENGLFFDG 

        70         80         90        100        110        120 
SSIEGFVEIE DSDMVLKPDL STLSVLPWRP SEKSVARIIC DVYRKNGKPF EGDPRGCLKR 

       130        140        150        160        170        180 
VLAEFKEEFK GEYFVGPEPE FFILKNENGK WVPGDDAGYF ELEPLDEGND LRRNIVFALE 

       190        200        210        220        230        240 
NLGFHVEASH HEVAPGQHEV DFKYDNAVKT ADSVITFKTT IKTLAKQSGV LATFMPKPFF 

       250        260        270        280        290        300 
GMNGSGMHCN QSIWLDGKPS FYDENNAHQL SDICLSYIGG ILEHTKALVS VTNPTVNSYK 

       310        320        330        340        350        360 
RLVPGYEAPV NIAWANSNRT SIIRVPAARG KGTRVEFRAP DPACNPYLAF TVMLAAGLDG 

       370        380        390        400        410        420 
VRRKLIAPEP VEKNIFAMSE AEKREANIDS VPSNLYDAIE ELRQDKVLKK ALGDHIFNKF 

       430        440 
IEIKTKEYDA YRTAVTDWEF NKYVRI 

« Hide

References

[1]"Nucleotide sequence and expression of the glutamine synthetase structural gene, glnA, of the archaebacterium Methanococcus voltae."
Possot O., Sibold L., Aubert J.-P.
Res. Microbiol. 140:355-371(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 33273 / DSM 1537 / NBRC 100457 / OCM 70 / PS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X53509 Genomic DNA. Translation: CAA37585.1.
PIRA43995.

3D structure databases

ProteinModelPortalP21154.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMSSF54368. SSF54368. 1 hit.
TIGRFAMsTIGR00653. GlnA. 1 hit.
PROSITEPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLNA_METVO
AccessionPrimary (citable) accession number: P21154
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: October 16, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families