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Protein

Glutamine synthetase

Gene

glnA

Organism
Methanococcus voltae
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase (EC:6.3.1.2)
Short name:
GS
Alternative name(s):
Glutamate--ammonia ligase
Gene namesi
Name:glnA
OrganismiMethanococcus voltae
Taxonomic identifieri2188 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Glutamine synthetasePRO_0000153207Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP21154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
TIGRFAMsiTIGR00653. GlnA. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21154-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSLEMALEY IKINNVKFLR FQFVDIHGEP KNIAYPVKLG TADGEEELMG
60 70 80 90 100
VLENGLFFDG SSIEGFVEIE DSDMVLKPDL STLSVLPWRP SEKSVARIIC
110 120 130 140 150
DVYRKNGKPF EGDPRGCLKR VLAEFKEEFK GEYFVGPEPE FFILKNENGK
160 170 180 190 200
WVPGDDAGYF ELEPLDEGND LRRNIVFALE NLGFHVEASH HEVAPGQHEV
210 220 230 240 250
DFKYDNAVKT ADSVITFKTT IKTLAKQSGV LATFMPKPFF GMNGSGMHCN
260 270 280 290 300
QSIWLDGKPS FYDENNAHQL SDICLSYIGG ILEHTKALVS VTNPTVNSYK
310 320 330 340 350
RLVPGYEAPV NIAWANSNRT SIIRVPAARG KGTRVEFRAP DPACNPYLAF
360 370 380 390 400
TVMLAAGLDG VRRKLIAPEP VEKNIFAMSE AEKREANIDS VPSNLYDAIE
410 420 430 440
ELRQDKVLKK ALGDHIFNKF IEIKTKEYDA YRTAVTDWEF NKYVRI
Length:446
Mass (Da):50,199
Last modified:May 1, 1991 - v1
Checksum:i95449E4DE8542690
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53509 Genomic DNA. Translation: CAA37585.1.
PIRiA43995.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53509 Genomic DNA. Translation: CAA37585.1.
PIRiA43995.

3D structure databases

ProteinModelPortaliP21154.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
TIGRFAMsiTIGR00653. GlnA. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence and expression of the glutamine synthetase structural gene, glnA, of the archaebacterium Methanococcus voltae."
    Possot O., Sibold L., Aubert J.-P.
    Res. Microbiol. 140:355-371(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 33273 / DSM 1537 / NBRC 100457 / OCM 70 / PS.

Entry informationi

Entry nameiGLNA_METVO
AccessioniPrimary (citable) accession number: P21154
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: July 22, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Lacks the tyrosine conserved in bacteria and other archaea, involved in feedback inhibition.Curated

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.