P21145 (MAL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Myelin and lymphocyte protein

Alternative name(s):
T-lymphocyte maturation-associated protein

Gene names

Name:

MAL

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	153 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function.
Subcellular location	Membrane; Multi-pass membrane protein.
Developmental stage	Expressed in the intermediate and late stages of T-cell differentiation.
Post-translational modification	Lipoprotein.
Sequence similarities	Belongs to the MAL family. Contains 1 MARVEL domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
PTM	Lipoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apical protein localization Traceable author statement PubMed 10739088. Source: UniProtKB cell differentiation Traceable author statement PubMed 10739088. Source: UniProtKB central nervous system development Traceable author statement PubMed 10739088. Source: UniProtKB induction of apoptosis Non-traceable author statement PubMed 10366425. Source: UniProtKB membrane raft polarization Traceable author statement PubMed 12153479. Source: UniProtKB myelination Non-traceable author statement PubMed 12153479. Source: UniProtKB
Cellular_component	apical plasma membrane Traceable author statement PubMed 10739088. Source: UniProtKB endoplasmic reticulum Inferred from direct assay Ref.3. Source: UniProtKB endosome Traceable author statement PubMed 9003426. Source: ProtInc extrinsic to membrane Inferred from electronic annotation. Source: Compara integral to plasma membrane Traceable author statement PubMed 9003426. Source: ProtInc membrane raft Inferred from direct assay PubMed 12153479. Source: UniProtKB
Molecular_function	apoptotic protease activator activity Non-traceable author statement PubMed 10366425. Source: UniProtKB channel activity Traceable author statement Ref.1. Source: ProtInc lipid binding Traceable author statement PubMed 10739088. Source: UniProtKB structural constituent of myelin sheath Inferred from direct assay PubMed 12153479. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
BTK	Q06187	5	EBI-3932027,EBI-624835
USP7	Q93009	3	EBI-3932027,EBI-302474

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: P21145-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: P21145-2)

The sequence of this isoform differs from the canonical sequence as follows:
     88-129: Missing.

Isoform C (identifier: P21145-3)

The sequence of this isoform differs from the canonical sequence as follows:
     32-87: Missing.

Isoform D (identifier: P21145-4)

The sequence of this isoform differs from the canonical sequence as follows:
     32-129: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 153	153	Myelin and lymphocyte protein		PRO_0000156805
Regions
	Topological domain	1 – 24	24	Cytoplasmic Potential
	Transmembrane	25 – 46	22	Helical; Potential
	Topological domain	47 – 53	7	Extracellular Potential
	Transmembrane	54 – 75	22	Helical; Potential
	Topological domain	76 – 92	17	Cytoplasmic Potential
	Transmembrane	93 – 114	22	Helical; Potential
	Topological domain	115 – 125	11	Extracellular Potential
	Transmembrane	126 – 147	22	Helical; Potential
	Topological domain	148 – 153	6	Cytoplasmic Potential
	Domain	18 – 151	134	MARVEL
Natural variations
	Alternative sequence	32 – 129	98	Missing in isoform D.		VSP_003162
	Alternative sequence	32 – 87	56	Missing in isoform C.		VSP_003163
	Alternative sequence	88 – 129	42	Missing in isoform B.		VSP_003164

Sequences

	Sequence		Length	Mass (Da)
	Isoform A [UniParc]. Last modified May 1, 1991. Version 1. Checksum: F821FC1C0ADBE775	FASTA	153	16,714
	10 20 30 40 50 60 MAPAAATGGS TLPSGFSVFT TLPDLLFIFE FIFGGLVWIL VASSLVPWPL VQGWVMFVSV 70 80 90 100 110 120 FCFVATTTLI ILYIIGAHGG ETSWVTLDAA YHCTAALFYL SASVLEALAT ITMQDGFTYR 130 140 150 HYHENIAAVV FSYIATLLYV VHAVFSLIRW KSS
	Isoform B [UniParc]. Checksum: 076826F85AF6E58B	FASTA	111	12,081
	10 20 30 40 50 60 MAPAAATGGS TLPSGFSVFT TLPDLLFIFE FIFGGLVWIL VASSLVPWPL VQGWVMFVSV 70 80 90 100 110 FCFVATTTLI ILYIIGAHGG ETSWVTLVFS YIATLLYVVH AVFSLIRWKS S
	Isoform C [UniParc]. Checksum: 831D98D55230C2DC	FASTA	97	10,621
	10 20 30 40 50 60 MAPAAATGGS TLPSGFSVFT TLPDLLFIFE FDAAYHCTAA LFYLSASVLE ALATITMQDG 70 80 90 FTYRHYHENI AAVVFSYIAT LLYVVHAVFS LIRWKSS
	Isoform D [UniParc]. Checksum: F943BC95A3AF4927	FASTA	55	5,989
	10 20 30 40 50 MAPAAATGGS TLPSGFSVFT TLPDLLFIFE FVFSYIATLL YVVHAVFSLI RWKSS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA cloning and sequence of MAL, a hydrophobic protein associated with human T-cell differentiation." Alonso M.A., Weissman S.M. Proc. Natl. Acad. Sci. U.S.A. 84:1997-2001(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Alternative splicing of human T-cell-specific MAL mRNA and its correlation with the exon/intron organization of the gene." Rancano C., Rubio T., Alonso M.A. Genomics 21:447-450(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[3]	"Genomic structure and subcellular localization of MAL, a human T-cell-specific proteolipid protein." Rancano C., Rubio T., Correas I., Alonso M.A. J. Biol. Chem. 269:8159-8164(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Lymphocyte and Placenta.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[5]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M15800 mRNA. Translation: AAA36196.1. X76678 mRNA. Translation: CAA54100.1. X76679 mRNA. Translation: CAA54101.1. X76680 mRNA. Translation: CAA54102.1. X76681 mRNA. Translation: CAA54103.1. X76220 , X76221, X76222, X76223 Genomic DNA. Translation: CAA53809.1. AK311844 mRNA. Translation: BAG34786.1. CR541879 mRNA. Translation: CAG46677.1. AC103563 Genomic DNA. Translation: AAY24121.1. CH471219 Genomic DNA. Translation: EAX10705.1. BC000458 mRNA. Translation: AAH00458.1. BC003006 mRNA. Translation: AAH03006.1.
IPI	IPI00007041. IPI00220712. IPI00220713. IPI00220714.
PIR	A29472.
RefSeq	NP_002362.1. NM_002371.3. NP_071883.1. NM_022438.2. NP_071884.1. NM_022439.2. NP_071885.1. NM_022440.2.
UniGene	Hs.80395.
3D structure databases
ProteinModelPortal	P21145.
ModBase	Search...
Protein-protein interaction databases
IntAct	P21145. 8 interactions.
STRING	9606.ENSP00000310880.
Polymorphism databases
DMDM	126719.
Proteomic databases
PRIDE	P21145.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000309988; ENSP00000310880; ENSG00000172005. ENST00000349807; ENSP00000322860; ENSG00000172005. ENST00000353004; ENSP00000306568; ENSG00000172005. ENST00000354078; ENSP00000304924; ENSG00000172005.
GeneID	4118.
KEGG	hsa:4118.
UCSC	uc002stx.1. human. uc002sty.1. human. uc002stz.1. human. uc002sua.1. human.
Organism-specific databases
CTD	4118.
GeneCards	GC02P095691.
H-InvDB	HIX0117680. HIX0117687.
HGNC	HGNC:6817. MAL.
MIM	188860. gene.
neXtProt	NX_P21145.
PharmGKB	PA30565.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG248454.
HOGENOM	HOG000231752.
HOVERGEN	HBG000925.
InParanoid	P21145.
OMA	FTTFPDL.
OrthoDB	EOG42NJ1Q.
PhylomeDB	P21145.
Gene expression databases
ArrayExpress	P21145.
Bgee	P21145.
CleanEx	HS_MAL.
Genevestigator	P21145.
GermOnline	ENSG00000172005. Homo sapiens.
Family and domain databases
InterPro	IPR013295. MAL. IPR008253. Marvel. IPR021128. MARVEL-like_dom. [Graphical view]
Pfam	PF01284. MARVEL. 1 hit. [Graphical view]
PRINTS	PR01884. MALPROTEIN.
PROSITE	PS51225. MARVEL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	4118.
NextBio	16170.
SOURCE	Search...

Entry information

Entry name

MAL_HUMAN

Accession

Primary (citable) accession number: P21145
Secondary accession number(s): Q6FH77

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
Last sequence update:	May 1, 1991
Last modified:	April 3, 2013
This is version 118 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.