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P21145

- MAL_HUMAN

UniProt

P21145 - MAL_HUMAN

Protein

Myelin and lymphocyte protein

Gene

MAL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function.

    GO - Molecular functioni

    1. channel activity Source: ProtInc
    2. lipid binding Source: UniProtKB
    3. peptidase activator activity involved in apoptotic process Source: UniProtKB
    4. protein binding Source: IntAct
    5. structural constituent of myelin sheath Source: UniProtKB

    GO - Biological processi

    1. apical protein localization Source: UniProtKB
    2. apoptotic process Source: UniProtKB
    3. cell differentiation Source: UniProtKB
    4. central nervous system development Source: UniProtKB
    5. membrane raft polarization Source: UniProtKB
    6. myelination Source: UniProtKB
    7. positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
    8. transmembrane transport Source: GOC

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myelin and lymphocyte protein
    Alternative name(s):
    T-lymphocyte maturation-associated protein
    Gene namesi
    Name:MAL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:6817. MAL.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB
    2. endoplasmic reticulum Source: UniProtKB
    3. endosome Source: ProtInc
    4. extrinsic component of membrane Source: Ensembl
    5. integral component of plasma membrane Source: ProtInc
    6. membrane raft Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30565.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 153153Myelin and lymphocyte proteinPRO_0000156805Add
    BLAST

    Post-translational modificationi

    Lipoprotein.

    Keywords - PTMi

    Lipoprotein

    Proteomic databases

    PRIDEiP21145.

    Expressioni

    Developmental stagei

    Expressed in the intermediate and late stages of T-cell differentiation.

    Gene expression databases

    BgeeiP21145.
    CleanExiHS_MAL.
    GenevestigatoriP21145.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BTKQ061875EBI-3932027,EBI-624835
    USP7Q930093EBI-3932027,EBI-302474

    Protein-protein interaction databases

    BioGridi110292. 2 interactions.
    IntActiP21145. 8 interactions.
    STRINGi9606.ENSP00000310880.

    Structurei

    3D structure databases

    ProteinModelPortaliP21145.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2424CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini47 – 537ExtracellularSequence Analysis
    Topological domaini76 – 9217CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini115 – 12511ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini148 – 1536CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4622HelicalSequence AnalysisAdd
    BLAST
    Transmembranei54 – 7522HelicalSequence AnalysisAdd
    BLAST
    Transmembranei93 – 11422HelicalSequence AnalysisAdd
    BLAST
    Transmembranei126 – 14722HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 151134MARVELPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MAL family.Curated
    Contains 1 MARVEL domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG248454.
    HOGENOMiHOG000231752.
    HOVERGENiHBG000925.
    InParanoidiP21145.
    OMAiVPIPLIQ.
    OrthoDBiEOG7XM30H.
    PhylomeDBiP21145.
    TreeFamiTF316174.

    Family and domain databases

    InterProiIPR013295. MAL.
    IPR008253. Marvel.
    [Graphical view]
    PfamiPF01284. MARVEL. 1 hit.
    [Graphical view]
    PRINTSiPR01884. MALPROTEIN.
    PROSITEiPS51225. MARVEL. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform A (identifier: P21145-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAPAAATGGS TLPSGFSVFT TLPDLLFIFE FIFGGLVWIL VASSLVPWPL    50
    VQGWVMFVSV FCFVATTTLI ILYIIGAHGG ETSWVTLDAA YHCTAALFYL 100
    SASVLEALAT ITMQDGFTYR HYHENIAAVV FSYIATLLYV VHAVFSLIRW 150
    KSS 153
    Length:153
    Mass (Da):16,714
    Last modified:May 1, 1991 - v1
    Checksum:iF821FC1C0ADBE775
    GO
    Isoform B (identifier: P21145-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         88-129: Missing.

    Show »
    Length:111
    Mass (Da):12,081
    Checksum:i076826F85AF6E58B
    GO
    Isoform C (identifier: P21145-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         32-87: Missing.

    Show »
    Length:97
    Mass (Da):10,621
    Checksum:i831D98D55230C2DC
    GO
    Isoform D (identifier: P21145-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         32-129: Missing.

    Show »
    Length:55
    Mass (Da):5,989
    Checksum:iF943BC95A3AF4927
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei32 – 12998Missing in isoform D. CuratedVSP_003162Add
    BLAST
    Alternative sequencei32 – 8756Missing in isoform C. CuratedVSP_003163Add
    BLAST
    Alternative sequencei88 – 12942Missing in isoform B. CuratedVSP_003164Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M15800 mRNA. Translation: AAA36196.1.
    X76678 mRNA. Translation: CAA54100.1.
    X76679 mRNA. Translation: CAA54101.1.
    X76680 mRNA. Translation: CAA54102.1.
    X76681 mRNA. Translation: CAA54103.1.
    X76220
    , X76221, X76222, X76223 Genomic DNA. Translation: CAA53809.1.
    AK311844 mRNA. Translation: BAG34786.1.
    CR541879 mRNA. Translation: CAG46677.1.
    AC103563 Genomic DNA. Translation: AAY24121.1.
    CH471219 Genomic DNA. Translation: EAX10705.1.
    BC000458 mRNA. Translation: AAH00458.1.
    BC003006 mRNA. Translation: AAH03006.1.
    CCDSiCCDS2006.1. [P21145-1]
    CCDS2007.1. [P21145-2]
    CCDS2008.1. [P21145-3]
    CCDS2009.1. [P21145-4]
    PIRiA29472.
    RefSeqiNP_002362.1. NM_002371.3. [P21145-1]
    NP_071883.1. NM_022438.2. [P21145-2]
    NP_071884.1. NM_022439.2. [P21145-3]
    NP_071885.1. NM_022440.2. [P21145-4]
    UniGeneiHs.80395.

    Genome annotation databases

    EnsembliENST00000309988; ENSP00000310880; ENSG00000172005. [P21145-1]
    ENST00000349807; ENSP00000322860; ENSG00000172005. [P21145-4]
    ENST00000353004; ENSP00000306568; ENSG00000172005. [P21145-2]
    ENST00000354078; ENSP00000304924; ENSG00000172005. [P21145-3]
    GeneIDi4118.
    KEGGihsa:4118.
    UCSCiuc002stx.2. human. [P21145-1]
    uc002sty.2. human. [P21145-3]
    uc002stz.2. human. [P21145-2]
    uc002sua.2. human. [P21145-4]

    Polymorphism databases

    DMDMi126719.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M15800 mRNA. Translation: AAA36196.1 .
    X76678 mRNA. Translation: CAA54100.1 .
    X76679 mRNA. Translation: CAA54101.1 .
    X76680 mRNA. Translation: CAA54102.1 .
    X76681 mRNA. Translation: CAA54103.1 .
    X76220
    , X76221 , X76222 , X76223 Genomic DNA. Translation: CAA53809.1 .
    AK311844 mRNA. Translation: BAG34786.1 .
    CR541879 mRNA. Translation: CAG46677.1 .
    AC103563 Genomic DNA. Translation: AAY24121.1 .
    CH471219 Genomic DNA. Translation: EAX10705.1 .
    BC000458 mRNA. Translation: AAH00458.1 .
    BC003006 mRNA. Translation: AAH03006.1 .
    CCDSi CCDS2006.1. [P21145-1 ]
    CCDS2007.1. [P21145-2 ]
    CCDS2008.1. [P21145-3 ]
    CCDS2009.1. [P21145-4 ]
    PIRi A29472.
    RefSeqi NP_002362.1. NM_002371.3. [P21145-1 ]
    NP_071883.1. NM_022438.2. [P21145-2 ]
    NP_071884.1. NM_022439.2. [P21145-3 ]
    NP_071885.1. NM_022440.2. [P21145-4 ]
    UniGenei Hs.80395.

    3D structure databases

    ProteinModelPortali P21145.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110292. 2 interactions.
    IntActi P21145. 8 interactions.
    STRINGi 9606.ENSP00000310880.

    Polymorphism databases

    DMDMi 126719.

    Proteomic databases

    PRIDEi P21145.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000309988 ; ENSP00000310880 ; ENSG00000172005 . [P21145-1 ]
    ENST00000349807 ; ENSP00000322860 ; ENSG00000172005 . [P21145-4 ]
    ENST00000353004 ; ENSP00000306568 ; ENSG00000172005 . [P21145-2 ]
    ENST00000354078 ; ENSP00000304924 ; ENSG00000172005 . [P21145-3 ]
    GeneIDi 4118.
    KEGGi hsa:4118.
    UCSCi uc002stx.2. human. [P21145-1 ]
    uc002sty.2. human. [P21145-3 ]
    uc002stz.2. human. [P21145-2 ]
    uc002sua.2. human. [P21145-4 ]

    Organism-specific databases

    CTDi 4118.
    GeneCardsi GC02P095691.
    H-InvDB HIX0117680.
    HIX0117687.
    HGNCi HGNC:6817. MAL.
    MIMi 188860. gene.
    neXtProti NX_P21145.
    PharmGKBi PA30565.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG248454.
    HOGENOMi HOG000231752.
    HOVERGENi HBG000925.
    InParanoidi P21145.
    OMAi VPIPLIQ.
    OrthoDBi EOG7XM30H.
    PhylomeDBi P21145.
    TreeFami TF316174.

    Miscellaneous databases

    GeneWikii MAL_(gene).
    GenomeRNAii 4118.
    NextBioi 16170.
    PROi P21145.
    SOURCEi Search...

    Gene expression databases

    Bgeei P21145.
    CleanExi HS_MAL.
    Genevestigatori P21145.

    Family and domain databases

    InterProi IPR013295. MAL.
    IPR008253. Marvel.
    [Graphical view ]
    Pfami PF01284. MARVEL. 1 hit.
    [Graphical view ]
    PRINTSi PR01884. MALPROTEIN.
    PROSITEi PS51225. MARVEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning and sequence of MAL, a hydrophobic protein associated with human T-cell differentiation."
      Alonso M.A., Weissman S.M.
      Proc. Natl. Acad. Sci. U.S.A. 84:1997-2001(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Alternative splicing of human T-cell-specific MAL mRNA and its correlation with the exon/intron organization of the gene."
      Rancano C., Rubio T., Alonso M.A.
      Genomics 21:447-450(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    3. "Genomic structure and subcellular localization of MAL, a human T-cell-specific proteolipid protein."
      Rancano C., Rubio T., Correas I., Alonso M.A.
      J. Biol. Chem. 269:8159-8164(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Lymphocyte and Placenta.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiMAL_HUMAN
    AccessioniPrimary (citable) accession number: P21145
    Secondary accession number(s): Q6FH77
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: May 1, 1991
    Last modified: October 1, 2014
    This is version 131 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3