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Protein

Myelin and lymphocyte protein

Gene

MAL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function.

GO - Molecular functioni

  • channel activity Source: ProtInc
  • lipid binding Source: UniProtKB
  • peptidase activator activity involved in apoptotic process Source: UniProtKB
  • structural constituent of myelin sheath Source: UniProtKB

GO - Biological processi

  • apical protein localization Source: UniProtKB
  • apoptotic process Source: UniProtKB
  • cell differentiation Source: UniProtKB
  • central nervous system development Source: UniProtKB
  • membrane raft polarization Source: UniProtKB
  • myelination Source: UniProtKB
  • positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
  • transmembrane transport Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin and lymphocyte protein
Alternative name(s):
T-lymphocyte maturation-associated protein
Gene namesi
Name:MAL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:6817. MAL.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei25 – 4622HelicalSequence AnalysisAdd
BLAST
Topological domaini47 – 537ExtracellularSequence Analysis
Transmembranei54 – 7522HelicalSequence AnalysisAdd
BLAST
Topological domaini76 – 9217CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei93 – 11422HelicalSequence AnalysisAdd
BLAST
Topological domaini115 – 12511ExtracellularSequence AnalysisAdd
BLAST
Transmembranei126 – 14722HelicalSequence AnalysisAdd
BLAST
Topological domaini148 – 1536CytoplasmicSequence Analysis

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB
  • endoplasmic reticulum Source: UniProtKB
  • endosome Source: ProtInc
  • extrinsic component of membrane Source: Ensembl
  • integral component of plasma membrane Source: ProtInc
  • membrane raft Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30565.

Polymorphism and mutation databases

BioMutaiMAL.
DMDMi126719.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 153153Myelin and lymphocyte proteinPRO_0000156805Add
BLAST

Post-translational modificationi

Lipoprotein.

Keywords - PTMi

Lipoprotein

Proteomic databases

PRIDEiP21145.

Expressioni

Developmental stagei

Expressed in the intermediate and late stages of T-cell differentiation.

Gene expression databases

BgeeiP21145.
CleanExiHS_MAL.
ExpressionAtlasiP21145. baseline and differential.
GenevisibleiP21145. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BTKQ061875EBI-3932027,EBI-624835
EDAQ928383EBI-3932027,EBI-529425
FIBCD1Q8N5393EBI-3932027,EBI-10200808
KLRC1P267153EBI-3932027,EBI-9018187
LDLRAD1Q5T7003EBI-3932027,EBI-10173166
LSMEM1Q8N8F73EBI-3932027,EBI-10200825
PTPRNQ16849-33EBI-3932027,EBI-10200782
SMIM3Q9BZL33EBI-3932027,EBI-741850
USP7Q930093EBI-3932027,EBI-302474

Protein-protein interaction databases

BioGridi110292. 9 interactions.
IntActiP21145. 15 interactions.
STRINGi9606.ENSP00000310880.

Structurei

3D structure databases

ProteinModelPortaliP21145.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 151134MARVELPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MAL family.Curated
Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG248454.
GeneTreeiENSGT00730000110762.
HOGENOMiHOG000231752.
HOVERGENiHBG000925.
InParanoidiP21145.
OMAiVPIPLIQ.
OrthoDBiEOG7XM30H.
PhylomeDBiP21145.
TreeFamiTF316174.

Family and domain databases

InterProiIPR013295. MAL.
IPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR01884. MALPROTEIN.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: P21145-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPAAATGGS TLPSGFSVFT TLPDLLFIFE FIFGGLVWIL VASSLVPWPL
60 70 80 90 100
VQGWVMFVSV FCFVATTTLI ILYIIGAHGG ETSWVTLDAA YHCTAALFYL
110 120 130 140 150
SASVLEALAT ITMQDGFTYR HYHENIAAVV FSYIATLLYV VHAVFSLIRW

KSS
Length:153
Mass (Da):16,714
Last modified:May 1, 1991 - v1
Checksum:iF821FC1C0ADBE775
GO
Isoform B (identifier: P21145-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-129: Missing.

Show »
Length:111
Mass (Da):12,081
Checksum:i076826F85AF6E58B
GO
Isoform C (identifier: P21145-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-87: Missing.

Show »
Length:97
Mass (Da):10,621
Checksum:i831D98D55230C2DC
GO
Isoform D (identifier: P21145-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-129: Missing.

Show »
Length:55
Mass (Da):5,989
Checksum:iF943BC95A3AF4927
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei32 – 12998Missing in isoform D. CuratedVSP_003162Add
BLAST
Alternative sequencei32 – 8756Missing in isoform C. CuratedVSP_003163Add
BLAST
Alternative sequencei88 – 12942Missing in isoform B. CuratedVSP_003164Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15800 mRNA. Translation: AAA36196.1.
X76678 mRNA. Translation: CAA54100.1.
X76679 mRNA. Translation: CAA54101.1.
X76680 mRNA. Translation: CAA54102.1.
X76681 mRNA. Translation: CAA54103.1.
X76220
, X76221, X76222, X76223 Genomic DNA. Translation: CAA53809.1.
AK311844 mRNA. Translation: BAG34786.1.
CR541879 mRNA. Translation: CAG46677.1.
AC103563 Genomic DNA. Translation: AAY24121.1.
CH471219 Genomic DNA. Translation: EAX10705.1.
BC000458 mRNA. Translation: AAH00458.1.
BC003006 mRNA. Translation: AAH03006.1.
CCDSiCCDS2006.1. [P21145-1]
CCDS2007.1. [P21145-2]
CCDS2008.1. [P21145-3]
CCDS2009.1. [P21145-4]
PIRiA29472.
RefSeqiNP_002362.1. NM_002371.3. [P21145-1]
NP_071883.1. NM_022438.2. [P21145-2]
NP_071884.1. NM_022439.2. [P21145-3]
NP_071885.1. NM_022440.2. [P21145-4]
UniGeneiHs.80395.

Genome annotation databases

EnsembliENST00000309988; ENSP00000310880; ENSG00000172005.
ENST00000349807; ENSP00000322860; ENSG00000172005. [P21145-4]
ENST00000353004; ENSP00000306568; ENSG00000172005. [P21145-2]
ENST00000354078; ENSP00000304924; ENSG00000172005. [P21145-3]
GeneIDi4118.
KEGGihsa:4118.
UCSCiuc002stx.2. human. [P21145-1]
uc002sty.2. human. [P21145-3]
uc002stz.2. human. [P21145-2]
uc002sua.2. human. [P21145-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15800 mRNA. Translation: AAA36196.1.
X76678 mRNA. Translation: CAA54100.1.
X76679 mRNA. Translation: CAA54101.1.
X76680 mRNA. Translation: CAA54102.1.
X76681 mRNA. Translation: CAA54103.1.
X76220
, X76221, X76222, X76223 Genomic DNA. Translation: CAA53809.1.
AK311844 mRNA. Translation: BAG34786.1.
CR541879 mRNA. Translation: CAG46677.1.
AC103563 Genomic DNA. Translation: AAY24121.1.
CH471219 Genomic DNA. Translation: EAX10705.1.
BC000458 mRNA. Translation: AAH00458.1.
BC003006 mRNA. Translation: AAH03006.1.
CCDSiCCDS2006.1. [P21145-1]
CCDS2007.1. [P21145-2]
CCDS2008.1. [P21145-3]
CCDS2009.1. [P21145-4]
PIRiA29472.
RefSeqiNP_002362.1. NM_002371.3. [P21145-1]
NP_071883.1. NM_022438.2. [P21145-2]
NP_071884.1. NM_022439.2. [P21145-3]
NP_071885.1. NM_022440.2. [P21145-4]
UniGeneiHs.80395.

3D structure databases

ProteinModelPortaliP21145.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110292. 9 interactions.
IntActiP21145. 15 interactions.
STRINGi9606.ENSP00000310880.

Polymorphism and mutation databases

BioMutaiMAL.
DMDMi126719.

Proteomic databases

PRIDEiP21145.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309988; ENSP00000310880; ENSG00000172005.
ENST00000349807; ENSP00000322860; ENSG00000172005. [P21145-4]
ENST00000353004; ENSP00000306568; ENSG00000172005. [P21145-2]
ENST00000354078; ENSP00000304924; ENSG00000172005. [P21145-3]
GeneIDi4118.
KEGGihsa:4118.
UCSCiuc002stx.2. human. [P21145-1]
uc002sty.2. human. [P21145-3]
uc002stz.2. human. [P21145-2]
uc002sua.2. human. [P21145-4]

Organism-specific databases

CTDi4118.
GeneCardsiGC02P095691.
H-InvDBHIX0117680.
HIX0117687.
HGNCiHGNC:6817. MAL.
MIMi188860. gene.
neXtProtiNX_P21145.
PharmGKBiPA30565.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG248454.
GeneTreeiENSGT00730000110762.
HOGENOMiHOG000231752.
HOVERGENiHBG000925.
InParanoidiP21145.
OMAiVPIPLIQ.
OrthoDBiEOG7XM30H.
PhylomeDBiP21145.
TreeFamiTF316174.

Miscellaneous databases

ChiTaRSiMAL. human.
GeneWikiiMAL_(gene).
GenomeRNAii4118.
NextBioi16170.
PROiP21145.
SOURCEiSearch...

Gene expression databases

BgeeiP21145.
CleanExiHS_MAL.
ExpressionAtlasiP21145. baseline and differential.
GenevisibleiP21145. HS.

Family and domain databases

InterProiIPR013295. MAL.
IPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR01884. MALPROTEIN.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and sequence of MAL, a hydrophobic protein associated with human T-cell differentiation."
    Alonso M.A., Weissman S.M.
    Proc. Natl. Acad. Sci. U.S.A. 84:1997-2001(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Alternative splicing of human T-cell-specific MAL mRNA and its correlation with the exon/intron organization of the gene."
    Rancano C., Rubio T., Alonso M.A.
    Genomics 21:447-450(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  3. "Genomic structure and subcellular localization of MAL, a human T-cell-specific proteolipid protein."
    Rancano C., Rubio T., Correas I., Alonso M.A.
    J. Biol. Chem. 269:8159-8164(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Lymphocyte and Placenta.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiMAL_HUMAN
AccessioniPrimary (citable) accession number: P21145
Secondary accession number(s): Q6FH77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: July 22, 2015
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.