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P21145 (MAL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Myelin and lymphocyte protein
Alternative name(s):
T-lymphocyte maturation-associated protein
Gene names
Name:MAL
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length153 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function.

Subcellular location

Membrane; Multi-pass membrane protein.

Developmental stage

Expressed in the intermediate and late stages of T-cell differentiation.

Post-translational modification

Lipoprotein.

Sequence similarities

Belongs to the MAL family.

Contains 1 MARVEL domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

USP7Q930093EBI-3932027,EBI-302474

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform A (identifier: P21145-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform B (identifier: P21145-2)

The sequence of this isoform differs from the canonical sequence as follows:
     88-129: Missing.
Isoform C (identifier: P21145-3)

The sequence of this isoform differs from the canonical sequence as follows:
     32-87: Missing.
Isoform D (identifier: P21145-4)

The sequence of this isoform differs from the canonical sequence as follows:
     32-129: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 153153Myelin and lymphocyte protein
PRO_0000156805

Regions

Topological domain1 – 2424Cytoplasmic Potential
Transmembrane25 – 4622Helical; Potential
Topological domain47 – 537Extracellular Potential
Transmembrane54 – 7522Helical; Potential
Topological domain76 – 9217Cytoplasmic Potential
Transmembrane93 – 11422Helical; Potential
Topological domain115 – 12511Extracellular Potential
Transmembrane126 – 14722Helical; Potential
Topological domain148 – 1536Cytoplasmic Potential
Domain18 – 151134MARVEL

Natural variations

Alternative sequence32 – 12998Missing in isoform D.
VSP_003162
Alternative sequence32 – 8756Missing in isoform C.
VSP_003163
Alternative sequence88 – 12942Missing in isoform B.
VSP_003164

Sequences

Sequence LengthMass (Da)Tools
Isoform A [UniParc].

Last modified May 1, 1991. Version 1.
Checksum: F821FC1C0ADBE775

FASTA15316,714
        10         20         30         40         50         60 
MAPAAATGGS TLPSGFSVFT TLPDLLFIFE FIFGGLVWIL VASSLVPWPL VQGWVMFVSV 

        70         80         90        100        110        120 
FCFVATTTLI ILYIIGAHGG ETSWVTLDAA YHCTAALFYL SASVLEALAT ITMQDGFTYR 

       130        140        150 
HYHENIAAVV FSYIATLLYV VHAVFSLIRW KSS

« Hide

Isoform B [UniParc].

Checksum: 076826F85AF6E58B
Show »

FASTA11112,081
Isoform C [UniParc].

Checksum: 831D98D55230C2DC
Show »

FASTA9710,621
Isoform D [UniParc].

Checksum: F943BC95A3AF4927
Show »

FASTA555,989

References

« Hide 'large scale' references
[1]"cDNA cloning and sequence of MAL, a hydrophobic protein associated with human T-cell differentiation."
Alonso M.A., Weissman S.M.
Proc. Natl. Acad. Sci. U.S.A. 84:1997-2001(1987) [PubMed: 3494249] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Genomic structure and subcellular localization of MAL, a human T-cell-specific proteolipid protein."
Rancano C., Rubio T., Correas I., Alonso M.A.
J. Biol. Chem. 269:8159-8164(1994) [PubMed: 8132541] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Lymphocyte and Placenta.
[3]"Alternative splicing of human T-cell-specific MAL mRNA and its correlation with the exon/intron organization of the gene."
Rancano C., Rubio T., Alonso M.A.
Genomics 21:447-450(1994) [PubMed: 8088843] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M15800 mRNA. Translation: AAA36196.1.
X76678 mRNA. Translation: CAA54100.1.
X76679 mRNA. Translation: CAA54101.1.
X76680 mRNA. Translation: CAA54102.1.
X76681 mRNA. Translation: CAA54103.1.
X76220 expand/collapse EMBL AC list , X76221, X76222, X76223 Genomic DNA. Translation: CAA53809.1.
BC000458 mRNA. Translation: AAH00458.1.
BC003006 mRNA. Translation: AAH03006.1.
IPIIPI00007041.
IPI00220712.
IPI00220713.
IPI00220714.
PIRA29472.
RefSeqNP_002362.1. NM_002371.2.
NP_071883.1. NM_022438.1.
NP_071884.1. NM_022439.1.
NP_071885.1. NM_022440.1.
UniGeneHs.80395.

3D structure databases

ProteinModelPortalP21145.
ModBaseSearch...

Protein-protein interaction databases

IntActP21145. 2 interactions.
STRINGP21145.

Polymorphism databases

DMDM126719.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000309988; ENSP00000310880; ENSG00000172005.
GeneID4118.
KEGGhsa:4118.
UCSCuc002stx.1. human.
uc002sty.1. human.
uc002stz.1. human.
uc002sua.1. human.

Organism-specific databases

CTD4118.
GeneCardsGC02P095691.
H-InvDBHIX0002256.
HGNCHGNC:6817. MAL.
MIM188860. gene.
neXtProtNX_P21145.
PharmGKBPA30565.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG20305.
HOGENOMHBG716713.
HOVERGENHBG000925.
InParanoidP21145.
OMALLFIFEF.
OrthoDBEOG42NJ1Q.
PhylomeDBP21145.

Gene expression databases

ArrayExpressP21145.
BgeeP21145.
CleanExHS_MAL.
GenevestigatorP21145.
GermOnlineENSG00000172005. Homo sapiens.

Family and domain databases

InterProIPR013295. MAL.
IPR008253. Marvel.
IPR021128. MARVEL-like_dom.
[Graphical view]
PfamPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSPR01884. MALPROTEIN.
PROSITEPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio16170.
SOURCESearch...

Entry information

Entry nameMAL_HUMAN
AccessionPrimary (citable) accession number: P21145
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: January 25, 2012
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents