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P21145 (MAL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myelin and lymphocyte protein
Alternative name(s):
T-lymphocyte maturation-associated protein
Gene names
Name:MAL
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length153 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function.

Subcellular location

Membrane; Multi-pass membrane protein.

Developmental stage

Expressed in the intermediate and late stages of T-cell differentiation.

Post-translational modification

Lipoprotein.

Sequence similarities

Belongs to the MAL family.

Contains 1 MARVEL domain.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   PTMLipoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapical protein localization

Traceable author statement PubMed 10739088. Source: UniProtKB

apoptotic process

Non-traceable author statement PubMed 10366425. Source: UniProtKB

cell differentiation

Traceable author statement PubMed 10739088. Source: UniProtKB

central nervous system development

Traceable author statement PubMed 10739088. Source: UniProtKB

membrane raft polarization

Traceable author statement PubMed 12153479. Source: UniProtKB

myelination

Non-traceable author statement PubMed 12153479. Source: UniProtKB

positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

Inferred from electronic annotation. Source: Ensembl

transmembrane transport

Traceable author statement Ref.1. Source: GOC

   Cellular_componentapical plasma membrane

Traceable author statement PubMed 10739088. Source: UniProtKB

endoplasmic reticulum

Inferred from direct assay Ref.3. Source: UniProtKB

endosome

Traceable author statement PubMed 9003426. Source: ProtInc

extrinsic component of membrane

Inferred from electronic annotation. Source: Ensembl

integral component of plasma membrane

Traceable author statement PubMed 9003426. Source: ProtInc

membrane raft

Inferred from direct assay PubMed 12153479. Source: UniProtKB

   Molecular_functionchannel activity

Traceable author statement Ref.1. Source: ProtInc

lipid binding

Traceable author statement PubMed 10739088. Source: UniProtKB

peptidase activator activity involved in apoptotic process

Non-traceable author statement PubMed 10366425. Source: UniProtKB

structural constituent of myelin sheath

Inferred from direct assay PubMed 12153479. Source: UniProtKB

Complete GO annotation...

Binary interactions

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform A (identifier: P21145-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform B (identifier: P21145-2)

The sequence of this isoform differs from the canonical sequence as follows:
     88-129: Missing.
Isoform C (identifier: P21145-3)

The sequence of this isoform differs from the canonical sequence as follows:
     32-87: Missing.
Isoform D (identifier: P21145-4)

The sequence of this isoform differs from the canonical sequence as follows:
     32-129: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 153153Myelin and lymphocyte protein
PRO_0000156805

Regions

Topological domain1 – 2424Cytoplasmic Potential
Transmembrane25 – 4622Helical; Potential
Topological domain47 – 537Extracellular Potential
Transmembrane54 – 7522Helical; Potential
Topological domain76 – 9217Cytoplasmic Potential
Transmembrane93 – 11422Helical; Potential
Topological domain115 – 12511Extracellular Potential
Transmembrane126 – 14722Helical; Potential
Topological domain148 – 1536Cytoplasmic Potential
Domain18 – 151134MARVEL

Natural variations

Alternative sequence32 – 12998Missing in isoform D.
VSP_003162
Alternative sequence32 – 8756Missing in isoform C.
VSP_003163
Alternative sequence88 – 12942Missing in isoform B.
VSP_003164

Sequences

Sequence LengthMass (Da)Tools
Isoform A [UniParc].

Last modified May 1, 1991. Version 1.
Checksum: F821FC1C0ADBE775

FASTA15316,714
        10         20         30         40         50         60 
MAPAAATGGS TLPSGFSVFT TLPDLLFIFE FIFGGLVWIL VASSLVPWPL VQGWVMFVSV 

        70         80         90        100        110        120 
FCFVATTTLI ILYIIGAHGG ETSWVTLDAA YHCTAALFYL SASVLEALAT ITMQDGFTYR 

       130        140        150 
HYHENIAAVV FSYIATLLYV VHAVFSLIRW KSS 

« Hide

Isoform B [UniParc].

Checksum: 076826F85AF6E58B
Show »

FASTA11112,081
Isoform C [UniParc].

Checksum: 831D98D55230C2DC
Show »

FASTA9710,621
Isoform D [UniParc].

Checksum: F943BC95A3AF4927
Show »

FASTA555,989

References

« Hide 'large scale' references
[1]"cDNA cloning and sequence of MAL, a hydrophobic protein associated with human T-cell differentiation."
Alonso M.A., Weissman S.M.
Proc. Natl. Acad. Sci. U.S.A. 84:1997-2001(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Alternative splicing of human T-cell-specific MAL mRNA and its correlation with the exon/intron organization of the gene."
Rancano C., Rubio T., Alonso M.A.
Genomics 21:447-450(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[3]"Genomic structure and subcellular localization of MAL, a human T-cell-specific proteolipid protein."
Rancano C., Rubio T., Correas I., Alonso M.A.
J. Biol. Chem. 269:8159-8164(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Lymphocyte and Placenta.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M15800 mRNA. Translation: AAA36196.1.
X76678 mRNA. Translation: CAA54100.1.
X76679 mRNA. Translation: CAA54101.1.
X76680 mRNA. Translation: CAA54102.1.
X76681 mRNA. Translation: CAA54103.1.
X76220 expand/collapse EMBL AC list , X76221, X76222, X76223 Genomic DNA. Translation: CAA53809.1.
AK311844 mRNA. Translation: BAG34786.1.
CR541879 mRNA. Translation: CAG46677.1.
AC103563 Genomic DNA. Translation: AAY24121.1.
CH471219 Genomic DNA. Translation: EAX10705.1.
BC000458 mRNA. Translation: AAH00458.1.
BC003006 mRNA. Translation: AAH03006.1.
PIRA29472.
RefSeqNP_002362.1. NM_002371.3.
NP_071883.1. NM_022438.2.
NP_071884.1. NM_022439.2.
NP_071885.1. NM_022440.2.
UniGeneHs.80395.

3D structure databases

ProteinModelPortalP21145.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110292. 2 interactions.
IntActP21145. 8 interactions.
STRING9606.ENSP00000310880.

Polymorphism databases

DMDM126719.

Proteomic databases

PRIDEP21145.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000309988; ENSP00000310880; ENSG00000172005. [P21145-1]
ENST00000349807; ENSP00000322860; ENSG00000172005. [P21145-4]
ENST00000353004; ENSP00000306568; ENSG00000172005. [P21145-2]
ENST00000354078; ENSP00000304924; ENSG00000172005. [P21145-3]
GeneID4118.
KEGGhsa:4118.
UCSCuc002stx.2. human. [P21145-1]
uc002sty.2. human. [P21145-3]
uc002stz.2. human. [P21145-2]
uc002sua.2. human. [P21145-4]

Organism-specific databases

CTD4118.
GeneCardsGC02P095691.
H-InvDBHIX0117680.
HIX0117687.
HGNCHGNC:6817. MAL.
MIM188860. gene.
neXtProtNX_P21145.
PharmGKBPA30565.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG248454.
HOGENOMHOG000231752.
HOVERGENHBG000925.
InParanoidP21145.
OMAKHYHENI.
OrthoDBEOG7XM30H.
PhylomeDBP21145.
TreeFamTF316174.

Gene expression databases

BgeeP21145.
CleanExHS_MAL.
GenevestigatorP21145.

Family and domain databases

InterProIPR013295. MAL.
IPR008253. Marvel.
[Graphical view]
PfamPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSPR01884. MALPROTEIN.
PROSITEPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMAL_(gene).
GenomeRNAi4118.
NextBio16170.
PROP21145.
SOURCESearch...

Entry information

Entry nameMAL_HUMAN
AccessionPrimary (citable) accession number: P21145
Secondary accession number(s): Q6FH77
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: April 16, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM