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P21139 (MA2C1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-mannosidase 2C1

EC=3.2.1.24
Alternative name(s):
Alpha-D-mannoside mannohydrolase
Mannosidase alpha class 2C member 1
Gene names
Name:Man2c1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length1040 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subcellular location

Endoplasmic reticulum.

Post-translational modification

A soluble isoform ofthe rat liver mannosidase is supposed to be derived from endoplasmic reticulum membrane alpha-mannosidase by proteolysis.

Sequence similarities

Belongs to the glycosyl hydrolase 38 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10401040Alpha-mannosidase 2C1
PRO_0000206909

Sites

Active site3711Nucleophile By similarity
Metal binding2591Zinc By similarity
Metal binding2611Zinc By similarity
Metal binding3711Zinc By similarity
Metal binding5761Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
P21139 [UniParc].

Last modified May 1, 1991. Version 1.
Checksum: 144F6EB97C8F7EA7

FASTA1,040115,971
        10         20         30         40         50         60 
MAAAPFLKHW RTTFERVEKF VSPIYFTDCN LRGRLFGDSC PVTLSSFLTP ERLPYEKAVQ 

        70         80         90        100        110        120 
QNFSPAQVGD SFGPTWWTCW FRVELVIPEV WVGKEVHLCW ESDGESLVWR DGEPVQGLTK 

       130        140        150        160        170        180 
EGEKTSYVLS ERLHAADPRS LTLYVEVACN GLLGAGKGSM IAAPDPEKMF QLSQAKLAVF 

       190        200        210        220        230        240 
HRDVHNLLVD LELLLGVAKG LGEDNQRSFQ ALYTANQMVN ICDPAQPETY PAAEALASKF 

       250        260        270        280        290        300 
FGQRGGESQH TIHATGHCHI DTAWLWPFKE TVRKCARSWS TAVKLMERNT EFTFACSQAQ 

       310        320        330        340        350        360 
QLEWVKNQYP GLYAQLQEFA CRGQFVPVGG TWVEMDGNLP SGEAMVRQFL QGQNFFLQEF 

       370        380        390        400        410        420 
GKMCSEFWLP DTFGYSAQLP QIMQGCGIKR FLTQKLSWNL VNSFPHHTFF WEGLDGSQVL 

       430        440        450        460        470        480 
VHFPPGDSYG MQGSVEEVLK TVTNNRDKGR TNHSGFLFGF GDGGGGPTQT MLDRLKRLGN 

       490        500        510        520        530        540 
TDGQPRVQLS SPGQLFTALE RDSGQLCTWV GELFLELHNG TYTTHAQLKK GNRECEQILH 

       550        560        570        580        590        600 
DVELLSSLAL ARSAQFLYPA VQLQRLWRLL LLNQFHDVVT GSCIQLVAED AMNYYEDIRS 

       610        620        630        640        650        660 
HGNTLLSAAA AALCAGEPGP KGLRHYQHTA LEAHRSVGTT QGLVGLTRLA LVTVPSIGYA 

       670        680        690        700        710        720 
PAPTPTSLQP LLPQQPVFVM QETDGSVTLD NGIIRVRLDP TGCLTSLVLV ASGREAIAEG 

       730        740        750        760        770        780 
ALGNQFVLFD DVPLYWDAWD VMDYHLETRK PVRGQAGTLA VGAEGGLRGS AWFLLQISPN 

       790        800        810        820        830        840 
SRLSQEVVLD VGCPYVRFHT EVHWHETHKF LKVEFPARVR SPQATYEIQF GHLQEADPQQ 

       850        860        870        880        890        900 
HSWDWARYEV WAHRWIDLSE CDFGLALLNN CKYGTSVRGN VLSLSLLRAP KAPDVTADMG 

       910        920        930        940        950        960 
RHEFTYALMP HKGSFQEAGV IQAAYNLNFP LLALPAPGPA PDTTWSAFSV SSPAVVLETI 

       970        980        990       1000       1010       1020 
KQAEKSHQHR TLVLRLYEAH GSHVDCWLHT SLPVQEATLC DLLEQRDPTG HLSLQDNRLK 

      1030       1040 
LTFSPFQVRS LLLVLQPPAN 

« Hide

References

[1]"Isolation, characterization, and expression of cDNA encoding a rat liver endoplasmic reticulum alpha-mannosidase."
Bischoff J., Moremen K., Lodish H.F.
J. Biol. Chem. 265:17110-17117(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
Strain: Sprague-Dawley.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M57547 mRNA. Translation: AAA41565.1.
PIRA38306.
RefSeqNP_640349.1. NM_139256.1.
UniGeneRn.11301.

3D structure databases

ProteinModelPortalP21139.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP21139. 1 interaction.
MINTMINT-3389982.
STRING10116.ENSRNOP00000041867.

Chemistry

BindingDBP21139.
ChEMBLCHEMBL2852.

Protein family/group databases

CAZyGH38. Glycoside Hydrolase Family 38.

Proteomic databases

PaxDbP21139.
PRIDEP21139.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID246136.
KEGGrno:246136.
UCSCRGD:628787. rat.

Organism-specific databases

CTD4123.
RGD628787. Man2c1.

Phylogenomic databases

eggNOGCOG0383.
HOGENOMHOG000048425.
HOVERGENHBG055567.
InParanoidP21139.
KOK01191.
PhylomeDBP21139.

Enzyme and pathway databases

SABIO-RKP21139.

Gene expression databases

GenevestigatorP21139.

Family and domain databases

Gene3D1.20.1270.50. 1 hit.
3.20.110.10. 1 hit.
InterProIPR011013. Gal_mutarotase_SF_dom.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR027291. Glyco_hydro_38/57_N.
IPR011682. Glyco_hydro_38_C.
IPR015341. Glyco_hydro_38_cen.
IPR000602. Glyco_hydro_38_N.
[Graphical view]
PfamPF09261. Alpha-mann_mid. 1 hit.
PF01074. Glyco_hydro_38. 1 hit.
PF07748. Glyco_hydro_38C. 1 hit.
[Graphical view]
SMARTSM00872. Alpha-mann_mid. 1 hit.
[Graphical view]
SUPFAMSSF74650. SSF74650. 1 hit.
SSF88713. SSF88713. 1 hit.
ProtoNetSearch...

Other

NextBio623390.
PROP21139.

Entry information

Entry nameMA2C1_RAT
AccessionPrimary (citable) accession number: P21139
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: April 16, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries