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Protein

Alpha-mannosidase 2C1

Gene

Man2c1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cleaves alpha 1,2-, alpha 1,3-, and alpha 1,6-linked mannose residues from glycoproteins (PubMed:2211613). Involved in the degradation of free oligosaccharides in the cytoplasm (By similarity).By similarity1 Publication

Catalytic activityi

Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.1 Publication

Cofactori

Co2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi259CobaltCurated1
Metal bindingi261CobaltCurated1
Active sitei371NucleophileBy similarity1
Metal bindingi371CobaltCurated1
Metal bindingi576CobaltCurated1

GO - Molecular functioni

  • alpha-mannosidase activity Source: RGD
  • carbohydrate binding Source: InterPro
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
LigandCobalt, Metal-binding

Enzyme and pathway databases

SABIO-RKiP21139.

Protein family/group databases

CAZyiGH38. Glycoside Hydrolase Family 38.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-mannosidase 2C1 (EC:3.2.1.241 Publication)
Alternative name(s):
Alpha-D-mannoside mannohydrolase
Mannosidase alpha class 2C member 1
Gene namesi
Name:Man2c1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628787. Man2c1.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

  • endoplasmic reticulum Source: RGD
  • vacuole Source: GO_Central

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2852.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002069091 – 1040Alpha-mannosidase 2C1Add BLAST1040

Proteomic databases

PaxDbiP21139.
PRIDEiP21139.

Expressioni

Tissue specificityi

Widely expressed. Highest expression in testis, adrenal gland, and kidney.1 Publication

Interactioni

Protein-protein interaction databases

IntActiP21139. 1 interactor.
MINTiMINT-3389982.
STRINGi10116.ENSRNOP00000041867.

Chemistry databases

BindingDBiP21139.

Structurei

3D structure databases

ProteinModelPortaliP21139.
SMRiP21139.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 38 family.Curated

Phylogenomic databases

eggNOGiKOG4342. Eukaryota.
COG0383. LUCA.
HOGENOMiHOG000048425.
HOVERGENiHBG055567.
InParanoidiP21139.
KOiK01191.
PhylomeDBiP21139.

Family and domain databases

Gene3Di1.20.1270.50. 1 hit.
3.20.110.10. 1 hit.
InterProiView protein in InterPro
IPR011013. Gal_mutarotase_SF_dom.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR027291. Glyco_hydro_38/57_N.
IPR011682. Glyco_hydro_38_C.
IPR015341. Glyco_hydro_38_cen.
IPR000602. Glyco_hydro_38_N.
IPR028995. Glyco_hydro_57/38_cen.
PfamiView protein in Pfam
PF09261. Alpha-mann_mid. 1 hit.
PF01074. Glyco_hydro_38. 1 hit.
PF07748. Glyco_hydro_38C. 1 hit.
SMARTiView protein in SMART
SM00872. Alpha-mann_mid. 1 hit.
SUPFAMiSSF74650. SSF74650. 1 hit.
SSF88688. SSF88688. 1 hit.
SSF88713. SSF88713. 1 hit.

Sequencei

Sequence statusi: Complete.

P21139-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAPFLKHW RTTFERVEKF VSPIYFTDCN LRGRLFGDSC PVTLSSFLTP
60 70 80 90 100
ERLPYEKAVQ QNFSPAQVGD SFGPTWWTCW FRVELVIPEV WVGKEVHLCW
110 120 130 140 150
ESDGESLVWR DGEPVQGLTK EGEKTSYVLS ERLHAADPRS LTLYVEVACN
160 170 180 190 200
GLLGAGKGSM IAAPDPEKMF QLSQAKLAVF HRDVHNLLVD LELLLGVAKG
210 220 230 240 250
LGEDNQRSFQ ALYTANQMVN ICDPAQPETY PAAEALASKF FGQRGGESQH
260 270 280 290 300
TIHATGHCHI DTAWLWPFKE TVRKCARSWS TAVKLMERNT EFTFACSQAQ
310 320 330 340 350
QLEWVKNQYP GLYAQLQEFA CRGQFVPVGG TWVEMDGNLP SGEAMVRQFL
360 370 380 390 400
QGQNFFLQEF GKMCSEFWLP DTFGYSAQLP QIMQGCGIKR FLTQKLSWNL
410 420 430 440 450
VNSFPHHTFF WEGLDGSQVL VHFPPGDSYG MQGSVEEVLK TVTNNRDKGR
460 470 480 490 500
TNHSGFLFGF GDGGGGPTQT MLDRLKRLGN TDGQPRVQLS SPGQLFTALE
510 520 530 540 550
RDSGQLCTWV GELFLELHNG TYTTHAQLKK GNRECEQILH DVELLSSLAL
560 570 580 590 600
ARSAQFLYPA VQLQRLWRLL LLNQFHDVVT GSCIQLVAED AMNYYEDIRS
610 620 630 640 650
HGNTLLSAAA AALCAGEPGP KGLRHYQHTA LEAHRSVGTT QGLVGLTRLA
660 670 680 690 700
LVTVPSIGYA PAPTPTSLQP LLPQQPVFVM QETDGSVTLD NGIIRVRLDP
710 720 730 740 750
TGCLTSLVLV ASGREAIAEG ALGNQFVLFD DVPLYWDAWD VMDYHLETRK
760 770 780 790 800
PVRGQAGTLA VGAEGGLRGS AWFLLQISPN SRLSQEVVLD VGCPYVRFHT
810 820 830 840 850
EVHWHETHKF LKVEFPARVR SPQATYEIQF GHLQEADPQQ HSWDWARYEV
860 870 880 890 900
WAHRWIDLSE CDFGLALLNN CKYGTSVRGN VLSLSLLRAP KAPDVTADMG
910 920 930 940 950
RHEFTYALMP HKGSFQEAGV IQAAYNLNFP LLALPAPGPA PDTTWSAFSV
960 970 980 990 1000
SSPAVVLETI KQAEKSHQHR TLVLRLYEAH GSHVDCWLHT SLPVQEATLC
1010 1020 1030 1040
DLLEQRDPTG HLSLQDNRLK LTFSPFQVRS LLLVLQPPAN
Length:1,040
Mass (Da):115,971
Last modified:May 1, 1991 - v1
Checksum:i144F6EB97C8F7EA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57547 mRNA. Translation: AAA41565.1.
PIRiA38306.
RefSeqiNP_640349.1. NM_139256.1.
UniGeneiRn.11301.

Genome annotation databases

GeneIDi246136.
KEGGirno:246136.
UCSCiRGD:628787. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMA2C1_RAT
AccessioniPrimary (citable) accession number: P21139
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: July 5, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families