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P21139

- MA2C1_RAT

UniProt

P21139 - MA2C1_RAT

Protein

Alpha-mannosidase 2C1

Gene

Man2c1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 May 1991)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi259 – 2591ZincBy similarity
    Metal bindingi261 – 2611ZincBy similarity
    Active sitei371 – 3711NucleophileBy similarity
    Metal bindingi371 – 3711ZincBy similarity
    Metal bindingi576 – 5761ZincBy similarity

    GO - Molecular functioni

    1. alpha-mannosidase activity Source: RGD
    2. carbohydrate binding Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. mannose metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    SABIO-RKP21139.

    Protein family/group databases

    CAZyiGH38. Glycoside Hydrolase Family 38.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-mannosidase 2C1 (EC:3.2.1.24)
    Alternative name(s):
    Alpha-D-mannoside mannohydrolase
    Mannosidase alpha class 2C member 1
    Gene namesi
    Name:Man2c1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi628787. Man2c1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: RGD

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10401040Alpha-mannosidase 2C1PRO_0000206909Add
    BLAST

    Post-translational modificationi

    A soluble isoform of the rat liver mannosidase is supposed to be derived from endoplasmic reticulum membrane alpha-mannosidase by proteolysis.

    Proteomic databases

    PaxDbiP21139.
    PRIDEiP21139.

    Expressioni

    Gene expression databases

    GenevestigatoriP21139.

    Interactioni

    Protein-protein interaction databases

    IntActiP21139. 1 interaction.
    MINTiMINT-3389982.
    STRINGi10116.ENSRNOP00000041867.

    Structurei

    3D structure databases

    ProteinModelPortaliP21139.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 38 family.Curated

    Phylogenomic databases

    eggNOGiCOG0383.
    HOGENOMiHOG000048425.
    HOVERGENiHBG055567.
    InParanoidiP21139.
    KOiK01191.
    PhylomeDBiP21139.

    Family and domain databases

    Gene3Di1.20.1270.50. 1 hit.
    3.20.110.10. 1 hit.
    InterProiIPR011013. Gal_mutarotase_SF_dom.
    IPR011330. Glyco_hydro/deAcase_b/a-brl.
    IPR027291. Glyco_hydro_38/57_N.
    IPR011682. Glyco_hydro_38_C.
    IPR015341. Glyco_hydro_38_cen.
    IPR000602. Glyco_hydro_38_N.
    IPR028995. Glyco_hydro_57/38_cen.
    [Graphical view]
    PfamiPF09261. Alpha-mann_mid. 1 hit.
    PF01074. Glyco_hydro_38. 1 hit.
    PF07748. Glyco_hydro_38C. 1 hit.
    [Graphical view]
    SMARTiSM00872. Alpha-mann_mid. 1 hit.
    [Graphical view]
    SUPFAMiSSF74650. SSF74650. 1 hit.
    SSF88688. SSF88688. 1 hit.
    SSF88713. SSF88713. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P21139-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAAPFLKHW RTTFERVEKF VSPIYFTDCN LRGRLFGDSC PVTLSSFLTP     50
    ERLPYEKAVQ QNFSPAQVGD SFGPTWWTCW FRVELVIPEV WVGKEVHLCW 100
    ESDGESLVWR DGEPVQGLTK EGEKTSYVLS ERLHAADPRS LTLYVEVACN 150
    GLLGAGKGSM IAAPDPEKMF QLSQAKLAVF HRDVHNLLVD LELLLGVAKG 200
    LGEDNQRSFQ ALYTANQMVN ICDPAQPETY PAAEALASKF FGQRGGESQH 250
    TIHATGHCHI DTAWLWPFKE TVRKCARSWS TAVKLMERNT EFTFACSQAQ 300
    QLEWVKNQYP GLYAQLQEFA CRGQFVPVGG TWVEMDGNLP SGEAMVRQFL 350
    QGQNFFLQEF GKMCSEFWLP DTFGYSAQLP QIMQGCGIKR FLTQKLSWNL 400
    VNSFPHHTFF WEGLDGSQVL VHFPPGDSYG MQGSVEEVLK TVTNNRDKGR 450
    TNHSGFLFGF GDGGGGPTQT MLDRLKRLGN TDGQPRVQLS SPGQLFTALE 500
    RDSGQLCTWV GELFLELHNG TYTTHAQLKK GNRECEQILH DVELLSSLAL 550
    ARSAQFLYPA VQLQRLWRLL LLNQFHDVVT GSCIQLVAED AMNYYEDIRS 600
    HGNTLLSAAA AALCAGEPGP KGLRHYQHTA LEAHRSVGTT QGLVGLTRLA 650
    LVTVPSIGYA PAPTPTSLQP LLPQQPVFVM QETDGSVTLD NGIIRVRLDP 700
    TGCLTSLVLV ASGREAIAEG ALGNQFVLFD DVPLYWDAWD VMDYHLETRK 750
    PVRGQAGTLA VGAEGGLRGS AWFLLQISPN SRLSQEVVLD VGCPYVRFHT 800
    EVHWHETHKF LKVEFPARVR SPQATYEIQF GHLQEADPQQ HSWDWARYEV 850
    WAHRWIDLSE CDFGLALLNN CKYGTSVRGN VLSLSLLRAP KAPDVTADMG 900
    RHEFTYALMP HKGSFQEAGV IQAAYNLNFP LLALPAPGPA PDTTWSAFSV 950
    SSPAVVLETI KQAEKSHQHR TLVLRLYEAH GSHVDCWLHT SLPVQEATLC 1000
    DLLEQRDPTG HLSLQDNRLK LTFSPFQVRS LLLVLQPPAN 1040
    Length:1,040
    Mass (Da):115,971
    Last modified:May 1, 1991 - v1
    Checksum:i144F6EB97C8F7EA7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M57547 mRNA. Translation: AAA41565.1.
    PIRiA38306.
    RefSeqiNP_640349.1. NM_139256.1.
    UniGeneiRn.11301.

    Genome annotation databases

    GeneIDi246136.
    KEGGirno:246136.
    UCSCiRGD:628787. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M57547 mRNA. Translation: AAA41565.1 .
    PIRi A38306.
    RefSeqi NP_640349.1. NM_139256.1.
    UniGenei Rn.11301.

    3D structure databases

    ProteinModelPortali P21139.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P21139. 1 interaction.
    MINTi MINT-3389982.
    STRINGi 10116.ENSRNOP00000041867.

    Chemistry

    BindingDBi P21139.
    ChEMBLi CHEMBL2852.

    Protein family/group databases

    CAZyi GH38. Glycoside Hydrolase Family 38.

    Proteomic databases

    PaxDbi P21139.
    PRIDEi P21139.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 246136.
    KEGGi rno:246136.
    UCSCi RGD:628787. rat.

    Organism-specific databases

    CTDi 4123.
    RGDi 628787. Man2c1.

    Phylogenomic databases

    eggNOGi COG0383.
    HOGENOMi HOG000048425.
    HOVERGENi HBG055567.
    InParanoidi P21139.
    KOi K01191.
    PhylomeDBi P21139.

    Enzyme and pathway databases

    SABIO-RK P21139.

    Miscellaneous databases

    NextBioi 623390.
    PROi P21139.

    Gene expression databases

    Genevestigatori P21139.

    Family and domain databases

    Gene3Di 1.20.1270.50. 1 hit.
    3.20.110.10. 1 hit.
    InterProi IPR011013. Gal_mutarotase_SF_dom.
    IPR011330. Glyco_hydro/deAcase_b/a-brl.
    IPR027291. Glyco_hydro_38/57_N.
    IPR011682. Glyco_hydro_38_C.
    IPR015341. Glyco_hydro_38_cen.
    IPR000602. Glyco_hydro_38_N.
    IPR028995. Glyco_hydro_57/38_cen.
    [Graphical view ]
    Pfami PF09261. Alpha-mann_mid. 1 hit.
    PF01074. Glyco_hydro_38. 1 hit.
    PF07748. Glyco_hydro_38C. 1 hit.
    [Graphical view ]
    SMARTi SM00872. Alpha-mann_mid. 1 hit.
    [Graphical view ]
    SUPFAMi SSF74650. SSF74650. 1 hit.
    SSF88688. SSF88688. 1 hit.
    SSF88713. SSF88713. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Isolation, characterization, and expression of cDNA encoding a rat liver endoplasmic reticulum alpha-mannosidase."
      Bischoff J., Moremen K., Lodish H.F.
      J. Biol. Chem. 265:17110-17117(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Strain: Sprague-Dawley.
      Tissue: Liver.

    Entry informationi

    Entry nameiMA2C1_RAT
    AccessioniPrimary (citable) accession number: P21139
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: May 1, 1991
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3