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P21139

- MA2C1_RAT

UniProt

P21139 - MA2C1_RAT

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Protein

Alpha-mannosidase 2C1

Gene

Man2c1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.

Cofactori

Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi259 – 2591ZincBy similarity
Metal bindingi261 – 2611ZincBy similarity
Active sitei371 – 3711NucleophileBy similarity
Metal bindingi371 – 3711ZincBy similarity
Metal bindingi576 – 5761ZincBy similarity

GO - Molecular functioni

  1. alpha-mannosidase activity Source: RGD
  2. carbohydrate binding Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. mannose metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

SABIO-RKP21139.

Protein family/group databases

CAZyiGH38. Glycoside Hydrolase Family 38.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-mannosidase 2C1 (EC:3.2.1.24)
Alternative name(s):
Alpha-D-mannoside mannohydrolase
Mannosidase alpha class 2C member 1
Gene namesi
Name:Man2c1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi628787. Man2c1.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10401040Alpha-mannosidase 2C1PRO_0000206909Add
BLAST

Post-translational modificationi

A soluble isoform of the rat liver mannosidase is supposed to be derived from endoplasmic reticulum membrane alpha-mannosidase by proteolysis.

Proteomic databases

PaxDbiP21139.
PRIDEiP21139.

Expressioni

Gene expression databases

GenevestigatoriP21139.

Interactioni

Protein-protein interaction databases

IntActiP21139. 1 interaction.
MINTiMINT-3389982.
STRINGi10116.ENSRNOP00000041867.

Structurei

3D structure databases

ProteinModelPortaliP21139.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 38 family.Curated

Phylogenomic databases

eggNOGiCOG0383.
HOGENOMiHOG000048425.
HOVERGENiHBG055567.
InParanoidiP21139.
KOiK01191.
PhylomeDBiP21139.

Family and domain databases

Gene3Di1.20.1270.50. 1 hit.
3.20.110.10. 1 hit.
InterProiIPR011013. Gal_mutarotase_SF_dom.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR027291. Glyco_hydro_38/57_N.
IPR011682. Glyco_hydro_38_C.
IPR015341. Glyco_hydro_38_cen.
IPR000602. Glyco_hydro_38_N.
IPR028995. Glyco_hydro_57/38_cen.
[Graphical view]
PfamiPF09261. Alpha-mann_mid. 1 hit.
PF01074. Glyco_hydro_38. 1 hit.
PF07748. Glyco_hydro_38C. 1 hit.
[Graphical view]
SMARTiSM00872. Alpha-mann_mid. 1 hit.
[Graphical view]
SUPFAMiSSF74650. SSF74650. 1 hit.
SSF88688. SSF88688. 1 hit.
SSF88713. SSF88713. 1 hit.

Sequencei

Sequence statusi: Complete.

P21139-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAAPFLKHW RTTFERVEKF VSPIYFTDCN LRGRLFGDSC PVTLSSFLTP
60 70 80 90 100
ERLPYEKAVQ QNFSPAQVGD SFGPTWWTCW FRVELVIPEV WVGKEVHLCW
110 120 130 140 150
ESDGESLVWR DGEPVQGLTK EGEKTSYVLS ERLHAADPRS LTLYVEVACN
160 170 180 190 200
GLLGAGKGSM IAAPDPEKMF QLSQAKLAVF HRDVHNLLVD LELLLGVAKG
210 220 230 240 250
LGEDNQRSFQ ALYTANQMVN ICDPAQPETY PAAEALASKF FGQRGGESQH
260 270 280 290 300
TIHATGHCHI DTAWLWPFKE TVRKCARSWS TAVKLMERNT EFTFACSQAQ
310 320 330 340 350
QLEWVKNQYP GLYAQLQEFA CRGQFVPVGG TWVEMDGNLP SGEAMVRQFL
360 370 380 390 400
QGQNFFLQEF GKMCSEFWLP DTFGYSAQLP QIMQGCGIKR FLTQKLSWNL
410 420 430 440 450
VNSFPHHTFF WEGLDGSQVL VHFPPGDSYG MQGSVEEVLK TVTNNRDKGR
460 470 480 490 500
TNHSGFLFGF GDGGGGPTQT MLDRLKRLGN TDGQPRVQLS SPGQLFTALE
510 520 530 540 550
RDSGQLCTWV GELFLELHNG TYTTHAQLKK GNRECEQILH DVELLSSLAL
560 570 580 590 600
ARSAQFLYPA VQLQRLWRLL LLNQFHDVVT GSCIQLVAED AMNYYEDIRS
610 620 630 640 650
HGNTLLSAAA AALCAGEPGP KGLRHYQHTA LEAHRSVGTT QGLVGLTRLA
660 670 680 690 700
LVTVPSIGYA PAPTPTSLQP LLPQQPVFVM QETDGSVTLD NGIIRVRLDP
710 720 730 740 750
TGCLTSLVLV ASGREAIAEG ALGNQFVLFD DVPLYWDAWD VMDYHLETRK
760 770 780 790 800
PVRGQAGTLA VGAEGGLRGS AWFLLQISPN SRLSQEVVLD VGCPYVRFHT
810 820 830 840 850
EVHWHETHKF LKVEFPARVR SPQATYEIQF GHLQEADPQQ HSWDWARYEV
860 870 880 890 900
WAHRWIDLSE CDFGLALLNN CKYGTSVRGN VLSLSLLRAP KAPDVTADMG
910 920 930 940 950
RHEFTYALMP HKGSFQEAGV IQAAYNLNFP LLALPAPGPA PDTTWSAFSV
960 970 980 990 1000
SSPAVVLETI KQAEKSHQHR TLVLRLYEAH GSHVDCWLHT SLPVQEATLC
1010 1020 1030 1040
DLLEQRDPTG HLSLQDNRLK LTFSPFQVRS LLLVLQPPAN
Length:1,040
Mass (Da):115,971
Last modified:May 1, 1991 - v1
Checksum:i144F6EB97C8F7EA7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M57547 mRNA. Translation: AAA41565.1.
PIRiA38306.
RefSeqiNP_640349.1. NM_139256.1.
UniGeneiRn.11301.

Genome annotation databases

GeneIDi246136.
KEGGirno:246136.
UCSCiRGD:628787. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M57547 mRNA. Translation: AAA41565.1 .
PIRi A38306.
RefSeqi NP_640349.1. NM_139256.1.
UniGenei Rn.11301.

3D structure databases

ProteinModelPortali P21139.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P21139. 1 interaction.
MINTi MINT-3389982.
STRINGi 10116.ENSRNOP00000041867.

Chemistry

BindingDBi P21139.
ChEMBLi CHEMBL2852.

Protein family/group databases

CAZyi GH38. Glycoside Hydrolase Family 38.

Proteomic databases

PaxDbi P21139.
PRIDEi P21139.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 246136.
KEGGi rno:246136.
UCSCi RGD:628787. rat.

Organism-specific databases

CTDi 4123.
RGDi 628787. Man2c1.

Phylogenomic databases

eggNOGi COG0383.
HOGENOMi HOG000048425.
HOVERGENi HBG055567.
InParanoidi P21139.
KOi K01191.
PhylomeDBi P21139.

Enzyme and pathway databases

SABIO-RK P21139.

Miscellaneous databases

NextBioi 623390.
PROi P21139.

Gene expression databases

Genevestigatori P21139.

Family and domain databases

Gene3Di 1.20.1270.50. 1 hit.
3.20.110.10. 1 hit.
InterProi IPR011013. Gal_mutarotase_SF_dom.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR027291. Glyco_hydro_38/57_N.
IPR011682. Glyco_hydro_38_C.
IPR015341. Glyco_hydro_38_cen.
IPR000602. Glyco_hydro_38_N.
IPR028995. Glyco_hydro_57/38_cen.
[Graphical view ]
Pfami PF09261. Alpha-mann_mid. 1 hit.
PF01074. Glyco_hydro_38. 1 hit.
PF07748. Glyco_hydro_38C. 1 hit.
[Graphical view ]
SMARTi SM00872. Alpha-mann_mid. 1 hit.
[Graphical view ]
SUPFAMi SSF74650. SSF74650. 1 hit.
SSF88688. SSF88688. 1 hit.
SSF88713. SSF88713. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Isolation, characterization, and expression of cDNA encoding a rat liver endoplasmic reticulum alpha-mannosidase."
    Bischoff J., Moremen K., Lodish H.F.
    J. Biol. Chem. 265:17110-17117(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Strain: Sprague-Dawley.
    Tissue: Liver.

Entry informationi

Entry nameiMA2C1_RAT
AccessioniPrimary (citable) accession number: P21139
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: October 1, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3