P21137 (KAPC_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
cAMP-dependent protein kinase catalytic subunit
Short name=PKA C
EC=2.7.11.11

Gene names

Name:	kin-1
ORF Names:	ZK909.2

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	404 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subunit structure	Composed of two regulatory chains and two catalytic chains.
Sequence similarities	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Ligand	ATP-binding Nucleotide-binding cAMP
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	morphogenesis of an epithelium Inferred from mutant phenotype. Source: WormBase nematode larval development Inferred from mutant phenotype. Source: WormBase oviposition Inferred from mutant phenotype. Source: WormBase
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cAMP-dependent protein kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 13 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.

Isoform e (identifier: P21137-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform a (identifier: P21137-2)

Also known as: Major;

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MPTRLDIVGN...SILDDPVEDF → MLKFLKPKSSDEGSSKDNKNSASL
     349-404: TPPSFSKGES...PQLEELFVEF → EAPFLPKCRG...EKCAKEFAEF

Isoform b (identifier: P21137-3)

Also known as: Minor;

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MPTRLDIVGN...SILDDPVEDF → MLKFLKPKSSDEGSSKDNKNSASL

Isoform c (identifier: P21137-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: MPTRLDIVGN...DFKQRWENPA → MEEEEWRRRL...SDHWSMKWLF
     348-404: ITPPSFSKGESNGRLFEALYPRVDGPADTRHFVEEVQEPTEFVIAATPQLEELFVEF → VSSYPI

Isoform d (identifier: P21137-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: MPTRLDIVGNLQFSSSTDNGDEDQEADVTACFVLPSPSSFSKLSILDDPVED → MSSSSNKKVQVKF

Isoform f (identifier: P21137-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MPTRLDIVGN...SILDDPVEDF → MLSSSFFRGSMKERKNEALKNHKSKYISGGYLETV
     349-404: TPPSFSKGES...PQLEELFVEF → EAPFLPKCRG...EKCAKEFAEF

Isoform g (identifier: P21137-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MPTRLDIVGNLQFSSSTDNGDEDQEADVTACFVLPSPSSFSKLSILDDPVEDF → MGSMVFIV
     349-404: TPPSFSKGES...PQLEELFVEF → EAPFLPKCRG...EKCAKEFAEF

Isoform h (identifier: P21137-8)

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MPTRLDIVGN...SILDDPVEDF → MGNAASGGSS...NGRLAAAETI
     349-404: TPPSFSKGES...PQLEELFVEF → EAPFLPKCRG...EKCAKEFAEF

Isoform i (identifier: P21137-9)

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MPTRLDIVGNLQFSSSTDNGDEDQEADVTACFVLPSPSSFSKLSILDDPVEDF → MGSMVFIV

Isoform j (identifier: P21137-10)

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MPTRLDIVGN...SILDDPVEDF → MGNAASGGSS...NGRLAAAETI

Isoform k (identifier: P21137-11)

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MPTRLDIVGN...SILDDPVEDF → MLSSSFFRGSMKERKNEALKNHKSKYISGGYLETV

Isoform l (identifier: P21137-12)

The sequence of this isoform differs from the canonical sequence as follows:
     349-404: TPPSFSKGES...PQLEELFVEF → EAPFLPKCRG...EKCAKEFAEF

Isoform m (identifier: P21137-13)

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: MPTRLDIVGNLQFSSSTDNGDEDQEADVTACFVLPSPSSFSKLSILDDPVED → MSSSSNKKVQVKF
     349-404: TPPSFSKGES...PQLEELFVEF → EAPFLPKCRG...EKCAKEFAEF

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 404	404	cAMP-dependent protein kinase catalytic subunit		PRO_0000086067
Regions
	Domain	81 – 335	255	Protein kinase
	Nucleotide binding	87 – 95	9	ATP By similarity
Sites
	Active site	204	1	Proton acceptor By similarity
	Binding site	110	1	ATP By similarity
Amino acid modifications
	Modified residue	233	1	Phosphothreonine Potential
	Modified residue	376	1	Phosphothreonine Potential
Natural variations
	Alternative sequence	1 – 72	72	MPTRL…WENPA → MEEEEWRRRLSAAIRREDEG SLEEDEEDEGFILHPLCRTG PLQMTVKASNSTTTLTPSST TTTSPSMPSSPSDSPSDDFS DDTNTSGVFPLTTALSFPVA PLSPRNTTSSITTGLVKKRR SSSSPEDICREKIPHILLKT SSGVVVPLASRGQRAPAITL QNPPPSAAIRTVPPPSFSTF SVRSLPFKTPNCGSKDDTDA ENMEGLDDDYLRQPTTSTSA PVSPIDHRQVRRGGRGVVVE SQVPNFTAEIFWLKTQLSDH WSMKWLF in isoform c.		VSP_004756
	Alternative sequence	1 – 53	53	MPTRL…PVEDF → MLKFLKPKSSDEGSSKDNKN SASL in isoform a and isoform b.		VSP_004751
	Alternative sequence	1 – 53	53	MPTRL…PVEDF → MLSSSFFRGSMKERKNEALK NHKSKYISGGYLETV in isoform f and isoform k.		VSP_004752
	Alternative sequence	1 – 53	53	MPTRL…PVEDF → MGSMVFIV in isoform g and isoform i.		VSP_004754
	Alternative sequence	1 – 53	53	MPTRL…PVEDF → MGNAASGGSSGGGGSARRGN GGGNNGSDYNNAMVFSNGRL AAAETI in isoform h and isoform j.		VSP_004753
	Alternative sequence	1 – 52	52	MPTRL…DPVED → MSSSSNKKVQVKF in isoform d and isoform m.		VSP_004750
	Alternative sequence	348 – 404	57	ITPPS…LFVEF → VSSYPI in isoform c.		VSP_004757
	Alternative sequence	349 – 404	56	TPPSF…LFVEF → EAPFLPKCRGPGDASNFDDY EEEPLRISGTEKCAKEFAEF in isoform a, isoform f, isoform g, isoform h, isoform l and isoform m.		VSP_004758
Experimental info
	Sequence conflict	148	1	F → L in AAA51610. Ref.1
	Sequence conflict	220	1	I → V in AAA51610. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform e [UniParc]. Last modified February 12, 2003. Version 3. Checksum: A7AF458E47B58876	FASTA	404	46,346
	10 20 30 40 50 60 MPTRLDIVGN LQFSSSTDNG DEDQEADVTA CFVLPSPSSF SKLSILDDPV EDFKEFLDKA 70 80 90 100 110 120 REDFKQRWEN PAQNTACLDD FDRIKTLGTG SFGRVMLVKH KQSGNYYAMK ILDKQKVVKL 130 140 150 160 170 180 KQVEHTLNEK RILQAIDFPF LVNMTFSFKD NSNLYMVLEF ISGGEMFSHL RRIGRFSEPH 190 200 210 220 230 240 SRFYAAQIVL AFEYLHSLDL IYRDLKPENL LIDSTGYLKI TDFGFAKRVK GRTWTLCGTP 250 260 270 280 290 300 EYLAPEIILS KGYNKAVDWW ALGVLIYEMA AGYPPFFADQ PIQIYEKIVS GKVKFPSHFS 310 320 330 340 350 360 NELKDLLKNL LQVDLTKRYG NLKNGVADIK NHKWFGSTDW IAIYQKKITP PSFSKGESNG 370 380 390 400 RLFEALYPRV DGPADTRHFV EEVQEPTEFV IAATPQLEEL FVEF
	Isoform a (Major) [UniParc]. Checksum: FC6F619DE13423ED	FASTA	359	41,376
	10 20 30 40 50 60 MLKFLKPKSS DEGSSKDNKN SASLKEFLDK AREDFKQRWE NPAQNTACLD DFDRIKTLGT 70 80 90 100 110 120 GSFGRVMLVK HKQSGNYYAM KILDKQKVVK LKQVEHTLNE KRILQAIDFP FLVNMTFSFK 130 140 150 160 170 180 DNSNLYMVLE FISGGEMFSH LRRIGRFSEP HSRFYAAQIV LAFEYLHSLD LIYRDLKPEN 190 200 210 220 230 240 LLIDSTGYLK ITDFGFAKRV KGRTWTLCGT PEYLAPEIIL SKGYNKAVDW WALGVLIYEM 250 260 270 280 290 300 AAGYPPFFAD QPIQIYEKIV SGKVKFPSHF SNELKDLLKN LLQVDLTKRY GNLKNGVADI 310 320 330 340 350 KNHKWFGSTD WIAIYQKKIE APFLPKCRGP GDASNFDDYE EEPLRISGTE KCAKEFAEF
	Isoform b (Minor) [UniParc]. Checksum: F223CB8D23855ED6	FASTA	375	43,207
	10 20 30 40 50 60 MLKFLKPKSS DEGSSKDNKN SASLKEFLDK AREDFKQRWE NPAQNTACLD DFDRIKTLGT 70 80 90 100 110 120 GSFGRVMLVK HKQSGNYYAM KILDKQKVVK LKQVEHTLNE KRILQAIDFP FLVNMTFSFK 130 140 150 160 170 180 DNSNLYMVLE FISGGEMFSH LRRIGRFSEP HSRFYAAQIV LAFEYLHSLD LIYRDLKPEN 190 200 210 220 230 240 LLIDSTGYLK ITDFGFAKRV KGRTWTLCGT PEYLAPEIIL SKGYNKAVDW WALGVLIYEM 250 260 270 280 290 300 AAGYPPFFAD QPIQIYEKIV SGKVKFPSHF SNELKDLLKN LLQVDLTKRY GNLKNGVADI 310 320 330 340 350 360 KNHKWFGSTD WIAIYQKKIT PPSFSKGESN GRLFEALYPR VDGPADTRHF VEEVQEPTEF 370 VIAATPQLEE LFVEF
	Isoform c [UniParc]. Checksum: A6801D3CC2562500	FASTA	548	61,664
	10 20 30 40 50 60 MEEEEWRRRL SAAIRREDEG SLEEDEEDEG FILHPLCRTG PLQMTVKASN STTTLTPSST 70 80 90 100 110 120 TTTSPSMPSS PSDSPSDDFS DDTNTSGVFP LTTALSFPVA PLSPRNTTSS ITTGLVKKRR 130 140 150 160 170 180 SSSSPEDICR EKIPHILLKT SSGVVVPLAS RGQRAPAITL QNPPPSAAIR TVPPPSFSTF 190 200 210 220 230 240 SVRSLPFKTP NCGSKDDTDA ENMEGLDDDY LRQPTTSTSA PVSPIDHRQV RRGGRGVVVE 250 260 270 280 290 300 SQVPNFTAEI FWLKTQLSDH WSMKWLFQNT ACLDDFDRIK TLGTGSFGRV MLVKHKQSGN 310 320 330 340 350 360 YYAMKILDKQ KVVKLKQVEH TLNEKRILQA IDFPFLVNMT FSFKDNSNLY MVLEFISGGE 370 380 390 400 410 420 MFSHLRRIGR FSEPHSRFYA AQIVLAFEYL HSLDLIYRDL KPENLLIDST GYLKITDFGF 430 440 450 460 470 480 AKRVKGRTWT LCGTPEYLAP EIILSKGYNK AVDWWALGVL IYEMAAGYPP FFADQPIQIY 490 500 510 520 530 540 EKIVSGKVKF PSHFSNELKD LLKNLLQVDL TKRYGNLKNG VADIKNHKWF GSTDWIAIYQ KKVSSYPI
	Isoform d [UniParc]. Checksum: A77B551D6E272197	FASTA	365	42,212
	10 20 30 40 50 60 MSSSSNKKVQ VKFFKEFLDK AREDFKQRWE NPAQNTACLD DFDRIKTLGT GSFGRVMLVK 70 80 90 100 110 120 HKQSGNYYAM KILDKQKVVK LKQVEHTLNE KRILQAIDFP FLVNMTFSFK DNSNLYMVLE 130 140 150 160 170 180 FISGGEMFSH LRRIGRFSEP HSRFYAAQIV LAFEYLHSLD LIYRDLKPEN LLIDSTGYLK 190 200 210 220 230 240 ITDFGFAKRV KGRTWTLCGT PEYLAPEIIL SKGYNKAVDW WALGVLIYEM AAGYPPFFAD 250 260 270 280 290 300 QPIQIYEKIV SGKVKFPSHF SNELKDLLKN LLQVDLTKRY GNLKNGVADI KNHKWFGSTD 310 320 330 340 350 360 WIAIYQKKIT PPSFSKGESN GRLFEALYPR VDGPADTRHF VEEVQEPTEF VIAATPQLEE LFVEF
	Isoform f [UniParc]. Checksum: 3FEFB33C4D9F77CC	FASTA	370	42,788
	10 20 30 40 50 60 MLSSSFFRGS MKERKNEALK NHKSKYISGG YLETVKEFLD KAREDFKQRW ENPAQNTACL 70 80 90 100 110 120 DDFDRIKTLG TGSFGRVMLV KHKQSGNYYA MKILDKQKVV KLKQVEHTLN EKRILQAIDF 130 140 150 160 170 180 PFLVNMTFSF KDNSNLYMVL EFISGGEMFS HLRRIGRFSE PHSRFYAAQI VLAFEYLHSL 190 200 210 220 230 240 DLIYRDLKPE NLLIDSTGYL KITDFGFAKR VKGRTWTLCG TPEYLAPEII LSKGYNKAVD 250 260 270 280 290 300 WWALGVLIYE MAAGYPPFFA DQPIQIYEKI VSGKVKFPSH FSNELKDLLK NLLQVDLTKR 310 320 330 340 350 360 YGNLKNGVAD IKNHKWFGST DWIAIYQKKI EAPFLPKCRG PGDASNFDDY EEEPLRISGT 370 EKCAKEFAEF
	Isoform g [UniParc]. Checksum: 72E31AE8EB2A7DD4	FASTA	343	39,647
	10 20 30 40 50 60 MGSMVFIVKE FLDKAREDFK QRWENPAQNT ACLDDFDRIK TLGTGSFGRV MLVKHKQSGN 70 80 90 100 110 120 YYAMKILDKQ KVVKLKQVEH TLNEKRILQA IDFPFLVNMT FSFKDNSNLY MVLEFISGGE 130 140 150 160 170 180 MFSHLRRIGR FSEPHSRFYA AQIVLAFEYL HSLDLIYRDL KPENLLIDST GYLKITDFGF 190 200 210 220 230 240 AKRVKGRTWT LCGTPEYLAP EIILSKGYNK AVDWWALGVL IYEMAAGYPP FFADQPIQIY 250 260 270 280 290 300 EKIVSGKVKF PSHFSNELKD LLKNLLQVDL TKRYGNLKNG VADIKNHKWF GSTDWIAIYQ 310 320 330 340 KKIEAPFLPK CRGPGDASNF DDYEEEPLRI SGTEKCAKEF AEF
	Isoform h [UniParc]. Checksum: 132C7749D7DB2D03	FASTA	381	43,054
	10 20 30 40 50 60 MGNAASGGSS GGGGSARRGN GGGNNGSDYN NAMVFSNGRL AAAETIKEFL DKAREDFKQR 70 80 90 100 110 120 WENPAQNTAC LDDFDRIKTL GTGSFGRVML VKHKQSGNYY AMKILDKQKV VKLKQVEHTL 130 140 150 160 170 180 NEKRILQAID FPFLVNMTFS FKDNSNLYMV LEFISGGEMF SHLRRIGRFS EPHSRFYAAQ 190 200 210 220 230 240 IVLAFEYLHS LDLIYRDLKP ENLLIDSTGY LKITDFGFAK RVKGRTWTLC GTPEYLAPEI 250 260 270 280 290 300 ILSKGYNKAV DWWALGVLIY EMAAGYPPFF ADQPIQIYEK IVSGKVKFPS HFSNELKDLL 310 320 330 340 350 360 KNLLQVDLTK RYGNLKNGVA DIKNHKWFGS TDWIAIYQKK IEAPFLPKCR GPGDASNFDD 370 380 YEEEPLRISG TEKCAKEFAE F
	Isoform i [UniParc]. Checksum: 944813B3CA3EF047	FASTA	359	41,478
	10 20 30 40 50 60 MGSMVFIVKE FLDKAREDFK QRWENPAQNT ACLDDFDRIK TLGTGSFGRV MLVKHKQSGN 70 80 90 100 110 120 YYAMKILDKQ KVVKLKQVEH TLNEKRILQA IDFPFLVNMT FSFKDNSNLY MVLEFISGGE 130 140 150 160 170 180 MFSHLRRIGR FSEPHSRFYA AQIVLAFEYL HSLDLIYRDL KPENLLIDST GYLKITDFGF 190 200 210 220 230 240 AKRVKGRTWT LCGTPEYLAP EIILSKGYNK AVDWWALGVL IYEMAAGYPP FFADQPIQIY 250 260 270 280 290 300 EKIVSGKVKF PSHFSNELKD LLKNLLQVDL TKRYGNLKNG VADIKNHKWF GSTDWIAIYQ 310 320 330 340 350 KKITPPSFSK GESNGRLFEA LYPRVDGPAD TRHFVEEVQE PTEFVIAATP QLEELFVEF
	Isoform j [UniParc]. Checksum: 8F4257A19C3CC0B6	FASTA	397	44,885
	10 20 30 40 50 60 MGNAASGGSS GGGGSARRGN GGGNNGSDYN NAMVFSNGRL AAAETIKEFL DKAREDFKQR 70 80 90 100 110 120 WENPAQNTAC LDDFDRIKTL GTGSFGRVML VKHKQSGNYY AMKILDKQKV VKLKQVEHTL 130 140 150 160 170 180 NEKRILQAID FPFLVNMTFS FKDNSNLYMV LEFISGGEMF SHLRRIGRFS EPHSRFYAAQ 190 200 210 220 230 240 IVLAFEYLHS LDLIYRDLKP ENLLIDSTGY LKITDFGFAK RVKGRTWTLC GTPEYLAPEI 250 260 270 280 290 300 ILSKGYNKAV DWWALGVLIY EMAAGYPPFF ADQPIQIYEK IVSGKVKFPS HFSNELKDLL 310 320 330 340 350 360 KNLLQVDLTK RYGNLKNGVA DIKNHKWFGS TDWIAIYQKK ITPPSFSKGE SNGRLFEALY 370 380 390 PRVDGPADTR HFVEEVQEPT EFVIAATPQL EELFVEF
	Isoform k [UniParc]. Checksum: 87FEAE1CC31AD9FB	FASTA	386	44,619
	10 20 30 40 50 60 MLSSSFFRGS MKERKNEALK NHKSKYISGG YLETVKEFLD KAREDFKQRW ENPAQNTACL 70 80 90 100 110 120 DDFDRIKTLG TGSFGRVMLV KHKQSGNYYA MKILDKQKVV KLKQVEHTLN EKRILQAIDF 130 140 150 160 170 180 PFLVNMTFSF KDNSNLYMVL EFISGGEMFS HLRRIGRFSE PHSRFYAAQI VLAFEYLHSL 190 200 210 220 230 240 DLIYRDLKPE NLLIDSTGYL KITDFGFAKR VKGRTWTLCG TPEYLAPEII LSKGYNKAVD 250 260 270 280 290 300 WWALGVLIYE MAAGYPPFFA DQPIQIYEKI VSGKVKFPSH FSNELKDLLK NLLQVDLTKR 310 320 330 340 350 360 YGNLKNGVAD IKNHKWFGST DWIAIYQKKI TPPSFSKGES NGRLFEALYP RVDGPADTRH 370 380 FVEEVQEPTE FVIAATPQLE ELFVEF
	Isoform l [UniParc]. Checksum: 9376F56725E780B5	FASTA	388	44,515
	10 20 30 40 50 60 MPTRLDIVGN LQFSSSTDNG DEDQEADVTA CFVLPSPSSF SKLSILDDPV EDFKEFLDKA 70 80 90 100 110 120 REDFKQRWEN PAQNTACLDD FDRIKTLGTG SFGRVMLVKH KQSGNYYAMK ILDKQKVVKL 130 140 150 160 170 180 KQVEHTLNEK RILQAIDFPF LVNMTFSFKD NSNLYMVLEF ISGGEMFSHL RRIGRFSEPH 190 200 210 220 230 240 SRFYAAQIVL AFEYLHSLDL IYRDLKPENL LIDSTGYLKI TDFGFAKRVK GRTWTLCGTP 250 260 270 280 290 300 EYLAPEIILS KGYNKAVDWW ALGVLIYEMA AGYPPFFADQ PIQIYEKIVS GKVKFPSHFS 310 320 330 340 350 360 NELKDLLKNL LQVDLTKRYG NLKNGVADIK NHKWFGSTDW IAIYQKKIEA PFLPKCRGPG 370 380 DASNFDDYEE EPLRISGTEK CAKEFAEF
	Isoform m [UniParc]. Checksum: C486DFDB5F4F033A	FASTA	349	40,381
	10 20 30 40 50 60 MSSSSNKKVQ VKFFKEFLDK AREDFKQRWE NPAQNTACLD DFDRIKTLGT GSFGRVMLVK 70 80 90 100 110 120 HKQSGNYYAM KILDKQKVVK LKQVEHTLNE KRILQAIDFP FLVNMTFSFK DNSNLYMVLE 130 140 150 160 170 180 FISGGEMFSH LRRIGRFSEP HSRFYAAQIV LAFEYLHSLD LIYRDLKPEN LLIDSTGYLK 190 200 210 220 230 240 ITDFGFAKRV KGRTWTLCGT PEYLAPEIIL SKGYNKAVDW WALGVLIYEM AAGYPPFFAD 250 260 270 280 290 300 QPIQIYEKIV SGKVKFPSHF SNELKDLLKN LLQVDLTKRY GNLKNGVADI KNHKWFGSTD 310 320 330 340 WIAIYQKKIE APFLPKCRGP GDASNFDDYE EEPLRISGTE KCAKEFAEF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, characterization, and expression of the gene for the catalytic subunit of cAMP-dependent protein kinase in Caenorhabditis elegans. Identification of highly conserved and unique isoforms generated by alternative splicing." Gross R.E., Bagchi S., Lu X., Rubin C.S. J. Biol. Chem. 265:6896-6907(1990) [PubMed: 2324104] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM B). Strain: Bristol N2.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M37119 , M37114, M37115, M37116, M37117, M37118 Genomic DNA. Translation: AAA51610.1. Z82096 Genomic DNA. Translation: CAD45613.1. Z82096 Genomic DNA. Translation: CAD45614.1. Z82096 Genomic DNA. Translation: CAD45615.1. Z82096, Z81511 Genomic DNA. Translation: CAD45616.1. Z82096, Z81511 Genomic DNA. Translation: CAD45617.1. Z82096, Z81511 Genomic DNA. Translation: CAD45618.1. Z82096, Z81511 Genomic DNA. Translation: CAD45619.1. Z82096, Z81511 Genomic DNA. Translation: CAD45620.1. Z82096, Z81511 Genomic DNA. Translation: CAD45621.1. Z82096, Z81511 Genomic DNA. Translation: CAD45622.1. Z82096, Z81511 Genomic DNA. Translation: CAD45623.1. Z82096, Z81511 Genomic DNA. Translation: CAB05034.1. Z82096, Z81511 Genomic DNA. Translation: CAB05035.1. Z81511, Z82096 Genomic DNA. Translation: CAB04168.1. Z81511, Z82096 Genomic DNA. Translation: CAB04169.1. Z81511, Z82096 Genomic DNA. Translation: CAD45583.1. Z81511, Z82096 Genomic DNA. Translation: CAD45584.1. Z81511, Z82096 Genomic DNA. Translation: CAD45585.1. Z81511, Z82096 Genomic DNA. Translation: CAD45586.1. Z81511, Z82096 Genomic DNA. Translation: CAD45587.1. Z81511, Z82096 Genomic DNA. Translation: CAD45588.1. Z81511, Z82096 Genomic DNA. Translation: CAD45589.1. Z81511, Z82096 Genomic DNA. Translation: CAD45590.1.
PIR	OKKWC1. A35755. OKKWC2. B35755. T21211. T21212.
RefSeq	NP_493605.1. NM_061204.2. NP_493606.1. NM_061205.2. NP_740954.1. NM_170958.2. NP_740955.1. NM_170959.3. NP_740956.1. NM_170960.2. NP_740957.1. NM_170961.1. NP_740958.1. NM_170962.2. NP_740959.1. NM_170963.1. NP_740960.1. NM_170964.2. NP_740961.1. NM_170965.1. NP_740962.1. NM_170966.1. NP_740963.1. NM_170967.2. NP_740964.1. NM_170968.2.
UniGene	Cel.177.
3D structure databases
ProteinModelPortal	P21137.
SMR	P21137. Positions 54-404.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-26547N.
MINT	MINT-1107666.
STRING	P21137.
Proteomic databases
PRIDE	P21137.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	ZK909.2e; ZK909.2e; ZK909.2.
GeneID	3565407.
KEGG	cel:ZK909.2.
UCSC	ZK909.2h.1. c. elegans.
Organism-specific databases
CTD	3565407.
WormBase	ZK909.2a; CE15473; WBGene00002189; kin-1. ZK909.2b; CE15475; WBGene00002189; kin-1. ZK909.2c; CE31755; WBGene00002189; kin-1. ZK909.2d; CE31756; WBGene00002189; kin-1. ZK909.2e; CE31757; WBGene00002189; kin-1. ZK909.2f; CE31758; WBGene00002189; kin-1. ZK909.2g; CE31759; WBGene00002189; kin-1. ZK909.2h; CE31760; WBGene00002189; kin-1. ZK909.2i; CE31761; WBGene00002189; kin-1. ZK909.2j; CE31762; WBGene00002189; kin-1. ZK909.2k; CE31763; WBGene00002189; kin-1. ZK909.2l; CE31764; WBGene00002189; kin-1. ZK909.2m; CE31765; WBGene00002189; kin-1.
Phylogenomic databases
eggNOG	meNOG05816.
InParanoid	P21137.
OMA	NAATANK.
PhylomeDB	P21137.
Enzyme and pathway databases
BRENDA	2.7.11.11. 1045.
Gene expression databases
ArrayExpress	P21137.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_kinase-like_dom. IPR008271. Ser/Thr_kinase_AS. IPR002290. Ser/Thr_kinase_dom. [Graphical view]
KO	K04345.
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	956345.

Entry information

Entry name

KAPC_CAEEL

Accession

Primary (citable) accession number: P21137
Secondary accession number(s): O18310, O18311

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
Last sequence update:	February 12, 2003
Last modified:	November 16, 2011
This is version 107 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project