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P21129

- P3_MOUSE

UniProt

P21129 - P3_MOUSE

Protein

P3 protein

Gene

Slc10a3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (30 Aug 2005)
      Previous versions | rss
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    Functioni

    The ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions.

    GO - Molecular functioni

    1. bile acid:sodium symporter activity Source: InterPro

    GO - Biological processi

    1. response to organic substance Source: MGI
    2. response to retinoic acid Source: MGI

    Keywords - Biological processi

    Symport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    P3 protein
    Alternative name(s):
    Solute carrier family 10 member 3
    Gene namesi
    Name:Slc10a3
    Synonyms:P3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:95048. Slc10a3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 473473P3 proteinPRO_0000052344Add
    BLAST

    Proteomic databases

    PRIDEiP21129.

    PTM databases

    PhosphoSiteiP21129.

    Expressioni

    Gene expression databases

    ArrayExpressiP21129.
    BgeeiP21129.
    GenevestigatoriP21129.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000045150.

    Structurei

    3D structure databases

    ProteinModelPortaliP21129.
    SMRiP21129. Positions 190-469.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei221 – 24121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei249 – 26921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei277 – 29721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei316 – 33621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei356 – 37621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei381 – 40121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei413 – 43321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei446 – 46621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0385.
    GeneTreeiENSGT00550000074505.
    HOGENOMiHOG000037944.
    HOVERGENiHBG002872.
    InParanoidiP21129.
    KOiK14343.
    OMAiPLIFVNK.
    PhylomeDBiP21129.
    TreeFamiTF315811.

    Family and domain databases

    InterProiIPR002657. BilAc/Na_symport.
    [Graphical view]
    PANTHERiPTHR10361. PTHR10361. 1 hit.
    PfamiPF01758. SBF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P21129-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVVKKSRGSS QQLPGLGGQG GCTGFVGMLG TALLFISLPW GAQVMASANI    50
    STALGHTSGH YLSIGDGSVT EFDFPEKSEG IIVISSQYTG QTNGTGPSPI 100
    LKVISLDTEV LTIKNVSAIT WSSGGGFVVG IHSGLAGLAP LHLQLMDFYE 150
    APPLLIEERR DFCIRVSPAE DLPSALNTNL GHFSENPILY LLLPLIFVNK 200
    CSFGCKVELE VLKELLQSPQ PMLLGLLGQF LVMPFYAFLM AKVFMLPKAL 250
    ALGLIITCSS PGGGGSYLFS LLLGGDVTLA ISMTFISTVA ATGFLPLSSA 300
    IYSYLLSIHE TLHVPISKIL GTLLFIAIPI AAGVVIKSKL PKFSELLLQV 350
    IKPFSFILLL GGLFLAYHMG VFILVGVRLP IVLVGFTVPL VGLLVGYSLA 400
    ICLKLPVAQR RTVSIEVGVQ NSLLALAMLQ LSLRRLQADY ASQAPFIVAL 450
    SGTSEMLALV IGQFIYSILF PVP 473
    Length:473
    Mass (Da):50,255
    Last modified:August 30, 2005 - v2
    Checksum:i9A2AD0A005DD1805
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK041958 mRNA. Translation: BAC31110.1.
    BC023050 mRNA. Translation: AAH23050.1.
    BC027440 mRNA. Translation: AAH27440.1.
    J04761 Genomic DNA. Translation: AAA40519.1.
    CCDSiCCDS30231.1.
    PIRiI54222.
    RefSeqiNP_001243033.1. NM_001256104.1.
    NP_663381.1. NM_145406.2.
    UniGeneiMm.19931.

    Genome annotation databases

    EnsembliENSMUST00000037967; ENSMUSP00000045150; ENSMUSG00000032806.
    ENSMUST00000073067; ENSMUSP00000072818; ENSMUSG00000032806.
    ENSMUST00000114146; ENSMUSP00000109783; ENSMUSG00000032806.
    GeneIDi214601.
    KEGGimmu:214601.
    UCSCiuc009tou.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK041958 mRNA. Translation: BAC31110.1 .
    BC023050 mRNA. Translation: AAH23050.1 .
    BC027440 mRNA. Translation: AAH27440.1 .
    J04761 Genomic DNA. Translation: AAA40519.1 .
    CCDSi CCDS30231.1.
    PIRi I54222.
    RefSeqi NP_001243033.1. NM_001256104.1.
    NP_663381.1. NM_145406.2.
    UniGenei Mm.19931.

    3D structure databases

    ProteinModelPortali P21129.
    SMRi P21129. Positions 190-469.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000045150.

    PTM databases

    PhosphoSitei P21129.

    Proteomic databases

    PRIDEi P21129.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000037967 ; ENSMUSP00000045150 ; ENSMUSG00000032806 .
    ENSMUST00000073067 ; ENSMUSP00000072818 ; ENSMUSG00000032806 .
    ENSMUST00000114146 ; ENSMUSP00000109783 ; ENSMUSG00000032806 .
    GeneIDi 214601.
    KEGGi mmu:214601.
    UCSCi uc009tou.2. mouse.

    Organism-specific databases

    CTDi 8273.
    MGIi MGI:95048. Slc10a3.

    Phylogenomic databases

    eggNOGi COG0385.
    GeneTreei ENSGT00550000074505.
    HOGENOMi HOG000037944.
    HOVERGENi HBG002872.
    InParanoidi P21129.
    KOi K14343.
    OMAi PLIFVNK.
    PhylomeDBi P21129.
    TreeFami TF315811.

    Miscellaneous databases

    NextBioi 374388.
    PROi P21129.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P21129.
    Bgeei P21129.
    Genevestigatori P21129.

    Family and domain databases

    InterProi IPR002657. BilAc/Na_symport.
    [Graphical view ]
    PANTHERi PTHR10361. PTHR10361. 1 hit.
    Pfami PF01758. SBF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Thymus.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    3. "Linkage and sequence conservation of the X-linked genes DXS253E (P3) and DXS254E (GdX) in mouse and man."
      Filippi M., Tribioli C., Toniolo D.
      Genomics 7:453-457(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 292-473.
      Strain: BALB/c.
      Tissue: Liver.

    Entry informationi

    Entry nameiP3_MOUSE
    AccessioniPrimary (citable) accession number: P21129
    Secondary accession number(s): Q8QZR2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3