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P21129 (P3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
P3 protein
Alternative name(s):
Solute carrier family 10 member 3
Gene names
Name:Slc10a3
Synonyms:P3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length473 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions.

Subcellular location

Membrane; Multi-pass membrane protein Probable.

Sequence similarities

Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 473473P3 protein
PRO_0000052344

Regions

Transmembrane25 – 4521Helical; Potential
Transmembrane221 – 24121Helical; Potential
Transmembrane249 – 26921Helical; Potential
Transmembrane277 – 29721Helical; Potential
Transmembrane316 – 33621Helical; Potential
Transmembrane356 – 37621Helical; Potential
Transmembrane381 – 40121Helical; Potential
Transmembrane413 – 43321Helical; Potential
Transmembrane446 – 46621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P21129 [UniParc].

Last modified August 30, 2005. Version 2.
Checksum: 9A2AD0A005DD1805

FASTA47350,255
        10         20         30         40         50         60 
MVVKKSRGSS QQLPGLGGQG GCTGFVGMLG TALLFISLPW GAQVMASANI STALGHTSGH 

        70         80         90        100        110        120 
YLSIGDGSVT EFDFPEKSEG IIVISSQYTG QTNGTGPSPI LKVISLDTEV LTIKNVSAIT 

       130        140        150        160        170        180 
WSSGGGFVVG IHSGLAGLAP LHLQLMDFYE APPLLIEERR DFCIRVSPAE DLPSALNTNL 

       190        200        210        220        230        240 
GHFSENPILY LLLPLIFVNK CSFGCKVELE VLKELLQSPQ PMLLGLLGQF LVMPFYAFLM 

       250        260        270        280        290        300 
AKVFMLPKAL ALGLIITCSS PGGGGSYLFS LLLGGDVTLA ISMTFISTVA ATGFLPLSSA 

       310        320        330        340        350        360 
IYSYLLSIHE TLHVPISKIL GTLLFIAIPI AAGVVIKSKL PKFSELLLQV IKPFSFILLL 

       370        380        390        400        410        420 
GGLFLAYHMG VFILVGVRLP IVLVGFTVPL VGLLVGYSLA ICLKLPVAQR RTVSIEVGVQ 

       430        440        450        460        470 
NSLLALAMLQ LSLRRLQADY ASQAPFIVAL SGTSEMLALV IGQFIYSILF PVP 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Thymus.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
[3]"Linkage and sequence conservation of the X-linked genes DXS253E (P3) and DXS254E (GdX) in mouse and man."
Filippi M., Tribioli C., Toniolo D.
Genomics 7:453-457(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 292-473.
Strain: BALB/c.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK041958 mRNA. Translation: BAC31110.1.
BC023050 mRNA. Translation: AAH23050.1.
BC027440 mRNA. Translation: AAH27440.1.
J04761 Genomic DNA. Translation: AAA40519.1.
CCDSCCDS30231.1.
PIRI54222.
RefSeqNP_001243033.1. NM_001256104.1.
NP_663381.1. NM_145406.2.
UniGeneMm.19931.

3D structure databases

ProteinModelPortalP21129.
SMRP21129. Positions 190-469.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000045150.

PTM databases

PhosphoSiteP21129.

Proteomic databases

PRIDEP21129.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000037967; ENSMUSP00000045150; ENSMUSG00000032806.
ENSMUST00000073067; ENSMUSP00000072818; ENSMUSG00000032806.
ENSMUST00000114146; ENSMUSP00000109783; ENSMUSG00000032806.
GeneID214601.
KEGGmmu:214601.
UCSCuc009tou.2. mouse.

Organism-specific databases

CTD8273.
MGIMGI:95048. Slc10a3.

Phylogenomic databases

eggNOGCOG0385.
GeneTreeENSGT00550000074505.
HOGENOMHOG000037944.
HOVERGENHBG002872.
InParanoidP21129.
KOK14343.
OMAPLIFVNK.
PhylomeDBP21129.
TreeFamTF315811.

Gene expression databases

ArrayExpressP21129.
BgeeP21129.
GenevestigatorP21129.

Family and domain databases

InterProIPR002657. BilAc/Na_symport.
[Graphical view]
PANTHERPTHR10361. PTHR10361. 1 hit.
PfamPF01758. SBF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio374388.
PROP21129.
SOURCESearch...

Entry information

Entry nameP3_MOUSE
AccessionPrimary (citable) accession number: P21129
Secondary accession number(s): Q8QZR2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: August 30, 2005
Last modified: July 9, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot