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Protein

P3 protein

Gene

Slc10a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions.

GO - Molecular functioni

  1. bile acid:sodium symporter activity Source: GO_Central

GO - Biological processi

  1. bile acid and bile salt transport Source: GO_Central
  2. response to organic substance Source: MGI
  3. response to retinoic acid Source: MGI
Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
P3 protein
Alternative name(s):
Solute carrier family 10 member 3
Gene namesi
Name:Slc10a3
Synonyms:P3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:95048. Slc10a3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4521HelicalSequence AnalysisAdd
BLAST
Transmembranei221 – 24121HelicalSequence AnalysisAdd
BLAST
Transmembranei249 – 26921HelicalSequence AnalysisAdd
BLAST
Transmembranei277 – 29721HelicalSequence AnalysisAdd
BLAST
Transmembranei316 – 33621HelicalSequence AnalysisAdd
BLAST
Transmembranei356 – 37621HelicalSequence AnalysisAdd
BLAST
Transmembranei381 – 40121HelicalSequence AnalysisAdd
BLAST
Transmembranei413 – 43321HelicalSequence AnalysisAdd
BLAST
Transmembranei446 – 46621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 473473P3 proteinPRO_0000052344Add
BLAST

Proteomic databases

PRIDEiP21129.

PTM databases

PhosphoSiteiP21129.

Expressioni

Gene expression databases

BgeeiP21129.
ExpressionAtlasiP21129. baseline and differential.
GenevestigatoriP21129.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045150.

Structurei

3D structure databases

ProteinModelPortaliP21129.
SMRiP21129. Positions 194-438.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0385.
GeneTreeiENSGT00550000074505.
HOGENOMiHOG000037944.
HOVERGENiHBG002872.
InParanoidiP21129.
KOiK14343.
OMAiYASQAPF.
PhylomeDBiP21129.
TreeFamiTF315811.

Family and domain databases

InterProiIPR002657. BilAc:Na_symport/Acr3.
IPR030210. SLC10A3.
[Graphical view]
PANTHERiPTHR10361. PTHR10361. 1 hit.
PTHR10361:SF3. PTHR10361:SF3. 1 hit.
PfamiPF01758. SBF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21129-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVKKSRGSS QQLPGLGGQG GCTGFVGMLG TALLFISLPW GAQVMASANI
60 70 80 90 100
STALGHTSGH YLSIGDGSVT EFDFPEKSEG IIVISSQYTG QTNGTGPSPI
110 120 130 140 150
LKVISLDTEV LTIKNVSAIT WSSGGGFVVG IHSGLAGLAP LHLQLMDFYE
160 170 180 190 200
APPLLIEERR DFCIRVSPAE DLPSALNTNL GHFSENPILY LLLPLIFVNK
210 220 230 240 250
CSFGCKVELE VLKELLQSPQ PMLLGLLGQF LVMPFYAFLM AKVFMLPKAL
260 270 280 290 300
ALGLIITCSS PGGGGSYLFS LLLGGDVTLA ISMTFISTVA ATGFLPLSSA
310 320 330 340 350
IYSYLLSIHE TLHVPISKIL GTLLFIAIPI AAGVVIKSKL PKFSELLLQV
360 370 380 390 400
IKPFSFILLL GGLFLAYHMG VFILVGVRLP IVLVGFTVPL VGLLVGYSLA
410 420 430 440 450
ICLKLPVAQR RTVSIEVGVQ NSLLALAMLQ LSLRRLQADY ASQAPFIVAL
460 470
SGTSEMLALV IGQFIYSILF PVP
Length:473
Mass (Da):50,255
Last modified:August 30, 2005 - v2
Checksum:i9A2AD0A005DD1805
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041958 mRNA. Translation: BAC31110.1.
BC023050 mRNA. Translation: AAH23050.1.
BC027440 mRNA. Translation: AAH27440.1.
J04761 Genomic DNA. Translation: AAA40519.1.
CCDSiCCDS30231.1.
PIRiI54222.
RefSeqiNP_001243033.1. NM_001256104.1.
NP_663381.1. NM_145406.2.
UniGeneiMm.19931.

Genome annotation databases

EnsembliENSMUST00000037967; ENSMUSP00000045150; ENSMUSG00000032806.
ENSMUST00000073067; ENSMUSP00000072818; ENSMUSG00000032806.
ENSMUST00000114146; ENSMUSP00000109783; ENSMUSG00000032806.
GeneIDi214601.
KEGGimmu:214601.
UCSCiuc009tou.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041958 mRNA. Translation: BAC31110.1.
BC023050 mRNA. Translation: AAH23050.1.
BC027440 mRNA. Translation: AAH27440.1.
J04761 Genomic DNA. Translation: AAA40519.1.
CCDSiCCDS30231.1.
PIRiI54222.
RefSeqiNP_001243033.1. NM_001256104.1.
NP_663381.1. NM_145406.2.
UniGeneiMm.19931.

3D structure databases

ProteinModelPortaliP21129.
SMRiP21129. Positions 194-438.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045150.

PTM databases

PhosphoSiteiP21129.

Proteomic databases

PRIDEiP21129.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037967; ENSMUSP00000045150; ENSMUSG00000032806.
ENSMUST00000073067; ENSMUSP00000072818; ENSMUSG00000032806.
ENSMUST00000114146; ENSMUSP00000109783; ENSMUSG00000032806.
GeneIDi214601.
KEGGimmu:214601.
UCSCiuc009tou.2. mouse.

Organism-specific databases

CTDi8273.
MGIiMGI:95048. Slc10a3.

Phylogenomic databases

eggNOGiCOG0385.
GeneTreeiENSGT00550000074505.
HOGENOMiHOG000037944.
HOVERGENiHBG002872.
InParanoidiP21129.
KOiK14343.
OMAiYASQAPF.
PhylomeDBiP21129.
TreeFamiTF315811.

Miscellaneous databases

NextBioi374388.
PROiP21129.
SOURCEiSearch...

Gene expression databases

BgeeiP21129.
ExpressionAtlasiP21129. baseline and differential.
GenevestigatoriP21129.

Family and domain databases

InterProiIPR002657. BilAc:Na_symport/Acr3.
IPR030210. SLC10A3.
[Graphical view]
PANTHERiPTHR10361. PTHR10361. 1 hit.
PTHR10361:SF3. PTHR10361:SF3. 1 hit.
PfamiPF01758. SBF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. "Linkage and sequence conservation of the X-linked genes DXS253E (P3) and DXS254E (GdX) in mouse and man."
    Filippi M., Tribioli C., Toniolo D.
    Genomics 7:453-457(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 292-473.
    Strain: BALB/c.
    Tissue: Liver.

Entry informationi

Entry nameiP3_MOUSE
AccessioniPrimary (citable) accession number: P21129
Secondary accession number(s): Q8QZR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: August 30, 2005
Last modified: February 4, 2015
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.