Reviewed, UniProtKB/Swiss-Prot P21128 (PP11_HUMAN)

Names and origin

Protein names	Recommended name:     Placental protein 11       Short name=PP11     EC=3.4.21.-
Organism	Homo sapiens (Human) [Complete proteome]
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	369 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Probable serine protease.
Tissue specificity	Placental specific, but also associated with various malignant neoplasms.
Post-translational modification	It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
Sequence similarities	Contains 1 SMB (somatomedin-B) domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Hydrolase Protease Serine protease
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	female pregnancy Ref.1 Inferred from expression pattern. Source: UniProtKB immune response Inferred from electronic annotation. Source: InterPro proteolysis Ref.1 Inferred from direct assay. Source: UniProtKB
Cellular component	cytoplasm Ref.1 Inferred from direct assay. Source: UniProtKB extracellular space Ref.1 Traceable author statement. Source: ProtInc plasma membrane Ref.3 Traceable author statement. Source: UniProtKB
Molecular function	growth factor activity Ref.3 Non-traceable author statement. Source: UniProtKB polysaccharide binding Inferred from electronic annotation. Source: InterPro scavenger receptor activity Inferred from electronic annotation. Source: InterPro serine-type peptidase activity Ref.1 Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Ref.1
	Chain	19 – 369	351	Placental protein 11		PRO_0000036405
Regions
	Domain	45 – 89	45	SMB
Amino acid modifications
	Disulfide bond	49 ↔ 65		Alternate By similarity
	Disulfide bond	49 ↔ 53		Alternate By similarity
	Disulfide bond	53 ↔ 83		Alternate By similarity
	Disulfide bond	63 ↔ 76		Alternate By similarity
	Disulfide bond	63 ↔ 65		Alternate By similarity
	Disulfide bond	69 ↔ 75		By similarity
	Disulfide bond	76 ↔ 83		Alternate By similarity
Natural variations
	Natural variant	31	1	E → Q: dbSNP rs6504.		VAR_014793
	Natural variant	31	1	E → V: dbSNP rs6505.		VAR_014794

Sequences

	Sequence		Length	Mass (Da)
	P21128-1 [UniParc]. Last modified February 1, 1991. Version 1. Checksum: F5935AE12D7E924C	FASTA	369	42,121
	10 20 30 40 50 60 MRACISLVLA VLCGLAWAED HKESEPLPQL EEETEEALAS NLYSAPTSCQ GRCYEAFDKH 70 80 90 100 110 120 HQCHCNARCQ EFGNCCKDFE SLCSDHEVSH SSDAITKEEI QSISEKIYRA DTNKAQKEDI 130 140 150 160 170 180 VLNSQNCISP SETRNQVDRC PKPLFTYVNE KLFSKPTYAA FINLLNNYQR ATGHGEHFSA 190 200 210 220 230 240 QELAEQDAFL REIMKTAVMK ELYSFLHHQN RYGSEQEFVD DLKNMWFGLY SRGNEEGDSS 250 260 270 280 290 300 GFEHVFSGEV KKGKVTGFHN WIRFYLEEKE GLVDYYSHIY DGPWDSYPDV LAMQFNWDGY 310 320 330 340 350 360 YKEVGSAFIG SSPEFEFALY SLCFIARPGK VCQLSLGGYP LAVRTYTWDK STYGNGKKYI ATAYIVSST

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of a cDNA encoding human placental protein 11, a putative serine protease with diagnostic significance as a tumor marker." Grundmann U., Roemisch J., Siebold B., Bohn H., Amann E. DNA Cell Biol. 9:243-250(1990) [PubMed: 2350438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 19-29. Tissue: Placenta.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"Homology of placental protein 11 and pea seed albumin 2 with vitronectin." Jenne D.E. Biochem. Biophys. Res. Commun. 176:1000-1006(1991) [PubMed: 1710108] [Abstract] Cited for: DOMAIN SOMATOMEDIN-B.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M32402 mRNA. Translation: AAA36464.1. M36109 mRNA. Translation: AAA36465.1. BC069715 mRNA. Translation: AAH69715.1. BC074763 mRNA. Translation: AAH74763.1. BC111782 mRNA. Translation: AAI11783.1.
IPI	IPI00006995.
PIR	A34614.
RefSeq	NP_006016.1.
UniGene	Hs.997
3D structure databases
SMR	P21128. Positions 46-87, 95-368.
ModBase	Search...
Protein-protein interaction databases
STRING	P21128.
Proteomic databases
PRIDE	P21128.
Genome annotation databases
Ensembl	ENST00000229003; ENSP00000229003; ENSG00000111405; Homo sapiens. [Genome view]
GeneID	8909.
KEGG	hsa:8909.
UCSC	uc001rpt.1. human.
Organism-specific databases
CTD	8909.
GeneCards	GC12M046389.
H-InvDB	HIX0036755.
HPA	HPA012388.
MIM	606720. gene.
Phylogenomic databases
eggNOG	prNOG05621.
HOVERGEN	P21128.
InParanoid	P21128.
Gene expression databases
ArrayExpress	P21128.
Bgee	P21128.
Genevestigator	P21128.
GermOnline	ENSG00000111405. Homo sapiens.
Family and domain databases
InterPro	IPR018998. Endoribonuclease_XendoU. IPR001212. Somatomedin_B. IPR020436. Somatomedin_B_chordata. [Graphical view]
Pfam	PF01033. Somatomedin_B. 1 hit. PF09412. XendoU. 1 hit. [Graphical view]
PRINTS	PR00022. SOMATOMEDINB.
SMART	SM00201. SO. 1 hit. [Graphical view]
PROSITE	PS00524. SMB_1. 1 hit. PS50958. SMB_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	33477.

Entry information

Entry name

PP11_HUMAN

Accession

Primary (citable) accession number: P21128
Secondary accession number(s): Q2NKJ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	February 1, 1991
Last modified:	January 19, 2010
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.