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Protein

Cyclin-dependent kinase 11B

Gene

CDK11B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression.4 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Enzyme regulationi

Phosphorylation at Thr-448 or Tyr-449 inactivates the enzyme, while phosphorylation at Thr-595 activates it.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei467ATPPROSITE-ProRule annotation1
Active sitei562Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi444 – 452ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  • poly(A) RNA binding Source: UniProtKB
  • protein kinase activity Source: ProtInc
  • protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

  • apoptotic process Source: UniProtKB
  • cell proliferation Source: ProtInc
  • mitotic nuclear division Source: UniProtKB
  • protein phosphorylation Source: UniProtKB
  • regulation of cell growth Source: UniProtKB
  • regulation of mRNA processing Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Apoptosis, Cell cycle

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS00232-MONOMER.
BRENDAi2.7.11.22. 2681.
ReactomeiR-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
SignaLinkiP21127.
SIGNORiP21127.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 11B (EC:2.7.11.22)
Alternative name(s):
Cell division cycle 2-like protein kinase 1
Short name:
CLK-1
Cell division protein kinase 11B
Galactosyltransferase-associated protein kinase p58/GTA
PITSLRE serine/threonine-protein kinase CDC2L1
p58 CLK-1
Gene namesi
Name:CDK11B
Synonyms:CDC2L1, CDK11, PITSLREA, PK58
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:1729. CDK11B.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: ProtInc
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi984.
PharmGKBiPA26262.

Chemistry databases

ChEMBLiCHEMBL5808.
GuidetoPHARMACOLOGYi1964.

Polymorphism and mutation databases

BioMutaiCDK11B.
DMDMi34978359.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000243111 – 795Cyclin-dependent kinase 11BAdd BLAST795

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei47PhosphoserineBy similarity1
Modified residuei72PhosphoserineBy similarity1
Modified residuei115Phosphoserine1 Publication1
Modified residuei283PhosphoserineBy similarity1
Modified residuei482Phosphoserine; by CDK71 Publication1
Modified residuei488Phosphothreonine; by CDK71 Publication1
Modified residuei589PhosphoserineCombined sources1
Modified residuei594PhosphotyrosineCombined sources1
Modified residuei595PhosphothreonineCombined sources1
Modified residuei751PhosphothreonineBy similarity1
Modified residuei752PhosphoserineBy similarity1

Post-translational modificationi

During FAS- or TNF-induced apoptosis, isoform SV9 is cleaved by caspases to produce p110C, a fragment that contains the C-terminal kinase domain.
Phosphorylation at Ser-115 creates a binding site for 14-3-3 proteins. p110C can be autophosphorylated.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP21127.
MaxQBiP21127.
PaxDbiP21127.
PeptideAtlasiP21127.
PRIDEiP21127.

PTM databases

iPTMnetiP21127.
PhosphoSitePlusiP21127.

Miscellaneous databases

PMAP-CutDBP21127.

Expressioni

Tissue specificityi

Expressed ubiquitously. Some evidence of isoform-specific tissue distribution.2 Publications

Inductioni

Isoform 7 is induced in G2/M phase of the cell cycle.1 Publication

Organism-specific databases

HPAiHPA025061.

Interactioni

Subunit structurei

Cleaved isoform SV9 (p110C) binds to the serine/threonine kinase PAK1 and RANBP9. p110C interacts with RNPS1. Isoform 7, but not isoform SV9, nor its cleavage product p110C, interacts with CCND3. Interacts with CCNL1 and CCNL2. Forms complexes with pre-mRNA-splicing factors, including at least SRSF1, SRSF2 AND SRSF7/SLU7. Interacts with isoform 5 of MYO18A (PubMed:25965346).5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
EIF3FO003033EBI-1298,EBI-711990
PAK1Q131534EBI-1298,EBI-1307

Protein-protein interaction databases

BioGridi107421. 41 interactors.
IntActiP21127. 16 interactors.
MINTiMINT-1400900.
STRINGi9606.ENSP00000384442.

Chemistry databases

BindingDBiP21127.

Structurei

3D structure databases

ProteinModelPortaliP21127.
SMRiP21127.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini438 – 723Protein kinasePROSITE-ProRule annotationAdd BLAST286

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi126 – 393Glu-richAdd BLAST268

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0663. Eukaryota.
ENOG410XQ50. LUCA.
HOVERGENiHBG014652.
InParanoidiP21127.
KOiK08818.
PhylomeDBiP21127.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (10)i

Sequence statusi: Complete.

This entry describes 10 isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

Isoform SV9 (identifier: P21127-1) [UniParc]FASTAAdd to basket
Also known as: CDK11-p110

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE
60 70 80 90 100
GELRDHRMEI TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKVHHR
110 120 130 140 150
KDEKRKEKRR HRSHSAEGGK HARVKEKERE HERRKRHREE QDKARREWER
160 170 180 190 200
QKRREMAREH SRRERDRLEQ LERKRERERK MREQQKEQRE QKERERRAEE
210 220 230 240 250
RRKEREARRE VSAHHRTMRE DYSDKVKASH WSRSPPRPPR ERFELGDGRK
260 270 280 290 300
PGEARPARAQ KPAQLKEEKM EERDLLSDLQ DISDSERKTS SAESSSAESG
310 320 330 340 350
SGSEEEEEEE EEEEEEGSTS EESEEEEEEE EEEEEETGSN SEEASEQSAE
360 370 380 390 400
EVSEEEMSED EERENENHLL VVPESRFDRD SGESEEAEEE VGEGTPQSSA
410 420 430 440 450
LTEGDYVPDS PALSPIELKQ ELPKYLPALQ GCRSVEEFQC LNRIEEGTYG
460 470 480 490 500
VVYRAKDKKT DEIVALKRLK MEKEKEGFPI TSLREINTIL KAQHPNIVTV
510 520 530 540 550
REIVVGSNMD KIYIVMNYVE HDLKSLMETM KQPFLPGEVK TLMIQLLRGV
560 570 580 590 600
KHLHDNWILH RDLKTSNLLL SHAGILKVGD FGLAREYGSP LKAYTPVVVT
610 620 630 640 650
LWYRAPELLL GAKEYSTAVD MWSVGCIFGE LLTQKPLFPG KSEIDQINKV
660 670 680 690 700
FKDLGTPSEK IWPGYSELPA VKKMTFSEHP YNNLRKRFGA LLSDQGFDLM
710 720 730 740 750
NKFLTYFPGR RISAEDGLKH EYFRETPLPI DPSMFPTWPA KSEQQRVKRG
760 770 780 790
TSPRPPEGGL GYSQLGDDDL KETGFHLTTT NQGASAAGPG FSLKF
Length:795
Mass (Da):92,707
Last modified:September 19, 2003 - v3
Checksum:iC07CEE9A4F7A6804
GO
Isoform SV1 (identifier: P21127-2) [UniParc]FASTAAdd to basket
Also known as: Alpha 2-1

The sequence of this isoform differs from the canonical sequence as follows:
     252-265: GEARPARAQKPAQL → V

Show »
Length:782
Mass (Da):91,331
Checksum:i63A4E5BDBE1411FE
GO
Isoform 2 (identifier: P21127-3) [UniParc]FASTAAdd to basket
Also known as: Alpha 2-2

The sequence of this isoform differs from the canonical sequence as follows:
     110-119: Missing.
     165-165: R → RGNDGVCLFR
     252-265: GEARPARAQKPAQL → V

Show »
Length:781
Mass (Da):91,218
Checksum:iEDEE50FC3D19E26D
GO
Isoform 3 (identifier: P21127-4) [UniParc]FASTAAdd to basket
Also known as: Alpha 1

The sequence of this isoform differs from the canonical sequence as follows:
     2-335: Missing.

Show »
Length:461
Mass (Da):51,925
Checksum:i6D054208C50D621C
GO
Isoform SV4 (identifier: P21127-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-269: Missing.

Show »
Length:526
Mass (Da):59,273
Checksum:i3DFF4854ED82B81B
GO
Isoform SV5 (identifier: P21127-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.
     35-37: LKN → MSQ
     110-119: Missing.
     252-265: GEARPARAQKPAQL → V

Show »
Length:738
Mass (Da):86,063
Checksum:i0885FB5ECECB398A
GO
Isoform 8 (identifier: P21127-8) [UniParc]FASTAAdd to basket
Also known as: Alpha 2-3

The sequence of this isoform differs from the canonical sequence as follows:
     110-119: Missing.
     252-265: GEARPARAQKPAQL → V

Show »
Length:772
Mass (Da):90,256
Checksum:i03929873CFBD1CF6
GO
Isoform SV10 (identifier: P21127-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: Missing.
     35-37: LKN → MSQ
     252-265: GEARPARAQKPAQL → V

Show »
Length:748
Mass (Da):87,138
Checksum:iA13766F2F6F8E00A
GO
Isoform SV11 (identifier: P21127-10) [UniParc]FASTAAdd to basket
Also known as: Alpha 2-4

The sequence of this isoform differs from the canonical sequence as follows:
     1-217: Missing.
     252-265: GEARPARAQKPAQL → V

Show »
Length:565
Mass (Da):63,937
Checksum:i6E088C8322ADB36A
GO
Isoform 7 (identifier: P21127-12) [UniParc]FASTAAdd to basket
Also known as: CDK11-p58

The sequence of this isoform differs from the canonical sequence as follows:
     1-356: Missing.

Note: Produced by alternative initiation at Met-357 of isoform SV9 via an internal ribosomal entry site (IRES).
Show »
Length:439
Mass (Da):49,555
Checksum:i2008B90F6CE66EF6
GO

Sequence cautioni

The sequence AAC83664 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAF36538 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti109Missing in AAA19582 (PubMed:8195233).Curated1
Sequence conflicti109Missing in AAA19583 (PubMed:8195233).Curated1
Sequence conflicti109Missing in AAC72079 (PubMed:9750192).Curated1
Sequence conflicti126E → K in AAA19582 (PubMed:8195233).Curated1
Sequence conflicti126E → K in AAA19583 (PubMed:8195233).Curated1
Sequence conflicti126E → K in AAA19586 (PubMed:8195233).Curated1
Sequence conflicti320S → T (Ref. 6) Curated1
Sequence conflicti324 – 326Missing in AAA19582 (PubMed:8195233).Curated3
Sequence conflicti324 – 326Missing in AAA19583 (PubMed:8195233).Curated3
Sequence conflicti324 – 326Missing in AAA19584 (PubMed:8195233).Curated3
Sequence conflicti324 – 326Missing in AAA19586 (PubMed:8195233).Curated3
Sequence conflicti436E → D (PubMed:1639388).Curated1
Sequence conflicti560H → Q (Ref. 6) Curated1
Sequence conflicti567N → T (Ref. 6) Curated1
Sequence conflicti678E → R (PubMed:8195233).Curated1
Sequence conflicti678E → R (Ref. 6) Curated1
Sequence conflicti694D → E (PubMed:1639388).Curated1
Sequence conflicti697F → C (Ref. 6) Curated1
Sequence conflicti712I → L (PubMed:1639388).Curated1
Sequence conflicti715E → Q (PubMed:1639388).Curated1
Sequence conflicti792S → R (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04195857R → C.2 PublicationsCorresponds to variant rs17424353dbSNPEnsembl.1
Natural variantiVAR_05777593R → W.Corresponds to variant rs1059831dbSNPEnsembl.1
Natural variantiVAR_062199109R → C.Corresponds to variant rs1059830dbSNPEnsembl.1
Natural variantiVAR_041959201R → W.1 Publication1
Natural variantiVAR_041960414S → L.1 Publication1
Natural variantiVAR_045577452V → A.1 Publication1
Natural variantiVAR_041961463I → V.1 Publication1
Natural variantiVAR_045578506G → S.1 Publication1
Natural variantiVAR_041962601L → Q.2 Publications1
Natural variantiVAR_041963641K → N.1 Publication1
Natural variantiVAR_041964670A → V.1 PublicationCorresponds to variant rs1059811dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0188341 – 356Missing in isoform 7. 1 PublicationAdd BLAST356
Alternative sequenceiVSP_0082751 – 269Missing in isoform SV4. 1 PublicationAdd BLAST269
Alternative sequenceiVSP_0082741 – 217Missing in isoform SV11. 3 PublicationsAdd BLAST217
Alternative sequenceiVSP_0082731 – 34Missing in isoform SV5 and isoform SV10. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_0082762 – 335Missing in isoform 3. 1 PublicationAdd BLAST334
Alternative sequenceiVSP_00827735 – 37LKN → MSQ in isoform SV5 and isoform SV10. 1 Publication3
Alternative sequenceiVSP_008278110 – 119Missing in isoform 2, isoform SV5 and isoform 8. 2 Publications10
Alternative sequenceiVSP_008279165R → RGNDGVCLFR in isoform 2. 1 Publication1
Alternative sequenceiVSP_008280252 – 265GEARP…KPAQL → V in isoform SV1, isoform 2, isoform SV5, isoform 8, isoform SV10 and isoform SV11. 3 PublicationsAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37712 mRNA. Translation: AAA36406.1. Sequence problems.
M88563
, M88553, M88554, M88555, M88558, M88559, M88560, M88561, M88562 Genomic DNA. Translation: AAB59449.1. Sequence problems.
U04815 mRNA. Translation: AAA19581.1.
U04816 mRNA. Translation: AAA19582.1.
U04817 mRNA. Translation: AAA19583.1.
U04818 mRNA. Translation: AAA19584.1.
U04824 mRNA. Translation: AAA19586.1.
AF067512 mRNA. Translation: AAC72077.1.
AF067513 mRNA. Translation: AAC72078.1.
AF067514 mRNA. Translation: AAC72079.1.
AF067515 mRNA. Translation: AAC72080.1.
AF067516 mRNA. Translation: AAC72081.1.
AF067517 mRNA. Translation: AAC72082.1.
AF080683
, AF080685, AF080686, AF080687, AF080688, AF092429, AF092430, AF080678, AF080679, AF080680, AF080681, AF080682 Genomic DNA. Translation: AAC83662.1.
AF080683
, AF080685, AF080686, AF080687, AF080688, AF092429, AF092430, AF080678, AF080679, AF080680, AF080681, AF080682 Genomic DNA. Translation: AAC83663.1.
AF080683
, AF080685, AF080686, AF080687, AF080688, AF092429, AF092430, AF080678, AF080679, AF080680, AF080681, AF080682 Genomic DNA. Translation: AAC83664.1. Sequence problems.
AF080683
, AF080685, AF080686, AF080687, AF080688, AF092429, AF092430, AF080678, AF080679, AF080680, AF080681, AF080682 Genomic DNA. Translation: AAC83665.1.
AF080683
, AF092430, AF080678, AF080679, AF080680, AF080681, AF080682 Genomic DNA. Translation: AAC83666.1.
AF174497 mRNA. Translation: AAF36538.1. Different initiation.
CCDSiCCDS72682.1. [P21127-9]
CCDS72683.1. [P21127-1]
CCDS72684.1. [P21127-2]
PIRiA38282.
B54024.
E54024.
F54024.
H54024.
T09568.
RefSeqiNP_277022.1. NM_033487.2. [P21127-5]
NP_277025.1. NM_033490.2. [P21127-10]
UniGeneiHs.651228.
Hs.709182.

Genome annotation databases

GeneIDi984.
KEGGihsa:984.

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37712 mRNA. Translation: AAA36406.1. Sequence problems.
M88563
, M88553, M88554, M88555, M88558, M88559, M88560, M88561, M88562 Genomic DNA. Translation: AAB59449.1. Sequence problems.
U04815 mRNA. Translation: AAA19581.1.
U04816 mRNA. Translation: AAA19582.1.
U04817 mRNA. Translation: AAA19583.1.
U04818 mRNA. Translation: AAA19584.1.
U04824 mRNA. Translation: AAA19586.1.
AF067512 mRNA. Translation: AAC72077.1.
AF067513 mRNA. Translation: AAC72078.1.
AF067514 mRNA. Translation: AAC72079.1.
AF067515 mRNA. Translation: AAC72080.1.
AF067516 mRNA. Translation: AAC72081.1.
AF067517 mRNA. Translation: AAC72082.1.
AF080683
, AF080685, AF080686, AF080687, AF080688, AF092429, AF092430, AF080678, AF080679, AF080680, AF080681, AF080682 Genomic DNA. Translation: AAC83662.1.
AF080683
, AF080685, AF080686, AF080687, AF080688, AF092429, AF092430, AF080678, AF080679, AF080680, AF080681, AF080682 Genomic DNA. Translation: AAC83663.1.
AF080683
, AF080685, AF080686, AF080687, AF080688, AF092429, AF092430, AF080678, AF080679, AF080680, AF080681, AF080682 Genomic DNA. Translation: AAC83664.1. Sequence problems.
AF080683
, AF080685, AF080686, AF080687, AF080688, AF092429, AF092430, AF080678, AF080679, AF080680, AF080681, AF080682 Genomic DNA. Translation: AAC83665.1.
AF080683
, AF092430, AF080678, AF080679, AF080680, AF080681, AF080682 Genomic DNA. Translation: AAC83666.1.
AF174497 mRNA. Translation: AAF36538.1. Different initiation.
CCDSiCCDS72682.1. [P21127-9]
CCDS72683.1. [P21127-1]
CCDS72684.1. [P21127-2]
PIRiA38282.
B54024.
E54024.
F54024.
H54024.
T09568.
RefSeqiNP_277022.1. NM_033487.2. [P21127-5]
NP_277025.1. NM_033490.2. [P21127-10]
UniGeneiHs.651228.
Hs.709182.

3D structure databases

ProteinModelPortaliP21127.
SMRiP21127.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107421. 41 interactors.
IntActiP21127. 16 interactors.
MINTiMINT-1400900.
STRINGi9606.ENSP00000384442.

Chemistry databases

BindingDBiP21127.
ChEMBLiCHEMBL5808.
GuidetoPHARMACOLOGYi1964.

PTM databases

iPTMnetiP21127.
PhosphoSitePlusiP21127.

Polymorphism and mutation databases

BioMutaiCDK11B.
DMDMi34978359.

Proteomic databases

EPDiP21127.
MaxQBiP21127.
PaxDbiP21127.
PeptideAtlasiP21127.
PRIDEiP21127.

Protocols and materials databases

DNASUi984.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi984.
KEGGihsa:984.

Organism-specific databases

CTDi984.
DisGeNETi984.
GeneCardsiCDK11B.
HGNCiHGNC:1729. CDK11B.
HPAiHPA025061.
MIMi176873. gene.
neXtProtiNX_P21127.
PharmGKBiPA26262.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0663. Eukaryota.
ENOG410XQ50. LUCA.
HOVERGENiHBG014652.
InParanoidiP21127.
KOiK08818.
PhylomeDBiP21127.

Enzyme and pathway databases

BioCyciZFISH:HS00232-MONOMER.
BRENDAi2.7.11.22. 2681.
ReactomeiR-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
SignaLinkiP21127.
SIGNORiP21127.

Miscellaneous databases

ChiTaRSiCDK11B. human.
GeneWikiiCDC2L1.
GenomeRNAii984.
PMAP-CutDBP21127.
PROiP21127.
SOURCEiSearch...

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD11B_HUMAN
AccessioniPrimary (citable) accession number: P21127
Secondary accession number(s): O95265
, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: September 19, 2003
Last modified: November 30, 2016
This is version 187 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Duplicated gene. CDK11A and CDK11B encode almost identical protein kinases of 110 kDa that contain at their C-termini the open reading frame of a smaller 58 kDa isoform which is expressed following IRES-mediated alternative initiation of translation.

Caution

Many references talk about 'p110 isoforms' but it is not yet known if this refers to CDK11A and/or CDK11B or one/some of the isoforms of each.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.