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Protein

Ubiquitin-like protein 4A

Gene

Ubl4a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like protein 4A
Alternative name(s):
Ubiquitin-like protein GDX
Gene namesi
Name:Ubl4a
Synonyms:Gdx, Ubl4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:95049. Ubl4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001148651 – 157Ubiquitin-like protein 4AAdd BLAST157

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei90PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP21126.
PaxDbiP21126.
PeptideAtlasiP21126.
PRIDEiP21126.

PTM databases

iPTMnetiP21126.
PhosphoSitePlusiP21126.

Expressioni

Gene expression databases

BgeeiENSMUSG00000015290.
CleanExiMM_UBL4.
ExpressionAtlasiP21126. baseline and differential.
GenevisibleiP21126. MM.

Interactioni

Subunit structurei

Component of the BAT3 complex, at least composed of BAG6/BAT3, UBL4A and GET4/TRC35.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000120461.

Structurei

3D structure databases

ProteinModelPortaliP21126.
SMRiP21126.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 76Ubiquitin-likePROSITE-ProRule annotationAdd BLAST76

Sequence similaritiesi

Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0001. Eukaryota.
COG5272. LUCA.
GeneTreeiENSGT00730000111022.
HOGENOMiHOG000185746.
HOVERGENiHBG072205.
InParanoidiP21126.
OMAiQRDYDRS.
OrthoDBiEOG091G0XVA.
TreeFamiTF354228.

Family and domain databases

InterProiIPR019956. Ubiquitin.
IPR029071. Ubiquitin-rel_dom.
IPR019954. Ubiquitin_CS.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
PRINTSiPR00348. UBIQUITIN.
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS00299. UBIQUITIN_1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21126-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLTVKALQG RECSLQVAED ELVSTLKHLV SDKLNVPVRQ QRLLFKGKAL
60 70 80 90 100
ADEKRLSDYN IGPNSKLNLV VKPLEKVLLE EGSAHRLVDS PATPIWQLIS
110 120 130 140 150
KVLARHFSVA DASRVLEQLQ RDYDRSLSRL TLDDIERLAS RFLHPEVTEA

MEKGFCK
Length:157
Mass (Da):17,801
Last modified:February 1, 1991 - v1
Checksum:i79280472F034D47E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04761 Genomic DNA. Translation: AAA40520.1.
BC010817 mRNA. Translation: AAH10817.1.
CCDSiCCDS30230.1.
PIRiI68527.
RefSeqiNP_001265200.1. NM_001278271.1.
NP_001265201.1. NM_001278272.1.
NP_663380.1. NM_145405.2.
UniGeneiMm.19931.
Mm.3979.

Genome annotation databases

EnsembliENSMUST00000155676; ENSMUSP00000120461; ENSMUSG00000015290.
ENSMUST00000178691; ENSMUSP00000136070; ENSMUSG00000015290.
GeneIDi100169864.
27643.
KEGGimmu:100169864.
mmu:27643.
UCSCiuc009tos.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04761 Genomic DNA. Translation: AAA40520.1.
BC010817 mRNA. Translation: AAH10817.1.
CCDSiCCDS30230.1.
PIRiI68527.
RefSeqiNP_001265200.1. NM_001278271.1.
NP_001265201.1. NM_001278272.1.
NP_663380.1. NM_145405.2.
UniGeneiMm.19931.
Mm.3979.

3D structure databases

ProteinModelPortaliP21126.
SMRiP21126.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000120461.

PTM databases

iPTMnetiP21126.
PhosphoSitePlusiP21126.

Proteomic databases

EPDiP21126.
PaxDbiP21126.
PeptideAtlasiP21126.
PRIDEiP21126.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000155676; ENSMUSP00000120461; ENSMUSG00000015290.
ENSMUST00000178691; ENSMUSP00000136070; ENSMUSG00000015290.
GeneIDi100169864.
27643.
KEGGimmu:100169864.
mmu:27643.
UCSCiuc009tos.2. mouse.

Organism-specific databases

CTDi8266.
MGIiMGI:95049. Ubl4.

Phylogenomic databases

eggNOGiKOG0001. Eukaryota.
COG5272. LUCA.
GeneTreeiENSGT00730000111022.
HOGENOMiHOG000185746.
HOVERGENiHBG072205.
InParanoidiP21126.
OMAiQRDYDRS.
OrthoDBiEOG091G0XVA.
TreeFamiTF354228.

Miscellaneous databases

PROiP21126.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015290.
CleanExiMM_UBL4.
ExpressionAtlasiP21126. baseline and differential.
GenevisibleiP21126. MM.

Family and domain databases

InterProiIPR019956. Ubiquitin.
IPR029071. Ubiquitin-rel_dom.
IPR019954. Ubiquitin_CS.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
PRINTSiPR00348. UBIQUITIN.
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS00299. UBIQUITIN_1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBL4A_MOUSE
AccessioniPrimary (citable) accession number: P21126
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 2, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.