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Protein

Ubiquitin-like protein 4A

Gene

Ubl4a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like protein 4A
Alternative name(s):
Ubiquitin-like protein GDX
Gene namesi
Name:Ubl4a
Synonyms:Gdx, Ubl4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:95049. Ubl4.

Subcellular locationi

  • Cytoplasmcytosol By similarity
  • Nucleus By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001148651 – 157Ubiquitin-like protein 4AAdd BLAST157

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki48Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei90PhosphoserineBy similarity1

Post-translational modificationi

Polyubiquitinated. Ubiquitination by AMFR and deubiquitination by USP13 may regulate the interaction between the BAG6/BAT3 complex and SGTA and therefore may regulate client proteins fate.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP21126.
PaxDbiP21126.
PeptideAtlasiP21126.
PRIDEiP21126.

PTM databases

iPTMnetiP21126.
PhosphoSitePlusiP21126.

Expressioni

Gene expression databases

BgeeiENSMUSG00000015290.
CleanExiMM_UBL4.
ExpressionAtlasiP21126. baseline and differential.
GenevisibleiP21126. MM.

Interactioni

Subunit structurei

Component of the BAG6/BAT3 complex, at least composed of BAG6, UBL4A and GET4/TRC35. Interacts with USP13; may be indirect via BAG6.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000120461.

Structurei

3D structure databases

ProteinModelPortaliP21126.
SMRiP21126.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 76Ubiquitin-likePROSITE-ProRule annotationAdd BLAST76

Phylogenomic databases

eggNOGiKOG0001. Eukaryota.
COG5272. LUCA.
GeneTreeiENSGT00730000111022.
HOGENOMiHOG000185746.
HOVERGENiHBG072205.
InParanoidiP21126.
OMAiQRDYDRS.
OrthoDBiEOG091G0XVA.
TreeFamiTF354228.

Family and domain databases

InterProiView protein in InterPro
IPR019956. Ubiquitin.
IPR029071. Ubiquitin-rel_dom.
IPR019954. Ubiquitin_CS.
IPR000626. Ubiquitin_dom.
PfamiView protein in Pfam
PF00240. ubiquitin. 1 hit.
PRINTSiPR00348. UBIQUITIN.
SMARTiView protein in SMART
SM00213. UBQ. 1 hit.
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiView protein in PROSITE
PS00299. UBIQUITIN_1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P21126-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLTVKALQG RECSLQVAED ELVSTLKHLV SDKLNVPVRQ QRLLFKGKAL
60 70 80 90 100
ADEKRLSDYN IGPNSKLNLV VKPLEKVLLE EGSAHRLVDS PATPIWQLIS
110 120 130 140 150
KVLARHFSVA DASRVLEQLQ RDYDRSLSRL TLDDIERLAS RFLHPEVTEA

MEKGFCK
Length:157
Mass (Da):17,801
Last modified:February 1, 1991 - v1
Checksum:i79280472F034D47E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04761 Genomic DNA. Translation: AAA40520.1.
BC010817 mRNA. Translation: AAH10817.1.
CCDSiCCDS30230.1.
PIRiI68527.
RefSeqiNP_001265200.1. NM_001278271.1.
NP_001265201.1. NM_001278272.1.
NP_663380.1. NM_145405.2.
UniGeneiMm.19931.
Mm.3979.

Genome annotation databases

EnsembliENSMUST00000155676; ENSMUSP00000120461; ENSMUSG00000015290.
ENSMUST00000178691; ENSMUSP00000136070; ENSMUSG00000015290.
GeneIDi100169864.
27643.
KEGGimmu:100169864.
mmu:27643.
UCSCiuc009tos.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04761 Genomic DNA. Translation: AAA40520.1.
BC010817 mRNA. Translation: AAH10817.1.
CCDSiCCDS30230.1.
PIRiI68527.
RefSeqiNP_001265200.1. NM_001278271.1.
NP_001265201.1. NM_001278272.1.
NP_663380.1. NM_145405.2.
UniGeneiMm.19931.
Mm.3979.

3D structure databases

ProteinModelPortaliP21126.
SMRiP21126.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000120461.

PTM databases

iPTMnetiP21126.
PhosphoSitePlusiP21126.

Proteomic databases

EPDiP21126.
PaxDbiP21126.
PeptideAtlasiP21126.
PRIDEiP21126.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000155676; ENSMUSP00000120461; ENSMUSG00000015290.
ENSMUST00000178691; ENSMUSP00000136070; ENSMUSG00000015290.
GeneIDi100169864.
27643.
KEGGimmu:100169864.
mmu:27643.
UCSCiuc009tos.2. mouse.

Organism-specific databases

CTDi8266.
MGIiMGI:95049. Ubl4.

Phylogenomic databases

eggNOGiKOG0001. Eukaryota.
COG5272. LUCA.
GeneTreeiENSGT00730000111022.
HOGENOMiHOG000185746.
HOVERGENiHBG072205.
InParanoidiP21126.
OMAiQRDYDRS.
OrthoDBiEOG091G0XVA.
TreeFamiTF354228.

Miscellaneous databases

PROiPR:P21126.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015290.
CleanExiMM_UBL4.
ExpressionAtlasiP21126. baseline and differential.
GenevisibleiP21126. MM.

Family and domain databases

InterProiView protein in InterPro
IPR019956. Ubiquitin.
IPR029071. Ubiquitin-rel_dom.
IPR019954. Ubiquitin_CS.
IPR000626. Ubiquitin_dom.
PfamiView protein in Pfam
PF00240. ubiquitin. 1 hit.
PRINTSiPR00348. UBIQUITIN.
SMARTiView protein in SMART
SM00213. UBQ. 1 hit.
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiView protein in PROSITE
PS00299. UBIQUITIN_1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUBL4A_MOUSE
AccessioniPrimary (citable) accession number: P21126
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: April 12, 2017
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.