ID   B5_VACCC                Reviewed;         317 AA.
AC   P21115;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   19-OCT-2011, entry version 65.
DE   RecName: Full=Plaque-size/host range protein;
DE   AltName: Full=Protein B5;
DE   Flags: Precursor;
GN   Name=PS/HR; ORFNames=B5R;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; dsDNA viruses, no RNA stage; Poxviridae; Chordopoxvirinae;
OC   Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=91021027; PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL   Virology 179:517-563(1990).
CC   -!- FUNCTION: Play a role in the dissolution of the outermost membrane
CC       of extracellular enveloped virions (EEV) to allow virion entry
CC       into host cells. Participates also in wrapping intracellular
CC       mature virions (IMV) to form intracellular enveloped virions (IEV)
CC       (By similarity).
CC   -!- SUBUNIT: Interacts with A33; this interaction is required for
CC       efficient targeting of A33 and B5 into enveloped virions.
CC       Interacts with A34; this interaction is required for the correct
CC       glycosylation, trafficking and stability of A34 and B5
CC       incorporation into extracellular enveloped virions (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Host membrane; Single-pass type I membrane
CC       protein (Potential). Virion. Note=B5 is found on extracellular
CC       virions but not on intracellular mature virions (By similarity).
CC   -!- SIMILARITY: Belongs to the receptors of complement activation
CC       (RCA) family.
CC   -!- SIMILARITY: Contains 4 Sushi (CCP/SCR) domains.
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DR   EMBL; M35027; AAA48201.1; -; Genomic_DNA.
DR   PIR; D42526; D42526.
DR   ProteinModelPortal; P21115; -.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019012; C:virion; IEA:UniProtKB-SubCell.
DR   GO; GO:0001848; F:complement binding; IEA:InterPro.
DR   GO; GO:0045916; P:negative regulation of complement activation; IEA:InterPro.
DR   InterPro; IPR011176; CIP_VAC_C3L.
DR   InterPro; IPR016060; Complement_control_module.
DR   InterPro; IPR000436; Sushi_SCR_CCP.
DR   Gene3D; G3DSA:2.10.70.10; Complement_control_module; 3.
DR   Pfam; PF00084; Sushi; 3.
DR   PIRSF; PIRSF002486; CIP_VAC_C3L; 1.
DR   SMART; SM00032; CCP; 4.
DR   SUPFAM; SSF57535; Complement_control_module; 3.
DR   PROSITE; PS50923; SUSHI; 3.
PE   3: Inferred from homology;
KW   Complete proteome; Disulfide bond; Host membrane; Membrane; Repeat;
KW   Signal; Sushi; Transmembrane; Transmembrane helix; Virion.
FT   SIGNAL        1     17       Potential.
FT   CHAIN        18    317       Plaque-size/host range protein.
FT                                /FTId=PRO_0000006017.
FT   TOPO_DOM     18    279       Extracellular (Potential).
FT   TRANSMEM    280    300       Helical; (Potential).
FT   TOPO_DOM    301    317       Cytoplasmic (Potential).
FT   DOMAIN       19     74       Sushi 1.
FT   DOMAIN       75    126       Sushi 2.
FT   DOMAIN      127    184       Sushi 3.
FT   DOMAIN      185    239       Sushi 4.
FT   DISULFID     21     61       By similarity.
FT   DISULFID     48     72       By similarity.
FT   DISULFID     76    110       By similarity.
FT   DISULFID    101    125       By similarity.
FT   DISULFID    130    171       By similarity.
FT   DISULFID    157    182       By similarity.
FT   DISULFID    186    225       By similarity.
FT   DISULFID    211    237       By similarity.
SQ   SEQUENCE   317 AA;  35109 MW;  B66E3E29EF3C2BA7 CRC64;
     MKTISVVTLL CVLPAVVYST CTVPTMNNAK LTSTETSFNN NQKVTFTCDQ GYHSSDPNAV
     CETDKWKYEN PCKKMCTVSD YISELYNKPL YEVNSTMTLS CNGETKYFRC EEKNGNTSWN
     DTVTCPNAEC QPLQLEHGSC QPVKEKYSFG EYMTINCDVG YEVIGASYIS CTANSWNVIP
     SCQQKCDIPS LSNGLISGST FSIGGVIHLS CKSGFILTGS PSSTCIDGKW NPVLPICVRT
     NEEFDPVDDG PDDETDLSKL SKDVVQYEQE IESLEATYHI IIVALTIMGV IFLISVIVLV
     CSCDKNNDQY KFHKLLP
//