ID   VB05_VACCC              Reviewed;         317 AA.
AC   P21115;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   24-NOV-2009, entry version 58.
DE   RecName: Full=Plaque-size/host range protein;
DE   AltName: Full=Protein B5;
DE   Flags: Precursor;
GN   Name=PS/HR; ORFNames=B5R;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; dsDNA viruses, no RNA stage; Poxviridae; Chordopoxvirinae;
OC   Orthopoxvirus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=91021027; PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [2]
RP   COMPLETE GENOME.
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL   Virology 179:517-563(1990).
CC   -!- FUNCTION: Regulation of plaque size and host range.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein (Potential).
CC   -!- SIMILARITY: Belongs to the receptors of complement activation
CC       (RCA) family.
CC   -!- SIMILARITY: Contains 4 Sushi (CCP/SCR) domains.
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DR   EMBL; M35027; AAA48201.1; -; Genomic_DNA.
DR   PIR; D42526; D42526.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0001848; F:complement binding; IEA:InterPro.
DR   GO; GO:0045916; P:negative regulation of complement activation; IEA:InterPro.
DR   InterPro; IPR011176; CIP_VAC_C3L.
DR   InterPro; IPR016060; Complement_control_module.
DR   InterPro; IPR000436; Sushi_SCR_CCP.
DR   Gene3D; G3DSA:2.10.70.10; Complement_control_module; 2.
DR   Pfam; PF00084; Sushi; 3.
DR   PIRSF; PIRSF002486; CIP_VAC_C3L; 1.
DR   SMART; SM00032; CCP; 4.
DR   PROSITE; PS50923; SUSHI; 3.
PE   3: Inferred from homology;
KW   Complete proteome; Disulfide bond; Membrane; Repeat; Signal; Sushi;
KW   Transmembrane.
FT   SIGNAL        1     17       Potential.
FT   CHAIN        18    317       Plaque-size/host range protein.
FT                                /FTId=PRO_0000006017.
FT   TOPO_DOM     18    279       Extracellular (Potential).
FT   TRANSMEM    280    300       Potential.
FT   TOPO_DOM    301    317       Cytoplasmic (Potential).
FT   DOMAIN       19     74       Sushi 1.
FT   DOMAIN       75    126       Sushi 2.
FT   DOMAIN      127    184       Sushi 3.
FT   DOMAIN      185    239       Sushi 4.
FT   DISULFID     21     61       By similarity.
FT   DISULFID     48     72       By similarity.
FT   DISULFID     76    110       By similarity.
FT   DISULFID    101    125       By similarity.
FT   DISULFID    130    171       By similarity.
FT   DISULFID    157    182       By similarity.
FT   DISULFID    186    225       By similarity.
FT   DISULFID    211    237       By similarity.
SQ   SEQUENCE   317 AA;  35109 MW;  B66E3E29EF3C2BA7 CRC64;
     MKTISVVTLL CVLPAVVYST CTVPTMNNAK LTSTETSFNN NQKVTFTCDQ GYHSSDPNAV
     CETDKWKYEN PCKKMCTVSD YISELYNKPL YEVNSTMTLS CNGETKYFRC EEKNGNTSWN
     DTVTCPNAEC QPLQLEHGSC QPVKEKYSFG EYMTINCDVG YEVIGASYIS CTANSWNVIP
     SCQQKCDIPS LSNGLISGST FSIGGVIHLS CKSGFILTGS PSSTCIDGKW NPVLPICVRT
     NEEFDPVDDG PDDETDLSKL SKDVVQYEQE IESLEATYHI IIVALTIMGV IFLISVIVLV
     CSCDKNNDQY KFHKLLP
//