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Protein

Methyl-coenzyme M reductase II subunit gamma

Gene

mrtG

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide.

Catalytic activityi

Methyl-CoM + CoB = CoM-S-S-CoB + methane.

Pathwayi: methyl-coenzyme M reduction

This protein is involved in step 1 of the subpathway that synthesizes methane from methyl-coenzyme M.
Proteins known to be involved in this subpathway in this organism are:
  1. Methyl-coenzyme M reductase subunit alpha (mcrA), Methyl-coenzyme M reductase I subunit gamma (mcrG), Methyl-coenzyme M reductase I subunit beta (mcrB), Methyl-coenzyme M reductase II subunit gamma (mrtG), Methyl-coenzyme M reductase II subunit beta (mrtB), Methyl-coenzyme M reductase II subunit alpha (mrtA)
This subpathway is part of the pathway methyl-coenzyme M reduction, which is itself part of One-carbon metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes methane from methyl-coenzyme M, the pathway methyl-coenzyme M reduction and in One-carbon metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processMethanogenesis

Enzyme and pathway databases

BioCyciMetaCyc:MRTGMAUTO-MONOMER
UniPathwayiUPA00646; UER00699

Names & Taxonomyi

Protein namesi
Recommended name:
Methyl-coenzyme M reductase II subunit gamma (EC:2.8.4.1)
Short name:
MCR II gamma
Alternative name(s):
Coenzyme-B sulfoethylthiotransferase gamma
Gene namesi
Name:mrtG
Ordered Locus Names:MTH_1130
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001474802 – 265Methyl-coenzyme M reductase II subunit gammaAdd BLAST264

Expressioni

Developmental stagei

There are two MCR complexes in this bacteria. MCR II is expressed in the early growth phase. Late growth cells contains mostly MCR I.

Interactioni

Subunit structurei

Hexamer of two alpha, two beta, and two gamma chains.

Protein-protein interaction databases

IntActiP21112, 1 interactor
STRINGi187420.MTH1130

Structurei

3D structure databases

ProteinModelPortaliP21112
SMRiP21112
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiarCOG04858 Archaea
COG4057 LUCA
KOiK00402
OMAiGHRNPGE
OrthoDBiPOG093Z08I2

Family and domain databases

CDDicd00539 MCR_gamma, 1 hit
Gene3Di3.90.320.20, 1 hit
InterProiView protein in InterPro
IPR009024 Me_CoM_Rdtase_Fd-like_fold
IPR003178 Me_CoM_Rdtase_gsu
IPR036994 Me_CoM_Rdtase_gsu_sf
PfamiView protein in Pfam
PF02240 MCR_gamma, 1 hit
PIRSFiPIRSF000264 Meth_CoM_rd_gama, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005845 Me_CoM_Rdtase_gsu, 1 hit
SUPFAMiSSF55088 SSF55088, 1 hit
TIGRFAMsiTIGR03259 met_CoM_red_gam, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21112-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTYKAQYTPG ETQIAENRRK HMDPDYEFRK LREVSDEDLV KVLGHRNPGE
60 70 80 90 100
SYKSVHPPLD EMDFEEDIVR DMVEPIQGAK EGVRVRYIQF ADSMYNAPAQ
110 120 130 140 150
PYDRARTYMW RYRGVDTGTL SGRQVIEMRE LDLEGVSKEL VETELFDPAT
160 170 180 190 200
TGIRGATVHG HSLRLDENGL MFDALQRYVF DEEKGHVVYV KDQVGRPLDE
210 220 230 240 250
PVDMGQPLGE DELKKITTIY RKDNIAMRDD KEAIEVVENI HTGRTMGGFG
260
MDVFKDDLRK RLGDD
Length:265
Mass (Da):30,567
Last modified:January 23, 2007 - v5
Checksum:iF1E6783AAE7A3CA8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti132D → V in AAA73438 (PubMed:7929010).Curated1
Sequence conflicti230D → DD in AAA73438 (PubMed:7929010).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09990 Genomic DNA Translation: AAA73438.1
AE000666 Genomic DNA Translation: AAB85619.1
PIRiT45149

Genome annotation databases

EnsemblBacteriaiAAB85619; AAB85619; MTH_1130
KEGGimth:MTH_1130
PATRICifig|187420.15.peg.1107

Similar proteinsi

Entry informationi

Entry nameiMCRZ_METTH
AccessioniPrimary (citable) accession number: P21112
Secondary accession number(s): O27202, Q50486
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 123 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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