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P21112

- MCRZ_METTH

UniProt

P21112 - MCRZ_METTH

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Protein

Methyl-coenzyme M reductase II subunit gamma

Gene

mrtG

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide.

Catalytic activityi

Methyl-CoM + CoB = CoM-S-S-CoB + methane.

Pathwayi

GO - Molecular functioni

  1. coenzyme-B sulfoethylthiotransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. methanogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Methanogenesis

Enzyme and pathway databases

BioCyciMetaCyc:MRTGMAUTO-MONOMER.
MTHE187420:GJNM-1132-MONOMER.
UniPathwayiUPA00646; UER00699.

Names & Taxonomyi

Protein namesi
Recommended name:
Methyl-coenzyme M reductase II subunit gamma (EC:2.8.4.1)
Short name:
MCR II gamma
Alternative name(s):
Coenzyme-B sulfoethylthiotransferase gamma
Gene namesi
Name:mrtG
Ordered Locus Names:MTH_1130
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
ProteomesiUP000005223: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 265264Methyl-coenzyme M reductase II subunit gammaPRO_0000147480Add
BLAST

Expressioni

Developmental stagei

There are two MCR complexes in this bacteria. MCR II is expressed in the early growth phase. Late growth cells contains mostly MCR I.

Interactioni

Subunit structurei

Hexamer of two alpha, two beta, and two gamma chains.

Protein-protein interaction databases

IntActiP21112. 1 interaction.
STRINGi187420.MTH1130.

Structurei

3D structure databases

ProteinModelPortaliP21112.
SMRiP21112. Positions 5-251.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG4057.
KOiK00402.
OMAiGHRNPGE.

Family and domain databases

Gene3Di3.90.320.20. 1 hit.
InterProiIPR009024. Me_CoM_Rdtase_Fd-like_fold.
IPR003178. Me_CoM_Rdtase_gsu.
[Graphical view]
PfamiPF02240. MCR_gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF000264. Meth_CoM_rd_gama. 1 hit.
ProDomiPD005845. Me_CoM_Rdtase_gsu. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF55088. SSF55088. 1 hit.
TIGRFAMsiTIGR03259. met_CoM_red_gam. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21112-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTYKAQYTPG ETQIAENRRK HMDPDYEFRK LREVSDEDLV KVLGHRNPGE
60 70 80 90 100
SYKSVHPPLD EMDFEEDIVR DMVEPIQGAK EGVRVRYIQF ADSMYNAPAQ
110 120 130 140 150
PYDRARTYMW RYRGVDTGTL SGRQVIEMRE LDLEGVSKEL VETELFDPAT
160 170 180 190 200
TGIRGATVHG HSLRLDENGL MFDALQRYVF DEEKGHVVYV KDQVGRPLDE
210 220 230 240 250
PVDMGQPLGE DELKKITTIY RKDNIAMRDD KEAIEVVENI HTGRTMGGFG
260
MDVFKDDLRK RLGDD
Length:265
Mass (Da):30,567
Last modified:January 23, 2007 - v5
Checksum:iF1E6783AAE7A3CA8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti132 – 1321D → V in AAA73438. (PubMed:7929010)Curated
Sequence conflicti230 – 2301D → DD in AAA73438. (PubMed:7929010)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09990 Genomic DNA. Translation: AAA73438.1.
AE000666 Genomic DNA. Translation: AAB85619.1.
PIRiT45149.
RefSeqiNP_276258.1. NC_000916.1.

Genome annotation databases

EnsemblBacteriaiAAB85619; AAB85619; MTH_1130.
GeneIDi1471538.
KEGGimth:MTH1130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09990 Genomic DNA. Translation: AAA73438.1 .
AE000666 Genomic DNA. Translation: AAB85619.1 .
PIRi T45149.
RefSeqi NP_276258.1. NC_000916.1.

3D structure databases

ProteinModelPortali P21112.
SMRi P21112. Positions 5-251.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P21112. 1 interaction.
STRINGi 187420.MTH1130.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB85619 ; AAB85619 ; MTH_1130 .
GeneIDi 1471538.
KEGGi mth:MTH1130.

Phylogenomic databases

eggNOGi COG4057.
KOi K00402.
OMAi GHRNPGE.

Enzyme and pathway databases

UniPathwayi UPA00646 ; UER00699 .
BioCyci MetaCyc:MRTGMAUTO-MONOMER.
MTHE187420:GJNM-1132-MONOMER.

Family and domain databases

Gene3Di 3.90.320.20. 1 hit.
InterProi IPR009024. Me_CoM_Rdtase_Fd-like_fold.
IPR003178. Me_CoM_Rdtase_gsu.
[Graphical view ]
Pfami PF02240. MCR_gamma. 1 hit.
[Graphical view ]
PIRSFi PIRSF000264. Meth_CoM_rd_gama. 1 hit.
ProDomi PD005845. Me_CoM_Rdtase_gsu. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF55088. SSF55088. 1 hit.
TIGRFAMsi TIGR03259. met_CoM_red_gam. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Growth phase-dependent transcription of the genes that encode the two methyl coenzyme M reductase isoenzymes and N5-methyltetrahydromethanopterin:coenzyme M methyltransferase in Methanobacterium thermoautotrophicum delta H."
    Pihl T.D., Sharma S., Reeve J.N.
    J. Bacteriol. 176:6384-6391(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.
  3. "Two genetically distinct methyl-coenzyme M reductases in Methanobacterium thermoautotrophicum strain Marburg and delta H."
    Rospert S., Linder D., Ellermann J., Thauer R.K.
    Eur. J. Biochem. 194:871-877(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-16.
    Strain: ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H.

Entry informationi

Entry nameiMCRZ_METTH
AccessioniPrimary (citable) accession number: P21112
Secondary accession number(s): O27202, Q50486
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: October 1, 2014
This is version 102 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways

External Data

Dasty 3