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Protein

Methyl-coenzyme M reductase II subunit beta

Gene

mrtB

Organism
Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide.

Catalytic activityi

Methyl-CoM + CoB = CoM-S-S-CoB + methane.

Pathwayi: methyl-coenzyme M reduction

This protein is involved in step 1 of the subpathway that synthesizes methane from methyl-coenzyme M.
Proteins known to be involved in this subpathway in this organism are:
  1. Methyl-coenzyme M reductase subunit alpha (mcrA), Methyl-coenzyme M reductase I subunit gamma (mcrG), Methyl-coenzyme M reductase I subunit beta (mcrB), Methyl-coenzyme M reductase II subunit gamma (mrtG), Methyl-coenzyme M reductase II subunit beta (mrtB), Methyl-coenzyme M reductase II subunit alpha (mrtA)
This subpathway is part of the pathway methyl-coenzyme M reduction, which is itself part of One-carbon metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes methane from methyl-coenzyme M, the pathway methyl-coenzyme M reduction and in One-carbon metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processMethanogenesis

Enzyme and pathway databases

BioCyciMetaCyc:MRTBMAUTO-MONOMER
MTHE187420:G1G16-1093-MONOMER
UniPathwayiUPA00646; UER00699

Names & Taxonomyi

Protein namesi
Recommended name:
Methyl-coenzyme M reductase II subunit beta (EC:2.8.4.1)
Short name:
MCR II beta
Alternative name(s):
Coenzyme-B sulfoethylthiotransferase beta
Gene namesi
Name:mrtB
Ordered Locus Names:MTH_1132
OrganismiMethanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri187420 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000005223 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001474692 – 443Methyl-coenzyme M reductase II subunit betaAdd BLAST442

Expressioni

Developmental stagei

There are two MCR complexes in this bacteria. MCR II is expressed in the early growth phase. Late growth cells contains mostly MCR I.

Interactioni

Subunit structurei

Hexamer of two alpha, two beta, and two gamma chains.

Protein-protein interaction databases

IntActiP21111, 1 interactor
STRINGi187420.MTH1132

Structurei

3D structure databases

ProteinModelPortaliP21111
SMRiP21111
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiarCOG04860 Archaea
COG4054 LUCA
KOiK00401
OMAiWALWNAY
OrthoDBiPOG093Z033X

Family and domain databases

Gene3Di1.20.840.10, 2 hits
3.30.70.470, 1 hit
InterProiView protein in InterPro
IPR008924 Me_CoM_Rdtase_asu/bsu_C
IPR015823 Me_CoM_Rdtase_asu_N_sub2
IPR003179 Me_CoM_Rdtase_bsu
IPR022679 Me_CoM_Rdtase_bsu_C
IPR022680 Me_CoM_Rdtase_bsu_N
IPR009024 Me_CoM_Rdtase_Fd-like_fold
PfamiView protein in Pfam
PF02241 MCR_beta, 1 hit
PF02783 MCR_beta_N, 1 hit
PIRSFiPIRSF000263 Meth_CoM_rd_beta, 1 hit
SUPFAMiSSF48081 SSF48081, 1 hit
SSF55088 SSF55088, 1 hit
TIGRFAMsiTIGR03257 met_CoM_red_bet, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPMYEDRIDL YGADGKLLEE DVPLEAVSPL KNPTIANLVS DVKRSVAVNL
60 70 80 90 100
AGIEGSLKKA ALGGKSNFIP GREVELPIVE NAEAIAEKVK RLVQTSEDDD
110 120 130 140 150
TNIRLINNGQ QILVQVPTTR MGVAADYTVS ALVTGAAVVQ AIIDEFDVDM
160 170 180 190 200
FDANAVKTAV MGRYPQTVDF TGANLSTLLG PPVLLEGLGY GLRNIMANHV
210 220 230 240 250
VAITRKNTLN ASALSSILEQ TAMFETGDAV GAFERMHLLG LAYQGLNANN
260 270 280 290 300
LLFDLVKENS KGTVGTVIAS LVERAIEDRV IKVASEMKSG YKMYEPADWA
310 320 330 340 350
LWNAYAATGL LAATIVNVGA ARAAQGVAST VLYYNDILEY ETGLPGVDFG
360 370 380 390 400
RAMGTAVGFS FFSHSIYGGG GPGIFHGNHV VTRHSKGFAL PCVAAAMCLD
410 420 430 440
AGTQMFSVEK TSGLIGSVYS EIDYFREPIV NVAKGAAEIK DQL
Length:443
Mass (Da):47,134
Last modified:January 23, 2007 - v4
Checksum:i462293DE946E994E
GO

Sequence cautioni

The sequence AAB85621 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti294Y → I in AAA73436 (PubMed:7929010).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09990 Genomic DNA Translation: AAA73436.1
AE000666 Genomic DNA Translation: AAB85621.1 Different initiation.
J04540 Genomic DNA Translation: AAB02353.1
PIRiG69017
T45147
RefSeqiWP_048060974.1, NC_000916.1

Genome annotation databases

EnsemblBacteriaiAAB85621; AAB85621; MTH_1132
GeneIDi1471540
KEGGimth:MTH_1132
PATRICifig|187420.15.peg.1109

Similar proteinsi

Entry informationi

Entry nameiMCRY_METTH
AccessioniPrimary (citable) accession number: P21111
Secondary accession number(s): O27204
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 122 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways

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