P21108 (PRPS3_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 116.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Ribose-phosphate pyrophosphokinase 3 EC=2.7.6.1 Alternative name(s): Phosphoribosyl pyrophosphate synthase 1-like 1 Short name=PRPS1-like 1 Phosphoribosyl pyrophosphate synthase III Short name=PRS-III | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Reference proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo![]() |
Protein attributes
| Sequence length | 318 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis. |
| Catalytic activity | ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. |
| Cofactor | Magnesium. |
| Enzyme regulation | Activated by magnesium and inorganic phosphate. |
| Pathway | |
| Subunit structure | Homodimer. The active form is probably a hexamer composed of 3 homodimers By similarity. |
| Tissue specificity | Testis. |
| Sequence similarities | Belongs to the ribose-phosphate pyrophosphokinase family. |
| Caution | According to Ref.1, this sequence initiates from a non-AUG codon; N-terminal ACG codon did serve as a start codon. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed Ref.1 | ||||||
| Chain | 2 – 318 | 317 | Ribose-phosphate pyrophosphokinase 3 | PRO_0000141078 | |||||
Regions | |||||||||
| Nucleotide binding | 96 – 101 | 6 | ATP By similarity | ||||||
| Region | 212 – 227 | 16 | Binding of phosphoribosylpyrophosphate Potential | ||||||
Sites | |||||||||
| Metal binding | 128 | 1 | Magnesium Potential | ||||||
| Metal binding | 130 | 1 | Magnesium Potential | ||||||
| Metal binding | 139 | 1 | Magnesium Potential | ||||||
| Metal binding | 143 | 1 | Magnesium Potential | ||||||
| Binding site | 130 | 1 | ATP By similarity | ||||||
Natural variations | |||||||||
| Natural variant | 279 | 1 | E → D. Ref.2 Corresponds to variant rs3800962 [ dbSNP | Ensembl ]. | VAR_050062 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "A human testis-specific mRNA for phosphoribosylpyrophosphate synthetase that initiates from a non-AUG codon." Taira M., Iizasa T., Shimada H., Kudoh J., Shimizu N., Tatibana M. J. Biol. Chem. 265:16491-16497(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-11. Tissue: Testis. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-279. Tissue: Testis. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | M57423 mRNA. Translation: AAB59463.1. BC062797 mRNA. Translation: AAH62797.2. |
| IPI | IPI00218371. |
| PIR | KIHUR3. A37893. |
| RefSeq | NP_787082.1. NM_175886.2. |
| UniGene | Hs.169284. |
3D structure databases | |
| ProteinModelPortal | P21108. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 9606.ENSP00000390134. |
PTM databases | |
| PhosphoSite | P21108. |
Polymorphism databases | |
| DMDM | 125585. |
2D gel databases | |
| SWISS-2DPAGE | P21108. |
Proteomic databases | |
| PRIDE | P21108. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 221823. |
| KEGG | hsa:221823. |
| UCSC | uc003stz.3. human. |
Organism-specific databases | |
| CTD | 221823. |
| GeneCards | GC07M018066. |
| H-InvDB | HIX0033604. |
| HGNC | HGNC:9463. PRPS1L1. |
| MIM | 611566. gene. |
| neXtProt | NX_P21108. |
| PharmGKB | PA33818. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | HOG000210451. |
| HOVERGEN | HBG001520. |
| InParanoid | P21108. |
| KO | K00948. |
Enzyme and pathway databases | |
| Reactome | REACT_111217. Metabolism. |
| UniPathway | UPA00087; UER00172. |
Gene expression databases | |
| CleanEx | HS_PRPS1L1. |
| Genevestigator | P21108. |
| GermOnline | ENSG00000153287. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000842. PRib_PP_synth_CS. IPR000836. PRibTrfase_dom. IPR005946. Rib-P_diPkinase. [Graphical view] |
| Pfam | PF00156. Pribosyltran. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01251. ribP_PPkin. 1 hit. |
| PROSITE | PS00114. PRPP_SYNTHASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| GenomeRNAi | 221823. |
| NextBio | 91465. |
| SOURCE | Search... |
Entry information
| Entry name | PRPS3_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P21108 Secondary accession number(s): Q6P5P6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 7 Human chromosome 7: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with
