UniProtKB - P21107 (TPM3_MOUSE)
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Tropomyosin alpha-3 chain
Tpm3
Functioni
GO - Molecular functioni
- actin filament binding Source: GO_Central
- structural constituent of muscle Source: GO_Central
GO - Biological processi
- actin filament organization Source: GO_Central
- muscle contraction Source: GO_Central
Keywordsi
Molecular function | Actin-binding, Muscle protein |
Enzyme and pathway databases
Reactomei | R-MMU-390522. Striated Muscle Contraction. R-MMU-445355. Smooth Muscle Contraction. |
Names & Taxonomyi
Protein namesi | Recommended name: Tropomyosin alpha-3 chainAlternative name(s): Gamma-tropomyosin Tropomyosin-3 |
Gene namesi | Name:Tpm3 Synonyms:Tpm-5, Tpm5 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1890149. Tpm3. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | ||||
ChainiPRO_0000205633 | 2 – 285 | Tropomyosin alpha-3 chainAdd BLAST | 284 | ||
Isoform 2 (identifier: P21107-2) | |||||
Initiator methioninei | RemovedBy similarity |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 2 | N-acetylmethionineBy similarity | 1 | ||
Modified residuei | 54 | PhosphothreonineBy similarity | 1 | ||
Modified residuei | 62 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 88 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 109 | PhosphothreonineBy similarity | 1 | ||
Modified residuei | 207 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 216 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 253 | PhosphothreonineBy similarity | 1 | ||
Modified residuei | 262 | PhosphotyrosineBy similarity | 1 | ||
Modified residuei | 272 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 283 | PhosphothreonineBy similarity | 1 | ||
Modified residuei | 284 | PhosphoserineCombined sources | 1 | ||
Isoform 2 (identifier: P21107-2) | |||||
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | ||
Modified residuei | 228 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P21107. |
MaxQBi | P21107. |
PeptideAtlasi | P21107. |
PRIDEi | P21107. |
2D gel databases
COMPLUYEAST-2DPAGEi | P21107. |
REPRODUCTION-2DPAGEi | P21107. |
SWISS-2DPAGEi | P21107. |
PTM databases
iPTMneti | P21107. |
PhosphoSitePlusi | P21107. |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000027940. |
CleanExi | MM_TPM3. |
ExpressionAtlasi | P21107. baseline and differential. |
Genevisiblei | P21107. MM. |
Interactioni
Subunit structurei
GO - Molecular functioni
- actin filament binding Source: GO_Central
Protein-protein interaction databases
BioGridi | 208522. 6 interactors. |
DIPi | DIP-32061N. |
IntActi | P21107. 6 interactors. |
MINTi | P21107. |
Structurei
3D structure databases
ProteinModelPortali | P21107. |
SMRi | P21107. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1 – 285 | By similarityAdd BLAST | 285 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
GeneTreei | ENSGT00550000074494. |
HOGENOMi | HOG000231521. |
HOVERGENi | HBG107404. |
InParanoidi | P21107. |
KOi | K09290. |
Family and domain databases
InterProi | View protein in InterPro IPR000533. Tropomyosin. |
Pfami | View protein in Pfam PF00261. Tropomyosin. 1 hit. |
PRINTSi | PR00194. TROPOMYOSIN. |
PROSITEi | View protein in PROSITE PS00326. TROPOMYOSIN. 1 hit. |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MMEAIKKKMQ MLKLDKENVL DRAEQAEAEQ KQAEERSKQL EDELATMQKK
60 70 80 90 100
LKGTEDELDK YSEALKDAQE KLELAEKKAA DAEAEVASLN RRIQLVEEEL
110 120 130 140 150
DRAQERLATA LQKLEEAEKA ADESERGMKV IENRALKDEE KMELQEIQLK
160 170 180 190 200
EAKHIAEEAD RKYEEVARKL VIIEGDLERT EERAELAESK CSELEEELKN
210 220 230 240 250
VTNNLKSLEA QAEKYSQKED KYEEEIKILT DKLKEAETRA EFAERSVAKL
260 270 280
EKTIDDLEDE LYAQKLKYKA ISDELDHALN DMTSI
The sequence of this isoform differs from the canonical sequence as follows:
1-81: MMEAIKKKMQ...LELAEKKAAD → MAGTTTIEAV...VEGERRAREQ
190-212: KCSELEEELKNVTNNLKSLEAQA → RCREMDEQIRLMDQNLKCLSAAE
260-285: ELYAQKLKYKAISDELDHALNDMTSI → KLKCTKEEHLCTQRMLDQTLLDLNEM
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 19 | V → F in AAA03725 (Ref. 2) Curated | 1 | |
Sequence conflicti | 112 | Q → R in AAA03725 (Ref. 2) Curated | 1 | |
Sequence conflicti | 181 | E → G in AAA03725 (Ref. 2) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006608 | 1 – 81 | MMEAI…KKAAD → MAGTTTIEAVKRKIQVLQQQ ADDAEERAERLQREVEGERR AREQ in isoform 2. 2 PublicationsAdd BLAST | 81 | |
Alternative sequenceiVSP_006609 | 190 – 212 | KCSEL…LEAQA → RCREMDEQIRLMDQNLKCLS AAE in isoform 2. 2 PublicationsAdd BLAST | 23 | |
Alternative sequenceiVSP_006610 | 260 – 285 | ELYAQ…DMTSI → KLKCTKEEHLCTQRMLDQTL LDLNEM in isoform 2. 2 PublicationsAdd BLAST | 26 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53753 mRNA. Translation: CAA37782.1. U04541 mRNA. Translation: AAA03725.1. AF317223 mRNA. Translation: AAG38596.1. AK088111 mRNA. Translation: BAC40150.1. AK088902 mRNA. Translation: BAC40643.1. X72633 mRNA. Translation: CAA51209.1. |
CCDSi | CCDS57223.1. [P21107-2] |
PIRi | I48852. S11390. |
RefSeqi | NP_001240667.1. NM_001253738.1. [P21107-2] NP_001280677.2. NM_001293748.1. [P21107-1] |
UniGenei | Mm.240839. Mm.421791. Mm.442249. Mm.490309. |
Genome annotation databases
Ensembli | ENSMUST00000029549; ENSMUSP00000029549; ENSMUSG00000027940. [P21107-2] |
GeneIDi | 59069. |
KEGGi | mmu:59069. |
UCSCi | uc008qbf.3. mouse. [P21107-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | TPM3_MOUSE | |
Accessioni | P21107Primary (citable) accession number: P21107 Secondary accession number(s): Q09021 Q9EPW3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1991 |
Last sequence update: | June 26, 2013 | |
Last modified: | February 28, 2018 | |
This is version 160 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |