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P21079

- PAP1_VACCC

UniProt

P21079 - PAP1_VACCC

Protein

Poly(A) polymerase catalytic subunit

Gene

PAPL

Organism
Vaccinia virus (strain Copenhagen) (VACV)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (01 Feb 1991)
      Previous versions | rss
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    Functioni

    Polymerase that creates the 3'-poly(A) tail of mRNA's.

    Catalytic activityi

    ATP + RNA(n) = diphosphate + RNA(n+1).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei202 – 2021By similarity
    Active sitei204 – 2041By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. polynucleotide adenylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    mRNA processing, Transcription

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Poly(A) polymerase catalytic subunit (EC:2.7.7.19)
    Alternative name(s):
    Poly(A) polymerase large subunit
    Short name:
    PAP-L
    VP55
    Gene namesi
    Name:PAPL
    ORF Names:E1L
    OrganismiVaccinia virus (strain Copenhagen) (VACV)
    Taxonomic identifieri10249 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000008269: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 479479Poly(A) polymerase catalytic subunitPRO_0000099106Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit.

    Structurei

    3D structure databases

    ProteinModelPortaliP21079.
    SMRiP21079. Positions 12-479.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR024231. Pox_polyA_pol_nucTrfase.
    IPR004976. Poxvirus_polyA_pol_cat.
    IPR024397. Poxvirus_polyA_pol_cat_C.
    IPR024398. Poxvirus_polyA_pol_cat_N.
    [Graphical view]
    PfamiPF03296. Pox_polyA_pol. 1 hit.
    PF12629. Pox_polyA_pol_C. 1 hit.
    PF12630. Pox_polyA_pol_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015693. VAC-48L_nuct. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P21079-1 [UniParc]FASTAAdd to Basket

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    MNRNPDQNTF PNITLKIIET YLGRVPSVNE YHMLKLQARN IQKITVFNKD    50
    IFVSLVKKNK KRFFSDVDTS ASEIKDRILS YFSKQTQTYN IGKLFTIIEL 100
    QSVLVTTYTD ILGVLTIKAP NVISSKISYN VTSMEELARD MLNSMNVAII 150
    DKAKVMGRHN VSSLVKNVNK LMEEYLRRHN KSCICYGSYS LYLINPNIRY 200
    GDIDILQTNS RTFLIDLAFL IKFITGNNII LSKIPYLRNY MVIKDENDNH 250
    IIDSFNIRQD TMNVVPKIFI DNIYIVDPTF QLLNMIKMFS QIDRLEDLSK 300
    DPEKFNARMA TMLEYVRYTH GIVFDGKRNN MPMKCIIDEN NRIVTVTTKD 350
    YFSFKKCLVY LDENVLSSDI LDLNADTSCD FESVTNSVYL IHDNIMYTYF 400
    SNTILLSDKG KVHEISARGL CAHILLYQML TSGEYKQCLS DLLNSMMNRD 450
    KIPIYSHTER DKKPGRHGFI NIEKDIIVF 479
    Length:479
    Mass (Da):55,580
    Last modified:February 1, 1991 - v1
    Checksum:i50AC0C13698BECA7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M35027 Genomic DNA. Translation: AAA48038.1.
    PIRiE42508.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M35027 Genomic DNA. Translation: AAA48038.1 .
    PIRi E42508.

    3D structure databases

    ProteinModelPortali P21079.
    SMRi P21079. Positions 12-479.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR024231. Pox_polyA_pol_nucTrfase.
    IPR004976. Poxvirus_polyA_pol_cat.
    IPR024397. Poxvirus_polyA_pol_cat_C.
    IPR024398. Poxvirus_polyA_pol_cat_N.
    [Graphical view ]
    Pfami PF03296. Pox_polyA_pol. 1 hit.
    PF12629. Pox_polyA_pol_C. 1 hit.
    PF12630. Pox_polyA_pol_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015693. VAC-48L_nuct. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Appendix to 'The complete DNA sequence of vaccinia virus'."
      Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P., Paoletti E.
      Virology 179:517-563(1990)
      Cited for: COMPLETE GENOME.

    Entry informationi

    Entry nameiPAP1_VACCC
    AccessioniPrimary (citable) accession number: P21079
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3