P21057 (A34_VACCC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein A34

Gene names

ORF Names:

A34R

Organism

Vaccinia virus (strain Copenhagen) (VACV) [Complete proteome]

Taxonomic identifier

10249 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Orthopoxvirus › Vaccinia virus

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	168 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for the envelopment of intracellular viral particles and egress of enveloped virions from the infected cell By similarity.
Subunit structure	Interacts with proteins A36 AND B5 By similarity.
Subcellular location	Virion membrane; Single-pass type II membrane protein Potential. Note: Present in the enveloped virion (EV) membrane By similarity.
Sequence similarities	Belongs to the chordopoxvirinae A34 protein family. Contains 1 C-type lectin domain.

Ontologies

Keywords
Cellular component	Membrane Virion
Domain	Signal-anchor Transmembrane Transmembrane helix
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW virion membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 168	168	Protein A34		PRO_0000099319
Regions
	Topological domain	1 – 14	14	Cytoplasmic
	Transmembrane	15 – 37	23	Helical; Potential
	Topological domain	38 – 168	131	Extracellular Potential
	Domain	54 – 163	110	C-type lectin
Amino acid modifications
	Disulfide bond	75 ↔ 162		By similarity
	Disulfide bond	141 ↔ 154		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P21057 [UniParc]. Last modified February 1, 1991. Version 1. Checksum: 32CCB4B0614D2255	FASTA	168	19,529
	10 20 30 40 50 60 MKSLNRQTVS MFKKLSVPAA IMMILSTIIS GIGTFLHYKE ELMPSACANG WIQYDKHCYL 70 80 90 100 110 120 DTNIKMSTDN AVYQCRKLRA RLPRPDTRHL RVLFSIFYKD YWVSLKKTNN KWLDINNDKD 130 140 150 160 IDISKLTNFK QLNSTTDAEA CYIYKSGKLV KTVCKSTQSV LCVKKFYK

References

[1]	"The complete DNA sequence of vaccinia virus." Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P., Paoletti E. Virology 179:247-266(1990) [PubMed: 2219722] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Appendix to 'The complete DNA sequence of vaccinia virus'." Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P., Paoletti E. Virology 179:517-563(1990) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M35027 Genomic DNA. Translation: AAA48161.1.
PIR	I42520.
3D structure databases
ProteinModelPortal	P21057.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001304. C-type_lectin. IPR016186. C-type_lectin-like. IPR016187. C-type_lectin_fold. [Graphical view]
Gene3D	G3DSA:3.10.100.10. C-type_lectin-like. 1 hit.
SMART	SM00034. CLECT. 1 hit. [Graphical view]
SUPFAM	SSF56436. C-type_lectin_fold. 1 hit.
PROSITE	PS00615. C_TYPE_LECTIN_1. False negative. PS50041. C_TYPE_LECTIN_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A34_VACCC

Accession

Primary (citable) accession number: P21057

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	February 1, 1991
Last modified:	October 19, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program