SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P21054

- N1_VACCC

UniProt

P21054 - N1_VACCC

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Protein N1
Gene
N1L
Organism
Vaccinia virus (strain Copenhagen) (VACV)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Bcl-2-like protein which contributes to virulence by preventing host NF-kappa-B activation in response to pro-inflammatory stimuli such as TNF-alpha or IL1B By similarity.

GO - Biological processi

  1. evasion or tolerance by virus of host immune response Source: UniProtKB-KW
  2. modulation by virus of host apoptotic process Source: UniProtKB-KW
  3. suppression by virus of host NF-kappaB transcription factor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Inhibition of host NF-kappa-B by virus, Modulation of host cell apoptosis by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Protein N1
Gene namesi
ORF Names:N1L
OrganismiVaccinia virus (strain Copenhagen) (VACV)
Taxonomic identifieri10249 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000008269: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 117117Protein N1
PRO_0000099632Add
BLAST

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 1413
Helixi17 – 193
Helixi24 – 285
Helixi29 – 335
Helixi36 – 4914
Helixi53 – 597
Helixi66 – 8318
Helixi91 – 10212
Helixi103 – 1053
Helixi106 – 1138

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2I39X-ray2.20A/B/C/D/E/F1-117[»]
2UXEX-ray2.90A/B/C/D/E/F1-117[»]
4BBBX-ray3.09A/B/C/D/E/F1-117[»]
4BBCX-ray3.10A/B/C/D/E/F1-117[»]
4BBDX-ray3.00A/B/C/D/E/F1-117[»]
ProteinModelPortaliP21054.
SMRiP21054. Positions 1-116.

Miscellaneous databases

EvolutionaryTraceiP21054.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR009353. Orthopox_N1.
IPR022819. Poxvirus.
[Graphical view]
PfamiPF06227. Poxvirus. 1 hit.
[Graphical view]
PIRSFiPIRSF003784. VAC_N1L. 1 hit.
ProDomiPD015763. Orthopox_N1. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P21054-1 [UniParc]FASTAAdd to Basket

« Hide

MRTLLIRYIL WRNDNDQTYY NDDFKKLMLL DELVDDGDVC TLIKNMRMTL    50
SDGPLLDRLN QPVNNIEDAK RMIAISAKVA RDIGERSEIR WEESFTILFR 100
MIETYFDDLM IDLYGEK 117
Length:117
Mass (Da):13,962
Last modified:February 1, 1991 - v1
Checksum:i9050C1FECEB1B90B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M35027 Genomic DNA. Translation: AAA48001.1.
PIRiE42504.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M35027 Genomic DNA. Translation: AAA48001.1 .
PIRi E42504.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2I39 X-ray 2.20 A/B/C/D/E/F 1-117 [» ]
2UXE X-ray 2.90 A/B/C/D/E/F 1-117 [» ]
4BBB X-ray 3.09 A/B/C/D/E/F 1-117 [» ]
4BBC X-ray 3.10 A/B/C/D/E/F 1-117 [» ]
4BBD X-ray 3.00 A/B/C/D/E/F 1-117 [» ]
ProteinModelPortali P21054.
SMRi P21054. Positions 1-116.
ModBasei Search...

Chemistry

BindingDBi P21054.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P21054.

Family and domain databases

InterProi IPR009353. Orthopox_N1.
IPR022819. Poxvirus.
[Graphical view ]
Pfami PF06227. Poxvirus. 1 hit.
[Graphical view ]
PIRSFi PIRSF003784. VAC_N1L. 1 hit.
ProDomi PD015763. Orthopox_N1. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Appendix to 'The complete DNA sequence of vaccinia virus'."
    Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P., Paoletti E.
    Virology 179:517-563(1990)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein."
    Aoyagi M., Zhai D., Jin C., Aleshin A.E., Stec B., Reed J.C., Liddington R.C.
    Protein Sci. 16:118-124(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
  4. "Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic protein."
    Cooray S., Bahar M.W., Abrescia N.G., McVey C.E., Bartlett N.W., Chen R.A., Stuart D.I., Grimes J.M., Smith G.L.
    J. Gen. Virol. 88:1656-1666(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).

Entry informationi

Entry nameiN1_VACCC
AccessioniPrimary (citable) accession number: P21054
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 13, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi