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P21054

- N1_VACCC

UniProt

P21054 - N1_VACCC

Protein

Protein N1

Gene

N1L

Organism
Vaccinia virus (strain Copenhagen) (VACV)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Bcl-2-like protein which contributes to virulence by preventing host NF-kappa-B activation in response to pro-inflammatory stimuli such as TNF-alpha or IL1B.By similarity

    GO - Biological processi

    1. evasion or tolerance by virus of host immune response Source: UniProtKB-KW
    2. modulation by virus of host apoptotic process Source: UniProtKB-KW
    3. suppression by virus of host NF-kappaB transcription factor activity Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction, Inhibition of host NF-kappa-B by virus, Modulation of host cell apoptosis by virus, Viral immunoevasion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein N1
    Gene namesi
    ORF Names:N1L
    OrganismiVaccinia virus (strain Copenhagen) (VACV)
    Taxonomic identifieri10249 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000008269: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 117117Protein N1PRO_0000099632Add
    BLAST

    Expressioni

    Keywords - Developmental stagei

    Early protein

    Interactioni

    Structurei

    Secondary structure

    1
    117
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi2 – 1413
    Helixi17 – 193
    Helixi24 – 285
    Helixi29 – 335
    Helixi36 – 4914
    Helixi53 – 597
    Helixi66 – 8318
    Helixi91 – 10212
    Helixi103 – 1053
    Helixi106 – 1138

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2I39X-ray2.20A/B/C/D/E/F1-117[»]
    2UXEX-ray2.90A/B/C/D/E/F1-117[»]
    4BBBX-ray3.09A/B/C/D/E/F1-117[»]
    4BBCX-ray3.10A/B/C/D/E/F1-117[»]
    4BBDX-ray3.00A/B/C/D/E/F1-117[»]
    ProteinModelPortaliP21054.
    SMRiP21054. Positions 1-116.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP21054.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the poxviridae N1 protein family.Curated

    Family and domain databases

    InterProiIPR009353. Orthopox_N1.
    IPR022819. Poxvirus.
    [Graphical view]
    PfamiPF06227. Poxvirus. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003784. VAC_N1L. 1 hit.
    ProDomiPD015763. Orthopox_N1. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    P21054-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRTLLIRYIL WRNDNDQTYY NDDFKKLMLL DELVDDGDVC TLIKNMRMTL    50
    SDGPLLDRLN QPVNNIEDAK RMIAISAKVA RDIGERSEIR WEESFTILFR 100
    MIETYFDDLM IDLYGEK 117
    Length:117
    Mass (Da):13,962
    Last modified:February 1, 1991 - v1
    Checksum:i9050C1FECEB1B90B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M35027 Genomic DNA. Translation: AAA48001.1.
    PIRiE42504.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M35027 Genomic DNA. Translation: AAA48001.1 .
    PIRi E42504.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2I39 X-ray 2.20 A/B/C/D/E/F 1-117 [» ]
    2UXE X-ray 2.90 A/B/C/D/E/F 1-117 [» ]
    4BBB X-ray 3.09 A/B/C/D/E/F 1-117 [» ]
    4BBC X-ray 3.10 A/B/C/D/E/F 1-117 [» ]
    4BBD X-ray 3.00 A/B/C/D/E/F 1-117 [» ]
    ProteinModelPortali P21054.
    SMRi P21054. Positions 1-116.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P21054.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P21054.

    Family and domain databases

    InterProi IPR009353. Orthopox_N1.
    IPR022819. Poxvirus.
    [Graphical view ]
    Pfami PF06227. Poxvirus. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003784. VAC_N1L. 1 hit.
    ProDomi PD015763. Orthopox_N1. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Appendix to 'The complete DNA sequence of vaccinia virus'."
      Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P., Paoletti E.
      Virology 179:517-563(1990)
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein."
      Aoyagi M., Zhai D., Jin C., Aleshin A.E., Stec B., Reed J.C., Liddington R.C.
      Protein Sci. 16:118-124(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
    4. "Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic protein."
      Cooray S., Bahar M.W., Abrescia N.G., McVey C.E., Bartlett N.W., Chen R.A., Stuart D.I., Grimes J.M., Smith G.L.
      J. Gen. Virol. 88:1656-1666(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).

    Entry informationi

    Entry nameiN1_VACCC
    AccessioniPrimary (citable) accession number: P21054
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3