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P21054

- N1_VACCC

UniProt

P21054 - N1_VACCC

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Protein

Protein N1

Gene

N1L

Organism
Vaccinia virus (strain Copenhagen) (VACV)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Bcl-2-like protein which contributes to virulence by preventing host NF-kappa-B activation in response to pro-inflammatory stimuli such as TNF-alpha or IL1B.By similarity

GO - Biological processi

  1. evasion or tolerance by virus of host immune response Source: UniProtKB-KW
  2. modulation by virus of host apoptotic process Source: UniProtKB-KW
  3. suppression by virus of host NF-kappaB transcription factor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Inhibition of host NF-kappa-B by virus, Modulation of host cell apoptosis by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Protein N1
Gene namesi
ORF Names:N1L
OrganismiVaccinia virus (strain Copenhagen) (VACV)
Taxonomic identifieri10249 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000008269: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 117117Protein N1PRO_0000099632Add
BLAST

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Structurei

Secondary structure

1
117
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 1413Combined sources
Helixi17 – 193Combined sources
Helixi24 – 285Combined sources
Helixi29 – 335Combined sources
Helixi36 – 4914Combined sources
Helixi53 – 597Combined sources
Helixi66 – 8318Combined sources
Helixi91 – 10212Combined sources
Helixi103 – 1053Combined sources
Helixi106 – 1138Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2I39X-ray2.20A/B/C/D/E/F1-117[»]
2UXEX-ray2.90A/B/C/D/E/F1-117[»]
4BBBX-ray3.09A/B/C/D/E/F1-117[»]
4BBCX-ray3.10A/B/C/D/E/F1-117[»]
4BBDX-ray3.00A/B/C/D/E/F1-117[»]
ProteinModelPortaliP21054.
SMRiP21054. Positions 1-116.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP21054.

Family & Domainsi

Sequence similaritiesi

Belongs to the poxviridae N1 protein family.Curated

Family and domain databases

InterProiIPR009353. Orthopox_N1.
IPR022819. Poxvirus.
[Graphical view]
PfamiPF06227. Poxvirus. 1 hit.
[Graphical view]
PIRSFiPIRSF003784. VAC_N1L. 1 hit.
ProDomiPD015763. Orthopox_N1. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P21054-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRTLLIRYIL WRNDNDQTYY NDDFKKLMLL DELVDDGDVC TLIKNMRMTL
60 70 80 90 100
SDGPLLDRLN QPVNNIEDAK RMIAISAKVA RDIGERSEIR WEESFTILFR
110
MIETYFDDLM IDLYGEK
Length:117
Mass (Da):13,962
Last modified:February 1, 1991 - v1
Checksum:i9050C1FECEB1B90B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35027 Genomic DNA. Translation: AAA48001.1.
PIRiE42504.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35027 Genomic DNA. Translation: AAA48001.1 .
PIRi E42504.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2I39 X-ray 2.20 A/B/C/D/E/F 1-117 [» ]
2UXE X-ray 2.90 A/B/C/D/E/F 1-117 [» ]
4BBB X-ray 3.09 A/B/C/D/E/F 1-117 [» ]
4BBC X-ray 3.10 A/B/C/D/E/F 1-117 [» ]
4BBD X-ray 3.00 A/B/C/D/E/F 1-117 [» ]
ProteinModelPortali P21054.
SMRi P21054. Positions 1-116.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi P21054.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P21054.

Family and domain databases

InterProi IPR009353. Orthopox_N1.
IPR022819. Poxvirus.
[Graphical view ]
Pfami PF06227. Poxvirus. 1 hit.
[Graphical view ]
PIRSFi PIRSF003784. VAC_N1L. 1 hit.
ProDomi PD015763. Orthopox_N1. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Appendix to 'The complete DNA sequence of vaccinia virus'."
    Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P., Paoletti E.
    Virology 179:517-563(1990)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein."
    Aoyagi M., Zhai D., Jin C., Aleshin A.E., Stec B., Reed J.C., Liddington R.C.
    Protein Sci. 16:118-124(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
  4. "Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic protein."
    Cooray S., Bahar M.W., Abrescia N.G., McVey C.E., Bartlett N.W., Chen R.A., Stuart D.I., Grimes J.M., Smith G.L.
    J. Gen. Virol. 88:1656-1666(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).

Entry informationi

Entry nameiN1_VACCC
AccessioniPrimary (citable) accession number: P21054
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 26, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3