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P21054 (N1_VACCC) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein N1
Gene names
ORF Names:N1L
OrganismVaccinia virus (strain Copenhagen) (VACV) [Complete proteome]
Taxonomic identifier10249 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length117 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Bcl-2-like protein which contributes to virulence by preventing host NF-kappa-B activation in response to pro-inflammatory stimuli such as TNF-alpha or IL1B By similarity.

Sequence similarities

Belongs to the poxviridae N1 protein family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 117117Protein N1
PRO_0000099632

Secondary structure

.................. 117
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P21054 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: 9050C1FECEB1B90B

FASTA11713,962
        10         20         30         40         50         60 
MRTLLIRYIL WRNDNDQTYY NDDFKKLMLL DELVDDGDVC TLIKNMRMTL SDGPLLDRLN 

        70         80         90        100        110 
QPVNNIEDAK RMIAISAKVA RDIGERSEIR WEESFTILFR MIETYFDDLM IDLYGEK 

« Hide

References

« Hide 'large scale' references
[1]"The complete DNA sequence of vaccinia virus."
Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P., Paoletti E.
Virology 179:247-266(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Appendix to 'The complete DNA sequence of vaccinia virus'."
Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P., Paoletti E.
Virology 179:517-563(1990)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein."
Aoyagi M., Zhai D., Jin C., Aleshin A.E., Stec B., Reed J.C., Liddington R.C.
Protein Sci. 16:118-124(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
[4]"Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic protein."
Cooray S., Bahar M.W., Abrescia N.G., McVey C.E., Bartlett N.W., Chen R.A., Stuart D.I., Grimes J.M., Smith G.L.
J. Gen. Virol. 88:1656-1666(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M35027 Genomic DNA. Translation: AAA48001.1.
PIRE42504.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2I39X-ray2.20A/B/C/D/E/F1-117[»]
2UXEX-ray2.90A/B/C/D/E/F1-117[»]
4BBBX-ray3.09A/B/C/D/E/F1-117[»]
4BBCX-ray3.10A/B/C/D/E/F1-117[»]
4BBDX-ray3.00A/B/C/D/E/F1-117[»]
ProteinModelPortalP21054.
SMRP21054. Positions 1-116.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBP21054.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR009353. Orthopox_N1.
IPR022819. Poxvirus.
[Graphical view]
PfamPF06227. Poxvirus. 1 hit.
[Graphical view]
PIRSFPIRSF003784. VAC_N1L. 1 hit.
ProDomPD015763. Orthopox_N1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other

EvolutionaryTraceP21054.

Entry information

Entry nameN1_VACCC
AccessionPrimary (citable) accession number: P21054
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 13, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references