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Protein

Core protein VP8

Gene

L4R

Organism
Vaccinia virus (strain Copenhagen) (VACV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Major core structural protein.By similarity

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Core protein VP8
Alternative name(s):
25 kDa major core protein
L4 core protein
P25K
Gene namesi
ORF Names:L4R
OrganismiVaccinia virus (strain Copenhagen) (VACV)
Taxonomic identifieri10249 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000008269 Componenti: Genome

Subcellular locationi

  • Virion By similarity

  • Note: Localizes to the virion core.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000405891 – 32By similarityAdd BLAST32
ChainiPRO_000004059033 – 251Core protein VP8Add BLAST219

Post-translational modificationi

Undergoes morphogenesis-associated proteolysis which cleaves the 28 kDa to a 25-kDa product. Proteolytic cleavage of major core proteins P4a (A10L), P4b (A3L), and VP8 (L4R), which occurs at a late stage of core formation, is required for production of infectious mature virions (MV) (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei18 – 19Cleavage; by core protease I7By similarity2
Sitei32 – 33Cleavage; by core protease I7By similarity2

Expressioni

Inductioni

Expressed in the late phase of the viral replicative cycle.

Keywords - Developmental stagei

Late protein

Family & Domainsi

Sequence similaritiesi

Belongs to the chordopoxvirinae VP8 family.Curated

Phylogenomic databases

OrthoDBiVOG090000OK.

Family and domain databases

InterProiView protein in InterPro
IPR007586. VP8_pox_nuc-bd.
PfamiView protein in Pfam
PF04498. Pox_VP8_L4R. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD011473. VP8_pox_nuc_bd. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20981-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLLENLIE EDTIFFAGSI SEYDDLQMVI AGAKSKFPRS MLSIFNIVPR
60 70 80 90 100
TMSKYELELI HNENITGAMF TTMYNIRNNL GLGDDKLTIE AIENYFLDPN
110 120 130 140 150
NEVMPLIINN TDMTAVIPKK SGRRKNKNMV IFRQGSSPIL CIFETRKKIN
160 170 180 190 200
IYKENMESAS TEYTPIGDNK ALISKYAGIN VLNVYSPSTS MRLNAIYGFT
210 220 230 240 250
NKNKLEKLST NKELESYSSS PLQEPIRLND FLGLLECVKK NIPLTDIPTK

D
Length:251
Mass (Da):28,461
Last modified:February 1, 1991 - v1
Checksum:iBA34200CFBC045B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35027 Genomic DNA. Translation: AAA48079.1.
PIRiB42513.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiVP8_VACCC
AccessioniPrimary (citable) accession number: P20981
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: March 15, 2017
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families