Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

T-cell ecto-ADP-ribosyltransferase 2

Gene

Art2b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has both NAD+ glycohydrolase and ADP-ribosyltransferase activity (to a lesser extent).

Catalytic activityi

NAD+ + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine.By similarity
NAD+ + H2O = ADP-D-ribose + nicotinamide.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei98NAD1
Binding sitei146NAD1
Binding sitei164NAD1
Binding sitei202NAD1
Active sitei216By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Hydrolase, Transferase

Keywords - Ligandi

NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell ecto-ADP-ribosyltransferase 2 (EC:2.4.2.31By similarity)
Alternative name(s):
ADP-ribosyltransferase C2 and C3 toxin-like 2
Short name:
ARTC2
Alloantigen Rt6.2
Mono(ADP-ribosyl)transferase 2B
NAD(+) glycohydrolase (EC:3.2.2.5By similarity)
T-cell NAD(P)(+)--arginine ADP-ribosyltransferase 2
T-cell mono(ADP-ribosyl)transferase 2
T-cell surface protein Rt6.2
Gene namesi
Name:Art2b
Synonyms:Rt6-b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3521. Art2b.

Subcellular locationi

GO - Cellular componenti

  • anchored component of plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000001932321 – 246T-cell ecto-ADP-ribosyltransferase 2Add BLAST226
PropeptideiPRO_0000019324247 – 275Removed in mature formBy similarityAdd BLAST29

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 243
Disulfide bondi141 ↔ 193
Modified residuei204ADP-ribosylarginine; by autocatalysis1 Publication1
Lipidationi246GPI-anchor amidated serineBy similarity1

Keywords - PTMi

ADP-ribosylation, Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP20974.
PRIDEiP20974.

PTM databases

PhosphoSitePlusiP20974.

Expressioni

Tissue specificityi

Postthymic T-cells.

Gene expression databases

BgeeiENSRNOG00000019687.
ExpressionAtlasiP20974. baseline and differential.
GenevisibleiP20974. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026644.

Structurei

Secondary structure

1275
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi25 – 28Combined sources4
Helixi42 – 59Combined sources18
Helixi61 – 77Combined sources17
Helixi78 – 80Combined sources3
Helixi89 – 98Combined sources10
Turni99 – 102Combined sources4
Helixi103 – 111Combined sources9
Turni112 – 115Combined sources4
Helixi117 – 119Combined sources3
Helixi123 – 135Combined sources13
Beta strandi142 – 150Combined sources9
Beta strandi152 – 154Combined sources3
Beta strandi156 – 158Combined sources3
Beta strandi166 – 170Combined sources5
Helixi172 – 175Combined sources4
Turni178 – 180Combined sources3
Beta strandi185 – 194Combined sources10
Helixi199 – 201Combined sources3
Helixi205 – 207Combined sources3
Beta strandi209 – 212Combined sources4
Beta strandi216 – 224Combined sources9
Turni225 – 227Combined sources3
Beta strandi228 – 236Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GXYX-ray1.71A/B21-246[»]
1GXZX-ray2.10A/B21-246[»]
1GY0X-ray2.08A21-246[»]
1OG1X-ray2.00A21-246[»]
1OG3X-ray2.60A21-246[»]
1OG4X-ray2.60A21-246[»]
ProteinModelPortaliP20974.
SMRiP20974.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20974.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J95D. Eukaryota.
ENOG410ZKT4. LUCA.
GeneTreeiENSGT00530000062975.
HOVERGENiHBG004464.
KOiK19980.
PhylomeDBiP20974.
TreeFamiTF335356.

Family and domain databases

InterProiIPR000768. ART.
[Graphical view]
PfamiPF01129. ART. 1 hit.
[Graphical view]
PRINTSiPR00970. RIBTRNSFRASE.
PROSITEiPS01291. ART. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20974-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSNICKFFL TWWLIQQVTG LTGPLMLDTA PNAFDDQYEG CVNKMEEKAP
60 70 80 90 100
LLLQEDFNMN AKLKVAWEEA KKRWNNIKPS RSYPKGFNDF HGTALVAYTG
110 120 130 140 150
SIAVDFNRAV REFKENPGQF HYKAFHYYLT RALQLLSNGD CHSVYRGTKT
160 170 180 190 200
RFHYTGAGSV RFGQFTSSSL SKKVAQSQEF FSDHGTLFII KTCLGVYIKE
210 220 230 240 250
FSFRPDQEEV LIPGYEVYQK VRTQGYNEIF LDSPKRKKSN YNCLYSSAGA
260 270
RESCVSLFLV VLPSLLVQLL CLAEP
Length:275
Mass (Da):31,438
Last modified:July 15, 1998 - v2
Checksum:iB3361D4E6FF77FC4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29T → K in CAC20897 (PubMed:11220625).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85193 mRNA. Translation: AAA42085.1.
AJ297708 Genomic DNA. Translation: CAC20897.1.
BC099070 mRNA. Translation: AAH99070.1.
X99123 mRNA. Translation: CAA67566.1.
X99122 mRNA. Translation: CAA67565.1.
PIRiA34866.
RefSeqiNP_942030.1. NM_198735.2.
XP_017444448.1. XM_017588959.1.
UniGeneiRn.107075.
Rn.214239.

Genome annotation databases

EnsembliENSRNOT00000026644; ENSRNOP00000026644; ENSRNOG00000019687.
GeneIDi293152.
KEGGirno:293152.
UCSCiRGD:3521. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85193 mRNA. Translation: AAA42085.1.
AJ297708 Genomic DNA. Translation: CAC20897.1.
BC099070 mRNA. Translation: AAH99070.1.
X99123 mRNA. Translation: CAA67566.1.
X99122 mRNA. Translation: CAA67565.1.
PIRiA34866.
RefSeqiNP_942030.1. NM_198735.2.
XP_017444448.1. XM_017588959.1.
UniGeneiRn.107075.
Rn.214239.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GXYX-ray1.71A/B21-246[»]
1GXZX-ray2.10A/B21-246[»]
1GY0X-ray2.08A21-246[»]
1OG1X-ray2.00A21-246[»]
1OG3X-ray2.60A21-246[»]
1OG4X-ray2.60A21-246[»]
ProteinModelPortaliP20974.
SMRiP20974.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026644.

PTM databases

PhosphoSitePlusiP20974.

Proteomic databases

PaxDbiP20974.
PRIDEiP20974.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026644; ENSRNOP00000026644; ENSRNOG00000019687.
GeneIDi293152.
KEGGirno:293152.
UCSCiRGD:3521. rat.

Organism-specific databases

CTDi11872.
RGDi3521. Art2b.

Phylogenomic databases

eggNOGiENOG410J95D. Eukaryota.
ENOG410ZKT4. LUCA.
GeneTreeiENSGT00530000062975.
HOVERGENiHBG004464.
KOiK19980.
PhylomeDBiP20974.
TreeFamiTF335356.

Miscellaneous databases

EvolutionaryTraceiP20974.

Gene expression databases

BgeeiENSRNOG00000019687.
ExpressionAtlasiP20974. baseline and differential.
GenevisibleiP20974. RN.

Family and domain databases

InterProiIPR000768. ART.
[Graphical view]
PfamiPF01129. ART. 1 hit.
[Graphical view]
PRINTSiPR00970. RIBTRNSFRASE.
PROSITEiPS01291. ART. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNAR2B_RAT
AccessioniPrimary (citable) accession number: P20974
Secondary accession number(s): P97912
, Q4FZV8, Q95576, Q9EPH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: July 15, 1998
Last modified: November 30, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.