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P20972 (PGK_METBR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk
OrganismMethanobacterium bryantii
Taxonomic identifier2161 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanobacterium

Protein attributes

Sequence length409 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer.

Subcellular location

Cytoplasm HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›409›409Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_0000146056

Regions

Nucleotide binding359 – 3624ATP By similarity
Region23 – 253Substrate binding By similarity
Region63 – 664Substrate binding By similarity

Sites

Binding site1201Substrate By similarity
Binding site1601Substrate By similarity
Binding site3331ATP By similarity

Experimental info

Non-terminal residue4091

Sequences

Sequence LengthMass (Da)Tools
P20972 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: 15C13298D649DCE4

FASTA40944,793
        10         20         30         40         50         60 
MSLPFYTIDD FNLEDKTVLV RVDINSPVDP STGSILDDTK IKLHAETIDE ISKKGAKTVV 

        70         80         90        100        110        120 
LAHQSRPGKK DFTTLQQHAK ALSNILNRPV DYIDDIFGTA AREEIKRLKK GDILLLENVR 

       130        140        150        160        170        180 
FYPEEILKRD PHQQAETHMV RKLYPIIDIF INDAFAAAHR SQPSLVGFAV KLPSGAGRIM 

       190        200        210        220        230        240 
EKELKSLYGA VDNAEKPCVY VLGGVKVDDS IMVLENVLRN GSADYVLTTG LVANIFLWAS 

       250        260        270        280        290        300 
GINLGKYNED FIINKGYIDF VEKGKQLLEE FDGQIKMPDD VAVCVDNARV EYCTKNIPNK 

       310        320        330        340        350        360 
PIYDIGTNTI TEYAKFIRDA KTIFANGPAG VFEQEGFSIG TEDILNTIAS SNGYSIIGGG 

       370        380        390        400 
HLAAAANQMG LSSGITHISS GGGASINLLA GEKLPVVEIL TEVKMKGRK 

« Hide

References

[1]"Cloning and sequencing the gene encoding 3-phosphoglycerate kinase from mesophilic Methanobacterium bryantii and thermophilic Methanothermus fervidus."
Fabry S., Heppner P., Dietmaier W., Hensel R.
Gene 91:19-25(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M55530 Genomic DNA. Translation: AAA72937.1.
PIRPN0007.

3D structure databases

ProteinModelPortalP20972.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_METBR
AccessionPrimary (citable) accession number: P20972
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: June 11, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways