P20962 (PTMS_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Parathymosin

Gene names

Name:

PTMS

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	102 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Parathymosin may mediate immune function by blocking the effect of prothymosin alpha which confers resistance to certain opportunistic infections.
Sequence similarities	Belongs to the pro/parathymosin family.

Ontologies

Keywords
Biological process	Immunity
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	DNA replication Traceable author statement PubMed 10854063. Source: ProtInc
Cellular_component	nucleus Traceable author statement PubMed 10854063. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.3
	Chain	2 – 102	101	Parathymosin		PRO_0000191632
Regions
	Compositional bias	36 – 90	55	Asp/Glu-rich (acidic)
Amino acid modifications
	Modified residue	2	1	N-acetylserine Ref.3
	Modified residue	4	1	N6-acetyllysine Ref.3
	Modified residue	5	1	Phosphoserine Ref.4 Ref.6
	Modified residue	15	1	N6-acetyllysine Ref.3
	Modified residue	92	1	N6-acetyllysine Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P20962 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 1B169F911B37B856	FASTA	102	11,530
	10 20 30 40 50 60 MSEKSVEAAA ELSAKDLKEK KEKVEEKASR KERKKEVVEE EENGAEEEEE ETAEDGEEED 70 80 90 100 EGEEEDEEEE EEDDEGPALK RAAEEEDEAD PKRQKTENGA SA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The sequence of human parathymosin deduced from a cloned human kidney cDNA." Clinton M., Frangou-Lazaridis M., Panneerselvam C., Horecker B.L. Biochem. Biophys. Res. Commun. 158:855-862(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney.
[2]	Lubec G., Chen W.-Q., Sun Y. Submitted (DEC-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 5-15, MASS SPECTROMETRY. Tissue: Fetal brain cortex.
[3]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2; LYS-4; LYS-15 AND LYS-92, MASS SPECTROMETRY, CLEAVAGE OF INITIATOR METHIONINE.
[4]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M24398 mRNA. Translation: AAA61185.1.
IPI	IPI00550020.
PIR	A32264.
RefSeq	NP_002815.3. NM_002824.4.
UniGene	Hs.504613.
3D structure databases
ProteinModelPortal	P20962.
ModBase	Search...
Protein-protein interaction databases
IntAct	P20962. 10 interactions.
MINT	MINT-5000299.
STRING	9606.ENSP00000310088.
PTM databases
PhosphoSite	P20962.
Polymorphism databases
DMDM	135846.
Proteomic databases
PaxDb	P20962.
PRIDE	P20962.
Protocols and materials databases
DNASU	5763.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000309083; ENSP00000310088; ENSG00000159335.
GeneID	5763.
KEGG	hsa:5763.
UCSC	uc001qqq.3. human.
Organism-specific databases
CTD	5763.
GeneCards	GC12P006875.
HGNC	HGNC:9629. PTMS.
HPA	HPA038186.
MIM	168440. gene.
neXtProt	NX_P20962.
PharmGKB	PA33973.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG85883.
HOGENOM	HOG000115773.
InParanoid	P20962.
OMA	DEGPVRK.
Gene expression databases
ArrayExpress	P20962.
Bgee	P20962.
CleanEx	HS_PTMS.
Genevestigator	P20962.
Family and domain databases
InterPro	IPR004931. Pro/parathymosin. [Graphical view]
PANTHER	PTHR22745. PTHR22745. 1 hit.
Pfam	PF03247. Prothymosin. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PTMS. human.
GenomeRNAi	5763.
NextBio	22422.
SOURCE	Search...

Entry information

Entry name

PTMS_HUMAN

Accession

Primary (citable) accession number: P20962

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 99 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.