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P20962

- PTMS_HUMAN

UniProt

P20962 - PTMS_HUMAN

Protein

Parathymosin

Gene

PTMS

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Parathymosin may mediate immune function by blocking the effect of prothymosin alpha which confers resistance to certain opportunistic infections.

    GO - Biological processi

    1. DNA replication Source: ProtInc
    2. immune system process Source: UniProtKB-KW

    Keywords - Biological processi

    Immunity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Parathymosin
    Gene namesi
    Name:PTMS
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:9629. PTMS.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: ProtInc

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33973.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 102101ParathymosinPRO_0000191632Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine2 Publications
    Modified residuei4 – 41N6-acetyllysine1 Publication
    Modified residuei5 – 51Phosphoserine2 Publications
    Modified residuei15 – 151N6-acetyllysine1 Publication
    Modified residuei92 – 921N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP20962.
    PaxDbiP20962.
    PRIDEiP20962.

    PTM databases

    PhosphoSiteiP20962.

    Expressioni

    Gene expression databases

    ArrayExpressiP20962.
    BgeeiP20962.
    CleanExiHS_PTMS.
    GenevestigatoriP20962.

    Organism-specific databases

    HPAiHPA038186.

    Interactioni

    Protein-protein interaction databases

    BioGridi111730. 32 interactions.
    IntActiP20962. 11 interactions.
    MINTiMINT-5000299.
    STRINGi9606.ENSP00000310088.

    Structurei

    3D structure databases

    ProteinModelPortaliP20962.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi36 – 9055Asp/Glu-rich (acidic)Add
    BLAST

    Sequence similaritiesi

    Belongs to the pro/parathymosin family.Curated

    Phylogenomic databases

    eggNOGiNOG85883.
    HOGENOMiHOG000115773.
    InParanoidiP20962.
    OMAiVEEPRSC.

    Family and domain databases

    InterProiIPR004931. Pro/parathymosin.
    [Graphical view]
    PANTHERiPTHR22745. PTHR22745. 1 hit.
    PfamiPF03247. Prothymosin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P20962-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEKSVEAAA ELSAKDLKEK KEKVEEKASR KERKKEVVEE EENGAEEEEE    50
    ETAEDGEEED EGEEEDEEEE EEDDEGPALK RAAEEEDEAD PKRQKTENGA 100
    SA 102
    Length:102
    Mass (Da):11,530
    Last modified:January 23, 2007 - v2
    Checksum:i1B169F911B37B856
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M24398 mRNA. Translation: AAA61185.1.
    CCDSiCCDS8560.1.
    PIRiA32264.
    RefSeqiNP_002815.3. NM_002824.4.
    UniGeneiHs.504613.

    Genome annotation databases

    EnsembliENST00000309083; ENSP00000310088; ENSG00000159335.
    GeneIDi5763.
    KEGGihsa:5763.
    UCSCiuc001qqq.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M24398 mRNA. Translation: AAA61185.1 .
    CCDSi CCDS8560.1.
    PIRi A32264.
    RefSeqi NP_002815.3. NM_002824.4.
    UniGenei Hs.504613.

    3D structure databases

    ProteinModelPortali P20962.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111730. 32 interactions.
    IntActi P20962. 11 interactions.
    MINTi MINT-5000299.
    STRINGi 9606.ENSP00000310088.

    PTM databases

    PhosphoSitei P20962.

    Proteomic databases

    MaxQBi P20962.
    PaxDbi P20962.
    PRIDEi P20962.

    Protocols and materials databases

    DNASUi 5763.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000309083 ; ENSP00000310088 ; ENSG00000159335 .
    GeneIDi 5763.
    KEGGi hsa:5763.
    UCSCi uc001qqq.3. human.

    Organism-specific databases

    CTDi 5763.
    GeneCardsi GC12P006875.
    HGNCi HGNC:9629. PTMS.
    HPAi HPA038186.
    MIMi 168440. gene.
    neXtProti NX_P20962.
    PharmGKBi PA33973.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG85883.
    HOGENOMi HOG000115773.
    InParanoidi P20962.
    OMAi VEEPRSC.

    Miscellaneous databases

    ChiTaRSi PTMS. human.
    GeneWikii PTMS_(gene).
    GenomeRNAii 5763.
    NextBioi 22422.
    PROi P20962.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P20962.
    Bgeei P20962.
    CleanExi HS_PTMS.
    Genevestigatori P20962.

    Family and domain databases

    InterProi IPR004931. Pro/parathymosin.
    [Graphical view ]
    PANTHERi PTHR22745. PTHR22745. 1 hit.
    Pfami PF03247. Prothymosin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of human parathymosin deduced from a cloned human kidney cDNA."
      Clinton M., Frangou-Lazaridis M., Panneerselvam C., Horecker B.L.
      Biochem. Biophys. Res. Commun. 158:855-862(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Kidney.
    2. Lubec G., Chen W.-Q., Sun Y.
      Submitted (DEC-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 5-15, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Fetal brain cortex.
    3. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2; LYS-4; LYS-15 AND LYS-92, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    4. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPTMS_HUMAN
    AccessioniPrimary (citable) accession number: P20962
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3