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Protein

Parathymosin

Gene

PTMS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Parathymosin may mediate immune function by blocking the effect of prothymosin alpha which confers resistance to certain opportunistic infections.

GO - Biological processi

  • DNA replication Source: ProtInc
  • immune system process Source: UniProtKB-KW

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Recommended name:
Parathymosin
Gene namesi
Name:PTMS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000159335.15
HGNCiHGNC:9629 PTMS
MIMi168440 gene
neXtProtiNX_P20962

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi5763
OpenTargetsiENSG00000159335
PharmGKBiPA33973

Polymorphism and mutation databases

BioMutaiPTMS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001916322 – 102ParathymosinAdd BLAST101

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineCombined sources1
Modified residuei4N6-acetyllysineCombined sources1
Modified residuei5PhosphoserineCombined sources1
Modified residuei13PhosphoserineBy similarity1
Modified residuei15N6-acetyllysineCombined sources1
Modified residuei52PhosphothreonineBy similarity1
Modified residuei92N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP20962
MaxQBiP20962
PaxDbiP20962
PeptideAtlasiP20962
PRIDEiP20962
TopDownProteomicsiP20962

PTM databases

iPTMnetiP20962
PhosphoSitePlusiP20962

Expressioni

Gene expression databases

BgeeiENSG00000159335
CleanExiHS_PTMS
ExpressionAtlasiP20962 baseline and differential

Organism-specific databases

HPAiHPA038186

Interactioni

Protein-protein interaction databases

BioGridi111730, 34 interactors
IntActiP20962, 11 interactors
MINTiP20962
STRINGi9606.ENSP00000310088

Structurei

3D structure databases

ProteinModelPortaliP20962
SMRiP20962
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi36 – 90Asp/Glu-rich (acidic)Add BLAST55

Sequence similaritiesi

Belongs to the pro/parathymosin family.Curated

Phylogenomic databases

eggNOGiENOG410J7IP Eukaryota
ENOG4111CKZ LUCA
GeneTreeiENSGT00910000146795
HOGENOMiHOG000115773
InParanoidiP20962
OMAiVEEPRSC

Family and domain databases

InterProiView protein in InterPro
IPR004931 Pro/parathymosin
PANTHERiPTHR22745 PTHR22745, 1 hit
PfamiView protein in Pfam
PF03247 Prothymosin, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20962-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEKSVEAAA ELSAKDLKEK KEKVEEKASR KERKKEVVEE EENGAEEEEE
60 70 80 90 100
ETAEDGEEED EGEEEDEEEE EEDDEGPALK RAAEEEDEAD PKRQKTENGA

SA
Length:102
Mass (Da):11,530
Last modified:January 23, 2007 - v2
Checksum:i1B169F911B37B856
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24398 mRNA Translation: AAA61185.1
CCDSiCCDS8560.1
PIRiA32264
RefSeqiNP_002815.3, NM_002824.5
UniGeneiHs.504613

Genome annotation databases

EnsembliENST00000309083; ENSP00000310088; ENSG00000159335
ENST00000619580; ENSP00000478828; ENSG00000159335
GeneIDi5763
KEGGihsa:5763
UCSCiuc001qqq.3 human

Similar proteinsi

Entry informationi

Entry nameiPTMS_HUMAN
AccessioniPrimary (citable) accession number: P20962
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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