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P20962 (PTMS_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Parathymosin
Gene names
Name:PTMS
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length102 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Parathymosin may mediate immune function by blocking the effect of prothymosin alpha which confers resistance to certain opportunistic infections.

Sequence similarities

Belongs to the pro/parathymosin family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.3
Chain2 – 102101Parathymosin
PRO_0000191632

Regions

Compositional bias36 – 9055Asp/Glu-rich (acidic)

Amino acid modifications

Modified residue21N-acetylserine Ref.3 Ref.7
Modified residue41N6-acetyllysine Ref.3
Modified residue51Phosphoserine Ref.4 Ref.6
Modified residue151N6-acetyllysine Ref.3
Modified residue921N6-acetyllysine Ref.3

Sequences

Sequence LengthMass (Da)Tools
P20962 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 1B169F911B37B856

FASTA10211,530
        10         20         30         40         50         60 
MSEKSVEAAA ELSAKDLKEK KEKVEEKASR KERKKEVVEE EENGAEEEEE ETAEDGEEED 

        70         80         90        100 
EGEEEDEEEE EEDDEGPALK RAAEEEDEAD PKRQKTENGA SA 

« Hide

References

« Hide 'large scale' references
[1]"The sequence of human parathymosin deduced from a cloned human kidney cDNA."
Clinton M., Frangou-Lazaridis M., Panneerselvam C., Horecker B.L.
Biochem. Biophys. Res. Commun. 158:855-862(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Kidney.
[2]Lubec G., Chen W.-Q., Sun Y.
Submitted (DEC-2008) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 5-15, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Fetal brain cortex.
[3]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2; LYS-4; LYS-15 AND LYS-92, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
[4]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[5]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M24398 mRNA. Translation: AAA61185.1.
PIRA32264.
RefSeqNP_002815.3. NM_002824.4.
UniGeneHs.504613.

3D structure databases

ProteinModelPortalP20962.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111730. 32 interactions.
IntActP20962. 11 interactions.
MINTMINT-5000299.
STRING9606.ENSP00000310088.

PTM databases

PhosphoSiteP20962.

Proteomic databases

PaxDbP20962.
PRIDEP20962.

Protocols and materials databases

DNASU5763.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000309083; ENSP00000310088; ENSG00000159335.
GeneID5763.
KEGGhsa:5763.
UCSCuc001qqq.3. human.

Organism-specific databases

CTD5763.
GeneCardsGC12P006875.
HGNCHGNC:9629. PTMS.
HPAHPA038186.
MIM168440. gene.
neXtProtNX_P20962.
PharmGKBPA33973.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG85883.
HOGENOMHOG000115773.
InParanoidP20962.
OMAVEEPRSC.

Gene expression databases

ArrayExpressP20962.
BgeeP20962.
CleanExHS_PTMS.
GenevestigatorP20962.

Family and domain databases

InterProIPR004931. Pro/parathymosin.
[Graphical view]
PANTHERPTHR22745. PTHR22745. 1 hit.
PfamPF03247. Prothymosin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPTMS. human.
GeneWikiPTMS_(gene).
GenomeRNAi5763.
NextBio22422.
PROP20962.
SOURCESearch...

Entry information

Entry namePTMS_HUMAN
AccessionPrimary (citable) accession number: P20962
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM