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Protein

Parathymosin

Gene

PTMS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Parathymosin may mediate immune function by blocking the effect of prothymosin alpha which confers resistance to certain opportunistic infections.

GO - Biological processi

  • DNA replication Source: ProtInc
  • immune system process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Parathymosin
Gene namesi
Name:PTMS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:9629. PTMS.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: ProtInc
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33973.

Polymorphism and mutation databases

BioMutaiPTMS.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 102101ParathymosinPRO_0000191632Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine2 Publications
Modified residuei4 – 41N6-acetyllysine1 Publication
Modified residuei5 – 51Phosphoserine2 Publications
Modified residuei15 – 151N6-acetyllysine1 Publication
Modified residuei92 – 921N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP20962.
PaxDbiP20962.
PRIDEiP20962.

PTM databases

PhosphoSiteiP20962.

Expressioni

Gene expression databases

BgeeiP20962.
CleanExiHS_PTMS.
ExpressionAtlasiP20962. baseline and differential.
GenevisibleiP20962. HS.

Organism-specific databases

HPAiHPA038186.

Interactioni

Protein-protein interaction databases

BioGridi111730. 32 interactions.
IntActiP20962. 11 interactions.
MINTiMINT-5000299.
STRINGi9606.ENSP00000310088.

Structurei

3D structure databases

ProteinModelPortaliP20962.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi36 – 9055Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the pro/parathymosin family.Curated

Phylogenomic databases

eggNOGiNOG85883.
GeneTreeiENSGT00730000111656.
HOGENOMiHOG000115773.
InParanoidiP20962.
OMAiVEEPRSC.

Family and domain databases

InterProiIPR004931. Pro/parathymosin.
[Graphical view]
PANTHERiPTHR22745. PTHR22745. 1 hit.
PfamiPF03247. Prothymosin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20962-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEKSVEAAA ELSAKDLKEK KEKVEEKASR KERKKEVVEE EENGAEEEEE
60 70 80 90 100
ETAEDGEEED EGEEEDEEEE EEDDEGPALK RAAEEEDEAD PKRQKTENGA

SA
Length:102
Mass (Da):11,530
Last modified:January 23, 2007 - v2
Checksum:i1B169F911B37B856
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24398 mRNA. Translation: AAA61185.1.
CCDSiCCDS8560.1.
PIRiA32264.
RefSeqiNP_002815.3. NM_002824.4.
UniGeneiHs.504613.

Genome annotation databases

EnsembliENST00000309083; ENSP00000310088; ENSG00000159335.
ENST00000619580; ENSP00000478828; ENSG00000159335.
GeneIDi5763.
KEGGihsa:5763.
UCSCiuc001qqq.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24398 mRNA. Translation: AAA61185.1.
CCDSiCCDS8560.1.
PIRiA32264.
RefSeqiNP_002815.3. NM_002824.4.
UniGeneiHs.504613.

3D structure databases

ProteinModelPortaliP20962.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111730. 32 interactions.
IntActiP20962. 11 interactions.
MINTiMINT-5000299.
STRINGi9606.ENSP00000310088.

PTM databases

PhosphoSiteiP20962.

Polymorphism and mutation databases

BioMutaiPTMS.

Proteomic databases

MaxQBiP20962.
PaxDbiP20962.
PRIDEiP20962.

Protocols and materials databases

DNASUi5763.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309083; ENSP00000310088; ENSG00000159335.
ENST00000619580; ENSP00000478828; ENSG00000159335.
GeneIDi5763.
KEGGihsa:5763.
UCSCiuc001qqq.3. human.

Organism-specific databases

CTDi5763.
GeneCardsiGC12P006875.
HGNCiHGNC:9629. PTMS.
HPAiHPA038186.
MIMi168440. gene.
neXtProtiNX_P20962.
PharmGKBiPA33973.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG85883.
GeneTreeiENSGT00730000111656.
HOGENOMiHOG000115773.
InParanoidiP20962.
OMAiVEEPRSC.

Miscellaneous databases

ChiTaRSiPTMS. human.
GeneWikiiPTMS_(gene).
GenomeRNAii5763.
NextBioi22422.
PROiP20962.
SOURCEiSearch...

Gene expression databases

BgeeiP20962.
CleanExiHS_PTMS.
ExpressionAtlasiP20962. baseline and differential.
GenevisibleiP20962. HS.

Family and domain databases

InterProiIPR004931. Pro/parathymosin.
[Graphical view]
PANTHERiPTHR22745. PTHR22745. 1 hit.
PfamiPF03247. Prothymosin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence of human parathymosin deduced from a cloned human kidney cDNA."
    Clinton M., Frangou-Lazaridis M., Panneerselvam C., Horecker B.L.
    Biochem. Biophys. Res. Commun. 158:855-862(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  2. Lubec G., Chen W.-Q., Sun Y.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 5-15, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Fetal brain cortex.
  3. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2; LYS-4; LYS-15 AND LYS-92, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  4. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiPTMS_HUMAN
AccessioniPrimary (citable) accession number: P20962
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: July 22, 2015
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.