Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P20961

- PAI1_RAT

UniProt

P20961 - PAI1_RAT

Protein

Plasminogen activator inhibitor 1

Gene

Serpine1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Feb 1991)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei369 – 3702Reactive bond

    GO - Molecular functioni

    1. protease binding Source: RGD
    2. serine-type endopeptidase inhibitor activity Source: RGD

    GO - Biological processi

    1. cellular response to ATP Source: RGD
    2. cellular response to cAMP Source: RGD
    3. cellular response to cGMP Source: RGD
    4. cellular response to cycloheximide Source: RGD
    5. cellular response to dexamethasone stimulus Source: RGD
    6. cellular response to drug Source: RGD
    7. cellular response to fibroblast growth factor stimulus Source: RGD
    8. cellular response to follicle-stimulating hormone stimulus Source: RGD
    9. cellular response to glucagon stimulus Source: RGD
    10. cellular response to glucose stimulus Source: RGD
    11. cellular response to gravity Source: RGD
    12. cellular response to growth factor stimulus Source: RGD
    13. cellular response to hydrogen peroxide Source: RGD
    14. cellular response to hypoxia Source: RGD
    15. cellular response to insulin stimulus Source: RGD
    16. cellular response to interleukin-1 Source: RGD
    17. cellular response to low-density lipoprotein particle stimulus Source: RGD
    18. cellular response to mechanical stimulus Source: RGD
    19. cellular response to metal ion Source: RGD
    20. cellular response to nerve growth factor stimulus Source: RGD
    21. cellular response to nicotine Source: RGD
    22. cellular response to organic cyclic compound Source: RGD
    23. cellular response to platelet-derived growth factor stimulus Source: RGD
    24. cellular response to potassium ion Source: RGD
    25. cellular response to transforming growth factor beta stimulus Source: RGD
    26. decidualization Source: RGD
    27. female gonad development Source: RGD
    28. glucose homeostasis Source: RGD
    29. mast cell activation Source: RGD
    30. negative regulation of cell migration Source: RGD
    31. negative regulation of endopeptidase activity Source: BHF-UCL
    32. negative regulation of gene expression Source: RGD
    33. negative regulation of proteolysis Source: RGD
    34. positive regulation of calcium ion import Source: RGD
    35. positive regulation of coagulation Source: RGD
    36. positive regulation of fibroblast proliferation Source: RGD
    37. positive regulation of gene expression Source: RGD
    38. positive regulation of keratinocyte migration Source: RGD
    39. positive regulation of receptor-mediated endocytosis Source: BHF-UCL
    40. regulation of proteolysis Source: RefGenome
    41. response to cytokine Source: RGD
    42. response to epidermal growth factor Source: RGD
    43. response to estrogen Source: RGD
    44. response to hyperoxia Source: RGD
    45. response to laminar fluid shear stress Source: RGD
    46. response to lipopolysaccharide Source: RGD
    47. response to reactive oxygen species Source: RGD
    48. response to starvation Source: RGD
    49. response to transforming growth factor beta Source: RGD
    50. tissue regeneration Source: RGD
    51. wound healing Source: RGD

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Protein family/group databases

    MEROPSiI04.020.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Plasminogen activator inhibitor 1
    Short name:
    PAI
    Short name:
    PAI-1
    Alternative name(s):
    Endothelial plasminogen activator inhibitor
    Serpin E1
    Gene namesi
    Name:Serpine1
    Synonyms:Pai1, Planh1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi3249. Serpine1.

    Subcellular locationi

    GO - Cellular componenti

    1. chromaffin granule Source: RGD
    2. extracellular matrix Source: RGD
    3. extracellular region Source: RGD
    4. extracellular space Source: RGD

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Chaini24 – 402379Plasminogen activator inhibitor 1PRO_0000032503Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi88 – 881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi232 – 2321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi288 – 2881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi352 – 3521N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP20961.
    PRIDEiP20961.

    Expressioni

    Gene expression databases

    GenevestigatoriP20961.

    Interactioni

    Subunit structurei

    Forms protease inhibiting heterodimer with TMPRSS7. Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation By similarity.By similarity

    Protein-protein interaction databases

    BioGridi246756. 2 interactions.
    STRINGi10116.ENSRNOP00000001916.

    Structurei

    3D structure databases

    ProteinModelPortaliP20961.
    SMRiP20961. Positions 27-402.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4826.
    HOGENOMiHOG000238519.
    HOVERGENiHBG106493.
    InParanoidiP20961.
    KOiK03982.
    PhylomeDBiP20961.

    Family and domain databases

    InterProiIPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P20961-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQMSSALTCL TLGLVLVFGK GFASPLPESH TAQQATNFGV KVFQHVVQAS    50
    KDRNVVFSPY GVSSVLAMLQ LTTAGKTRQQ IQDAMGFNIS ERGTAPALRK 100
    LSKELMGSWN KNEISTADAI FVQRDLELVQ GFMPHFFKLF RTTVKQVDFS 150
    EVERARFIIN DWVERHTKGM ISDLLAKGAV NELTRLVLVN ALYFNGQWKT 200
    PFLEASTHQR LFHKSDGSTI SVPMMAQNNK FNYTEFTTPD GHEYDILELP 250
    YHGETLSMFI AAPFEKDVPL SAITNILDAE LIRQWKSNMT RLPRLLILPK 300
    FSLETEVDLR GPLEKLGMTD IFSSTQADFT SLSDQEQLSV AQALQKVKIE 350
    VNESGTVASS STAILVSARM APTEMVLDRS FLFVVRHNPT ETILFMGQLM 400
    EP 402
    Length:402
    Mass (Da):45,010
    Last modified:February 1, 1991 - v1
    Checksum:i2B639140F475EB53
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J05206 Genomic DNA. Translation: AAA41796.1.
    M24067 mRNA. Translation: AAA56856.1.
    PIRiA35032.
    RefSeqiNP_036752.1. NM_012620.1.
    UniGeneiRn.29367.

    Genome annotation databases

    GeneIDi24617.
    KEGGirno:24617.
    UCSCiRGD:3249. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J05206 Genomic DNA. Translation: AAA41796.1 .
    M24067 mRNA. Translation: AAA56856.1 .
    PIRi A35032.
    RefSeqi NP_036752.1. NM_012620.1.
    UniGenei Rn.29367.

    3D structure databases

    ProteinModelPortali P20961.
    SMRi P20961. Positions 27-402.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 246756. 2 interactions.
    STRINGi 10116.ENSRNOP00000001916.

    Chemistry

    BindingDBi P20961.
    ChEMBLi CHEMBL2155.

    Protein family/group databases

    MEROPSi I04.020.

    Proteomic databases

    PaxDbi P20961.
    PRIDEi P20961.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 24617.
    KEGGi rno:24617.
    UCSCi RGD:3249. rat.

    Organism-specific databases

    CTDi 5054.
    RGDi 3249. Serpine1.

    Phylogenomic databases

    eggNOGi COG4826.
    HOGENOMi HOG000238519.
    HOVERGENi HBG106493.
    InParanoidi P20961.
    KOi K03982.
    PhylomeDBi P20961.

    Miscellaneous databases

    NextBioi 603870.
    PROi P20961.

    Gene expression databases

    Genevestigatori P20961.

    Family and domain databases

    InterProi IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of the rat plasminogen activator inhibitor-1 gene."
      Bruzdzinski C.J., Riordan-Johnson M., Nordby E.C., Suter S.M., Gelehrter T.D.
      J. Biol. Chem. 265:2078-2085(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Cloning and sequencing of cDNA for the rat plasminogen activator inhibitor-1."
      Zeheb R., Gelehrter T.D.
      Gene 73:459-468(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiPAI1_RAT
    AccessioniPrimary (citable) accession number: P20961
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3