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Protein

Insulin-like growth factor-binding protein 3

Gene

IGFBP3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor binding

Enzyme and pathway databases

ReactomeiR-BTA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-BTA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands
R-BTA-8957275 Post-translational protein phosphorylation

Protein family/group databases

MEROPSiI31.952

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 3
Short name:
IBP-3
Short name:
IGF-binding protein 3
Short name:
IGFBP-3
Gene namesi
Name:IGFBP3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi

Organism-specific databases

VGNCiVGNC:30085 IGFBP3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 271 PublicationAdd BLAST27
ChainiPRO_000001437728 – 291Insulin-like growth factor-binding protein 3Add BLAST264

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi136N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei148PhosphoserineBy similarity1
Glycosylationi199N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei201PhosphoserineBy similarity1
Disulfide bondi213 ↔ 240PROSITE-ProRule annotation
Disulfide bondi251 ↔ 262PROSITE-ProRule annotation
Disulfide bondi264 ↔ 285PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP20959
PRIDEiP20959

Expressioni

Tissue specificityi

Plasma; expressed by most tissues.

Gene expression databases

BgeeiENSBTAG00000003994
ExpressionAtlasiP20959 baseline and differential

Interactioni

Subunit structurei

Interacts with HN. Interacts with TMEM219 (By similarity). Binds IGF2 more than IGF1. Forms a ternary complex of about 140 to 150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS). Interacts with XLKD1.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000047769

Structurei

3D structure databases

ProteinModelPortaliP20959
SMRiP20959
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 119IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST84
Domaini210 – 285Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni28 – 134IGF-bindingSequence analysisAdd BLAST107

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi138 – 161Ser/Thr-richAdd BLAST24
Compositional biasi192 – 208Ser/Thr-richAdd BLAST17

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHZU Eukaryota
ENOG4111MF3 LUCA
GeneTreeiENSGT00550000074457
HOGENOMiHOG000253012
HOVERGENiHBG002631
InParanoidiP20959
KOiK10138
OMAiKGDVHCY
OrthoDBiEOG091G0EIN
TreeFamiTF331211

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR012211 IGFBP-3
IPR000867 IGFBP-like
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PANTHERiPTHR11551 PTHR11551, 1 hit
PTHR11551:SF3 PTHR11551:SF3, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01976 IGFBPFAMILY
PR01979 IGFBPFAMILY3
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20959-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRARPALWA AALTALTLLR GPPAARAGAG TMGAGPVVRC EPCDARAVAQ
60 70 80 90 100
CAPPPPSPPC AELVREPGCG CCLTCALREG QPCGVYTERC GSGLRCQPPP
110 120 130 140 150
GDPRPLQALL DGRGLCANAS AVGRLRPYLL PSASGNGSES EEDHSMGSTE
160 170 180 190 200
NQAGPSTHRV PVSKFHPIHT KMDVIKKGHA KDSQRYKVDY ESQSTDTQNF
210 220 230 240 250
SSESKRETEY GPCRREMEDT LNHLKFLNML SPRGIHIPNC DKKGFYKKKQ
260 270 280 290
CRPSKGRKRG FCWCVDKYGQ PLPGFDVKGK GDVHCYSMES K
Length:291
Mass (Da):31,570
Last modified:February 7, 2006 - v3
Checksum:i19DEC2F09528AE12
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5 – 7RPA → PPR in AAA30582 (PubMed:1711841).Curated3
Sequence conflicti66 – 67EP → DA in AAA30582 (PubMed:1711841).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76478 mRNA Translation: AAA30582.1
AF305199 mRNA Translation: AAG29824.1
AF305712 Genomic DNA Translation: AAG29825.1
BC149336 mRNA Translation: AAI49337.1
U83465 Genomic DNA Translation: AAB41430.1
PIRiJN0064
RefSeqiNP_776981.1, NM_174556.1
UniGeneiBt.64897

Genome annotation databases

EnsembliENSBTAT00000053426; ENSBTAP00000047769; ENSBTAG00000003994
GeneIDi282261
KEGGibta:282261

Entry informationi

Entry nameiIBP3_BOVIN
AccessioniPrimary (citable) accession number: P20959
Secondary accession number(s): A6QPI3, Q9GJV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 7, 2006
Last modified: March 28, 2018
This is version 145 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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