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Protein

Conidiophore development regulator abaA

Gene

abaA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation (PubMed:2655931, PubMed:2196567). They act individually and together to regulate their own expression and that of numerous other sporulation-specific gene (PubMed:2655931, PubMed:2823119). Controls temporal and spatial specificity in Aspergillus development (PubMed:2655931, PubMed:7704830). Directs the differentiation of phialides and is continuously required for maintenance of their function (PubMed:2152124). Expression of abaA leads to activation of brlA and wetA, cessation of vegetative growth, and accentuated cellular vacuolization (PubMed:2655931). Binds to the sequence 5'-CATTCY-3', where Y is a pyrimidine, making both major- and minor-groove contacts (PubMed:8139553). Multiple abaA binding sites are present in the cis-acting regulatory regions of several developmentally controlled structural genes as well as those of the upstream regulatory gene brlA, the downstream regulatory gene wetA, and abaA itself (PubMed:8139553).6 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi135 – 200TEAPROSITE-ProRule annotationAdd BLAST66

GO - Molecular functioni

  • transcription factor activity, sequence-specific DNA binding Source: ASPGD
  • transcription regulatory region DNA binding Source: ASPGD

GO - Biological processi

  • conidium formation Source: ASPGD
  • phialide development Source: ASPGD
  • positive regulation of conidium formation Source: ASPGD
  • positive regulation of phialide development Source: ASPGD
  • regulation of transcription, DNA-templated Source: ASPGD
  • regulation of transcription from RNA polymerase II promoter Source: ASPGD
  • sporulation resulting in formation of a cellular spore Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Conidiation, Sporulation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Conidiophore development regulator abaACurated
Gene namesi
Name:abaA1 Publication
ORF Names:AN0422
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome VIII
  • UP000005890 Componenti: Partially assembled WGS sequence

Subcellular locationi

  • Nucleus By similarity

  • Note: localizes to the nuclei of phialides and terminal cells of mature conidia (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Prevents the formation of normal conidiophores (PubMed:2823119, PubMed:2152124). Fails to form any viable conidia, even though it does produce morphologically normal phialides(PubMed:2655931).3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002059401 – 796Conidiophore development regulator abaAAdd BLAST796

Expressioni

Inductioni

Expression is induced during conidiation, after conidiophore vesicles, metullae, and phialides had formed (PubMed:2823119). Negatively regulated by velC (PubMed:24587098). In the promoter, a 45-base-pair region encompassing the major and minor abaA transcription initiation sites contains directly repeated sequences related to the mammalian initiator (Inr) element and is sufficient for correct transcription initiation and for developmental induction (PubMed:2117702).3 Publications

Structurei

3D structure databases

ProteinModelPortaliP20945.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni341 – 362Leucine-zipper-likeAdd BLAST22

Sequence similaritiesi

Belongs to the TEC1 family.Curated
Contains 1 TEA DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000211157.
InParanoidiP20945.
KOiK09448.
OMAiWWAKLFT.
OrthoDBiEOG092C3ML5.

Family and domain databases

InterProiIPR000818. TEA/ATTS_dom.
[Graphical view]
PfamiPF01285. TEA. 1 hit.
[Graphical view]
PRINTSiPR00065. TEADOMAIN.
SMARTiSM00426. TEA. 1 hit.
[Graphical view]
PROSITEiPS00554. TEA_1. 1 hit.
PS51088. TEA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P20945-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATDWQPECM VSQNQAALES IGAHSDRALQ NTSGNVQAYS DSLAHHDTTG
60 70 80 90 100
RDDPLQHYTL KYPHPPVPVP SHPLPTATAN LYHPQLLSHR YQVKKLRRLQ
110 120 130 140 150
SNGSSYAGSR RGRSYLKSQK YLEYRARPRR DTGKDGEPVW SDELEDAFQQ
160 170 180 190 200
ALEANPPMGR RKWSERGKSY GRNELIAEYI YKLTGKRRTR KQVSSHLQVL
210 220 230 240 250
DSFLKGDPDW ERLVREQSDR STAQTQPVGP RWRTSMDHLP SSHYGTHATS
260 270 280 290 300
SYPEPMRLMP PYSADLQLPQ YSPTSTQQDT NNNTIQGLSF DMWVSAPNKP
310 320 330 340 350
DRIDDAYHLY TRLQGDQRQP PMPLEDLKNW RVSFPHLSSS LSDVNDPLNC
360 370 380 390 400
EIILLETNLE LMDDFPPMGS RLGIHLELDI ANPMSGTAPT VNQMENWTCS
410 420 430 440 450
TYIYEDGRRT MEAYHNLTKP HTTKVKPPFE SSWWAKTFTK LTQDKREAES
460 470 480 490 500
TGHHHAADER TRRYFHSLTA VQEIRATVPP SLRRLQNHYP GSPAEESKRM
510 520 530 540 550
AIILWKFRQT RPNEVGTTTW RKLITSPDRA LTNSPRPSTA IDLPPLSLDS
560 570 580 590 600
ILLSKPTSNL YQAPPQHHDL LHQNAPSQQS WSLYQPSHDH VNSLYHSAGA
610 620 630 640 650
FDFLNSITKP EEGLSDKTAP TSVLDPFPNL TQQTTSQTAG INVSSGTPVM
660 670 680 690 700
LQIPDLSLSS NLGTYGLGHE SHYVPSHHNA ANLHDHSSTT GLGHYFAPST
710 720 730 740 750
QSLDEISHSH APWSAPNTTI SGDTSGGNYH HLPFTTSDHS VTVSRESHQN
760 770 780 790
HSFEGLLPSD DLVGIVGGLS GDPNMNGAGP EHTSSAYAEH TAVEAV
Length:796
Mass (Da):89,171
Last modified:May 1, 2007 - v3
Checksum:i934AC9510AAA1CCE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti631T → I in AAA33286 (PubMed:2655931).Curated1
Sequence conflicti641I → T in AAA33286 (PubMed:2655931).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04850 Genomic DNA. Translation: AAA33286.1.
AACD01000007 Genomic DNA. Translation: EAA66521.1.
BN001308 Genomic DNA. Translation: CBF89518.1.
PIRiA32434.
RefSeqiXP_658026.1. XM_652934.1.

Genome annotation databases

EnsemblFungiiCADANIAT00002276; CADANIAP00002276; CADANIAG00002276.
EAA66521; EAA66521; AN0422.2.
GeneIDi2876199.
KEGGiani:AN0422.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04850 Genomic DNA. Translation: AAA33286.1.
AACD01000007 Genomic DNA. Translation: EAA66521.1.
BN001308 Genomic DNA. Translation: CBF89518.1.
PIRiA32434.
RefSeqiXP_658026.1. XM_652934.1.

3D structure databases

ProteinModelPortaliP20945.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANIAT00002276; CADANIAP00002276; CADANIAG00002276.
EAA66521; EAA66521; AN0422.2.
GeneIDi2876199.
KEGGiani:AN0422.2.

Phylogenomic databases

HOGENOMiHOG000211157.
InParanoidiP20945.
KOiK09448.
OMAiWWAKLFT.
OrthoDBiEOG092C3ML5.

Family and domain databases

InterProiIPR000818. TEA/ATTS_dom.
[Graphical view]
PfamiPF01285. TEA. 1 hit.
[Graphical view]
PRINTSiPR00065. TEADOMAIN.
SMARTiSM00426. TEA. 1 hit.
[Graphical view]
PROSITEiPS00554. TEA_1. 1 hit.
PS51088. TEA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiABAA_EMENI
AccessioniPrimary (citable) accession number: P20945
Secondary accession number(s): C8VTG3, Q5BGA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: May 1, 2007
Last modified: November 30, 2016
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.