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Protein

Phosducin

Gene

Pdc

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits the transcriptional activation activity of the cone-rod homeobox CRX (By similarity). May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism.By similarity

GO - Biological processi

Keywordsi

Biological processSensory transduction, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
Phosducin
Short name:
PHD
Alternative name(s):
33 kDa phototransducing protein
Protein MEKA
Rod photoreceptor 1
Short name:
RPR-1
Gene namesi
Name:Pdc
Synonyms:Rpr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi3277. Pdc.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001637541 – 246PhosducinAdd BLAST246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei73Phosphoserine; by PKABy similarity1

Post-translational modificationi

Light-induced changes in cyclic nucleotide levels modulate the phosphorylation of this protein by cAMP kinase.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP20942.
PRIDEiP20942.

PTM databases

iPTMnetiP20942.
PhosphoSitePlusiP20942.

Expressioni

Gene expression databases

BgeeiENSRNOG00000002517.
GenevisibleiP20942. RN.

Interactioni

Subunit structurei

Interacts with CRX (By similarity). Forms a complex with the beta and gamma subunits of the GTP-binding protein, transducin.By similarity

Protein-protein interaction databases

BioGridi247382. 1 interactor.
DIPiDIP-41816N.
IntActiP20942. 1 interactor.
MINTiMINT-197623.
STRINGi10116.ENSRNOP00000003405.

Structurei

Secondary structure

1246
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi21 – 36Combined sources16
Beta strandi40 – 42Combined sources3
Beta strandi56 – 59Combined sources4
Helixi62 – 64Combined sources3
Helixi74 – 82Combined sources9
Helixi87 – 105Combined sources19
Beta strandi113 – 116Combined sources4
Helixi120 – 129Combined sources10
Beta strandi135 – 141Combined sources7
Helixi148 – 159Combined sources12
Beta strandi165 – 171Combined sources7
Helixi172 – 175Combined sources4
Turni178 – 180Combined sources3
Helixi183 – 185Combined sources3
Beta strandi187 – 193Combined sources7
Beta strandi196 – 201Combined sources6
Helixi204 – 207Combined sources4
Helixi214 – 222Combined sources9
Turni223 – 225Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B9XX-ray3.00C1-246[»]
1B9YX-ray3.00C1-246[»]
2TRCX-ray2.40P14-230[»]
ProteinModelPortaliP20942.
SMRiP20942.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20942.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni111 – 246Thioredoxin foldBy similarityAdd BLAST136

Sequence similaritiesi

Belongs to the phosducin family.Curated

Phylogenomic databases

eggNOGiKOG3171. Eukaryota.
ENOG4110DRD. LUCA.
GeneTreeiENSGT00530000062970.
HOGENOMiHOG000232010.
HOVERGENiHBG003456.
InParanoidiP20942.
KOiK08327.
OMAiCMQDMHQ.
OrthoDBiEOG091G0ISM.
PhylomeDBiP20942.
TreeFamiTF315179.

Family and domain databases

CDDicd02987. Phd_like_Phd. 1 hit.
Gene3Di1.10.168.10. 2 hits.
InterProiView protein in InterPro
IPR001200. Phosducin.
IPR023196. Phosducin_N_dom_sf.
IPR024253. Phosducin_thioredoxin-like_dom.
IPR036249. Thioredoxin-like_sf.
PfamiView protein in Pfam
PF02114. Phosducin. 1 hit.
PRINTSiPR00677. PHOSDUCIN.
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

P20942-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEAASQSLE EDFEGQATHT GPKGVINDWR KFKLESEDGD SIPPSKKEIL
60 70 80 90 100
RQMSSPQSRD DKDSKERMSR KMSIQEYELI HQDKEDEGCL RKYRRQCMQD
110 120 130 140 150
MHQKLSFGPR YGFVYELETG EQFLETIEKE QKVTTIVVNI YEDGVRGCDA
160 170 180 190 200
LNSSLECLAA EYPMVKFCKI RASNTGAGDR FSSDVLPTLL VYKGGELISN
210 220 230 240
FISVAEQFAE DFFAADVESF LNEYGLLPER EIHDLGQTNT EDEDIE
Length:246
Mass (Da):28,129
Last modified:February 1, 1991 - v1
Checksum:i3C48ABCB4E5E3D04
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39G → S in AAA41841 (PubMed:2071146).Curated1
Sequence conflicti88G → V in AAA41841 (PubMed:2071146).Curated1
Sequence conflicti119T → S in AAA41841 (PubMed:2071146).Curated1
Sequence conflicti211D → E in AAA41841 (PubMed:2071146).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti191V → I. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33528 mRNA. Translation: AAA40604.1.
M33530 mRNA. Translation: AAA40603.1.
M60738 mRNA. Translation: AAA41841.1.
PIRiA39903.
JH0216.
RefSeqiNP_037004.1. NM_012872.1.
UniGeneiRn.9739.

Genome annotation databases

EnsembliENSRNOT00000003405; ENSRNOP00000003405; ENSRNOG00000002517.
GeneIDi25343.
KEGGirno:25343.
UCSCiRGD:3277. rat.

Similar proteinsi

Entry informationi

Entry nameiPHOS_RAT
AccessioniPrimary (citable) accession number: P20942
Secondary accession number(s): Q63420
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 22, 2017
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families