Phosducin - Rattus norvegicus (Rat)

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P20942 (PHOS_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 99. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Phosducin
Short name=PHD

Alternative name(s):
33 kDa phototransducing protein
Protein MEKA
Rod photoreceptor 1
Short name=RPR-1

Gene names

Name:	Pdc
Synonyms:	Rpr1

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism.
Subunit structure	Forms a complex with the beta and gamma subunits of the GTP-binding protein, transducin.
Subcellular location	Cytoplasm › cytosol. Cell projection › cilium › photoreceptor outer segment. Photoreceptor inner segment. Note: Outer and inner segments of the rod cells.
Post-translational modification	Light-induced changes in cyclic nucleotide levels modulate the phosphorylation of this protein by cAMP kinase.
Sequence similarities	Belongs to the phosducin family.

Ontologies

Keywords
Biological process	Sensory transduction Vision
Cellular component	Cell projection Cilium Cytoplasm
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	response to stimulus Inferred from electronic annotation. Source: UniProtKB-KW visual perception Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell photoreceptor inner segment Inferred from electronic annotation. Source: UniProtKB-SubCell photoreceptor outer segment Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 246

246

Phosducin

PRO_0000163754

Amino acid modifications

Modified residue

Phosphoserine; by PKA Ref.1

Natural variations

Natural variant

191

V → I.

Experimental info

Sequence conflict

G → S in AAA41841. Ref.2

Sequence conflict

G → V in AAA41841. Ref.2

Sequence conflict

119

T → S in AAA41841. Ref.2

Sequence conflict

211

D → E in AAA41841. Ref.2

Secondary structure

246

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P20942 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: 3C48ABCB4E5E3D04
Show »

FASTA

246

28,129

        10         20         30         40         50         60 
MEEAASQSLE EDFEGQATHT GPKGVINDWR KFKLESEDGD SIPPSKKEIL RQMSSPQSRD 

        70         80         90        100        110        120 
DKDSKERMSR KMSIQEYELI HQDKEDEGCL RKYRRQCMQD MHQKLSFGPR YGFVYELETG 

       130        140        150        160        170        180 
EQFLETIEKE QKVTTIVVNI YEDGVRGCDA LNSSLECLAA EYPMVKFCKI RASNTGAGDR 

       190        200        210        220        230        240 
FSSDVLPTLL VYKGGELISN FISVAEQFAE DFFAADVESF LNEYGLLPER EIHDLGQTNT 


EDEDIE

« Hide

References

[1]	"Analysis of the human, bovine and rat 33-kDa proteins and cDNA in retina and pineal gland." Abe T., Nakabayashi H., Tamada H., Takagi T., Sakuragi S., Yamaki K., Shinohara T. Gene 91:209-215(1990) [PubMed: 2210381] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Pineal gland and Retina.
[2]	"Rat pineal gland phosducin: cDNA isolation, nucleotide sequence, and chromosomal assignment in the mouse." Craft C.M., Lolley R.N., Seldin M.F., Lee R.H. Genomics 10:400-409(1991) [PubMed: 2071146] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pineal gland.
[3]	"A molecular mechanism for the phosphorylation-dependent regulation of heterotrimeric G-proteins by phosducin. Structural analysis of phosducin and its phosphorylation-regulated interaction with transducin beta-gamma." Gaudet R., Savage J.R., McLaughlin J.N., Willardson B.M., Sigler P.B. Mol. Cell 3:649-660(1999) [PubMed: 10360181] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF COMPLEX WITH G-BETA AND G-GAMMA.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M33528 mRNA. Translation: AAA40604.1.
M33530 mRNA. Translation: AAA40603.1.
M60738 mRNA. Translation: AAA41841.1.

IPI

IPI00326074.

PIR

A39903.
JH0216.

RefSeq

NP_037004.1. NM_012872.1.

UniGene

Rn.9739.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1B9X	X-ray	3.00	C	1-246	[»]
1B9Y	X-ray	3.00	C	1-246	[»]
2TRC	X-ray	2.40	P	14-230	[»]

ProteinModelPortal

P20942.

SMR

P20942. Positions 14-230.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-41816N.

MINT

MINT-197623.

STRING

P20942.

PTM databases

PhosphoSite

P20942.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSRNOT00000003405; ENSRNOP00000003405; ENSRNOG00000002517.

GeneID

25343.

KEGG

rno:25343.

UCSC

NM_012872. rat.

Organism-specific databases

CTD

5132.

RGD

3277. Pdc.

Phylogenomic databases

eggNOG

roNOG04594.

GeneTree

ENSGT00530000062970.

HOVERGEN

HBG003456.

InParanoid

P20942.

OMA

NEYGLLP.

OrthoDB

EOG4RBQKG.

PhylomeDB

P20942.

Gene expression databases

ArrayExpress

P20942.

Genevestigator

P20942.

GermOnline

ENSRNOG00000002517. Rattus norvegicus.

Family and domain databases

InterPro

IPR001200. Phosducin.
IPR023196. Phosducin_dom2.
IPR024253. Phosducin_thioredoxin-like_dom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]

Gene3D

G3DSA:1.10.168.10. Phosducin_dom2. 1 hit.
G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.

K08327.

Pfam

PF02114. Phosducin. 1 hit.
[Graphical view]

PRINTS

PR00677. PHOSDUCIN.

SUPFAM

SSF52833. Thiordxn-like_fd. 1 hit.

ProtoNet

Search...

Other

NextBio

606259.

Entry information

Entry name

PHOS_RAT

Accession

Primary (citable) accession number: P20942
Secondary accession number(s): Q63420

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	February 1, 1991
Last modified:	November 16, 2011
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Amino acid modifications

Natural variations

Experimental info

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents