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Protein

Phosducin

Gene

Pdc

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits the transcriptional activation activity of the cone-rod homeobox CRX (By similarity). May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sensory transduction, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
Phosducin
Short name:
PHD
Alternative name(s):
33 kDa phototransducing protein
Protein MEKA
Rod photoreceptor 1
Short name:
RPR-1
Gene namesi
Name:Pdc
Synonyms:Rpr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi3277. Pdc.

Subcellular locationi

  • Cytoplasmcytosol By similarity
  • Nucleus By similarity
  • Cell projectionciliumphotoreceptor outer segment By similarity
  • Photoreceptor inner segment By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246PhosducinPRO_0000163754Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei73 – 731Phosphoserine; by PKABy similarity

Post-translational modificationi

Light-induced changes in cyclic nucleotide levels modulate the phosphorylation of this protein by cAMP kinase.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP20942.
PRIDEiP20942.

PTM databases

iPTMnetiP20942.
PhosphoSiteiP20942.

Expressioni

Gene expression databases

GenevisibleiP20942. RN.

Interactioni

Subunit structurei

Interacts with CRX (By similarity). Forms a complex with the beta and gamma subunits of the GTP-binding protein, transducin.By similarity

Protein-protein interaction databases

BioGridi247382. 1 interaction.
DIPiDIP-41816N.
MINTiMINT-197623.
STRINGi10116.ENSRNOP00000003405.

Structurei

Secondary structure

1
246
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi21 – 3616Combined sources
Beta strandi40 – 423Combined sources
Beta strandi56 – 594Combined sources
Helixi62 – 643Combined sources
Helixi74 – 829Combined sources
Helixi87 – 10519Combined sources
Beta strandi113 – 1164Combined sources
Helixi120 – 12910Combined sources
Beta strandi135 – 1417Combined sources
Helixi148 – 15912Combined sources
Beta strandi165 – 1717Combined sources
Helixi172 – 1754Combined sources
Turni178 – 1803Combined sources
Helixi183 – 1853Combined sources
Beta strandi187 – 1937Combined sources
Beta strandi196 – 2016Combined sources
Helixi204 – 2074Combined sources
Helixi214 – 2229Combined sources
Turni223 – 2253Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1B9XX-ray3.00C1-246[»]
1B9YX-ray3.00C1-246[»]
2TRCX-ray2.40P14-230[»]
ProteinModelPortaliP20942.
SMRiP20942. Positions 14-230.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20942.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni111 – 246136Thioredoxin foldBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the phosducin family.Curated

Phylogenomic databases

eggNOGiKOG3171. Eukaryota.
ENOG4110DRD. LUCA.
GeneTreeiENSGT00530000062970.
HOGENOMiHOG000232010.
HOVERGENiHBG003456.
InParanoidiP20942.
KOiK08327.
OMAiCMQDMHQ.
OrthoDBiEOG091G0ISM.
PhylomeDBiP20942.
TreeFamiTF315179.

Family and domain databases

Gene3Di1.10.168.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR001200. Phosducin.
IPR023196. Phosducin_N_dom.
IPR024253. Phosducin_thioredoxin-like_dom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF02114. Phosducin. 1 hit.
[Graphical view]
PRINTSiPR00677. PHOSDUCIN.
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

P20942-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEAASQSLE EDFEGQATHT GPKGVINDWR KFKLESEDGD SIPPSKKEIL
60 70 80 90 100
RQMSSPQSRD DKDSKERMSR KMSIQEYELI HQDKEDEGCL RKYRRQCMQD
110 120 130 140 150
MHQKLSFGPR YGFVYELETG EQFLETIEKE QKVTTIVVNI YEDGVRGCDA
160 170 180 190 200
LNSSLECLAA EYPMVKFCKI RASNTGAGDR FSSDVLPTLL VYKGGELISN
210 220 230 240
FISVAEQFAE DFFAADVESF LNEYGLLPER EIHDLGQTNT EDEDIE
Length:246
Mass (Da):28,129
Last modified:February 1, 1991 - v1
Checksum:i3C48ABCB4E5E3D04
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391G → S in AAA41841 (PubMed:2071146).Curated
Sequence conflicti88 – 881G → V in AAA41841 (PubMed:2071146).Curated
Sequence conflicti119 – 1191T → S in AAA41841 (PubMed:2071146).Curated
Sequence conflicti211 – 2111D → E in AAA41841 (PubMed:2071146).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti191 – 1911V → I.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33528 mRNA. Translation: AAA40604.1.
M33530 mRNA. Translation: AAA40603.1.
M60738 mRNA. Translation: AAA41841.1.
PIRiA39903.
JH0216.
RefSeqiNP_037004.1. NM_012872.1.
UniGeneiRn.9739.

Genome annotation databases

EnsembliENSRNOT00000003405; ENSRNOP00000003405; ENSRNOG00000002517.
GeneIDi25343.
KEGGirno:25343.
UCSCiRGD:3277. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33528 mRNA. Translation: AAA40604.1.
M33530 mRNA. Translation: AAA40603.1.
M60738 mRNA. Translation: AAA41841.1.
PIRiA39903.
JH0216.
RefSeqiNP_037004.1. NM_012872.1.
UniGeneiRn.9739.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1B9XX-ray3.00C1-246[»]
1B9YX-ray3.00C1-246[»]
2TRCX-ray2.40P14-230[»]
ProteinModelPortaliP20942.
SMRiP20942. Positions 14-230.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247382. 1 interaction.
DIPiDIP-41816N.
MINTiMINT-197623.
STRINGi10116.ENSRNOP00000003405.

PTM databases

iPTMnetiP20942.
PhosphoSiteiP20942.

Proteomic databases

PaxDbiP20942.
PRIDEiP20942.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003405; ENSRNOP00000003405; ENSRNOG00000002517.
GeneIDi25343.
KEGGirno:25343.
UCSCiRGD:3277. rat.

Organism-specific databases

CTDi5132.
RGDi3277. Pdc.

Phylogenomic databases

eggNOGiKOG3171. Eukaryota.
ENOG4110DRD. LUCA.
GeneTreeiENSGT00530000062970.
HOGENOMiHOG000232010.
HOVERGENiHBG003456.
InParanoidiP20942.
KOiK08327.
OMAiCMQDMHQ.
OrthoDBiEOG091G0ISM.
PhylomeDBiP20942.
TreeFamiTF315179.

Miscellaneous databases

EvolutionaryTraceiP20942.
PROiP20942.

Gene expression databases

GenevisibleiP20942. RN.

Family and domain databases

Gene3Di1.10.168.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR001200. Phosducin.
IPR023196. Phosducin_N_dom.
IPR024253. Phosducin_thioredoxin-like_dom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF02114. Phosducin. 1 hit.
[Graphical view]
PRINTSiPR00677. PHOSDUCIN.
SUPFAMiSSF52833. SSF52833. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPHOS_RAT
AccessioniPrimary (citable) accession number: P20942
Secondary accession number(s): Q63420
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: September 7, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.