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Protein

Ras GTPase-activating protein 1

Gene

RASA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1.2 Publications

GO - Molecular functioni

  • glycoprotein binding Source: UniProtKB
  • GTPase activator activity Source: Reactome
  • GTPase binding Source: UniProtKB
  • potassium channel inhibitor activity Source: UniProtKB
  • receptor binding Source: UniProtKB

GO - Biological processi

  • blood vessel morphogenesis Source: UniProtKB
  • embryo development Source: UniProtKB
  • ephrin receptor signaling pathway Source: Reactome
  • intracellular signal transduction Source: UniProtKB
  • MAPK cascade Source: Reactome
  • mitotic cytokinesis Source: UniProtKB
  • negative regulation of cell adhesion Source: UniProtKB
  • negative regulation of cell-matrix adhesion Source: UniProtKB
  • negative regulation of neuron apoptotic process Source: UniProtKB
  • negative regulation of Ras protein signal transduction Source: GO_Central
  • regulation of actin filament polymerization Source: UniProtKB
  • regulation of cell shape Source: UniProtKB
  • regulation of RNA metabolic process Source: UniProtKB
  • signal transduction Source: UniProtKB
  • vasculogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145715-MONOMER.
ReactomeiR-HSA-186763. Downstream signal transduction.
R-HSA-3928662. EPHB-mediated forward signaling.
R-HSA-5218921. VEGFR2 mediated cell proliferation.
R-HSA-5658442. Regulation of RAS by GAPs.
R-HSA-6802949. Signaling by RAS mutants.
R-HSA-8849471. PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.
SignaLinkiP20936.
SIGNORiP20936.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras GTPase-activating protein 1
Short name:
GAP
Short name:
GTPase-activating protein
Short name:
RasGAP
Alternative name(s):
Ras p21 protein activator
p120GAP
Gene namesi
Name:RASA1
Synonyms:GAP, RASA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:9871. RASA1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: Reactome
  • intrinsic component of the cytoplasmic side of the plasma membrane Source: GO_Central
  • ruffle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Mutations in the SH2 domain of RASA seem to be oncogenic and cause basal cell carcinomas.

Capillary malformation-arteriovenous malformation (CMAVM)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by atypical capillary malformations that are multiple, small, round to oval in shape and pinkish red in color. These capillary malformations are associated with either arteriovenous malformation, arteriovenous fistula, or Parkes Weber syndrome.
See also OMIM:608354
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_072088528Y → C in CMAVM. 1 PublicationCorresponds to variant rs145752649dbSNPEnsembl.1
Natural variantiVAR_072089530V → D in CMAVM. 1 Publication1
Natural variantiVAR_017744540C → Y in CMAVM. 1 PublicationCorresponds to variant rs137853217dbSNPEnsembl.1
Natural variantiVAR_072090626A → E in CMAVM. 1 Publication1
Natural variantiVAR_072091763E → V in CMAVM; unknown pathological significance. 1 PublicationCorresponds to variant rs373098580dbSNPEnsembl.1
Parkes Weber syndrome (PKWS)
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionDisorder characterized by a cutaneous flush with underlying multiple micro-arteriovenous fistulas, in association with soft tissue and skeletal hypertrophy of the affected limb.
See also OMIM:608355

Keywords - Diseasei

Disease mutation, Tumor suppressor

Organism-specific databases

DisGeNETi5921.
MalaCardsiRASA1.
MIMi608354. phenotype.
608355. phenotype.
OpenTargetsiENSG00000145715.
Orphaneti137667. Capillary malformation - arteriovenous malformation.
90307. Parkes Weber syndrome.
PharmGKBiPA34232.

Polymorphism and mutation databases

BioMutaiRASA1.
DMDMi121743.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000566361 – 1047Ras GTPase-activating protein 1Add BLAST1047

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei615PhosphotyrosineCombined sources1
Modified residuei831PhosphoserineCombined sources1

Post-translational modificationi

The N-terminus is blocked.
Phosphorylated by SRC and LCK. The phosphorylation SRC inhibits its ability to stimulate the Ras-GTPase activity, whereas phosphorylation by LCK does not display any effect on stimulation activity.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP20936.
MaxQBiP20936.
PaxDbiP20936.
PeptideAtlasiP20936.
PRIDEiP20936.

PTM databases

iPTMnetiP20936.
PhosphoSitePlusiP20936.

Miscellaneous databases

PMAP-CutDBP20936.

Expressioni

Tissue specificityi

In placental villi, detected only in the trophoblast layer (cytotrophoblast and syncytiotrophoblast). Not detected in stromal, endothelial or Hofbauer cells (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000145715.
CleanExiHS_RASA1.
ExpressionAtlasiP20936. baseline and differential.
GenevisibleiP20936. HS.

Organism-specific databases

HPAiCAB007789.

Interactioni

Subunit structurei

Interacts with SQSTM1. Interacts with SPSB1; the interaction does not promote degradation. Interacts with CAV2 (tyrosine phosphorylated form). Directly interacts with NCK1. Interacts with PDGFRB (tyrosine phosphorylated). Interacts (via SH2 domain) with the 'Tyr-9' phosphorylated form of PDPK1.8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ABI1Q8IZP02EBI-1026476,EBI-375446
ARP1027516EBI-1026476,EBI-608057
CAPNS1P046323EBI-1026476,EBI-711828
DLC1Q96QB17EBI-1026476,EBI-2608428
EGFRP005337EBI-1026476,EBI-297353
ERBB2P046268EBI-1026476,EBI-641062
ERBB3P218606EBI-1026476,EBI-720706
GAB1Q1348025EBI-1026476,EBI-517684
KITP1072116EBI-1026476,EBI-1379503
METP0858115EBI-1026476,EBI-1039152
NCK1P163336EBI-1026476,EBI-389883
PDGFRBP096193EBI-1026476,EBI-641237

GO - Molecular functioni

  • GTPase binding Source: UniProtKB
  • receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi111856. 54 interactors.
DIPiDIP-144N.
IntActiP20936. 54 interactors.
MINTiMINT-195165.
STRINGi9606.ENSP00000274376.

Structurei

Secondary structure

11047
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi283 – 288Combined sources6
Beta strandi296 – 298Combined sources3
Beta strandi306 – 312Combined sources7
Beta strandi316 – 322Combined sources7
Turni323 – 325Combined sources3
Beta strandi328 – 332Combined sources5
Helixi333 – 335Combined sources3
Beta strandi336 – 338Combined sources3
Helixi346 – 348Combined sources3
Beta strandi350 – 352Combined sources3
Helixi358 – 366Combined sources9
Beta strandi371 – 378Combined sources8
Beta strandi380 – 382Combined sources3
Beta strandi386 – 391Combined sources6
Beta strandi401 – 404Combined sources4
Turni405 – 407Combined sources3
Beta strandi408 – 413Combined sources6
Helixi419 – 426Combined sources8
Helixi720 – 723Combined sources4
Helixi724 – 730Combined sources7
Helixi736 – 744Combined sources9
Beta strandi746 – 748Combined sources3
Helixi749 – 762Combined sources14
Helixi766 – 780Combined sources15
Helixi784 – 786Combined sources3
Turni787 – 789Combined sources3
Helixi793 – 805Combined sources13
Helixi807 – 823Combined sources17
Helixi832 – 834Combined sources3
Helixi841 – 860Combined sources20
Helixi861 – 865Combined sources5
Helixi868 – 884Combined sources17
Helixi891 – 900Combined sources10
Turni901 – 904Combined sources4
Helixi905 – 910Combined sources6
Turni912 – 916Combined sources5
Helixi924 – 941Combined sources18
Beta strandi946 – 949Combined sources4
Helixi951 – 956Combined sources6
Helixi957 – 974Combined sources18
Helixi992 – 1004Combined sources13
Helixi1006 – 1013Combined sources8
Helixi1020 – 1038Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WERX-ray1.60A714-1047[»]
1WQ1X-ray2.50G714-1047[»]
2GQINMR-A282-339[»]
2GSBNMR-A341-446[»]
2J05X-ray1.50A/B281-341[»]
2J06X-ray1.80A/B281-341[»]
2M51NMR-A281-341[»]
4FSSX-ray2.25A/B/C281-341[»]
ProteinModelPortaliP20936.
SMRiP20936.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP20936.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini181 – 272SH2 1PROSITE-ProRule annotationAdd BLAST92
Domaini279 – 341SH3PROSITE-ProRule annotationAdd BLAST63
Domaini351 – 441SH2 2PROSITE-ProRule annotationAdd BLAST91
Domaini474 – 577PHPROSITE-ProRule annotationAdd BLAST104
Domaini581 – 676C2PROSITE-ProRule annotationAdd BLAST96
Domaini748 – 942Ras-GAPPROSITE-ProRule annotationAdd BLAST195

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 22Poly-Gly6
Compositional biasi135 – 141Poly-Pro7
Compositional biasi163 – 168Poly-Glu6

Sequence similaritiesi

Contains 1 C2 domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 Ras-GAP domain.PROSITE-ProRule annotation
Contains 2 SH2 domains.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiKOG3508. Eukaryota.
ENOG410XPU1. LUCA.
GeneTreeiENSGT00760000119092.
HOGENOMiHOG000007794.
HOVERGENiHBG057470.
InParanoidiP20936.
KOiK04352.
OMAiDPHEGKI.
OrthoDBiEOG091G022Q.
PhylomeDBiP20936.
TreeFamiTF105301.

Family and domain databases

Gene3Di1.10.506.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.30.505.10. 2 hits.
InterProiIPR000008. C2_dom.
IPR028554. p120-RasGAP.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR023152. RasGAP_CS.
IPR001936. RasGAP_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR10194:SF19. PTHR10194:SF19. 1 hit.
PfamiPF00168. C2. 1 hit.
PF00169. PH. 1 hit.
PF00616. RasGAP. 1 hit.
PF00017. SH2. 2 hits.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
SM00252. SH2. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS50001. SH2. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P20936-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMAAEAGSEE GGPVTAGAGG GGAAAGSSAY PAVCRVKIPA ALPVAAAPYP
60 70 80 90 100
GLVETGVAGT LGGGAALGSE FLGAGSVAGA LGGAGLTGGG TAAGVAGAAA
110 120 130 140 150
GVAGAAVAGP SGDMALTKLP TSLLAETLGP GGGFPPLPPP PYLPPLGAGL
160 170 180 190 200
GTVDEGDSLD GPEYEEEEVA IPLTAPPTNQ WYHGKLDRTI AEERLRQAGK
210 220 230 240 250
SGSYLIRESD RRPGSFVLSF LSQMNVVNHF RIIAMCGDYY IGGRRFSSLS
260 270 280 290 300
DLIGYYSHVS CLLKGEKLLY PVAPPEPVED RRRVRAILPY TKVPDTDEIS
310 320 330 340 350
FLKGDMFIVH NELEDGWMWV TNLRTDEQGL IVEDLVEEVG REEDPHEGKI
360 370 380 390 400
WFHGKISKQE AYNLLMTVGQ VCSFLVRPSD NTPGDYSLYF RTNENIQRFK
410 420 430 440 450
ICPTPNNQFM MGGRYYNSIG DIIDHYRKEQ IVEGYYLKEP VPMQDQEQVL
460 470 480 490 500
NDTVDGKEIY NTIRRKTKDA FYKNIVKKGY LLKKGKGKRW KNLYFILEGS
510 520 530 540 550
DAQLIYFESE KRATKPKGLI DLSVCSVYVV HDSLFGRPNC FQIVVQHFSE
560 570 580 590 600
EHYIFYFAGE TPEQAEDWMK GLQAFCNLRK SSPGTSNKRL RQVSSLVLHI
610 620 630 640 650
EEAHKLPVKH FTNPYCNIYL NSVQVAKTHA REGQNPVWSE EFVFDDLPPD
660 670 680 690 700
INRFEITLSN KTKKSKDPDI LFMRCQLSRL QKGHATDEWF LLSSHIPLKG
710 720 730 740 750
IEPGSLRVRA RYSMEKIMPE EEYSEFKELI LQKELHVVYA LSHVCGQDRT
760 770 780 790 800
LLASILLRIF LHEKLESLLL CTLNDREISM EDEATTLFRA TTLASTLMEQ
810 820 830 840 850
YMKATATQFV HHALKDSILK IMESKQSCEL SPSKLEKNED VNTNLTHLLN
860 870 880 890 900
ILSELVEKIF MASEILPPTL RYIYGCLQKS VQHKWPTNTT MRTRVVSGFV
910 920 930 940 950
FLRLICPAIL NPRMFNIISD SPSPIAARTL ILVAKSVQNL ANLVEFGAKE
960 970 980 990 1000
PYMEGVNPFI KSNKHRMIMF LDELGNVPEL PDTTEHSRTD LSRDLAALHE
1010 1020 1030 1040
ICVAHSDELR TLSNERGAQQ HVLKKLLAIT ELLQQKQNQY TKTNDVR
Length:1,047
Mass (Da):116,403
Last modified:February 1, 1991 - v1
Checksum:iC35B6567F5BC5370
GO
Isoform 2 (identifier: P20936-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-177: Missing.
     178-180: TNQ → MKG

Show »
Length:870
Mass (Da):100,398
Checksum:iB328E701911065F9
GO
Isoform 3 (identifier: P20936-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     538-539: PN → CS
     540-1047: Missing.

Note: No experimental confirmation available.
Show »
Length:539
Mass (Da):58,037
Checksum:iD6D38EBC43450273
GO
Isoform 4 (identifier: P20936-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MMAAEAGSEEGGP → MRTGYSSVPSKLR
     14-180: Missing.

Note: No experimental confirmation available.
Show »
Length:880
Mass (Da):101,546
Checksum:iFE89B3A1E8126DD6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti789R → A AA sequence (PubMed:8360177).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_002650398R → L in basal cell carcinomas. 1 PublicationCorresponds to variant rs137853214dbSNPEnsembl.1
Natural variantiVAR_002651400K → E in basal cell carcinomas. 1 PublicationCorresponds to variant rs137853215dbSNPEnsembl.1
Natural variantiVAR_002652401I → V in basal cell carcinomas. 1 PublicationCorresponds to variant rs137853216dbSNPEnsembl.1
Natural variantiVAR_072088528Y → C in CMAVM. 1 PublicationCorresponds to variant rs145752649dbSNPEnsembl.1
Natural variantiVAR_072089530V → D in CMAVM. 1 Publication1
Natural variantiVAR_017744540C → Y in CMAVM. 1 PublicationCorresponds to variant rs137853217dbSNPEnsembl.1
Natural variantiVAR_072090626A → E in CMAVM. 1 Publication1
Natural variantiVAR_072091763E → V in CMAVM; unknown pathological significance. 1 PublicationCorresponds to variant rs373098580dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0016251 – 177Missing in isoform 2. 2 PublicationsAdd BLAST177
Alternative sequenceiVSP_0574321 – 13MMAAE…EEGGP → MRTGYSSVPSKLR in isoform 4. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_05743314 – 180Missing in isoform 4. 1 PublicationAdd BLAST167
Alternative sequenceiVSP_001626178 – 180TNQ → MKG in isoform 2. 2 Publications3
Alternative sequenceiVSP_057434538 – 539PN → CS in isoform 3. 1 Publication2
Alternative sequenceiVSP_057435540 – 1047Missing in isoform 3. 1 PublicationAdd BLAST508

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23379 mRNA. Translation: AAA52517.1.
M23612 mRNA. Translation: AAA35865.1.
AK300263 mRNA. Translation: BAG62024.1.
AK312739 mRNA. Translation: BAG35610.1.
CR749722 mRNA. Translation: CAH18488.2.
AC010410 Genomic DNA. No translation available.
AC018754 Genomic DNA. No translation available.
AC035142 Genomic DNA. No translation available.
AC126776 Genomic DNA. No translation available.
BC033015 mRNA. Translation: AAH33015.1.
CCDSiCCDS34200.1. [P20936-1]
CCDS47243.1. [P20936-2]
PIRiA40121.
B40121.
RefSeqiNP_002881.1. NM_002890.2. [P20936-1]
NP_072179.1. NM_022650.2. [P20936-2]
UniGeneiHs.664080.

Genome annotation databases

EnsembliENST00000274376; ENSP00000274376; ENSG00000145715. [P20936-1]
ENST00000456692; ENSP00000411221; ENSG00000145715. [P20936-2]
ENST00000512763; ENSP00000422008; ENSG00000145715. [P20936-4]
ENST00000515800; ENSP00000423395; ENSG00000145715. [P20936-3]
GeneIDi5921.
KEGGihsa:5921.
UCSCiuc003kiw.4. human. [P20936-1]
uc011ctv.3. human.
uc063fdq.1. human.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23379 mRNA. Translation: AAA52517.1.
M23612 mRNA. Translation: AAA35865.1.
AK300263 mRNA. Translation: BAG62024.1.
AK312739 mRNA. Translation: BAG35610.1.
CR749722 mRNA. Translation: CAH18488.2.
AC010410 Genomic DNA. No translation available.
AC018754 Genomic DNA. No translation available.
AC035142 Genomic DNA. No translation available.
AC126776 Genomic DNA. No translation available.
BC033015 mRNA. Translation: AAH33015.1.
CCDSiCCDS34200.1. [P20936-1]
CCDS47243.1. [P20936-2]
PIRiA40121.
B40121.
RefSeqiNP_002881.1. NM_002890.2. [P20936-1]
NP_072179.1. NM_022650.2. [P20936-2]
UniGeneiHs.664080.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WERX-ray1.60A714-1047[»]
1WQ1X-ray2.50G714-1047[»]
2GQINMR-A282-339[»]
2GSBNMR-A341-446[»]
2J05X-ray1.50A/B281-341[»]
2J06X-ray1.80A/B281-341[»]
2M51NMR-A281-341[»]
4FSSX-ray2.25A/B/C281-341[»]
ProteinModelPortaliP20936.
SMRiP20936.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111856. 54 interactors.
DIPiDIP-144N.
IntActiP20936. 54 interactors.
MINTiMINT-195165.
STRINGi9606.ENSP00000274376.

PTM databases

iPTMnetiP20936.
PhosphoSitePlusiP20936.

Polymorphism and mutation databases

BioMutaiRASA1.
DMDMi121743.

Proteomic databases

EPDiP20936.
MaxQBiP20936.
PaxDbiP20936.
PeptideAtlasiP20936.
PRIDEiP20936.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274376; ENSP00000274376; ENSG00000145715. [P20936-1]
ENST00000456692; ENSP00000411221; ENSG00000145715. [P20936-2]
ENST00000512763; ENSP00000422008; ENSG00000145715. [P20936-4]
ENST00000515800; ENSP00000423395; ENSG00000145715. [P20936-3]
GeneIDi5921.
KEGGihsa:5921.
UCSCiuc003kiw.4. human. [P20936-1]
uc011ctv.3. human.
uc063fdq.1. human.

Organism-specific databases

CTDi5921.
DisGeNETi5921.
GeneCardsiRASA1.
GeneReviewsiRASA1.
HGNCiHGNC:9871. RASA1.
HPAiCAB007789.
MalaCardsiRASA1.
MIMi139150. gene.
608354. phenotype.
608355. phenotype.
neXtProtiNX_P20936.
OpenTargetsiENSG00000145715.
Orphaneti137667. Capillary malformation - arteriovenous malformation.
90307. Parkes Weber syndrome.
PharmGKBiPA34232.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3508. Eukaryota.
ENOG410XPU1. LUCA.
GeneTreeiENSGT00760000119092.
HOGENOMiHOG000007794.
HOVERGENiHBG057470.
InParanoidiP20936.
KOiK04352.
OMAiDPHEGKI.
OrthoDBiEOG091G022Q.
PhylomeDBiP20936.
TreeFamiTF105301.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145715-MONOMER.
ReactomeiR-HSA-186763. Downstream signal transduction.
R-HSA-3928662. EPHB-mediated forward signaling.
R-HSA-5218921. VEGFR2 mediated cell proliferation.
R-HSA-5658442. Regulation of RAS by GAPs.
R-HSA-6802949. Signaling by RAS mutants.
R-HSA-8849471. PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.
SignaLinkiP20936.
SIGNORiP20936.

Miscellaneous databases

ChiTaRSiRASA1. human.
EvolutionaryTraceiP20936.
GeneWikiiRAS_p21_protein_activator_1.
GenomeRNAii5921.
PMAP-CutDBP20936.
PROiP20936.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145715.
CleanExiHS_RASA1.
ExpressionAtlasiP20936. baseline and differential.
GenevisibleiP20936. HS.

Family and domain databases

Gene3Di1.10.506.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.30.505.10. 2 hits.
InterProiIPR000008. C2_dom.
IPR028554. p120-RasGAP.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR023152. RasGAP_CS.
IPR001936. RasGAP_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR10194:SF19. PTHR10194:SF19. 1 hit.
PfamiPF00168. C2. 1 hit.
PF00169. PH. 1 hit.
PF00616. RasGAP. 1 hit.
PF00017. SH2. 2 hits.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
SM00252. SH2. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS50001. SH2. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRASA1_HUMAN
AccessioniPrimary (citable) accession number: P20936
Secondary accession number(s): B2R6W3
, B4DTL2, Q68CU6, Q9UDI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 30, 2016
This is version 201 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.