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Protein

Protein EVI2A

Gene

Evi2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May complex with itself or/and other proteins within the membrane, to function as part of a cell-surface receptor.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein EVI2A
Alternative name(s):
Ecotropic viral integration site 2A protein
Short name:
EVI-2A
Gene namesi
Name:Evi2a
Synonyms:Evi-2, Evi-2a, Evi2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:95458. Evi2a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 125106ExtracellularSequence analysisAdd
BLAST
Transmembranei126 – 15126HelicalSequence analysisAdd
BLAST
Topological domaini152 – 22372CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Expression of this gene is altered by viral integration and this altered expression may predispose cells to myeloid disease (PubMed:2167436).

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 223204Protein EVI2APRO_0000021212Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi28 – 281N-linked (GlcNAc...)Sequence analysis
Glycosylationi46 – 461N-linked (GlcNAc...)Sequence analysis
Glycosylationi55 – 551N-linked (GlcNAc...)Sequence analysis
Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence analysis
Modified residuei197 – 1971PhosphoserineCombined sources
Modified residuei203 – 2031PhosphoserineCombined sources

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP20934.
PeptideAtlasiP20934.
PRIDEiP20934.

PTM databases

iPTMnetiP20934.
PhosphoSiteiP20934.

Expressioni

Gene expression databases

CleanExiMM_EVI2A.
ExpressionAtlasiP20934. baseline and differential.
GenevisibleiP20934. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099526.

Family & Domainsi

Sequence similaritiesi

Belongs to the EVI2A family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKC1. Eukaryota.
ENOG410XXMV. LUCA.
GeneTreeiENSGT00390000003004.
HOGENOMiHOG000069955.
HOVERGENiHBG051513.
InParanoidiP20934.
OMAiLHLAFLM.
OrthoDBiEOG78SQK0.
TreeFamiTF336075.

Family and domain databases

InterProiIPR008608. Ectropic_vir_integratn_site_2A.
[Graphical view]
PANTHERiPTHR15568. PTHR15568. 1 hit.
PfamiPF05399. EVI2A. 1 hit.
[Graphical view]
PIRSFiPIRSF019625. EVI_S2A. 1 hit.
ProDomiPD037847. EVI_S2A. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P20934-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHKGQYLHL VFLMTTVWAS SSSGTRPNYT HLWASSVTAS GSSNQNGSSR
60 70 80 90 100
HPSDNNTNLV TPAVGHKVSA TDKPASSPPV PLASTSTLKS STPHAFRNSS
110 120 130 140 150
PTAEIKSQGE TFKKEVCEEN TSNTAMLICL IVIAVLFLIC TFLFLSTVVL
160 170 180 190 200
ANKVSSLKRS KQVGKRQPRS NGDFLASSGL WTAESDTWKR AKELTGSNLL
210 220
LQSPGVLTAA RERKHEEGTE KLN
Length:223
Mass (Da):24,087
Last modified:October 3, 2012 - v2
Checksum:iB49013A0F5C7CFBD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti135 – 1351V → A in AAA37583 (PubMed:2167436).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34896 mRNA. Translation: AAA37583.1.
M34897 mRNA. Translation: AAA37584.1.
AK044098 mRNA. Translation: BAC31775.1.
AK046407 mRNA. Translation: BAC32711.1.
AK160302 mRNA. Translation: BAE35731.1.
AK162958 mRNA. Translation: BAE37135.1.
AK170527 mRNA. Translation: BAE41859.1.
AK171594 mRNA. Translation: BAE42550.1.
AL591174 Genomic DNA. Translation: CAI24839.1.
CH466556 Genomic DNA. Translation: EDL15609.1.
BC038124 mRNA. Translation: AAH38124.1.
CCDSiCCDS25122.1.
PIRiA36462.
RefSeqiNP_001028883.1. NM_001033711.1.
NP_034291.1. NM_010161.3.
UniGeneiMm.439665.

Genome annotation databases

EnsembliENSMUST00000103236; ENSMUSP00000099526; ENSMUSG00000078771.
ENSMUST00000170799; ENSMUSP00000125936; ENSMUSG00000078771.
GeneIDi14017.
KEGGimmu:14017.
UCSCiuc007kkq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34896 mRNA. Translation: AAA37583.1.
M34897 mRNA. Translation: AAA37584.1.
AK044098 mRNA. Translation: BAC31775.1.
AK046407 mRNA. Translation: BAC32711.1.
AK160302 mRNA. Translation: BAE35731.1.
AK162958 mRNA. Translation: BAE37135.1.
AK170527 mRNA. Translation: BAE41859.1.
AK171594 mRNA. Translation: BAE42550.1.
AL591174 Genomic DNA. Translation: CAI24839.1.
CH466556 Genomic DNA. Translation: EDL15609.1.
BC038124 mRNA. Translation: AAH38124.1.
CCDSiCCDS25122.1.
PIRiA36462.
RefSeqiNP_001028883.1. NM_001033711.1.
NP_034291.1. NM_010161.3.
UniGeneiMm.439665.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099526.

PTM databases

iPTMnetiP20934.
PhosphoSiteiP20934.

Proteomic databases

PaxDbiP20934.
PeptideAtlasiP20934.
PRIDEiP20934.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103236; ENSMUSP00000099526; ENSMUSG00000078771.
ENSMUST00000170799; ENSMUSP00000125936; ENSMUSG00000078771.
GeneIDi14017.
KEGGimmu:14017.
UCSCiuc007kkq.1. mouse.

Organism-specific databases

CTDi2123.
MGIiMGI:95458. Evi2a.

Phylogenomic databases

eggNOGiENOG410IKC1. Eukaryota.
ENOG410XXMV. LUCA.
GeneTreeiENSGT00390000003004.
HOGENOMiHOG000069955.
HOVERGENiHBG051513.
InParanoidiP20934.
OMAiLHLAFLM.
OrthoDBiEOG78SQK0.
TreeFamiTF336075.

Miscellaneous databases

PROiP20934.
SOURCEiSearch...

Gene expression databases

CleanExiMM_EVI2A.
ExpressionAtlasiP20934. baseline and differential.
GenevisibleiP20934. MM.

Family and domain databases

InterProiIPR008608. Ectropic_vir_integratn_site_2A.
[Graphical view]
PANTHERiPTHR15568. PTHR15568. 1 hit.
PfamiPF05399. EVI2A. 1 hit.
[Graphical view]
PIRSFiPIRSF019625. EVI_S2A. 1 hit.
ProDomiPD037847. EVI_S2A. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Evi-2, a common integration site involved in murine myeloid leukemogenesis."
    Buchberg A.M., Bedigian H.G., Jenkins N.A., Copeland N.G.
    Mol. Cell. Biol. 10:4658-4666(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INVOLVEMENT IN MYELOGENOUS LEUKEMIA.
    Strain: C57BL/6J.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Brain cortex, Corpora quadrigemina, Medulla oblongata and Spinal cord.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  6. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197 AND SER-203, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen.

Entry informationi

Entry nameiEVI2A_MOUSE
AccessioniPrimary (citable) accession number: P20934
Secondary accession number(s): Q6DKP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 3, 2012
Last modified: July 6, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.