ID   NEBU_HUMAN              Reviewed;        6669 AA.
AC   P20929; F8WCL5; F8WCP0; Q15346; Q53QQ2; Q53TG8;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   14-MAY-2014, sequence version 5.
DT   27-MAR-2024, entry version 212.
DE   RecName: Full=Nebulin;
GN   Name=NEB;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), AND VARIANTS ASN-1027; HIS-1301;
RP   MET-1491; CYS-3360; THR-4401 AND VAL-6546.
RX   PubMed=7739042; DOI=10.1016/s0022-2836(95)80052-2;
RA   Labeit S., Kolmerer B.;
RT   "The complete primary structure of human nebulin and its correlation to
RT   muscle structure.";
RL   J. Mol. Biol. 248:308-315(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 6263-6329.
RX   PubMed=1682316; DOI=10.1016/s0021-9258(18)54843-2;
RA   Jin J.P., Wang K.;
RT   "Cloning, expression, and protein interaction of human nebulin fragments
RT   composed of varying numbers of sequence modules.";
RL   J. Biol. Chem. 266:21215-21223(1991).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1811-1939.
RX   PubMed=3397062; DOI=10.1016/0888-7543(88)90009-2;
RA   Zeviani M., Darras B.T., Rizzuto R., Salviati G., Betto R., Bonilla E.,
RA   Miranda A.F., Du J., Samitt C., Dickson G., Walsh F.S., Dimauro S.,
RA   Francke U., Schon E.A.;
RT   "Cloning and expression of human nebulin cDNAs and assignment of the gene
RT   to chromosome 2q31-q32.";
RL   Genomics 2:249-256(1988).
RN   [5]
RP   INTERACTION WITH TTN.
RX   PubMed=12482578; DOI=10.1016/s0014-5793(02)03655-4;
RA   Ma K., Wang K.;
RT   "Interaction of nebulin SH3 domain with titin PEVK and myopalladin:
RT   implications for the signaling and assembly role of titin and nebulin.";
RL   FEBS Lett. 532:273-278(2002).
RN   [6]
RP   SUBUNIT, AND INTERACTION WITH DES.
RX   PubMed=23615443; DOI=10.1091/mbc.e12-11-0840;
RA   Baker L.K., Gillis D.C., Sharma S., Ambrus A., Herrmann H., Conover G.M.;
RT   "Nebulin binding impedes mutant desmin filament assembly.";
RL   Mol. Biol. Cell 24:1918-1932(2013).
RN   [7]
RP   STRUCTURE BY NMR OF 6610-6669.
RX   PubMed=9514727; DOI=10.1006/jmbi.1997.1521;
RA   Politou A.S., Millevoi S., Gautel M., Kolmerer B., Pastore A.;
RT   "SH3 in muscles: solution structure of the SH3 domain from nebulin.";
RL   J. Mol. Biol. 276:189-202(1998).
RN   [8]
RP   INVOLVEMENT IN NEM2, AND INVOLVEMENT IN AMC6.
RX   PubMed=10051637; DOI=10.1073/pnas.96.5.2305;
RA   Pelin K., Hilpelae P., Donner K., Sewry C., Akkari P.A., Wilton S.D.,
RA   Wattanasirichaigoon D., Bang M.-L., Centner T., Hanefeld F., Odent S.,
RA   Fardeau M., Urtizberea J.A., Muntoni F., Dubowitz V., Beggs A.H.,
RA   Laing N.G., Labeit S., de la Chapelle A., Wallgren-Pettersson C.;
RT   "Mutations in the nebulin gene associated with autosomal recessive nemaline
RT   myopathy.";
RL   Proc. Natl. Acad. Sci. U.S.A. 96:2305-2310(1999).
RN   [9]
RP   INVOLVEMENT IN AMC6.
RX   PubMed=21798101; DOI=10.1186/2044-5040-1-23;
RA   Lawlor M.W., Ottenheijm C.A., Lehtokari V.L., Cho K., Pelin K.,
RA   Wallgren-Pettersson C., Granzier H., Beggs A.H.;
RT   "Novel mutations in NEB cause abnormal nebulin expression and markedly
RT   impaired muscle force generation in severe nemaline myopathy.";
RL   Skelet. Muscle 1:23-23(2011).
RN   [10]
RP   INTERACTION WITH SVIL.
RX   PubMed=18639526; DOI=10.1016/j.bbrc.2008.07.036;
RA   Lee M.-A., Joo Y.M., Lee Y.M., Kim H.S., Kim J.-H., Choi J.-K., Ahn S.-J.,
RA   Min B.-I., Kim C.-R.;
RT   "Archvillin anchors in the Z-line of skeletal muscle via the nebulin C-
RT   terminus.";
RL   Biochem. Biophys. Res. Commun. 374:320-324(2008).
RN   [11]
RP   VARIANT AMC6 974-ARG--ILE-6669 DEL, AND INVOLVEMENT IN AMC6.
RX   PubMed=26578207; DOI=10.1186/s13023-015-0364-0;
RA   Todd E.J., Yau K.S., Ong R., Slee J., McGillivray G., Barnett C.P.,
RA   Haliloglu G., Talim B., Akcoren Z., Kariminejad A., Cairns A., Clarke N.F.,
RA   Freckmann M.L., Romero N.B., Williams D., Sewry C.A., Colley A., Ryan M.M.,
RA   Kiraly-Borri C., Sivadorai P., Allcock R.J., Beeson D., Maxwell S.,
RA   Davis M.R., Laing N.G., Ravenscroft G.;
RT   "Next generation sequencing in a large cohort of patients presenting with
RT   neuromuscular disease before or at birth.";
RL   Orphanet J. Rare Dis. 10:148-148(2015).
RN   [12]
RP   VARIANTS AMC6 4561-TYR--ILE-6669 DEL AND 4626-TYR--ILE-6669 DEL, AND
RP   INVOLVEMENT IN AMC6.
RX   PubMed=29274205; DOI=10.1002/ajmg.a.38577;
RA   Ahmed A.A., Skaria P., Safina N.P., Thiffault I., Kats A., Taboada E.,
RA   Habeebu S., Saunders C.;
RT   "Arthrogryposis and pterygia as lethal end manifestations of genetically
RT   defined congenital myopathies.";
RL   Am. J. Med. Genet. A 176:359-367(2018).
CC   -!- FUNCTION: This giant muscle protein may be involved in maintaining the
CC       structural integrity of sarcomeres and the membrane system associated
CC       with the myofibrils. Binds and stabilize F-actin.
CC   -!- SUBUNIT: Monomer and homooligomer (PubMed:23615443). Interacts with
CC       TTN/titin (PubMed:12482578). Interacts with SVIL (PubMed:18639526).
CC       Interacts (via nebulin repeats 160-164) with DES (PubMed:23615443).
CC       {ECO:0000269|PubMed:12482578, ECO:0000269|PubMed:18639526,
CC       ECO:0000269|PubMed:23615443}.
CC   -!- INTERACTION:
CC       P20929; O75923: DYSF; NbExp=6; IntAct=EBI-1049657, EBI-2799016;
CC       P20929; O60662: KLHL41; NbExp=8; IntAct=EBI-1049657, EBI-5353084;
CC       P20929; Q86TC9: MYPN; NbExp=2; IntAct=EBI-1049657, EBI-2562606;
CC       P20929; Q07889: SOS1; NbExp=3; IntAct=EBI-1049657, EBI-297487;
CC       P20929; O95425: SVIL; NbExp=4; IntAct=EBI-1049657, EBI-487145;
CC       P20929; Q8WZ42: TTN; NbExp=6; IntAct=EBI-1049657, EBI-681210;
CC       P20929-4; O60662: KLHL41; NbExp=5; IntAct=EBI-9531519, EBI-5353084;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere. Cytoplasm,
CC       cytoskeleton.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1;
CC         IsoId=P20929-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P20929-2; Sequence=VSP_054445, VSP_054446, VSP_054447,
CC                                  VSP_054448;
CC       Name=3;
CC         IsoId=P20929-3; Sequence=VSP_054445, VSP_054446, VSP_054448;
CC       Name=4;
CC         IsoId=P20929-4; Sequence=VSP_054444;
CC   -!- TISSUE SPECIFICITY: Muscle specific. Located in the thin filament of
CC       striated muscle.
CC   -!- DISEASE: Nemaline myopathy 2 (NEM2) [MIM:256030]: A form of nemaline
CC       myopathy. Nemaline myopathies are muscular disorders characterized by
CC       muscle weakness of varying severity and onset, and abnormal thread-like
CC       or rod-shaped structures in muscle fibers on histologic examination.
CC       {ECO:0000269|PubMed:10051637}. Note=The disease is caused by variants
CC       affecting the gene represented in this entry.
CC   -!- DISEASE: Arthrogryposis multiplex congenita 6 (AMC6) [MIM:619334]: A
CC       form of arthrogryposis multiplex congenita, a developmental condition
CC       characterized by multiple joint contractures resulting from reduced or
CC       absent fetal movements. AMC6 is an autosomal recessive lethal form.
CC       Death usually occurs in utero or in infancy.
CC       {ECO:0000269|PubMed:10051637, ECO:0000269|PubMed:21798101,
CC       ECO:0000269|PubMed:26578207, ECO:0000269|PubMed:29274205}. Note=The
CC       disease is caused by variants affecting the gene represented in this
CC       entry.
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DR   EMBL; X83957; CAA58788.1; -; mRNA.
DR   EMBL; AC009497; AAY14651.1; -; Genomic_DNA.
DR   EMBL; AC107052; AAY14977.1; -; Genomic_DNA.
DR   EMBL; AC116650; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; M19669; AAA59917.1; -; mRNA.
DR   CCDS; CCDS46424.1; -. [P20929-4]
DR   CCDS; CCDS54407.1; -. [P20929-2]
DR   CCDS; CCDS54408.1; -. [P20929-3]
DR   PIR; A29979; A29979.
DR   PIR; B29979; B29979.
DR   PIR; S55024; S55024.
DR   RefSeq; NP_004534.2; NM_004543.4. [P20929-4]
DR   PDB; 1ARK; NMR; -; A=6610-6669.
DR   PDB; 1NEB; NMR; -; A=6610-6669.
DR   PDB; 6Y17; X-ray; 1.56 A; C/D=6610-6669.
DR   PDBsum; 1ARK; -.
DR   PDBsum; 1NEB; -.
DR   PDBsum; 6Y17; -.
DR   SMR; P20929; -.
DR   BioGRID; 110783; 57.
DR   IntAct; P20929; 36.
DR   MINT; P20929; -.
DR   STRING; 9606.ENSP00000484342; -.
DR   CarbonylDB; P20929; -.
DR   GlyGen; P20929; 3 sites, 1 O-linked glycan (3 sites).
DR   iPTMnet; P20929; -.
DR   PhosphoSitePlus; P20929; -.
DR   SwissPalm; P20929; -.
DR   BioMuta; NEB; -.
DR   DMDM; 313104310; -.
DR   EPD; P20929; -.
DR   jPOST; P20929; -.
DR   MassIVE; P20929; -.
DR   PeptideAtlas; P20929; -.
DR   ProteomicsDB; 31194; -.
DR   ProteomicsDB; 31219; -.
DR   ProteomicsDB; 53825; -. [P20929-1]
DR   Antibodypedia; 1171; 142 antibodies from 26 providers.
DR   DNASU; 4703; -.
DR   Ensembl; ENST00000397345.8; ENSP00000380505.3; ENSG00000183091.21. [P20929-2]
DR   Ensembl; ENST00000409198.5; ENSP00000386259.1; ENSG00000183091.21. [P20929-4]
DR   Ensembl; ENST00000427231.7; ENSP00000416578.2; ENSG00000183091.21. [P20929-3]
DR   GeneID; 4703; -.
DR   KEGG; hsa:4703; -.
DR   MANE-Select; ENST00000397345.8; ENSP00000380505.3; NM_001164508.2; NP_001157980.2. [P20929-2]
DR   UCSC; uc002txu.3; human. [P20929-1]
DR   AGR; HGNC:7720; -.
DR   CTD; 4703; -.
DR   DisGeNET; 4703; -.
DR   GeneCards; NEB; -.
DR   HGNC; HGNC:7720; NEB.
DR   HPA; ENSG00000183091; Group enriched (skeletal muscle, tongue).
DR   MalaCards; NEB; -.
DR   MIM; 161650; gene.
DR   MIM; 256030; phenotype.
DR   MIM; 619334; phenotype.
DR   neXtProt; NX_P20929; -.
DR   OpenTargets; ENSG00000183091; -.
DR   Orphanet; 171439; Childhood-onset nemaline myopathy.
DR   Orphanet; 399103; Distal nebulin myopathy.
DR   Orphanet; 171433; Intermediate nemaline myopathy.
DR   Orphanet; 33108; Lethal multiple pterygium syndrome.
DR   Orphanet; 171430; Severe congenital nemaline myopathy.
DR   Orphanet; 171436; Typical nemaline myopathy.
DR   PharmGKB; PA31530; -.
DR   VEuPathDB; HostDB:ENSG00000183091; -.
DR   GeneTree; ENSGT00940000154533; -.
DR   HOGENOM; CLU_000024_0_0_1; -.
DR   InParanoid; P20929; -.
DR   OMA; WRYREQY; -.
DR   OrthoDB; 3816962at2759; -.
DR   TreeFam; TF319104; -.
DR   PathwayCommons; P20929; -.
DR   Reactome; R-HSA-390522; Striated Muscle Contraction.
DR   SignaLink; P20929; -.
DR   SIGNOR; P20929; -.
DR   BioGRID-ORCS; 4703; 13 hits in 1141 CRISPR screens.
DR   ChiTaRS; NEB; human.
DR   EvolutionaryTrace; P20929; -.
DR   GenomeRNAi; 4703; -.
DR   Pharos; P20929; Tbio.
DR   PRO; PR:P20929; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; P20929; Protein.
DR   Bgee; ENSG00000183091; Expressed in gluteal muscle and 126 other cell types or tissues.
DR   ExpressionAtlas; P20929; baseline and differential.
DR   GO; GO:0015629; C:actin cytoskeleton; TAS:ProtInc.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR   GO; GO:0030018; C:Z disc; IDA:UniProtKB.
DR   GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR   GO; GO:0008307; F:structural constituent of muscle; TAS:ProtInc.
DR   GO; GO:0071691; P:cardiac muscle thin filament assembly; IBA:GO_Central.
DR   GO; GO:0007517; P:muscle organ development; TAS:ProtInc.
DR   GO; GO:0030832; P:regulation of actin filament length; NAS:UniProtKB.
DR   GO; GO:0007525; P:somatic muscle development; NAS:UniProtKB.
DR   CDD; cd11933; SH3_Nebulin_C; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR013998; Nebulin-like.
DR   InterPro; IPR000900; Nebulin_repeat.
DR   InterPro; IPR035629; Nebulin_SH3.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR11039; NEBULIN; 1.
DR   PANTHER; PTHR11039:SF37; NEBULIN; 1.
DR   Pfam; PF00880; Nebulin; 105.
DR   Pfam; PF14604; SH3_9; 1.
DR   PRINTS; PR00510; NEBULIN.
DR   SMART; SM00227; NEBU; 181.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS51216; NEBULIN; 181.
DR   PROSITE; PS50002; SH3; 1.
DR   Genevisible; P20929; HS.
PE   1: Evidence at protein level;
KW   3D-structure; Actin-binding; Alternative splicing; Cytoplasm; Cytoskeleton;
KW   Disease variant; Muscle protein; Nemaline myopathy; Reference proteome;
KW   Repeat; SH3 domain.
FT   CHAIN           1..6669
FT                   /note="Nebulin"
FT                   /id="PRO_0000096775"
FT   REPEAT          76..107
FT                   /note="Nebulin 1"
FT   REPEAT          113..143
FT                   /note="Nebulin 2"
FT   REPEAT          148..178
FT                   /note="Nebulin 3"
FT   REPEAT          183..213
FT                   /note="Nebulin 4"
FT   REPEAT          218..248
FT                   /note="Nebulin 5"
FT   REPEAT          253..283
FT                   /note="Nebulin 6"
FT   REPEAT          289..318
FT                   /note="Nebulin 7"
FT   REPEAT          324..354
FT                   /note="Nebulin 8"
FT   REPEAT          363..393
FT                   /note="Nebulin 9"
FT   REPEAT          398..428
FT                   /note="Nebulin 10"
FT   REPEAT          434..464
FT                   /note="Nebulin 11"
FT   REPEAT          502..532
FT                   /note="Nebulin 12"
FT   REPEAT          537..567
FT                   /note="Nebulin 13"
FT   REPEAT          573..603
FT                   /note="Nebulin 14"
FT   REPEAT          611..641
FT                   /note="Nebulin 15"
FT   REPEAT          681..711
FT                   /note="Nebulin 16"
FT   REPEAT          749..779
FT                   /note="Nebulin 17"
FT   REPEAT          784..814
FT                   /note="Nebulin 18"
FT   REPEAT          820..850
FT                   /note="Nebulin 19"
FT   REPEAT          858..888
FT                   /note="Nebulin 20"
FT   REPEAT          893..923
FT                   /note="Nebulin 21"
FT   REPEAT          924..954
FT                   /note="Nebulin 22"
FT   REPEAT          959..990
FT                   /note="Nebulin 23"
FT   REPEAT          993..1023
FT                   /note="Nebulin 24"
FT   REPEAT          1028..1058
FT                   /note="Nebulin 25"
FT   REPEAT          1064..1094
FT                   /note="Nebulin 26"
FT   REPEAT          1102..1132
FT                   /note="Nebulin 27"
FT   REPEAT          1137..1167
FT                   /note="Nebulin 28"
FT   REPEAT          1168..1198
FT                   /note="Nebulin 29"
FT   REPEAT          1204..1234
FT                   /note="Nebulin 30"
FT   REPEAT          1237..1267
FT                   /note="Nebulin 31"
FT   REPEAT          1272..1302
FT                   /note="Nebulin 32"
FT   REPEAT          1308..1338
FT                   /note="Nebulin 33"
FT   REPEAT          1346..1376
FT                   /note="Nebulin 34"
FT   REPEAT          1381..1411
FT                   /note="Nebulin 35"
FT   REPEAT          1412..1442
FT                   /note="Nebulin 36"
FT   REPEAT          1448..1478
FT                   /note="Nebulin 37"
FT   REPEAT          1481..1511
FT                   /note="Nebulin 38"
FT   REPEAT          1516..1546
FT                   /note="Nebulin 39"
FT   REPEAT          1552..1582
FT                   /note="Nebulin 40"
FT   REPEAT          1590..1620
FT                   /note="Nebulin 41"
FT   REPEAT          1625..1655
FT                   /note="Nebulin 42"
FT   REPEAT          1656..1686
FT                   /note="Nebulin 43"
FT   REPEAT          1692..1722
FT                   /note="Nebulin 44"
FT   REPEAT          1725..1755
FT                   /note="Nebulin 45"
FT   REPEAT          1760..1790
FT                   /note="Nebulin 46"
FT   REPEAT          1796..1826
FT                   /note="Nebulin 47"
FT   REPEAT          1834..1864
FT                   /note="Nebulin 48"
FT   REPEAT          1869..1899
FT                   /note="Nebulin 49"
FT   REPEAT          1900..1930
FT                   /note="Nebulin 50"
FT   REPEAT          1936..1966
FT                   /note="Nebulin 51"
FT   REPEAT          1969..1999
FT                   /note="Nebulin 52"
FT   REPEAT          2004..2034
FT                   /note="Nebulin 53"
FT   REPEAT          2040..2070
FT                   /note="Nebulin 54"
FT   REPEAT          2078..2108
FT                   /note="Nebulin 55"
FT   REPEAT          2113..2143
FT                   /note="Nebulin 56"
FT   REPEAT          2144..2174
FT                   /note="Nebulin 57"
FT   REPEAT          2180..2210
FT                   /note="Nebulin 58"
FT   REPEAT          2213..2243
FT                   /note="Nebulin 59"
FT   REPEAT          2248..2278
FT                   /note="Nebulin 60"
FT   REPEAT          2284..2314
FT                   /note="Nebulin 61"
FT   REPEAT          2322..2352
FT                   /note="Nebulin 62"
FT   REPEAT          2357..2387
FT                   /note="Nebulin 63"
FT   REPEAT          2388..2418
FT                   /note="Nebulin 64"
FT   REPEAT          2423..2453
FT                   /note="Nebulin 65"
FT   REPEAT          2456..2486
FT                   /note="Nebulin 66"
FT   REPEAT          2491..2521
FT                   /note="Nebulin 67"
FT   REPEAT          2527..2557
FT                   /note="Nebulin 68"
FT   REPEAT          2565..2595
FT                   /note="Nebulin 69"
FT   REPEAT          2600..2630
FT                   /note="Nebulin 70"
FT   REPEAT          2631..2661
FT                   /note="Nebulin 71"
FT   REPEAT          2666..2696
FT                   /note="Nebulin 72"
FT   REPEAT          2699..2729
FT                   /note="Nebulin 73"
FT   REPEAT          2734..2764
FT                   /note="Nebulin 74"
FT   REPEAT          2770..2800
FT                   /note="Nebulin 75"
FT   REPEAT          2808..2838
FT                   /note="Nebulin 76"
FT   REPEAT          2843..2873
FT                   /note="Nebulin 77"
FT   REPEAT          2874..2904
FT                   /note="Nebulin 78"
FT   REPEAT          2909..2939
FT                   /note="Nebulin 79"
FT   REPEAT          2942..2972
FT                   /note="Nebulin 80"
FT   REPEAT          2977..3007
FT                   /note="Nebulin 81"
FT   REPEAT          3013..3043
FT                   /note="Nebulin 82"
FT   REPEAT          3051..3081
FT                   /note="Nebulin 83"
FT   REPEAT          3086..3116
FT                   /note="Nebulin 84"
FT   REPEAT          3117..3147
FT                   /note="Nebulin 85"
FT   REPEAT          3152..3182
FT                   /note="Nebulin 86"
FT   REPEAT          3185..3215
FT                   /note="Nebulin 87"
FT   REPEAT          3220..3250
FT                   /note="Nebulin 88"
FT   REPEAT          3256..3286
FT                   /note="Nebulin 89"
FT   REPEAT          3294..3324
FT                   /note="Nebulin 90"
FT   REPEAT          3329..3359
FT                   /note="Nebulin 91"
FT   REPEAT          3360..3390
FT                   /note="Nebulin 92"
FT   REPEAT          3395..3425
FT                   /note="Nebulin 93"
FT   REPEAT          3428..3458
FT                   /note="Nebulin 94"
FT   REPEAT          3463..3493
FT                   /note="Nebulin 95"
FT   REPEAT          3499..3529
FT                   /note="Nebulin 96"
FT   REPEAT          3537..3567
FT                   /note="Nebulin 97"
FT   REPEAT          3572..3602
FT                   /note="Nebulin 98"
FT   REPEAT          3603..3633
FT                   /note="Nebulin 99"
FT   REPEAT          3638..3668
FT                   /note="Nebulin 100"
FT   REPEAT          3671..3701
FT                   /note="Nebulin 101"
FT   REPEAT          3706..3736
FT                   /note="Nebulin 102"
FT   REPEAT          3742..3772
FT                   /note="Nebulin 103"
FT   REPEAT          3780..3810
FT                   /note="Nebulin 104"
FT   REPEAT          3815..3845
FT                   /note="Nebulin 105"
FT   REPEAT          3846..3876
FT                   /note="Nebulin 106"
FT   REPEAT          3914..3944
FT                   /note="Nebulin 107"
FT   REPEAT          3949..3979
FT                   /note="Nebulin 108"
FT   REPEAT          3984..4014
FT                   /note="Nebulin 109"
FT   REPEAT          4021..4052
FT                   /note="Nebulin 110"
FT   REPEAT          4057..4087
FT                   /note="Nebulin 111"
FT   REPEAT          4088..4118
FT                   /note="Nebulin 112"
FT   REPEAT          4123..4153
FT                   /note="Nebulin 113"
FT   REPEAT          4156..4186
FT                   /note="Nebulin 114"
FT   REPEAT          4191..4220
FT                   /note="Nebulin 115"
FT   REPEAT          4226..4256
FT                   /note="Nebulin 116"
FT   REPEAT          4264..4294
FT                   /note="Nebulin 117"
FT   REPEAT          4299..4329
FT                   /note="Nebulin 118"
FT   REPEAT          4330..4360
FT                   /note="Nebulin 119"
FT   REPEAT          4365..4395
FT                   /note="Nebulin 120"
FT   REPEAT          4400..4430
FT                   /note="Nebulin 121"
FT   REPEAT          4435..4465
FT                   /note="Nebulin 122"
FT   REPEAT          4471..4501
FT                   /note="Nebulin 123"
FT   REPEAT          4544..4574
FT                   /note="Nebulin 124"
FT   REPEAT          4575..4605
FT                   /note="Nebulin 125"
FT   REPEAT          4610..4640
FT                   /note="Nebulin 126"
FT   REPEAT          4645..4675
FT                   /note="Nebulin 127"
FT   REPEAT          4680..4710
FT                   /note="Nebulin 128"
FT   REPEAT          4716..4746
FT                   /note="Nebulin 129"
FT   REPEAT          4754..4784
FT                   /note="Nebulin 130"
FT   REPEAT          4789..4819
FT                   /note="Nebulin 131"
FT   REPEAT          4820..4850
FT                   /note="Nebulin 132"
FT   REPEAT          4855..4885
FT                   /note="Nebulin 133"
FT   REPEAT          4890..4920
FT                   /note="Nebulin 134"
FT   REPEAT          4926..4956
FT                   /note="Nebulin 135"
FT   REPEAT          4961..4991
FT                   /note="Nebulin 136"
FT   REPEAT          4997..5027
FT                   /note="Nebulin 137"
FT   REPEAT          5032..5062
FT                   /note="Nebulin 138"
FT   REPEAT          5067..5097
FT                   /note="Nebulin 139"
FT   REPEAT          5137..5167
FT                   /note="Nebulin 140"
FT   REPEAT          5172..5202
FT                   /note="Nebulin 141"
FT   REPEAT          5207..5237
FT                   /note="Nebulin 142"
FT   REPEAT          5242..5272
FT                   /note="Nebulin 143"
FT   REPEAT          5277..5307
FT                   /note="Nebulin 144"
FT   REPEAT          5312..5342
FT                   /note="Nebulin 145"
FT   REPEAT          5347..5377
FT                   /note="Nebulin 146"
FT   REPEAT          5382..5412
FT                   /note="Nebulin 147"
FT   REPEAT          5417..5447
FT                   /note="Nebulin 148"
FT   REPEAT          5452..5482
FT                   /note="Nebulin 149"
FT   REPEAT          5488..5518
FT                   /note="Nebulin 150"
FT   REPEAT          5523..5553
FT                   /note="Nebulin 151"
FT   REPEAT          5558..5588
FT                   /note="Nebulin 152"
FT   REPEAT          5593..5623
FT                   /note="Nebulin 153"
FT   REPEAT          5628..5658
FT                   /note="Nebulin 154"
FT   REPEAT          5665..5695
FT                   /note="Nebulin 155"
FT   REPEAT          5702..5732
FT                   /note="Nebulin 156"
FT   REPEAT          5736..5766
FT                   /note="Nebulin 157"
FT   REPEAT          5771..5801
FT                   /note="Nebulin 158"
FT   REPEAT          5808..5838
FT                   /note="Nebulin 159"
FT   REPEAT          5843..5873
FT                   /note="Nebulin 160"
FT   REPEAT          5878..5908
FT                   /note="Nebulin 161"
FT   REPEAT          5911..5943
FT                   /note="Nebulin 162"
FT   REPEAT          5950..5980
FT                   /note="Nebulin 163"
FT   REPEAT          5987..6017
FT                   /note="Nebulin 164"
FT   REPEAT          6025..6055
FT                   /note="Nebulin 165"
FT   REPEAT          6060..6090
FT                   /note="Nebulin 166"
FT   REPEAT          6095..6125
FT                   /note="Nebulin 167"
FT   REPEAT          6130..6160
FT                   /note="Nebulin 168"
FT   REPEAT          6161..6191
FT                   /note="Nebulin 169"
FT   REPEAT          6192..6222
FT                   /note="Nebulin 170"
FT   REPEAT          6223..6253
FT                   /note="Nebulin 171"
FT   REPEAT          6255..6284
FT                   /note="Nebulin 172"
FT   REPEAT          6285..6315
FT                   /note="Nebulin 173"
FT   REPEAT          6316..6346
FT                   /note="Nebulin 174"
FT   REPEAT          6347..6377
FT                   /note="Nebulin 175"
FT   REPEAT          6378..6408
FT                   /note="Nebulin 176"
FT   REPEAT          6414..6444
FT                   /note="Nebulin 177"
FT   REPEAT          6449..6479
FT                   /note="Nebulin 178"
FT   DOMAIN          6610..6669
FT                   /note="SH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   REGION          34..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          6457..6612
FT                   /note="Interaction with SVIL"
FT                   /evidence="ECO:0000269|PubMed:18639526"
FT   REGION          6529..6566
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          6583..6607
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        34..52
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        6529..6549
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         2959..2960
FT                   /note="IT -> LN (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:7739042"
FT                   /id="VSP_054444"
FT   VAR_SEQ         2973
FT                   /note="D -> DKTQIHIMPDTPEIMLARMNKINYSESLYKLANEEAKKKGYDLRSDA
FT                   IPIVAAKASRDIISDYKYKDGYCKQLGHHIGARNIEDDPKMMWSMHVAKIQSDREYKKD
FT                   FEKWKTKFSSPVDMLGVVLAKKCQTLVSDVDYKNYLHEWTCLPDQSDVIHARQAYDLQS
FT                   DNIYKSDLQWLRGIGWVPIGSMDVVKCKRATEILSDNIYRQPPDKLKFTSVTDSLEQVL
FT                   AKNNALNMNKRLYTEAWDKD (in isoform 2 and isoform 3)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_054445"
FT   VAR_SEQ         3854..3859
FT                   /note="DIIQAK -> DIIQAKKAYDLQSDSVYKADLEWLRGIGWMPEGSVEMNRVKV
FT                   AQDLVNERLYRTRPEALSFTSIVDTPEVVLAKANSLQISEKLYQEAWNKDKSNITIPSD
FT                   TPEMLQAHINALQISNKLYQKDWNDAKQKGYDIRADAIEIKHAKASREIASEYKYKEGY
FT                   RKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIHNTPLDMMSIVQAKK
FT                   CQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDLEWLKGIGWLPEGSV
FT                   EVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQISEPLYRDAWEKEKA
FT                   NVNVPADTPLMLQSKINALQISNKRYQQAWEDVKMTGYDLRADAIGIQHAKASRDIASD
FT                   YLYKTAYEKQKGHYIGCRSAKEDPKLVWAANVLKMQNDRLYKKAYNDHKAKISIPVDMV
FT                   SISAAKEGQALASDVDYRHYLHHWSCFPDQNDVIQARKAYDLQSDSVYKADLEWLRGIG
FT                   WMPEGSVEMNRVKVAQDLVNERLYRTRPEALSFTSIVDTPEVVLAKANSLQISEKLYQE
FT                   AWNKDKSNITIPSDTPEMLQAHINALQISNKLYQKDWNDTKQKGYDIRADAIEIKHAKA
FT                   SREIASEYKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSDREYKKAYEKSKGIH
FT                   NTPLDMMSIVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKKAYDLQSDNLYKSDL
FT                   EWLKGIGWLPEGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVDTPEVIQAKINAVQI
FT                   SEPLYRNAWEKEKANVNVPADTPLMLQSKINALQISNKRYQQAWEDVKMTGYDLRADAI
FT                   GIQHAKASRDIASDYLYKTAYEKQKGHYIGCRSAKEDPKLVWAANVLKMQNDRLYKKAY
FT                   NDHKAKISIPVDMVSISAAKEGQALASDVDYRHYLHHWSCFPDQNDVIQARKAYDLQSD
FT                   SVYKADLEWLRGIGWMPEGSVEMNRVKVAQDLVNERLYRTRPEALSFTSIVDTPEVVLA
FT                   KANSLQISEKLYQEAWNKDKSNITIPSDTPEMLQAHINALQISNKLYQKDWNDTKQKGY
FT                   DIRADAIEIKHAKASREIASEYKYKEGYRKQLGHHMGFRTLQDDPKSVWAIHAAKIQSD
FT                   REYKKAYEKSKGIHNTPLDMMSIVQAKKCQVLVSDIDYRNYLHQWTCLPDQNDVIQAKK
FT                   AYDLQSDNLYKSDLEWLKGIGWLPEGSVEVMRVKNAQNLLNERLYRIKPEALKFTSIVD
FT                   TPEVIQAKINAVQISEPLYRDAWEKEKANVNVPADTPLMLQSKINALQISNKRYQQAWE
FT                   DVKMTGYDLRADAIGIQHAKASRDIASDYLYKTAYEKQKGHYIGCRSAKEDPKLVWAAN
FT                   VLKMQNDRLYKKAYNDHKAKISIPVDMVSISAAKEGQALASDVDYRHYLHRWSCFPDQN
FT                   DVIQAR (in isoform 2 and isoform 3)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_054446"
FT   VAR_SEQ         5404..5436
FT                   /note="KKYRADYEQRKDKYHLVVDEPRHLLAKTAGDQI -> RKYKSSAKMFLQHGC
FT                   NEILRPDMLTALYNSHMW (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_054447"
FT   VAR_SEQ         6272..6273
FT                   /note="NF -> NFSSILYKENLSKGTPLPVTPEMERVKLNQENFSSVLYKENVGKGI
FT                   PIPITPEMERVKHNQENFSSVLYKENLGTGIPIPITPEMQRVKHNQENLSSVLYKENMG
FT                   KGTPLPVTPEMERVKHNQENISSVLYKENMGKGTPLPVTPEMERVKHNQENI (in
FT                   isoform 2 and isoform 3)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_054448"
FT   VARIANT         146
FT                   /note="T -> A (in dbSNP:rs4077109)"
FT                   /id="VAR_047692"
FT   VARIANT         191
FT                   /note="E -> Q (in dbSNP:rs35686968)"
FT                   /id="VAR_047693"
FT   VARIANT         974..6669
FT                   /note="Missing (in AMC6)"
FT                   /evidence="ECO:0000269|PubMed:26578207"
FT                   /id="VAR_085714"
FT   VARIANT         1027
FT                   /note="K -> N (in dbSNP:rs6735208)"
FT                   /evidence="ECO:0000269|PubMed:7739042"
FT                   /id="VAR_047694"
FT   VARIANT         1301
FT                   /note="Y -> H (in dbSNP:rs6711382)"
FT                   /evidence="ECO:0000269|PubMed:7739042"
FT                   /id="VAR_047695"
FT   VARIANT         1469
FT                   /note="E -> D (in dbSNP:rs34800215)"
FT                   /id="VAR_047696"
FT   VARIANT         1479
FT                   /note="V -> I (in dbSNP:rs34577613)"
FT                   /id="VAR_047697"
FT   VARIANT         1491
FT                   /note="V -> M (in dbSNP:rs7426114)"
FT                   /evidence="ECO:0000269|PubMed:7739042"
FT                   /id="VAR_047698"
FT   VARIANT         1969
FT                   /note="Y -> H (in dbSNP:rs34532796)"
FT                   /id="VAR_047699"
FT   VARIANT         2613
FT                   /note="K -> N (in dbSNP:rs13013209)"
FT                   /id="VAR_047700"
FT   VARIANT         2773
FT                   /note="R -> Q (in dbSNP:rs35974308)"
FT                   /id="VAR_047701"
FT   VARIANT         2912
FT                   /note="S -> P (in dbSNP:rs6713162)"
FT                   /id="VAR_047702"
FT   VARIANT         2952
FT                   /note="V -> G (in dbSNP:rs13024542)"
FT                   /id="VAR_047703"
FT   VARIANT         3360
FT                   /note="W -> C (in dbSNP:rs10172023)"
FT                   /evidence="ECO:0000269|PubMed:7739042"
FT                   /id="VAR_047704"
FT   VARIANT         3887
FT                   /note="S -> T (in dbSNP:rs35227368)"
FT                   /id="VAR_047705"
FT   VARIANT         4271
FT                   /note="P -> L (in dbSNP:rs4327235)"
FT                   /id="VAR_047706"
FT   VARIANT         4337
FT                   /note="N -> S (in dbSNP:rs16830236)"
FT                   /id="VAR_047707"
FT   VARIANT         4401
FT                   /note="R -> T (in dbSNP:rs2288210)"
FT                   /evidence="ECO:0000269|PubMed:7739042"
FT                   /id="VAR_047708"
FT   VARIANT         4561..6669
FT                   /note="Missing (in AMC6)"
FT                   /evidence="ECO:0000269|PubMed:29274205"
FT                   /id="VAR_085715"
FT   VARIANT         4626..6669
FT                   /note="Missing (in AMC6)"
FT                   /evidence="ECO:0000269|PubMed:29274205"
FT                   /id="VAR_085716"
FT   VARIANT         5030
FT                   /note="D -> V (in dbSNP:rs2288200)"
FT                   /id="VAR_024240"
FT   VARIANT         5463
FT                   /note="R -> P (in dbSNP:rs16830171)"
FT                   /id="VAR_047709"
FT   VARIANT         5934
FT                   /note="G -> E (in dbSNP:rs3732309)"
FT                   /id="VAR_021888"
FT   VARIANT         6131
FT                   /note="T -> I (in dbSNP:rs34368668)"
FT                   /id="VAR_056953"
FT   VARIANT         6546
FT                   /note="I -> V (in dbSNP:rs1061305)"
FT                   /evidence="ECO:0000269|PubMed:7739042"
FT                   /id="VAR_056954"
FT   CONFLICT        727
FT                   /note="E -> D (in Ref. 1; CAA58788)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        781
FT                   /note="K -> R (in Ref. 1; CAA58788)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1290
FT                   /note="N -> S (in Ref. 1; CAA58788)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1305
FT                   /note="A -> R (in Ref. 1; CAA58788)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1389
FT                   /note="S -> T (in Ref. 1; CAA58788)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1549
FT                   /note="A -> R (in Ref. 1; CAA58788)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1939
FT                   /note="P -> L (in Ref. 4; AAA59917)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2023
FT                   /note="M -> I (in Ref. 1; CAA58788)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2613
FT                   /note="K -> Y (in Ref. 1; CAA58788)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        3796
FT                   /note="G -> E (in Ref. 1; CAA58788)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        3838
FT                   /note="D -> Y (in Ref. 1; CAA58788)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        5038
FT                   /note="T -> P (in Ref. 1; CAA58788)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        5132
FT                   /note="K -> E (in Ref. 1; CAA58788)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        5432..5433
FT                   /note="AG -> RS (in Ref. 1; CAA58788)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        6289
FT                   /note="A -> P (in Ref. 1; CAA58788)"
FT                   /evidence="ECO:0000305"
FT   STRAND          6615..6619
FT                   /evidence="ECO:0007829|PDB:6Y17"
FT   STRAND          6624..6628
FT                   /evidence="ECO:0007829|PDB:1ARK"
FT   STRAND          6636..6652
FT                   /evidence="ECO:0007829|PDB:6Y17"
FT   TURN            6653..6655
FT                   /evidence="ECO:0007829|PDB:6Y17"
FT   STRAND          6658..6662
FT                   /evidence="ECO:0007829|PDB:6Y17"
FT   HELIX           6663..6665
FT                   /evidence="ECO:0007829|PDB:6Y17"
FT   STRAND          6666..6668
FT                   /evidence="ECO:0007829|PDB:6Y17"
SQ   SEQUENCE   6669 AA;  772914 MW;  AD93D9B6FB3D8161 CRC64;
     MADDEDYEEV VEYYTEEVVY EEVPGETITK IYETTTTRTS DYEQSETSKP ALAQPALAQP
     ASAKPVERRK VIRKKVDPSK FMTPYIAHSQ KMQDLFSPNK YKEKFEKTKG QPYASTTDTP
     ELRRIKKVQD QLSEVKYRMD GDVAKTICHV DEKAKDIEHA KKVSQQVSKV LYKQNWEDTK
     DKYLLPPDAP ELVQAVKNTA MFSKKLYTED WEADKSLFYP YNDSPELRRV AQAQKALSDV
     AYKKGLAEQQ AQFTPLADPP DIEFAKKVTN QVSKQKYKED YENKIKGKWS ETPCFEVANA
     RMNADNISTR KYQEDFENMK DQIYFMQTET PEYKMNKKAG VAASKVKYKE DYEKNKGKAD
     YNVLPASENP QLRQLKAAGD ALSDKLYKEN YEKTKAKSIN YCETPKFKLD TVLQNFSSDK
     KYKDSYLKDI LGHYVGSFED PYHSHCMKVT AQNSDKNYKA EYEEDRGKGF FPQTITQEYE
     AIKKLDQCKD HTYKVHPDKT KFTQVTDSPV LLQAQVNSKQ LSDLNYKAKH ESEKFKCHIP
     PDTPAFIQHK VNAYNLSDNL YKQDWEKSKA KKFDIKVDAI PLLAAKANTK NTSDVMYKKD
     YEKNKGKMIG VLSINDDPKM LHSLKVAKNQ SDRLYKENYE KTKAKSMNYC ETPKYQLDTQ
     LKNFSEARYK DLYVKDVLGH YVGSMEDPYH THCMKVAAQN SDKSYKAEYE EDKGKCYFPQ
     TITQEYEAIK KLDQCKDHTY KVHPDKTKFT AVTDSPVLLQ AQLNTKQLSD LNYKAKHEGE
     KFKCHIPADA PQFIQHRVNA YNLSDNVYKQ DWEKSKAKKF DIKVDAIPLL AAKANTKNTS
     DVMYKKDYEK SKGKMIGALS INDDPKMLHS LKTAKNQSDR EYRKDYEKSK TIYTAPLDML
     QVTQAKKSQA IASDVDYKHI LHSYSYPPDS INVDLAKKAY ALQSDVEYKA DYNSWMKGCG
     WVPFGSLEME KAKRASDILN EKKYRQHPDT LKFTSIEDAP ITVQSKINQA QRSDIAYKAK
     GEEIIHKYNL PPDLPQFIQA KVNAYNISEN MYKADLKDLS KKGYDLRTDA IPIRAAKAAR
     QAASDVQYKK DYEKAKGKMV GFQSLQDDPK LVHYMNVAKI QSDREYKKDY EKTKSKYNTP
     HDMFNVVAAK KAQDVVSNVN YKHSLHHYTY LPDAMDLELS KNMMQIQSDN VYKEDYNNWM
     KGIGWIPIGS LDVEKVKKAG DALNEKKYRQ HPDTLKFTSI VDSPVMVQAK QNTKQVSDIL
     YKAKGEDVKH KYTMSPDLPQ FLQAKCNAYN ISDVCYKRDW YDLIAKGNNV LGDAIPITAA
     KASRNIASDY KYKEAYEKSK GKHVGFRSLQ DDPKLVHYMN VAKLQSDREY KKNYENTKTS
     YHTPGDMVSI TAAKMAQDVA TNVNYKQPLH HYTYLPDAMS LEHTRNVNQI QSDNVYKDEY
     NSFLKGIGWI PIGSLEVEKV KKAGDALNER KYRQHPDTVK FTSVPDSMGM VLAQHNTKQL
     SDLNYKVEGE KLKHKYTIDP ELPQFIQAKV NALNMSDAHY KADWKKTIAK GYDLRPDAIP
     IVAAKSSRNI ASDCKYKEAY EKAKGKQVGF LSLQDDPKLV HYMNVAKIQS DREYKKGYEA
     SKTKYHTPLD MVSVTAAKKS QEVATNANYR QSYHHYTLLP DALNVEHSRN AMQIQSDNLY
     KSDFTNWMKG IGWVPIESLE VEKAKKAGEI LSEKKYRQHP EKLKFTYAMD TMEQALNKSN
     KLNMDKRLYT EKWNKDKTTI HVMPDTPDIL LSRVNQITMS DKLYKAGWEE EKKKGYDLRP
     DAIAIKAARA SRDIASDYKY KKAYEQAKGK HIGFRSLEDD PKLVHFMQVA KMQSDREYKK
     GYEKSKTSFH TPVDMLSVVA AKKSQEVATN ANYRNVIHTY NMLPDAMSFE LAKNMMQIQS
     DNQYKADYAD FMKGIGWLPL GSLEAEKNKK AMEIISEKKY RQHPDTLKYS TLMDSMNMVL
     AQNNAKIMNE HLYKQAWEAD KTKVHIMPDI PQIILAKANA INMSDKLYKL SLEESKKKGY
     DLRPDAIPIK AAKASRDIAS DYKYKYNYEK GKGKMVGFRS LEDDPKLVHS MQVAKMQSDR
     EYKKNYENTK TSYHTPADML SVTAAKDAQA NITNTNYKHL IHKYILLPDA MNIELTRNMN
     RIQSDNEYKQ DYNEWYKGLG WSPAGSLEVE KAKKATEYAS DQKYRQHPSN FQFKKLTDSM
     DMVLAKQNAH TMNKHLYTID WNKDKTKIHV MPDTPDILQA KQNQTLYSQK LYKLGWEEAL
     KKGYDLPVDA ISVQLAKASR DIASDYKYKQ GYRKQLGHHV GFRSLQDDPK LVLSMNVAKM
     QSEREYKKDF EKWKTKFSSP VDMLGVVLAK KCQELVSDVD YKNYLHQWTC LPDQNDVVQA
     KKVYELQSEN LYKSDLEWLR GIGWSPLGSL EAEKNKRASE IISEKKYRQP PDRNKFTSIP
     DAMDIVLAKT NAKNRSDRLY REAWDKDKTQ IHIMPDTPDI VLAKANLINT SDKLYRMGYE
     ELKRKGYDLP VDAIPIKAAK ASREIASEYK YKEGFRKQLG HHIGARNIED DPKMMWSMHV
     AKIQSDREYK KDFEKWKTKF SSPVDMLGVV LAKKCQTLVS DVDYKNYLHQ WTCLPDQSDV
     IHARQAYDLQ SDNLYKSDLQ WLKGIGWMTS GSLEDEKNKR ATQILSDHVY RQHPDQFKFS
     SLMDSIPMVL AKNNAITMNH RLYTEAWDKD KTTVHIMPDT PEVLLAKQNK VNYSEKLYKL
     GLEEAKRKGY DMRVDAIPIK AAKASRDIAS EFKYKEGYRK QLGHHIGARA IRDDPKMMWS
     MHVAKIQSDR EYKKDFEKWK TKFSSPVDML GVVLAKKCQT LVSDVDYKNY LHQWTCLPDQ
     SDVIHARQAY DLQSDNMYKS DLQWMRGIGW VSIGSLDVEK CKRATEILSD KIYRQPPDRF
     KFTSVTDSLE QVLAKNNAIT MNKRLYTEAW DKDKTQIHIM PDTPEIMLAR QNKINYSETL
     YKLANEEAKK KGYDLRSDAI PIVAAKASRD VISDYKYKDG YRKQLGHHIG ARNIEDDPKM
     MWSMHVAKIQ SDREYKKDFE KWKTKFSSPV DMLGVVLAKK CQTLVSDVDY KNYLHEWTCL
     PDQNDVIHAR QAYDLQSDNI YKSDLQWLRG IGWVPIGSMD VVKCKRAAEI LSDNIYRQPP
     DKLKFTSVTD SLEQVLAKNN ALNMNKRLYT EAWDKDKTQV HIMPDTPEIM LARQNKINYS
     ESLYRQAMEE AKKEGYDLRS DAIPIVAAKA SRDIASDYKY KEAYRKQLGH HIGARAVHDD
     PKIMWSLHIA KVQSDREYKK DFEKYKTRYS SPVDMLGIVL AKKCQTLVSD VDYKHPLHEW
     ICLPDQNDII HARKAYDLQS DNLYKSDLEW MKGIGWVPID SLEVVRAKRA GELLSDTIYR
     QRPETLKFTS ITDTPEQVLA KNNALNMNKR LYTEAWDNDK KTIHVMPDTP EIMLAKLNRI
     NYSDKLYKLA LEESKKEGYD LRLDAIPIQA AKASRDIASD YKYKEGYRKQ LGHHIGARNI
     KDDPKMMWSI HVAKIQSDRE YKKEFEKWKT KFSSPVDMLG VVLAKKCQIL VSDIDYKHPL
     HEWTCLPDQN DVIQARKAYD LQSDAIYKSD LEWLRGIGWV PIGSVEVEKV KRAGEILSDR
     KYRQPADQLK FTCITDTPEI VLAKNNALTM SKHLYTEAWD ADKTSIHVMP DTPDILLAKS
     NSANISQKLY TKGWDESKMK DYDLRADAIS IKSAKASRDI ASDYKYKEAY EKQKGHHIGA
     QSIEDDPKIM CAIHAGKIQS EREYKKEFQK WKTKFSSPVD MLSILLAKKC QTLVTDIDYR
     NYLHEWTCMP DQNDIIQAKK AYDLQSDALY KADLEWLRGI GWMPQGSPEV LRVKNAQNIF
     CDSVYRTPVV NLKYTSIVDT PEVVLAKSNA ENISIPKYRE VWDKDKTSIH IMPDTPEINL
     ARANALNVSN KLYREGWDEM KAGCDVRLDA IPIQAAKASR EIASDYKYKL DHEKQKGHYV
     GTLTARDDNK IRWALIADKL QNEREYRLDW AKWKAKIQSP VDMLSILHSK NSQALVSDMD
     YRNYLHQWTC MPDQNDVIQA KKAYELQSDN VYKADLEWLR GIGWMPNDSV SVNHAKHAAD
     IFSEKKYRTK IETLNFTPVD DRVDYVTAKQ SGEILDDIKY RKDWNATKSK YTLTETPLLH
     TAQEAARILD QYLYKEGWER QKATGYILPP DAVPFVHAHH CNDVQSELKY KAEHVKQKGH
     YVGVPTMRDD PKLVWFEHAG QIQNERLYKE DYHKTKAKIN IPADMVSVLA AKQGQTLVSD
     IDYRNYLHQW MCHPDQNDVI QARKAYDLQS DNVYRADLEW LRGIGWIPLD SVDHVRVTKN
     QEMMSQIKYK KNALENYPNF RSVVDPPEIV LAKINSVNQS DVKYKETFNK AKGKYTFSPD
     TPHISHSKDM GKLYSTILYK GAWEGTKAYG YTLDERYIPI VGAKHADLVN SELKYKETYE
     KQKGHYLAGK VIGEFPGVVH CLDFQKMRSA LNYRKHYEDT KANVHIPNDM MNHVLAKRCQ
     YILSDLEYRH YFHQWTSLLE EPNVIRVRNA QEILSDNVYK DDLNWLKGIG CYVWDTPQIL
     HAKKSYDLQS QLQYTAAGKE NLQNYNLVTD TPLYVTAVQS GINASEVKYK ENYHQIKDKY
     TTVLETVDYD RTRNLKNLYS SNLYKEAWDR VKATSYILPS STLSLTHAKN QKHLASHIKY
     REEYEKFKAL YTLPRSVDDD PNTARCLRVG KLNIDRLYRS VYEKNKMKIH IVPDMVEMVT
     AKDSQKKVSE IDYRLRLHEW ICHPDLQVND HVRKVTDQIS DIVYKDDLNW LKGIGCYVWD
     TPEILHAKHA YDLRDDIKYK AHMLKTRNDY KLVTDTPVYV QAVKSGKQLS DAVYHYDYVH
     SVRGKVAPTT KTVDLDRALH AYKLQSSNLY KTSLRTLPTG YRLPGDTPHF KHIKDTRYMS
     SYFKYKEAYE HTKAYGYTLG PKDVPFVHVR RVNNVTSERL YRELYHKLKD KIHTTPDTPE
     IRQVKKTQEA VSELIYKSDF FKMQGHMISL PYTPQVIHCR YVGDITSDIK YKEDLQVLKG
     FGCFLYDTPD MVRSRHLRKL WSNYLYTDKA RKMRDKYKVV LDTPEYRKVQ ELKTHLSELV
     YRAAGKKQKS IFTSVPDTPD LLRAKRGQKL QSQYLYVELA TKERPHHHAG NQTTALKHAK
     DVKDMVSEKK YKIQYEKMKD KYTPVPDTPI LIRAKRAYWN ASDLRYKETF QKTKGKYHTV
     KDALDIVYHR KVTDDISKIK YKENYMSQLG IWRSIPDRPE HFHHRAVTDT VSDVKYKEDL
     TWLKGIGCYA YDTPDFTLAE KNKTLYSKYK YKEVFERTKS DFKYVADSPI NRHFKYATQL
     MNEKKYRADY EQRKDKYHLV VDEPRHLLAK TAGDQISQIK YRKNYEKSKD KFTSIVDTPE
     HLRTTKVNKQ ISDILYKLEY NKAKPRGYTT IHDTPMLLHV RKVKDEVSDL KYKEVYQRNK
     SNCTIEPDAV HIKAAKDAYK VNTNLDYKKQ YEANKAHWKW TPDRPDFLQA AKSSLQQSDF
     EYKLDREFLK GCKLSVTDDK NTVLALRNTL IESDLKYKEK HVKERGTCHA VPDTPQILLA
     KTVSNLVSEN KYKDHVKKHL AQGSYTTLPE TRDTVHVKEV TKHVSDTNYK KKFVKEKGKS
     NYSIMLEPPE VKHAMEVAKK QSDVAYRKDA KENLHYTTVA DRPDIKKATQ AAKQASEVEY
     RAKHRKEGSH GLSMLGRPDI EMAKKAAKLS SQVKYRENFD KEKGKTPKYN PKDSQLYKVM
     KDANNLASEV KYKADLKKLH KPVTDMKESL IMNHVLNTSQ LASSYQYKKK YEKSKGHYHT
     IPDNLEQLHL KEATELQSIV KYKEKYEKER GKPMLDFETP TYITAKESQQ MQSGKEYRKD
     YEESIKGRNL TGLEVTPALL HVKYATKIAS EKEYRKDLEE SIRGKGLTEM EDTPDMLRAK
     NATQILNEKE YKRDLELEVK GRGLNAMANE TPDFMRARNA TDIASQIKYK QSAEMEKANF
     TSVVDTPEII HAQQVKNLSS QKKYKEDAEK SMSYYETVLD TPEIQRVREN QKNFSLLQYQ
     CDLKNSKGKI TVVQDTPEIL RVKENQKNFS SVLYKEDVSP GTAIGKTPEM MRVKQTQDHI
     SSVKYKEAIG QGTPIPDLPE VKRVKETQKH ISSVMYKENL GTGIPTTVTP EIERVKRNQE
     NFSSVLYKEN LGKGIPTPIT PEMERVKRNQ ENFSSVLYKE NMGKGTPLAV TPEMERVKHN
     QENISSVLYK ENVGKATATP VTPEMQRVKR NQENISSVLY KENLGKATPT PFTPEMERVK
     RNQENFSSVL YKENMRKATP TPVTPEMERA KRNQENISSV LYSDSFRKQI QGKAAYVLDT
     PEMRRVRETQ RHISTVKYHE DFEKHKGCFT PVVTDPITER VKKNMQDFSD INYRGIQRKV
     VEMEQKRNDQ DQETITGLRV WRTNPGSVFD YDPAEDNIQS RSLHMINVQA QRRSREQSRS
     ASALSISGGE EKSEHSEAPD HHLSTYSDGG VFAVSTAYKH AKTTELPQQR SSSVATQQTT
     VSSIPSHPST AGKIFRAMYD YMAADADEVS FKDGDAIINV QAIDEGWMYG TVQRTGRTGM
     LPANYVEAI
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