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P20921 (FRDB_PROVU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Fumarate reductase iron-sulfur subunit

EC=1.3.5.1
Gene names
Name:frdB
OrganismProteus vulgaris
Taxonomic identifier585 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus

Protein attributes

Sequence length245 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth.

Catalytic activity

Succinate + a quinone = fumarate + a quinol.

Cofactor

Binds 1 2Fe-2S cluster.

Binds 1 3Fe-4S cluster.

Binds 1 4Fe-4S cluster.

Subunit structure

Fumarate dehydrogenase forms part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, and two hydrophobic anchor proteins.

Sequence similarities

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

Contains 1 2Fe-2S ferredoxin-type domain.

Contains 1 4Fe-4S ferredoxin-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 245244Fumarate reductase iron-sulfur subunit
PRO_0000158706

Regions

Domain13 – 98862Fe-2S ferredoxin-type
Domain141 – 170304Fe-4S ferredoxin-type

Sites

Metal binding591Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding641Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding671Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding791Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1501Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1531Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1561Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1601Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2061Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2121Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2161Iron-sulfur 2 (4Fe-4S) By similarity

Sequences

Sequence LengthMass (Da)Tools
P20921 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: CEA17E28C8A390C2

FASTA24527,331
        10         20         30         40         50         60 
MADDMKHVKM EVMRYNPETD DAPHFVTYDV PYDEQTSLLD ALGYIKDNLA PDLSYRWSCR 

        70         80         90        100        110        120 
MAICGSCGMM VNRVPKLACK TFMRDYPNGV RIEALGNFPV ERDLVVDMTH FIESLEAIKP 

       130        140        150        160        170        180 
YILGNDRKPS EGPNKQTPAQ MAKYHQFSGC INCGLCYAAC PQFGLNPEFI GPAAITLAQR 

       190        200        210        220        230        240 
YNTDSRDHGA KERMPQLNGE NGVWSCTFVG YCSEVCPKHV DPAAAIQQGK AASAQDFVIA 


MLKPR 

« Hide

References

[1]"Nucleotide sequence and comparative analysis of the frd operon encoding the fumarate reductase of Proteus vulgaris. Extensive sequence divergence of the membrane anchors and absence of an frd-linked ampC cephalosporinase gene."
Cole S.T.
Eur. J. Biochem. 167:481-488(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X06144 Genomic DNA. Translation: CAA29502.1.
PIRRDEBIV. S00108.

3D structure databases

ProteinModelPortalP20921.
SMRP20921. Positions 4-245.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.10.20.30. 1 hit.
InterProIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamPF13085. Fer2_3. 1 hit.
PF13183. Fer4_8. 1 hit.
[Graphical view]
SUPFAMSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsTIGR00384. dhsB. 1 hit.
PROSITEPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFRDB_PROVU
AccessionPrimary (citable) accession number: P20921
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families