Reviewed,
UniProtKB/Swiss-Prot P20916 (MAG_HUMAN)
Last modified
July 13, 2010.
Version 114.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and originHide
| Protein names | Recommended name: Myelin-associated glycoprotein Alternative name(s): Siglec-4a | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributesHide
| Sequence length | 626 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)Hide
| Function | Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3-linked sialic acid By similarity. |
| Subunit structure | Binds to RTN4R By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. Contains 4 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain. |
OntologiesHide
| Keywords | |
|---|---|
| Biological process | Cell adhesion |
| Cellular component | Membrane |
| Coding sequence diversity | Polymorphism |
| Domain | Immunoglobulin domain Repeat Signal Transmembrane |
| Ligand | Lectin |
| PTM | Disulfide bond Glycoprotein Lipoprotein Palmitate |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of axonogenesisInferred from Experiment. Source: Reactome |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from Experiment. Source: Reactome |
| Molecular function | sugar binding Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)Hide
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 19 | 19 | |||||||||
| Chain | 20 – 626 | 607 | Myelin-associated glycoprotein | PRO_0000014856 | |||||||
Regions | |||||||||||
| Topological domain | 20 – 516 | 497 | Extracellular Potential | ||||||||
| Transmembrane | 517 – 536 | 20 | Helical; Potential | ||||||||
| Topological domain | 537 – 626 | 90 | Cytoplasmic Potential | ||||||||
| Domain | 22 – 120 | 99 | Ig-like V-type | ||||||||
| Domain | 139 – 237 | 99 | Ig-like C2-type 1 | ||||||||
| Domain | 241 – 325 | 85 | Ig-like C2-type 2 | ||||||||
| Domain | 327 – 412 | 86 | Ig-like C2-type 3 | ||||||||
| Domain | 413 – 508 | 96 | Ig-like C2-type 4 | ||||||||
Sites | |||||||||||
| Binding site | 118 | 1 | Sialic acid By similarity | ||||||||
| Site | 332 | 1 | Not glycosylated | ||||||||
Amino acid modifications | |||||||||||
| Lipidation | 531 | 1 | S-palmitoyl cysteine By similarity | ||||||||
| Glycosylation | 99 | 1 | N-linked (GlcNAc...) Ref.5 | ||||||||
| Glycosylation | 106 | 1 | N-linked (GlcNAc...); partial Ref.5 | ||||||||
| Glycosylation | 223 | 1 | N-linked (GlcNAc...) Ref.5 | ||||||||
| Glycosylation | 246 | 1 | N-linked (GlcNAc...) Ref.5 | ||||||||
| Glycosylation | 315 | 1 | N-linked (GlcNAc...) Ref.5 | ||||||||
| Glycosylation | 406 | 1 | N-linked (GlcNAc...) Ref.5 | ||||||||
| Glycosylation | 450 | 1 | N-linked (GlcNAc...) Ref.5 | ||||||||
| Glycosylation | 454 | 1 | N-linked (GlcNAc...) Ref.5 | ||||||||
| Disulfide bond | 37 ↔ 165 | By similarity | |||||||||
| Disulfide bond | 42 ↔ 100 | By similarity | |||||||||
| Disulfide bond | 159 ↔ 217 | By similarity | |||||||||
| Disulfide bond | 261 ↔ 305 | By similarity | |||||||||
| Disulfide bond | 347 ↔ 392 | By similarity | |||||||||
| Disulfide bond | 421 ↔ 430 | By similarity | |||||||||
| Disulfide bond | 432 ↔ 488 | By similarity | |||||||||
Natural variations | |||||||||||
| Natural variant | 202 | 1 | L → M. [dbSNP:rs11084810] | VAR_059399 | |||||||
Experimental info | |||||||||||
| Sequence conflict | 614 | 1 | T → S Ref.2 | ||||||||
SequencesHide
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ReferencesHide
| « Hide 'large scale' references | |
| [1] | "cDNA cloning and amino acid sequence for human myelin-associated glycoprotein." Sato S., Fujita N., Kurihara T., Kuwano R., Sakimura K., Takahashi Y., Miyatake T. Biochem. Biophys. Res. Commun. 163:1473-1480(1989) [PubMed: 2476987] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Molecular cloning of human myelin-associated glycoprotein." Spagnol G., Williams M., Srinivasan J., Golier J., Bauer D., Lebo R.V., Latov N. J. Neurosci. Res. 24:137-142(1989) [PubMed: 2479762] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain. |
| [3] | "The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. Lucas S.M.Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [5] | "Identification of the glycosylated sequons of human myelin-associated glycoprotein." Burger D., Pidoux L., Steck A.J. Biochem. Biophys. Res. Commun. 197:457-464(1993) [PubMed: 7505568] [Abstract] Cited for: GLYCOSYLATION AT ASN-99; ASN-106; ASN-223; ASN-246; ASN-315; ASN-406; ASN-450 AND ASN-454, LACK OF GLYCOSYLATION AT ASN-332. |
| + | Additional computationally mapped references. |
Cross-referencesHide
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | M29273 mRNA. Translation: AAA59545.1. AC002132 Genomic DNA. Translation: AAB58805.1. BC053347 mRNA. Translation: AAH53347.1. |
| IPI | IPI00026237. |
| PIR | A61084. |
| RefSeq | NP_002352.1. NP_542167.1. |
| UniGene | Hs.643440 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P20916. |
PTM databases | |
| PhosphoSite | P20916. |
Proteomic databases | |
| PRIDE | P20916. |
Genome annotation databases | |
| Ensembl | ENST00000262624; ENSP00000262624; ENSG00000105695; Homo sapiens. [Genome view] |
| GeneID | 4099. |
| KEGG | hsa:4099. |
| UCSC | uc002nyy.1. human. |
Organism-specific databases | |
| CTD | 4099. |
| GeneCards | GC19P040474. |
| HGNC | HGNC:6783. MAG. |
| HPA | CAB009345. HPA012499. |
| MIM | 159460. gene. |
| PharmGKB | PA30541. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG09606. |
| HOVERGEN | HBG006317. |
| InParanoid | P20916. |
| OMA | IINTPNI. |
| OrthoDB | EOG9P5NVG. |
| PhylomeDB | P20916. |
Enzyme and pathway databases | |
| Pathway_Interaction_DB | p75ntrpathway. p75(NTR)-mediated signaling. |
| Reactome | REACT_11061. Signalling by NGF. REACT_604. Hemostasis. REACT_6900. Signaling in Immune system. |
Gene expression databases | |
| ArrayExpress | P20916. |
| Bgee | P20916. |
| CleanEx | HS_MAG. |
| Genevestigator | P20916. |
| GermOnline | ENSG00000105695. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR013162. CD80_C2-set. IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003599. Ig_sub. IPR003598. Ig_sub2. [Graphical view] |
| Gene3D | G3DSA:2.60.40.10. Ig-like_fold. 3 hits. |
| Pfam | PF08205. C2-set_2. 1 hit. PF07679. I-set. 2 hits. [Graphical view] |
| SMART | SM00409. IG. 1 hit. SM00408. IGc2. 2 hits. [Graphical view] |
| PROSITE | PS50835. IG_LIKE. 3 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 16074. |
| PMAP-CutDB | P20916. |
| SOURCE | Search... |
Entry informationHide
| Entry name | MAG_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P20916 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documentsHide
| Human chromosome 19 Human chromosome 19: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


