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P20916

- MAG_HUMAN

UniProt

P20916 - MAG_HUMAN

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Protein
Myelin-associated glycoprotein
Gene
MAG, GMA
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3-linked sialic acid By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei118 – 1181Sialic acid By similarity
Sitei332 – 3321Not glycosylated

GO - Biological processi

  1. blood coagulation Source: Reactome
  2. cell adhesion Source: UniProtKB-KW
  3. leukocyte migration Source: Reactome
  4. negative regulation of axonogenesis Source: Reactome
  5. neurotrophin TRK receptor signaling pathway Source: Reactome
  6. regulation of axonogenesis Source: Reactome
  7. substantia nigra development Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Lectin

Enzyme and pathway databases

ReactomeiREACT_12560. Basigin interactions.
REACT_13815. Axonal growth inhibition (RHOA activation).

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin-associated glycoprotein
Alternative name(s):
Siglec-4a
Gene namesi
Name:MAG
Synonyms:GMA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:6783. MAG.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 516497Extracellular Reviewed prediction
Add
BLAST
Transmembranei517 – 53620Helical; Reviewed prediction
Add
BLAST
Topological domaini537 – 62690Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Schmidt-Lanterman incisure Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. paranode region of axon Source: Ensembl
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30541.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919
Add
BLAST
Chaini20 – 626607Myelin-associated glycoprotein
PRO_0000014856Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 165 By similarity
Disulfide bondi42 ↔ 100 By similarity
Glycosylationi99 – 991N-linked (GlcNAc...)1 Publication
Glycosylationi106 – 1061N-linked (GlcNAc...); partial1 Publication
Disulfide bondi159 ↔ 217 By similarity
Glycosylationi223 – 2231N-linked (GlcNAc...)1 Publication
Glycosylationi246 – 2461N-linked (GlcNAc...)1 Publication
Disulfide bondi261 ↔ 305 By similarity
Glycosylationi315 – 3151N-linked (GlcNAc...)1 Publication
Disulfide bondi347 ↔ 392 By similarity
Glycosylationi406 – 4061N-linked (GlcNAc...)1 Publication
Disulfide bondi421 ↔ 430 By similarity
Disulfide bondi432 ↔ 488 By similarity
Glycosylationi450 – 4501N-linked (GlcNAc...)1 Publication
Glycosylationi454 – 4541N-linked (GlcNAc...)1 Publication
Lipidationi531 – 5311S-palmitoyl cysteine By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP20916.
PRIDEiP20916.

PTM databases

PhosphoSiteiP20916.

Miscellaneous databases

PMAP-CutDBP20916.

Expressioni

Gene expression databases

ArrayExpressiP20916.
BgeeiP20916.
CleanExiHS_MAG.
GenevestigatoriP20916.

Organism-specific databases

HPAiCAB009345.
HPA012499.

Interactioni

Subunit structurei

Binds to RTN4R By similarity.

Protein-protein interaction databases

BioGridi110273. 11 interactions.
DIPiDIP-58523N.
IntActiP20916. 1 interaction.
MINTiMINT-3009422.
STRINGi9606.ENSP00000262624.

Structurei

3D structure databases

ProteinModelPortaliP20916.
SMRiP20916. Positions 26-503.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 12099Ig-like V-type
Add
BLAST
Domaini139 – 23799Ig-like C2-type 1
Add
BLAST
Domaini241 – 32585Ig-like C2-type 2
Add
BLAST
Domaini327 – 41286Ig-like C2-type 3
Add
BLAST
Domaini413 – 50896Ig-like C2-type 4
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG290903.
HOGENOMiHOG000113464.
HOVERGENiHBG006317.
InParanoidiP20916.
KOiK06771.
OMAiCQASFPN.
OrthoDBiEOG7JDQX2.
PhylomeDBiP20916.
TreeFamiTF332441.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 2 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P20916-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MIFLTALPLF WIMISASRGG HWGAWMPSSI SAFEGTCVSI PCRFDFPDEL    50
RPAVVHGVWY FNSPYPKNYP PVVFKSRTQV VHESFQGRSR LLGDLGLRNC 100
TLLLSNVSPE LGGKYYFRGD LGGYNQYTFS EHSVLDIVNT PNIVVPPEVV 150
AGTEVEVSCM VPDNCPELRP ELSWLGHEGL GEPAVLGRLR EDEGTWVQVS 200
LLHFVPTREA NGHRLGCQAS FPNTTLQFEG YASMDVKYPP VIVEMNSSVE 250
AIEGSHVSLL CGADSNPPPL LTWMRDGTVL REAVAESLLL ELEEVTPAED 300
GVYACLAENA YGQDNRTVGL SVMYAPWKPT VNGTMVAVEG ETVSILCSTQ 350
SNPDPILTIF KEKQILSTVI YESELQLELP AVSPEDDGEY WCVAENQYGQ 400
RATAFNLSVE FAPVLLLESH CAAARDTVQC LCVVKSNPEP SVAFELPSRN 450
VTVNESEREF VYSERSGLVL TSILTLRGQA QAPPRVICTA RNLYGAKSLE 500
LPFQGAHRLM WAKIGPVGAV VAFAILIAIV CYITQTRRKK NVTESPSFSA 550
GDNPPVLFSS DFRISGAPEK YESERRLGSE RRLLGLRGEP PELDLSYSHS 600
DLGKRPTKDS YTLTEELAEY AEIRVK 626
Length:626
Mass (Da):69,069
Last modified:February 1, 1991 - v1
Checksum:iED2D36B24F21CAAA
GO
Isoform 2 (identifier: P20916-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     574-626: ERRLGSERRLLGLRGEPPELDLSYSHSDLGKRPTKDSYTLTEELAEYAEIRVK → KEVSTLESH

Note: No experimental confirmation available.

Show »
Length:582
Mass (Da):63,966
Checksum:iA063EDC5681F3638
GO
Isoform 3 (identifier: P20916-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: Missing.

Note: No experimental confirmation available.

Show »
Length:601
Mass (Da):66,224
Checksum:iE51F6F12D9B87B35
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti202 – 2021L → M.1 Publication
Corresponds to variant rs11084810 [ dbSNP | Ensembl ].
VAR_059399

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2525Missing in isoform 3.
VSP_045843Add
BLAST
Alternative sequencei574 – 62653ERRLG…EIRVK → KEVSTLESH in isoform 2.
VSP_042688Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti614 – 6141T → S1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M29273 mRNA. Translation: AAA59545.1.
AK294644 mRNA. Translation: BAH11831.1.
AC002132 Genomic DNA. Translation: AAB58805.1.
AD000684 Genomic DNA. No translation available.
BC053347 mRNA. Translation: AAH53347.1.
BC093045 mRNA. Translation: AAH93045.1.
CCDSiCCDS12455.1. [P20916-1]
CCDS12456.1. [P20916-2]
CCDS56090.1. [P20916-3]
PIRiA61084.
RefSeqiNP_001186145.1. NM_001199216.1. [P20916-3]
NP_002352.1. NM_002361.3. [P20916-1]
NP_542167.1. NM_080600.2. [P20916-2]
UniGeneiHs.643440.

Genome annotation databases

EnsembliENST00000361922; ENSP00000355234; ENSG00000105695. [P20916-2]
ENST00000392213; ENSP00000376048; ENSG00000105695. [P20916-1]
ENST00000537831; ENSP00000440695; ENSG00000105695. [P20916-3]
GeneIDi4099.
KEGGihsa:4099.
UCSCiuc002nyx.2. human. [P20916-2]
uc002nyy.2. human. [P20916-1]

Polymorphism databases

DMDMi126689.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Siglec-4

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M29273 mRNA. Translation: AAA59545.1 .
AK294644 mRNA. Translation: BAH11831.1 .
AC002132 Genomic DNA. Translation: AAB58805.1 .
AD000684 Genomic DNA. No translation available.
BC053347 mRNA. Translation: AAH53347.1 .
BC093045 mRNA. Translation: AAH93045.1 .
CCDSi CCDS12455.1. [P20916-1 ]
CCDS12456.1. [P20916-2 ]
CCDS56090.1. [P20916-3 ]
PIRi A61084.
RefSeqi NP_001186145.1. NM_001199216.1. [P20916-3 ]
NP_002352.1. NM_002361.3. [P20916-1 ]
NP_542167.1. NM_080600.2. [P20916-2 ]
UniGenei Hs.643440.

3D structure databases

ProteinModelPortali P20916.
SMRi P20916. Positions 26-503.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110273. 11 interactions.
DIPi DIP-58523N.
IntActi P20916. 1 interaction.
MINTi MINT-3009422.
STRINGi 9606.ENSP00000262624.

Chemistry

BindingDBi P20916.
ChEMBLi CHEMBL5807.

PTM databases

PhosphoSitei P20916.

Polymorphism databases

DMDMi 126689.

Proteomic databases

PaxDbi P20916.
PRIDEi P20916.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000361922 ; ENSP00000355234 ; ENSG00000105695 . [P20916-2 ]
ENST00000392213 ; ENSP00000376048 ; ENSG00000105695 . [P20916-1 ]
ENST00000537831 ; ENSP00000440695 ; ENSG00000105695 . [P20916-3 ]
GeneIDi 4099.
KEGGi hsa:4099.
UCSCi uc002nyx.2. human. [P20916-2 ]
uc002nyy.2. human. [P20916-1 ]

Organism-specific databases

CTDi 4099.
GeneCardsi GC19P035787.
H-InvDB HIX0080123.
HGNCi HGNC:6783. MAG.
HPAi CAB009345.
HPA012499.
MIMi 159460. gene.
neXtProti NX_P20916.
PharmGKBi PA30541.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG290903.
HOGENOMi HOG000113464.
HOVERGENi HBG006317.
InParanoidi P20916.
KOi K06771.
OMAi CQASFPN.
OrthoDBi EOG7JDQX2.
PhylomeDBi P20916.
TreeFami TF332441.

Enzyme and pathway databases

Reactomei REACT_12560. Basigin interactions.
REACT_13815. Axonal growth inhibition (RHOA activation).

Miscellaneous databases

GeneWikii Myelin-associated_glycoprotein.
GenomeRNAii 4099.
NextBioi 16074.
PMAP-CutDB P20916.
PROi P20916.
SOURCEi Search...

Gene expression databases

ArrayExpressi P20916.
Bgeei P20916.
CleanExi HS_MAG.
Genevestigatori P20916.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
InterProi IPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view ]
Pfami PF08205. C2-set_2. 1 hit.
PF07679. I-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
SM00408. IGc2. 2 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and amino acid sequence for human myelin-associated glycoprotein."
    Sato S., Fujita N., Kurihara T., Kuwano R., Sakimura K., Takahashi Y., Miyatake T.
    Biochem. Biophys. Res. Commun. 163:1473-1480(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT MET-202.
    Tissue: Brain.
  4. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  6. "Identification of the glycosylated sequons of human myelin-associated glycoprotein."
    Burger D., Pidoux L., Steck A.J.
    Biochem. Biophys. Res. Commun. 197:457-464(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-99; ASN-106; ASN-223; ASN-246; ASN-315; ASN-406; ASN-450 AND ASN-454, LACK OF GLYCOSYLATION AT ASN-332.

Entry informationi

Entry nameiMAG_HUMAN
AccessioniPrimary (citable) accession number: P20916
Secondary accession number(s): B7Z2E5, F5GYC0, Q567S4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: September 3, 2014
This is version 152 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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