ID   HM19_XENLA              Reviewed;         105 AA.
AC   P20913;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   22-FEB-2023, entry version 101.
DE   RecName: Full=Homeotic protein NRL-19;
DE            Short=XlNRL-19;
DE   Flags: Fragment;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Neurula;
RX   PubMed=2235499; DOI=10.1093/nar/18.20.6131;
RA   Baltzinger M., Stiegler P., Remy P.;
RT   "Cloning and sequencing of POU-boxes expressed in Xenopus laevis neurula
RT   embryos.";
RL   Nucleic Acids Res. 18:6131-6131(1990).
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the POU transcription factor family. Class-3
CC       subfamily. {ECO:0000305}.
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DR   EMBL; X54680; CAA38494.1; -; mRNA.
DR   PIR; S12180; S12180.
DR   AlphaFoldDB; P20913; -.
DR   SMR; P20913; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR013847; POU.
DR   InterPro; IPR000327; POU_dom.
DR   PANTHER; PTHR11636; POU DOMAIN; 1.
DR   PANTHER; PTHR11636:SF133; POU DOMAIN, CLASS 3, TRANSCRIPTION FACTOR 1; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF00157; Pou; 1.
DR   PRINTS; PR00028; POUDOMAIN.
DR   SMART; SM00352; POU; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR   PROSITE; PS00465; POU_2; 1.
DR   PROSITE; PS51179; POU_3; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           <1..>105
FT                   /note="Homeotic protein NRL-19"
FT                   /id="PRO_0000100767"
FT   DOMAIN          <1..49
FT                   /note="POU-specific"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00530"
FT   DNA_BIND        67..>105
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   NON_TER         1
FT   NON_TER         105
SQ   SEQUENCE   105 AA;  11682 MW;  C8C05AA3686409B3 CRC64;
     QADVGLALGT LYGNVFSQTT ICRFEALQLS FKYMCKLKPL LNKWLEETDS TTESPINLDK
     IAAQGRKRKK RTSIEVGVKG ALENHFLKCP KPSAHEITSL ADSLQ
//